Exposure to indoor background radiation and urinary concentrations of 8-hydroxydeoxyguanosine, a marker of oxidative DNA damage. (1/20)

We investigated whether exposure to indoor [gamma]-radiation and radon might be associated with enough free radical formation to increase urinary concentrations of 8-hydroxydeoxyguanosine (8-OHdG), a sensitive marker of DNA damage, due to a hydroxyl radical attack at the C8 of guanine. Indoor radon and [gamma]-radiation levels were measured in 32 dwellings for 6 months by solid-state nuclear track detectors and thermoluminescent dosimeters, respectively. Urine samples for 8-OHdG determinations were obtained from 63 healthy adult subjects living in the measured dwellings. An overall tendency toward increasing levels of 8-OHdG with increasing levels of radon and [gamma]-radiation was seen in the females, presumably due to their estimated longer occupancy in the dwellings measured. Different models were considered for females, with the steepest slopes obtained for [gamma]-radiation with a coefficient of 0.500 (log nmol/l of 8-OHdG for each unit increase of [gamma]-radiation on a log scale) (p<0.01), and increasing to 0.632 (p = 0.035), but with larger variance, when radon was included in the model. In conclusion, there seems to be an effect of indoor radioactivity on the urinary excretion of 8-OHdG for females, who are estimated to have a higher occupancy in the dwellings measured than for males, for whom occupational and other agents may also influence 8-OHdG excretion. ree radicals; [gamma]-radiation; radon.  (+info)

Cancer risk around the nuclear power plants of Trillo and Zorita (Spain). (2/20)

AIM: To investigate the association between cancer risk and proximity of place of residence to the Guadalajara nuclear power plants: Trillo and Zorita. METHODS: Case-control study. Cases were patients admitted with cancer and controls were non-tumorous patients, both admitted to Guadalajara Hospital (period 1988-99). Exposure factor: place of residence (areas within 10, 20, and 30 km of each plant). Odds ratios (ORs) of those areas closest to the plants were calculated with respect to those furthest away; a linear trend analysis was also performed. RESULTS: In the extreme areas in the vicinity of Trillo, an OR of 1.71 was obtained (95% CI 1.15 to 2.53), increasing in magnitude in the subgroup of more radioinducible tumours and in the period considered as post-latency (1997-99). Risk increased linearly with proximity to the two plants, significantly in Trillo (p < 0.01) but not in Zorita (p = 0.19). CONCLUSIONS: There is an association between proximity of residence to Trillo and cancer risk, although the limitations of the study should be kept in mind when interpreting the possible causal relation.  (+info)


The current status of radiation protection in Canada is discussed in the last of a three-part series. Particular emphasis has been placed on the role of the Radiation Protection Division of the Department of National Health and Welfare. A radioactive fallout study program has been established involving the systematic collection of air and precipitation samples from 24 locations, soil samples from 23 locations, fresh-milk samples from 16 locations, wheat samples from nine areas and human-bone specimens from various hospitals throughout Canada. A whole-body-counting facility and a special study of fallout in Northern areas have also been initiated. For any age group, the highest average strontium-90 concentration in human bone so far reported has been less than four picocuries per gram of calcium compared with the maximum permissible level of 67 derived from the International Committee on Radiation Protection (ICRP) recommendations. By the end of 1963 a general downward trend of levels of radioactivity detected in other parts of the program has been observed. Programs to assess the contribution to the radiation exposure of members of the population from medical x-rays, nuclear reactor operations and natural background-radiation sources have also been described. The annual genetically significant dose from diagnostic x-ray examinations in Canadian public hospitals has been estimated to be 25.8 mrem. Results from the reactor-environment monitoring programs have not suggested the presence of radioactivity beyond that contributed from fallout.  (+info)

Radon in homes and risk of lung cancer: collaborative analysis of individual data from 13 European case-control studies. (4/20)

OBJECTIVE: To determine the risk of lung cancer associated with exposure at home to the radioactive disintegration products of naturally occurring radon gas. DESIGN: Collaborative analysis of individual data from 13 case-control studies of residential radon and lung cancer. SETTING: Nine European countries. SUBJECTS: 7148 cases of lung cancer and 14,208 controls. MAIN OUTCOME MEASURES: Relative risks of lung cancer and radon gas concentrations in homes inhabited during the previous 5-34 years measured in becquerels (radon disintegrations per second) per cubic metre (Bq/m3) of household air. RESULTS: The mean measured radon concentration in homes of people in the control group was 97 Bq/m3, with 11% measuring > 200 and 4% measuring > 400 Bq/m3. For cases of lung cancer the mean concentration was 104 Bq/m3. The risk of lung cancer increased by 8.4% (95% confidence interval 3.0% to 15.8%) per 100 Bq/m3 increase in measured radon (P = 0.0007). This corresponds to an increase of 16% (5% to 31%) per 100 Bq/m3 increase in usual radon--that is, after correction for the dilution caused by random uncertainties in measuring radon concentrations. The dose-response relation seemed to be linear with no threshold and remained significant (P = 0.04) in analyses limited to individuals from homes with measured radon < 200 Bq/m3. The proportionate excess risk did not differ significantly with study, age, sex, or smoking. In the absence of other causes of death, the absolute risks of lung cancer by age 75 years at usual radon concentrations of 0, 100, and 400 Bq/m3 would be about 0.4%, 0.5%, and 0.7%, respectively, for lifelong non-smokers, and about 25 times greater (10%, 12%, and 16%) for cigarette smokers. CONCLUSIONS: Collectively, though not separately, these studies show appreciable hazards from residential radon, particularly for smokers and recent ex-smokers, and indicate that it is responsible for about 2% of all deaths from cancer in Europe.  (+info)

Archeo-cell biology: carbon dating is not just for pots and dinosaurs. (5/20)

Defining the life span of specific human cell populations is limited by our inability to mark the exact time when cells are born in a way that can be detected over many years. In this issue of Cell, Spalding et al. (2005) describe a clever strategy for retrospectively birth dating human cells in vivo, based on their incorporation of 14C during a peak in atmospheric levels of this isotope resulting from above-ground nuclear arms testing in the 1950s.  (+info)

Indoor radon and lung cancer. Estimating the risks. (6/20)

Radon is ubiquitous in indoor environments. Epidemiologic studies of underground miners with exposure to radon and experimental evidence have established that radon causes lung cancer. The finding that this naturally occurring carcinogen is present in the air of homes and other buildings has raised concern about the lung cancer risk to the general population from radon. I review current approaches for assessing the risk of indoor radon, emphasizing the extrapolation of the risks for miners to the general population. Although uncertainties are inherent in this risk assessment, the present evidence warrants identifying homes that have unacceptably high concentrations.  (+info)

Indoor-atmospheric radon-related radioactivity affected by a change of ventilation strategy. (7/20)

The present author has kept observation for concentrations of atmospheric radon, radon progeny and thoron progeny for several years at the campus of Fukushima Medical University. Accidentally, in the midst of an observation term, i.e., February 2005, the facility management group of the university changed a strategy for the manner of ventilation, probably because of a recession: (I) tidy everyday ventilation of 7:30-24:00 into (II) shortened weekday ventilation of 8: 00-21 : 00 with weekend halts. This change of ventilation manner brought a clear alteration for the concentrations of radon-related natural radioactivity in indoor air. The present paper concerns an investigation of the effect of the ventilation strategy on the indoor-atmospheric radon-related radioactivity.  (+info)

Indoor radon concentrations and assessment of doses in four districts of the Punjab Province - Pakistan. (8/20)

Seasonal indoor radon measurement studies have been carried out in four districts, namely, Jhelum, Chakwal, Rawalpindi and Attock of the Punjab Province. In this regard, CR-39 based detectors were installed in bedrooms, drawing rooms and kitchens of 40 randomly selected houses in each district. After exposing to radon in each season, CR-39 detectors were etched in 6M NaOH at 80 degrees C and counted under an optical microscope. Indoor radon activity concentrations in the houses surveyed ranged from 15 +/- 4 to 176 +/- 7 Bq m(-3) with an overall average value of 55 +/- 31 Bq m(-3). The observed annual average values are greater than the world average of 40 Bq m(-3). Maximum indoor radon concentration levels were observed in winter season whereas minimum levels were observed in summer season. None of the measured radon concentration value exceeded the action level of 200-400 Bq m(-3). The season/annual ratios for different type of dwellings varied from 0.87 +/- 0.93 to 1.14 +/- 1.10. The mean annual estimated effective dose received by the residents of the studied area was found to be 1.39 +/- 0.78 mSv. The annual estimated effective dose is less than the recommended action level (3-10 mSv).  (+info)