Genistein stimulates MCF-7 breast cancer cell growth by inducing acid ceramidase (ASAH1) gene expression.
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Acid ceramidase expression modulates the sensitivity of A375 melanoma cells to dacarbazine.
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Identification of cystatin SA as a novel inhibitor of acid ceramidase.
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Acid ceramidase (ASAH1) is a global regulator of steroidogenic capacity and adrenocortical gene expression.
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Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B.
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DNA damage induces down-regulation of UDP-glucose ceramide glucosyltransferase, increases ceramide levels and triggers apoptosis in p53-deficient cancer cells.
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Novel biochemical abnormalities and genotype in Farber disease.
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Farber disease caused by acid ceramidase deficiency is characterised by a triad of painful and swollen joints, subcutaneous nodules, and laryngeal involvement. A one year old female with overlapping features of the classical and type 5 variants is reported. Sialuria and elevated plasma chitotriosidase were unusual findings. A novel mutation of the ASAH 1 gene was detected from DNA extracted from the umbilical stump. (+info)
Spinal muscular atrophy associated with progressive myoclonic epilepsy is caused by mutations in ASAH1.
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