**Uncertainty**: The condition in which reasonable knowledge regarding risks, benefits, or the future is not available.

**Bayes Theorem**: A theorem in probability theory named for Thomas Bayes (1702-1761). In epidemiology, it is used to obtain the probability of disease in a group of people with some characteristic on the basis of the overall rate of that disease and of the likelihood of that characteristic in healthy and diseased individuals. The most familiar application is in clinical decision analysis where it is used for estimating the probability of a particular diagnosis given the appearance of some symptoms or test result.

**Models, Statistical**: Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.

**Clinical Chemistry Tests**: Laboratory tests demonstrating the presence of physiologically significant substances in the blood, urine, tissue, and body fluids with application to the diagnosis or therapy of disease.

**Models, Theoretical**: Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.

**Monte Carlo Method**: In statistics, a technique for numerically approximating the solution of a mathematical problem by studying the distribution of some random variable, often generated by a computer. The name alludes to the randomness characteristic of the games of chance played at the gambling casinos in Monte Carlo. (From Random House Unabridged Dictionary, 2d ed, 1993)

**Decision Theory**: A theoretical technique utilizing a group of related constructs to describe or prescribe how individuals or groups of people choose a course of action when faced with several alternatives and a variable amount of knowledge about the determinants of the outcomes of those alternatives.

**Decision Making**: The process of making a selective intellectual judgment when presented with several complex alternatives consisting of several variables, and usually defining a course of action or an idea.

**Algorithms**: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.

**Computer Simulation**: Computer-based representation of physical systems and phenomena such as chemical processes.

**Cost-Benefit Analysis**: A method of comparing the cost of a program with its expected benefits in dollars (or other currency). The benefit-to-cost ratio is a measure of total return expected per unit of money spent. This analysis generally excludes consideration of factors that are not measured ultimately in economic terms. Cost effectiveness compares alternative ways to achieve a specific set of results.

**Radiometry**: The measurement of radiation by photography, as in x-ray film and film badge, by Geiger-Mueller tube, and by SCINTILLATION COUNTING.

**Quality-Adjusted Life Years**: A measurement index derived from a modification of standard life-table procedures and designed to take account of the quality as well as the duration of survival. This index can be used in assessing the outcome of health care procedures or services. (BIOETHICS Thesaurus, 1994)

**Models, Biological**: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.

**Reproducibility of Results**: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.

**Markov Chains**: A stochastic process such that the conditional probability distribution for a state at any future instant, given the present state, is unaffected by any additional knowledge of the past history of the system.

**Radiotherapy Planning, Computer-Assisted**: Computer-assisted mathematical calculations of beam angles, intensities of radiation, and duration of irradiation in radiotherapy.

**Probability**: The study of chance processes or the relative frequency characterizing a chance process.

**Calibration**: Determination, by measurement or comparison with a standard, of the correct value of each scale reading on a meter or other measuring instrument; or determination of the settings of a control device that correspond to particular values of voltage, current, frequency or other output.

**Models, Economic**: Statistical models of the production, distribution, and consumption of goods and services, as well as of financial considerations. For the application of statistics to the testing and quantifying of economic theories MODELS, ECONOMETRIC is available.

**Risk Assessment**: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)

**Proton Therapy**: The use of an external beam of PROTONS as radiotherapy.

**Climate Change**: Any significant change in measures of climate (such as temperature, precipitation, or wind) lasting for an extended period (decades or longer). It may result from natural factors such as changes in the sun's intensity, natural processes within the climate system such as changes in ocean circulation, or human activities.

**Data Interpretation, Statistical**: Application of statistical procedures to analyze specific observed or assumed facts from a particular study.

**Conservation of Natural Resources**: The protection, preservation, restoration, and rational use of all resources in the total environment.

**Decision Support Techniques**: Mathematical or statistical procedures used as aids in making a decision. They are frequently used in medical decision-making.

**Likelihood Functions**: Functions constructed from a statistical model and a set of observed data which give the probability of that data for various values of the unknown model parameters. Those parameter values that maximize the probability are the maximum likelihood estimates of the parameters.

**Baltic States**: The collective name for the republics of ESTONIA; LATVIA; and LITHUANIA on the eastern shore of the Baltic Sea. (Webster's New Geographical Dictionary, 1988, p111)

**Environmental Monitoring**: The monitoring of the level of toxins, chemical pollutants, microbial contaminants, or other harmful substances in the environment (soil, air, and water), workplace, or in the bodies of people and animals present in that environment.

**Great Britain**

**Signal Detection, Psychological**: Psychophysical technique that permits the estimation of the bias of the observer as well as detectability of the signal (i.e., stimulus) in any sensory modality. (From APA, Thesaurus of Psychological Index Terms, 8th ed.)

**Sensitivity and Specificity**: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)

**Radiotherapy Setup Errors**: Mistakes committed in the preparations for radiotherapy, including errors in positioning of patients, alignment radiation beams, or calculation of radiation doses.

**Stochastic Processes**: Processes that incorporate some element of randomness, used particularly to refer to a time series of random variables.

**Fuzzy Logic**: Approximate, quantitative reasoning that is concerned with the linguistic ambiguity which exists in natural or synthetic language. At its core are variables such as good, bad, and young as well as modifiers such as more, less, and very. These ordinary terms represent fuzzy sets in a particular problem. Fuzzy logic plays a key role in many medical expert systems.

**Forecasting**: The prediction or projection of the nature of future problems or existing conditions based upon the extrapolation or interpretation of existing scientific data or by the application of scientific methodology.

**Reference Standards**: A basis of value established for the measure of quantity, weight, extent or quality, e.g. weight standards, standard solutions, methods, techniques, and procedures used in diagnosis and therapy.

**Body Burden**: The total amount of a chemical, metal or radioactive substance present at any time after absorption in the body of man or animal.

**Time Factors**: Elements of limited time intervals, contributing to particular results or situations.

**Climate**: The longterm manifestations of WEATHER. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

**Ecosystem**: A functional system which includes the organisms of a natural community together with their environment. (McGraw Hill Dictionary of Scientific and Technical Terms, 4th ed)

**Atmosphere**: The gaseous envelope surrounding a planet or similar body. (From Random House Unabridged Dictionary, 2d ed)

**Four-Dimensional Computed Tomography**: Three-dimensional computed tomographic imaging with the added dimension of time, to follow motion during imaging.

**Randomized Controlled Trials as Topic**: Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.

**Bias (Epidemiology)**: Any deviation of results or inferences from the truth, or processes leading to such deviation. Bias can result from several sources: one-sided or systematic variations in measurement from the true value (systematic error); flaws in study design; deviation of inferences, interpretations, or analyses based on flawed data or data collection; etc. There is no sense of prejudice or subjectivity implied in the assessment of bias under these conditions.

**Therapeutic Equipoise**: Expectation of real uncertainty on the part of the investigator regarding the comparative therapeutic merits of each arm in a trial.

**Cues**: Signals for an action; that specific portion of a perceptual field or pattern of stimuli to which a subject has learned to respond.

**Technology Assessment, Biomedical**: Evaluation of biomedical technology in relation to cost, efficacy, utilization, etc., and its future impact on social, ethical, and legal systems.

**Environmental Exposure**: The exposure to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals.

**Chamaemelum**: A plant genus of the family ASTERACEAE that is used in folk medicine as CHAMOMILE. Other plants with similar common names include MATRICARIA; TRIPLEUROSPERMUM and ANTHEMIS.

**Models, Genetic**: Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.

**Greenhouse Effect**: The effect of GLOBAL WARMING and the resulting increase in world temperatures. The predicted health effects of such long-term climatic change include increased incidence of respiratory, water-borne, and vector-borne diseases.

**Knowledge**: The body of truths or facts accumulated in the course of time, the cumulated sum of information, its volume and nature, in any civilization, period, or country.

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