Immunoreactive somatostatin in Warthin's tumor.
(62/66)
The presence of somatostatin (SRIF) in the neoplastic epithelial cells of certain Warthin's tumors arising in the human parotid gland was found immunohistochemically, whereas the other parotid gland tumors, such as pleomorphic adenoma, oxyphilic adenoma, mucoepidermoid tumor, adenocarcinoma, and adenoid cystic carcinoma, did not show positive immunoreactivity for SRIF. The SRIF-positive Warthin's tumor had dense core granules immunoreactive with anti-SRIF serum. Moreover, a comparatively high concentration of immunoreactive SRIF was detected by radioimmunoassay in an SRIF-positive Warthin's tumor, although the other tumors also contained low levels of immunoreactive SRIF. (+info)
Malignant Warthin's tumour: an ultrastructural study.
(63/66)
Undifferentiated malignant cells in a Warthin's tumour (adenolymphoma) were studied by light and electron microscopy. The ultrastructure of these cells indicated that they were poorly differentiated adenocarcinoma arising from the glandular component of the Warthin's tumour. Some differences between this case and previous ultrastructural studies are described. (+info)
Cigarette smoking and Warthin's tumor.
(64/66)
The etiology of Warthin's tumor, a benign parotid gland tumor, is unknown. Recent evidence suggests a possible relation with cigarette smoking as well as increasing incidence. We reviewed the medical record of subjects with a major salivary gland tumor newly diagnosed in Jefferson County, Alabama, from 1968 to 1989, and identified 149 Warthin's tumors. The 533 cases with other major salivary gland tumors were used as controls. The analysis showed that 96% of Warthin's tumors occurred in whites. The relative incidence of Warthin's tumor among smokers versus nonsmokers was 7.6 for men (95 percent confidence interval 3.2-18.3; p < 0.001) and 17.4 for women (95 percent confidence interval 6.5-54.7; p < 0.001). Smokers of both sexes with Warthin's tumor smoked more heavily than did those with other salivary gland tumors (p < 0.001). From 1968 through 1988, Warthin's tumors steadily increased in number and as a proportion of salivary gland tumors (males, p = 0.003; females, p = 0.008). We also observed a significant increase in the incidence rate for Warthin's tumor (p = 0.041) but not for other salivary gland tumors. We conclude that Warthin's tumor is strongly associated with cigarette smoking and that the incidence rate is increasing. The disease is rare in blacks. (+info)