5-Amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole
Oxadiazoles
Oxadiazoles are heterocyclic organic compounds consisting of a five-membered ring containing two carbon atoms, one nitrogen atom, and two oxygen atoms (one as a part of the oxadiazole ring and the other as a substituent or part of a larger molecule), which can exist in various isomeric forms and are known for their versatile biological activities, including anti-inflammatory, antiviral, antibacterial, and antitumor properties.
Vinyl Compounds
Vinyl compounds, in the context of medical materials, refer to synthetic polymers made from vinyl chloride or vinyl acetate monomers, which are used in the production of various medical devices and supplies such as blood bags, intravenous (IV) bags, tubing, and gloves due to their flexibility, transparency, and resistance to chemicals and heat.
Vinyl Chloride
Nitro Compounds
FANFT
Nitrofurans
Nitrofurans are a group of synthetic antibacterial agents, characterized by a nitrofuran moiety, that exhibit broad-spectrum antimicrobial activity, primarily targeting gram-positive and gram-negative bacteria in the urinary tract, and are used mainly for the treatment and prevention of lower urinary tract infections.
Thiadiazoles
Quinoxalines
Guanylate Cyclase
Nitric Oxide Donors
A diverse group of agents, with unique chemical structures and biochemical requirements, which generate NITRIC OXIDE. These compounds have been used in the treatment of cardiovascular diseases and the management of acute myocardial infarction, acute and chronic congestive heart failure, and surgical control of blood pressure. (Adv Pharmacol 1995;34:361-81)
Molecular Structure
Structure-Activity Relationship
Receptor, Adenosine A2A
Cyclic GMP
Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)
Magnetic Resonance Spectroscopy
Amino Acids
Adenosine A2 Receptor Antagonists
Compounds that selectively bind to and block the activation of ADENOSINE A2 RECEPTORS.
Antifungal Agents
Polyvinyls
'Polyvinyls' is a term that refers to a group of polymers synthesized from vinyl chloride, including polyvinyl chloride (PVC) and polyvinylidene chloride (PVDC), which are widely used in various medical applications such as manufacturing of medical devices, tubing, packaging materials, and pharmaceutical containers due to their chemical resistance, durability, and versatility.
Nitric Oxide
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Nitroblue Tetrazolium
Thiazoles
Adenosine A2 Receptor Agonists
Compounds that selectively bind to and activate ADENOSINE A2 RECEPTORS.
Nitroreductases
Enzymes which reduce nitro groups (NITRO COMPOUNDS) and other nitrogenous compounds.
Furylfuramide
Purinergic P1 Receptor Antagonists
Enzyme Inhibitors
Polyvinyl Chloride
Triazoles
Receptors, Purinergic P1
A class of cell surface receptors that prefer ADENOSINE to other endogenous PURINES. Purinergic P1 receptors are widespread in the body including the cardiovascular, respiratory, immune, and nervous systems. There are at least two pharmacologically distinguishable types (A1 and A2, or Ri and Ra).
Triazines
Sequence Homology, Amino Acid
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
Polyvinyl Alcohol
Antimutagenic Agents
Urinary Bladder Neoplasms
Tumors or cancer of the URINARY BLADDER.
Ferula
Phenethylamines
Adenosine-5'-(N-ethylcarboxamide)
A stable adenosine A1 and A2 receptor agonist. Experimentally, it inhibits cAMP and cGMP phosphodiesterase activity.
Pyelitis
Trinitrotoluene
Acrylates
Adenosine
Carcinogens
Thermolysin
Amino Acid Substitution
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
Hemangiosarcoma
Furans
Cloning, Molecular
Receptor, Adenosine A1
A subtype of ADENOSINE RECEPTOR that is found expressed in a variety of tissues including the BRAIN and DORSAL HORN NEURONS. The receptor is generally considered to be coupled to the GI, INHIBITORY G-PROTEIN which causes down regulation of CYCLIC AMP.
Urinary Bladder
Oxidation-Reduction
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Neoplasms, Experimental
Perfume
Stereoisomerism
Indazoles
Dichloroethylenes
Urethane
Antineoplastic agent that is also used as a veterinary anesthetic. It has also been used as an intermediate in organic synthesis. Urethane is suspected to be a carcinogen.