Toxicity Tests, Acute
Toxicity Tests
An array of tests used to determine the toxicity of a substance to living systems. These include tests on clinical drugs, foods, and environmental pollutants.
Toxicity Tests, Subchronic
Toxicity Tests, Chronic
Lethal Dose 50
Toxicity Tests, Subacute
Morinda
Animal Testing Alternatives
Water Pollutants, Chemical
Daphnia
Skin Irritancy Tests
Amphipoda
An order of mostly marine CRUSTACEA containing more than 5500 species in over 100 families. Like ISOPODA, the other large order in the superorder Peracarida, members are shrimp-like in appearance, have sessile compound eyes, and no carapace. But unlike Isopoda, they possess thoracic gills and their bodies are laterally compressed.
Toxicology
Artemia
Plant Extracts
Dose-Response Relationship, Drug
No-Observed-Adverse-Effect Level
Phencyclidine
A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.
Body Weight
Rats, Sprague-Dawley
Inhalation Exposure
Lipidoses
Ethyl Chloride
A gas that condenses under slight pressure. Because of its low boiling point ethyl chloride sprayed on skin produces an intense cold by evaporation. Cold blocks nerve conduction. Ethyl chloride has been used in surgery but is primarily used to relieve local pain in sports medicine.
Rats, Inbred F344
Environmental Pollutants
Body Burden
Ethylene Glycols
Fluoxetine
Drug Administration Schedule
Clinical Chemistry Tests
Carcinogenicity Tests
Tests to experimentally measure the tumor-producing/cancer cell-producing potency of an agent by administering the agent (e.g., benzanthracenes) and observing the quantity of tumors or the cell transformation developed over a given period of time. The carcinogenicity value is usually measured as milligrams of agent administered per tumor developed. Though this test differs from the DNA-repair and bacterial microsome MUTAGENICITY TESTS, researchers often attempt to correlate the finding of carcinogenicity values and mutagenicity values.
Dichloroethylenes
Mud Therapy
Liver
Dibutyl Phthalate
Rats, Wistar
Administration, Inhalation
Tracheitis
Tetrachlorodibenzodioxin
Haloperidol
A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)