effects on non-target dells in vitro. ,br,,br, ,strong,Technology,/strong,,br, We offer a novel combination therapy that comprises the combined administration of individually non-toxic concentrations of a chimeric toxin and the triterpenoid saponin for an enhanced tumor cell-specific cytotoxic effect while non-target cells are not affected at the effective concentration. The combination therapy could be a new tool for the tumor therapy. Main characteristics are: Lower required doses of immunotoxin, High cytotoxity and high specifity, Reduction of undesired side effects. ,br, ,b,Benefits:,/b,,ul, ,li,Tumor-specific targeting and extinction of tumor cells by chimeric toxins,/li, ,li,Reduction of undesired adverse effects of systemic applications,/li, ,li,Combination with saponins enhances rate of immunotoxin uptake and efficiency of chimeric toxin in target cells,/li, ,li,Combined application allows doses reduction of cytotoxic agent and minimize adverse effects without impairing efficacy,/li, ...