AnatomyDiseasesAnalytical, Diagnostic and Therapeutic Techniques and EquipmentAnthropology, Education, Sociology and Social Phenomena
HyperostosisAcquired Hyperostosis SyndromeHyperostosis, Diffuse Idiopathic SkeletalHyperostosis Frontalis InternaHyperostosis, SternocostoclavicularExostosesSyndromeMelorheostosisAnkylosisPaleopathologyPapilloma, InvertedOsteitisHyperostosis, Cortical, CongenitalSpinal OsteophytosisParanasal SinusesSkullCervical VertebraeBone Diseases, DevelopmentalMeningiomaSpinal DiseasesFibulaParanasal Sinus NeoplasmsSternumLongitudinal LigamentsMeningeal NeoplasmsSkull Base NeoplasmsTomography, X-Ray ComputedNose NeoplasmsBone and BonesDown Syndrome

Clinical and radiologic evolution of synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: a single center study of a cohort of 71 subjects. (17/31)

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Diffuse idiopathic skeletal hyperostosis in the Medici, Grand Dukes of Florence (XVI century). (18/31)

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Efficacy of antibiotic therapy for SAPHO syndrome is lost after its discontinuation: an interventional study. (19/31)

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Two different causes of acute respiratory failure in a patient with diffuse idiopathic skeletal hyperostosis and ankylosed cervical spine. (20/31)

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SAPHO syndrome: is a range of pathogen-associated rheumatic diseases extended? (21/31)

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Pancreatic hamartoma and SAPHO syndrome: a case report. (22/31)

We report the first case of an association of pancreatic hamartoma with SAPHO syndrome mimicking disseminated bone metastases. A 46 year old male with intermittent back pain for 10 years, relieved by NSAIDs and desquamation erythemathous palmo-plantar eruption one year before, presented with symptoms of duodenal stenosis, a cystic tumor at the head of the pancreas and osteoformative (hyperostosis) and osteodestructive (osteitis) lesions of the clavicle, mandible, lumbar spine. The bone lesions resembled bone metastases, but an inflammatory infiltrate and fibrosis were found on the excisional biopsy of left clavicle, compatible with the SAPHO syndrome. The pancreatic tumor grew rapidly and showed a histological aspect of malignancy at laparoscopy. A cephalic duodenopancreatectomy was performed, but the histological findings established the diagnosis of pancreatic hamartoma. Several months later, the bone Tc99m scintigraphy was normal.  (+info)

Biologic therapy in refractory chronic non-bacterial osteomyelitis of childhood. (23/31)

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SAPHO syndrome associated with hidradenitis suppurativa successfully treated with infliximab and methotrexate. (24/31)

SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, and osteitis) is a rare chronic inflammatory musculoskeletal disorder of unknown etiology observed in children and young adults, which involves both osteo-articular inflammation and skin abnormalities. We review the case of a 22-year-old male, who presented with a 5-year history of hidradenitis suppurativa (HS), acne vulgaris, joint stiffness, and pain. Previous ineffective treatments included isotretinoin and oral antibiotics. Marked improvement of all cutaneous features was noticed after the first dose of infliximab and methotrexate; continued treatment resulted in the complete remission of the arthritis and enthesopathy. This case report demonstrates the efficacy and safety of infliximab and methotrexate in refractory SAPHO syndrome.  (+info)