A case of hypopituitarism and type V hyperlipidemia. (17/47)

A 29-year-old woman developed hypopituitarism following removal of a pituitary chromophobe adenoma, and this was complicated by type V hyperlipidemia and obesity.  (+info)

Visual evoked potentials in the assessment of patients with non-functioning chromophobe adenomas. (18/47)

The results of visual evoked potential (VEP) examination in 34 patients with histologically confirmed chromophobe adenoma are described and discussed in relation to the clinical, radiological and surgical findings. The VEP is shown to be a reliable method of assessing the function of the intracranial visual pathways which is often more sensitive than conventional methods of examination.  (+info)

Sequential growth hormone deficiency and acromegaly. (19/47)

This is the case of a patient with a pituitary tumour presenting initially with growth hormone deficiency and requiring treatment with human growth hormone. Eight years later he represented with acromegaly. This sequence of events has not to my knowledge been reported previously.  (+info)

Pituitary adenoma and orbital haemangioma: a case report. (20/47)

A 43-year-old woman with a pituitary tumour had unexplained right proptosis. Orbital x-rays and ultrasound were normal, but computed tomography showed an intraconal tumour, which had typical features of a cavernous haemangioma on carotid angiography. Both tumours were resected and confirmed histologically.  (+info)

Surgical experience with a microscopic transsphenoidal approach to pituitary tumors and non-neoplastic parasellar conditions. (21/47)

Improved surgical microscopes and intraoperative radiofluoroscopic television have revived the transsphenoidal approach to pituitary tumors. The transsphenoidal approach offers an alternative to craniotomy, and in certain situations it has distinct advantages. The reported experience includes the common pituitary tumors, hypersecreting microadenomas, cerebrospinal rhinorrhea and parasellar aneurysms. The surgical technique, indications and contraindications, and results in 44 transsphenoidal operations are described.  (+info)

Responsiveness of growth hormone-deficient children to human growth hormone. Effect of replacement therapy for one year. (22/47)

Previous studies have shown that growth hormone (GH)-deficient children are more responsive to exogenous human growth hormone (HGH) than non-GH-deficient children. In six GH-deficient children, velocity of linear growth was less than 2.5 cm/yr. By the metabolic balance study technique, anabolic responses (increments in elemental balances) were measured to a 7 day course of 0.0532 U HGH/kg body weight (BW)(3/4) per day (dose B) and to 0.168 U/kg BW(3/4) per day (dose C). They were then treated for 1 yr with HGH at a dose intermediate between B and C. Velocity of linear growth accelerated to 15-25 cm/yr for the first 4-7 mo, then declined to 0-8 cm/yr. At 12 mo, responsiveness to doses B and C was measured again; the responses were only 20-60% as great as before treatment. After 3 mo without HGH treatment, responsiveness to the anabolic effects of doses B and C returned to the magnitudes observed before treatment. A low titer of plasma antibodies to HGH was detected in two of the six children at the end of the year's treatment; these titers showed little change after 3 mo without HGH. Thus the hyperresponsiveness of GH-deficient subjects to exogenous HGH, compared to non-GH-deficient individuals, declines during long-term HGH treatment and is restored by 3 mo interruption of treatment. These changes in peripheral responsiveness may be related to the decline in velocity of linear growth which occurs after 4-7 mo of continuous treatment. When HGH was withdrawn after 12 mo, all six patients exhibited negative balances of N, P, Na, and K and loss of BW. Ratios of elemental balances showed about half the weight loss to represent protoplasm, and about half extracellular fluid. These observations indicate a role of GH in the continuing regulation of nitrogen and mineral metabolism in addition to its function as a growth-promoting hormone.  (+info)

Intracranial dissemination of pituitary adenomas. (23/47)

Two unusual cases of pituitary adenomas giving distant secondary deposits inside the cranial cavity are presented. The authors comment on the accessible literature and the possible routes and cause of the spread. Finally they discuss the problematic nomenclature and classification of these tumours.  (+info)

Binasal hemianopia. (24/47)

Three patients with nasal visual field defects are described. In each case it is believed that compression of the lateral fibres of the optic nerve by the anterior cerebral or internal carotid artery was the cause. Binasal hemianopia can thus be produced by a single lesion and is as much a true hemianopia as the common bitemporal one. The value of careful neuroradiological investigation to display the relationships of a tumour to the chiasma, optic nerves, and related vessels and thus explain the field defects is demonstrated.  (+info)