A type of extracellular vesicle, containing RNA and proteins, that is secreted into the extracellular space by EXOCYTOSIS when MULTIVESICULAR BODIES fuse with the PLASMA MEMBRANE.

Membrane-limited structures derived from the plasma membrane or various intracellular membranes which function in storage, transport or metabolism.

Ubiquitously-expressed tetraspanin proteins that are found in late ENDOSOMES and LYSOSOMES and have been implicated in intracellular transport of proteins.

Extracellular vesicles generated by the shedding of CELL MEMBRANE blebs.

Cellular release of material within membrane-limited vesicles by fusion of the vesicles with the CELL MEMBRANE.

Endosomes containing intraluminal vesicles which are formed by the inward budding of the endosome membrane. Multivesicular bodies (MVBs) may fuse with other organelles such as LYSOSOMES or fuse back with the PLASMA MEMBRANE releasing their contents by EXOCYTOSIS. The MVB intraluminal vesicles released into the extracellular environment are known as EXOSOMES.

Vesicles derived from the GOLGI APPARATUS containing material to be released at the cell surface.

Electron microscopy in which the ELECTRONS or their reaction products that pass down through the specimen are imaged below the plane of the specimen.