DiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceNamed GroupsHealth CareGeographicals
Databases, FactualDatabases, GeneticDatabases as TopicDatabases, ProteinDatabases, BibliographicDatabases, Nucleic AcidInternetInformation Storage and RetrievalDatabase Management SystemsSoftwareUser-Computer InterfaceComputational BiologySystems IntegrationAlgorithmsExpressed Sequence TagsRandomized Controlled Trials as TopicDatabases, ChemicalMEDLINEGenomicsSequence AlignmentData MiningAbstracting and Indexing as TopicSequence Analysis, ProteinSequence Analysis, DNATerminology as TopicMolecular Sequence DataProteinsInformation SystemsPubMedComputer GraphicsDatabases, PharmaceuticalComputer Communication NetworksOnline SystemsVocabulary, ControlledMolecular Sequence AnnotationProgramming LanguagesPhylogenyAmino Acid SequenceCD-ROMPeriodicals as TopicSearch EngineSoftware DesignGene Expression ProfilingEvidence-Based MedicineTreatment OutcomeReview Literature as TopicUnited StatesGenomeProtein Interaction MappingBase SequenceKnowledge BasesPublicationsReproducibility of ResultsPublication BiasCost-Benefit AnalysisDirectories as TopicDocumentationMedical Records Systems, ComputerizedNational Library of Medicine (U.S.)Risk FactorsNatural Language ProcessingMedical Record LinkageGene LibraryResearch DesignMetabolic Networks and PathwaysMeta-Analysis as TopicBibliometricsPharmacoepidemiologySequence Homology, Amino AcidGenome, HumanCluster AnalysisSequence AnalysisChromosome MappingProteomeGreat BritainArtificial IntelligenceGenome, PlantSubject HeadingsProteomicsDrug Information ServicesEnzymesMedical InformaticsInformation DisseminationClassificationUnified Medical Language SystemInformaticsMEDLARSData CollectionSensitivity and SpecificityMolecular BiologyEvolution, MolecularInternational Classification of DiseasesSequence Analysis, RNADictionaries as TopicPattern Recognition, AutomatedOligonucleotide Array Sequence AnalysisBiomedical ResearchHypermediaBiomedical TechnologyDNA, Complementary

Database for crude drugs and Kampo medicine. (1/72)

A wiki-based repository for crude drugs and Kampo medicine is introduced. It provides taxonomic and chemical information for 158 crude drugs and 348 prescriptions of the traditional Kampo medicine in Japan, which is a variation of ancient Chinese medicine. The system is built on MediaWiki with extensions for inline page search and for sending user-input elements to the server. These functions together realize implementation of word checks and data integration at the user-level. In this scheme, any user can participate in creating an integrated database with controlled vocabularies on the wiki system. Our implementation and data are accessible at http://metabolomics.jp/wiki/.  (+info)

Protein pharmacophore selection using hydration-site analysis. (2/72)

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Fingerprint-based in silico models for the prediction of P-glycoprotein substrates and inhibitors. (3/72)

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Prescribing without evidence - pregnancy. (4/72)

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Drug-drug interaction through molecular structure similarity analysis. (5/72)

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[Approaching the "evidence-practice gap" in pharmaceutical risk management: analysis of healthcare claim data]. (6/72)

The concept of evidence-based medicine (EBM) has promulgated among healthcare professionals in recent years, on the other hand, the problem of underuse of useful clinical evidence is coming to be important. This is called as evidence-practice gap. The major concern about evidence-practice gap is insufficient implementation of evidence-based effective treatment, however, the perspective can be extended to measures to improve drug safety and prevention of drug related adverse events. First, this article reviews the characteristics of the database of receipt (healthcare claims) and the usefulness for research purpose of pharmacoepidemiology. Second, as the real example of the study on evidence-practice gap by using the receipt database, the case of ergot-derived anti-Parkinson drugs, of which risk of valvulopathy has been identified, is introduced. The receipt analysis showed that more than 70% of Parkinson's disease patients prescribed with cabergoline or pergolide did not undergo echocardiography despite the revision of the product label recommendation. Afterwards, the issues of pharmaceutical risk management and risk communication will be discussed.  (+info)

Rational drug repositioning guided by an integrated pharmacological network of protein, disease and drug. (7/72)

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Exploration of the association rules mining technique for the signal detection of adverse drug events in spontaneous reporting systems. (8/72)

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