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The fractal geometry of nutrient exchange surfaces does not provide an explanation for 3/4-power metabolic scaling. (1/86)

BACKGROUND: A prominent theoretical explanation for 3/4-power allometric scaling of metabolism proposes that the nutrient exchange surface of capillaries has properties of a space-filling fractal. The theory assumes that nutrient exchange surface area has a fractal dimension equal to or greater than 2 and less than or equal to 3 and that the volume filled by the exchange surface area has a fractal dimension equal to or greater than 3 and less than or equal to 4. RESULTS: It is shown that contradicting predictions can be derived from the assumptions of the model. When errors in the model are corrected, it is shown to predict that metabolic rate is proportional to body mass (proportional scaling). CONCLUSION: The presence of space-filling fractal nutrient exchange surfaces does not provide a satisfactory explanation for 3/4-power metabolic rate scaling.  (+info)

Estimating cerebral oxygen metabolism from fMRI with a dynamic multicompartment Windkessel model. (2/86)

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Different types of cell-to-cell connections mediated by nanotubular structures. (3/86)

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Solution NMR structure determination of proteins revisited. (4/86)

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Astrocytes as the glucose shunt for glutamatergic neurons at high activity: an in silico study. (5/86)

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Effect of novel negative allosteric modulators of neuronal nicotinic receptors on cells expressing native and recombinant nicotinic receptors: implications for drug discovery. (6/86)

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Elementary mode analysis: a useful metabolic pathway analysis tool for characterizing cellular metabolism. (7/86)

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Metabolism of echinacoside, a good antioxidant, in rats: isolation and identification of its biliary metabolites. (8/86)

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