Benz(a)Anthracenes
9,10-Dimethyl-1,2-benzanthracene
Benzopyrenes
Carcinogens
Polycyclic Hydrocarbons, Aromatic
A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)
Papilloma
Biotransformation
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
Mammary Neoplasms, Experimental
Benzo(a)pyrene
Chrysenes
1,2-Benzphenanthrenes. POLYCYCLIC COMPOUNDS obtained from coal tar.
Mutagens
Mutagenicity Tests
Pseudomonadaceae
Mice, Inbred SENCAR
Mice selectively bred for hypersusceptibility to two-stage chemical skin carcinogenesis. They are also hypersusceptible to UV radiation tumorigenesis with single high-dose, but not chronic low-dose, exposures. SENCAR (SENsitive to CARcinogenesis) mice are used in research as an animal model for tumor production.
Epoxy Compounds
Epoxide Hydrolases
Anthraquinones
Compounds based on ANTHRACENES which contain two KETONES in any position. Substitutions can be in any position except on the ketone groups.
Neoplasms, Experimental
Mucorales
Phenanthrenes
Soil Pollutants
Substances which pollute the soil. Use for soil pollutants in general or for which there is no specific heading.
Structure-Activity Relationship
Topoisomerase Inhibitors
Compounds that inhibit the activity of DNA TOPOISOMERASES.
Sphingomonadaceae
Chromatography, Thin Layer
Anticarcinogenic Agents
DNA Topoisomerases
Enzymes that regulate the topology of DNA by actions such as breaking, relaxing, passing, and rejoining strands of DNA in cells. These enzymes are important components of the DNA replication system. They are classified by their substrate specificities. DNA TOPOISOMERASE I enzymes act on a single strand of DNA. DNA TOPOISOMERASE II enzymes act on double strands of DNA.