A family of GTPASE-ACTIVATING PROTEINS that are specific for RAC GTP-BINDING PROTEINS.

A GTPase activating protein that is specific for RAC GTP-BINDING PROTEINS. It is expressed primarily in the brain and may be involved in signal transduction. The alternatively spliced form of CHIMERIN 1 (alpha-2 Chimerin) contains an additional src homology domain and is expressed in both the brain and testes.

Proto-oncogene protein bcr is a serine-threonine kinase that functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION. It is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients.

PROTEINS that specifically activate the GTP-phosphohydrolase activity of RAS PROTEINS.

A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.

Male germ cells derived from SPERMATOGONIA. The euploid primary spermatocytes undergo MEIOSIS and give rise to the haploid secondary spermatocytes which in turn give rise to SPERMATIDS.

A sub-family of RHO GTP-BINDING PROTEINS that is involved in regulating the organization of cytoskeletal filaments. This enzyme was formerly listed as EC 3.6.1.47.