Milk Thistle: The plant Silybum marianum in the family ASTERACEAE containing the bioflavonoid complex SILYMARIN. For centuries this has been used traditionally to treat liver disease. Silybum marianum (L.) Gaertn. = Carduus marianus L.Silymarin: A mixture of flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum. It consists primarily of silybin and its isomers, silicristin and silidianin. Silymarin displays antioxidant and membrane stabilizing activity. It protects various tissues and organs against chemical injury, and shows potential as an antihepatoxic agent.Flavonolignans: Heterodimers of FLAVONOIDS bound to LIGNANS.Cimicifuga: A plant genus of the family RANUNCULACEAE that contains triterpenoid saponins. Remifemin from C. racemosa is used to suppress LUTEINIZING HORMONE. It is reclassified by some to ACTAEA. The common name of black snakeroot is also used with ASARUM and SANICULA.Hydrastis: A plant genus of the family RANUNCULACEAE. Members contain BERBERINE.Herb-Drug Interactions: The effect of herbs, other PLANTS, or PLANT EXTRACTS on the activity, metabolism, or toxicity of drugs.Milk, HumanCarduus: A plant genus of the family ASTERACEAE. Members contain arctiin and onopordopicrin.Mushroom Poisoning: Poisoning from ingestion of mushrooms, primarily from, but not restricted to, toxic varieties.Genitalia: The external and internal organs related to reproduction.Amanita: A genus of fungi of the family Agaricaceae, order Agaricales; most species are poisonous.Plant Extracts: Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.Echinops Plant: A plant genus of the family ASTERACEAE. Members contain a pseudoguaiane sesquiterpene. San-fang-feng is the root of E. grijisii used in DRUGS, CHINESE HERBAL.Phytotherapy: Use of plants or herbs to treat diseases or to alleviate pain.Protective Agents: Synthetic or natural substances which are given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent.Plant Preparations: Material prepared from plants.Milk Proteins: The major protein constituents of milk are CASEINS and whey proteins such as LACTALBUMIN and LACTOGLOBULINS. IMMUNOGLOBULINS occur in high concentrations in COLOSTRUM and in relatively lower concentrations in milk. (Singleton and Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed, p554)Estrous Cycle: The period of cyclic physiological and behavior changes in non-primate female mammals that exhibit ESTRUS. The estrous cycle generally consists of 4 or 5 distinct periods corresponding to the endocrine status (PROESTRUS; ESTRUS; METESTRUS; DIESTRUS; and ANESTRUS).Cirsium: A plant genus of the family ASTERACEAE. Members contain pectolinarin (a flavonoid glycoside).Mutagenicity Tests: Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests.Carcinogenicity Tests: Tests to experimentally measure the tumor-producing/cancer cell-producing potency of an agent by administering the agent (e.g., benzanthracenes) and observing the quantity of tumors or the cell transformation developed over a given period of time. The carcinogenicity value is usually measured as milligrams of agent administered per tumor developed. Though this test differs from the DNA-repair and bacterial microsome MUTAGENICITY TESTS, researchers often attempt to correlate the finding of carcinogenicity values and mutagenicity values.