Serum protein fractions in rheumatoid pneumoconiosis without arthritis.
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Fractionation of the serum proteins by filter-paper electrophoresis in 14 coal-miners who had the characteristic radiological opacities of rheumatoid pneumoconiosis but no evidence of rheumatoid arthritis showed a reduction in the mean level of albumin and increases in the alpha-2 and gamma-globulins compared with the values in non-arthritic miners with simple coal-workers' pneumoconiosis and in normal subjects. The changes were smaller than those found in miners with both rheumatoid arthritis and the radiological appearances of rheumatoid pneumoconiosis (Caplan's syndrome) and the mean levels did not differ significantly from those found in non-arthritic miners with progressive massive fibrosis. It is concluded that estimation of the serum protein fractions, unlike tests for rheumatoid factors, is unlikely to help in the differential diagnosis of unusual opacities seen on chest radiographs of miners without arthritis. (+info)
Rheumatoid pneumoconiosis (Caplan's syndrome) with a classical presentation.
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Pulmonary function in coal workers with Caplan's syndrome and non-rheumatoid complicated pneumosoniosis.
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This retrospective study compares the pulmonary function of 24 coal workers with Caplan's syndrome with that of 36 subjects with non-rheumatoid progressive massive fibrosis (PMF). Allowing for differences in radiographical category, age, years worked underground, and smoking, obstruction to air flow as reflected in the one-second forced expiratory volume, the vital capacity, and the ratio of residual volume to total lung capacity, was significantly less in subjects with Caplan's syndrome. No significant differences in transfer factor were found. These findings may be explained by the different pathological features of the two entities. Selection bias does not appear to be responsible for the differences observed between the groups, but studies designed to eliminate this would be desirable. (+info)