Molecular Structure
Sulfur Compounds
Volatile Organic Compounds
Structure-Activity Relationship
Plant Extracts
Drug Evaluation, Preclinical
Magnetic Resonance Spectroscopy
Heterocyclic Compounds
Inhibitory Concentration 50
Biphenyl Compounds
Small Molecule Libraries
Organotin Compounds
Aniline Compounds
Aniline compounds, also known as aromatic amines, are organic chemicals derived from aniline (aminobenzene), characterized by the substitution of hydrogen atoms in the benzene ring with amino groups (-NH2).
Spiro Compounds
Chromatography, High Pressure Liquid
Stereoisomerism
Drug Design
The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.
Dose-Response Relationship, Drug
Nitroso Compounds
Organometallic Compounds
Organoselenium Compounds
Drug Screening Assays, Antitumor
Organophosphorus Compounds
Azo Compounds
Gas Chromatography-Mass Spectrometry
A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.
Epoxy Compounds
Volatilization
High-Throughput Screening Assays
Quaternary Ammonium Compounds
p-Methoxy-N-methylphenethylamine
Hydrocarbons, Aromatic
Enzyme Inhibitors
Mass Spectrometry
Benzyl Compounds
Organic Chemicals
Terphenyl Compounds
Cell Line, Tumor
A cell line derived from cultured tumor cells.
Triterpenes
Furans
Oxidation-Reduction
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Allyl Compounds
Models, Molecular
Spectrophotometry, Ultraviolet
Glycosides
Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)
Heterocyclic Compounds, 2-Ring
Picrates
Picrates are salts of picric acid, an explosive organic compound previously used as a yellow dye and antiseptic, which are now primarily used in chemical research and industrial applications. Please note that picrates should be handled with care due to their potential explosiveness when heated or subjected to friction.
Spectrophotometry, Infrared
Plants, Medicinal
Quantitative Structure-Activity Relationship
Indicators and Reagents
Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)
Biotransformation
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Bicyclo Compounds
Biodegradation, Environmental
Chromatography, Thin Layer
Microbial Sensitivity Tests
Sesquiterpenes
Sesquiterpenes are a class of terpenes consisting of three isoprene units, forming a 15-carbon skeleton, which can be found in various plant essential oils and are known for their diverse chemical structures and biological activities, including anti-inflammatory, antimicrobial, and cytotoxic properties.