An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal CELL MEMBRANES. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.

An imidazole antifungal agent that is used topically and by intravenous infusion.

An imidazole derivative that is commonly used as a topical antifungal agent.

Infection of the VULVA and VAGINA with a fungus of the genus CANDIDA.

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.

An antifungal agent used in the treatment of TINEA infections.

Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.

A major class of calcium-activated potassium channels that were originally discovered in ERYTHROCYTES. They are found primarily in non-excitable CELLS and set up electrical gradients for PASSIVE ION TRANSPORT.

Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).

A mitosporic fungal genus and an anamorphic form of Arthroderma. Various species attack the skin, nails, and hair.

Inflammation of the head of the PENIS, glans penis.

'Benzene derivatives' are organic compounds that contain a benzene ring as the core structure, with various functional groups attached to it, and can have diverse chemical properties and uses, including as solvents, intermediates in chemical synthesis, and pharmaceuticals.

Dermatological pruritic lesion in the feet, caused by Trichophyton rubrum, T. mentagrophytes, or Epidermophyton floccosum.

A flat, flexible strip of material used to cover or fasten together damaged tissue.

A water-soluble medicinal preparation applied to the skin.

A fungal genus which grows in the epidermis and is the cause of TINEA.

A unicellular budding fungus which is the principal pathogenic species causing CANDIDIASIS (moniliasis).

An inhibitor of drug metabolism and CYTOCHROME P-450 ENZYME SYSTEM activity.

Five membered rings containing a NITROGEN atom.

Fungal infection of keratinized tissues such as hair, skin and nails. The main causative fungi include MICROSPORUM; TRICHOPHYTON; and EPIDERMOPHYTON.

Devices worn in the vagina to provide support to displaced uterus or rectum. Pessaries are used in conditions such as UTERINE PROLAPSE; CYSTOCELE; or RECTOCELE.

A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.

Inflammation of the VULVA and the VAGINA, characterized by discharge, burning, and PRURITUS.