(17/70) A novel phenol-bound pectic polysaccharide from Decalepis hamiltonii with multi-step ulcer preventive activity.

AIM: To investigate H(+), K(+)-ATPase inhibition, anti-H pylori, antioxidant, and the in vivo antiulcer potential of a pectic polysaccharide from Swallow root (Decalepis hamiltonii; SRPP). METHODS: SRPP, with known sugar composition [rhamnose: arabinose: xylose: galactose in the ratio of 16:50:2:32 (w/w), with 141 mg/g of uronic acid] was examined for anti-ulcer potency in vivo against swim/ethanol stress-induction in animal models. Ulcer index, antioxidant/antioxidant enzymes, H(+), K(+)-ATPase and gastric mucin levels were determined to assess the anti-ulcer potency. Anti-H pylori activity was also determined by viable colony count and electron microscopic studies. RESULTS: SRPP, containing phenolics at 0.12 g GAE/g, prevented stress-induced gastric ulcers in animal models by 80%-85%. Down regulation of gastric mucin 2-3 fold, antioxidant/antioxidant enzymes and upregulation of 3 fold of H(+), K(+)-ATPase in ulcerous animals were normalized upon treatment with SRPP. Histopathological analysis revealed protection to the disrupted gastric mucosal layer and epithelial glands. SRPP also inhibited H(+), K(+)-ATPase in vitro, at an IC(50) of 77 microg/mL as opposed to that of 19.3 microg/mL of Lansoprazole and H pylori growth at Minimum Inhibitory Concentration (MIC) of 150 microg/mL. In addition, free radical scavenging (IC(50)-40 microg/mL) and reducing power (3200 U/g) activities were also observed. CONCLUSION: SRPP, with defined sugar composition and phenolics, exhibited multi-potent free radical scavenging, antioxidant, anti-H pylori, inhibition of H(+), K(+)-ATPase and gastric mucosal protective activities. In addition, SRPP is non-toxic as opposed to other known anti-ulcer drugs, and therefore may be employed as a potential alternative for ulcer management.  (+info)

(18/70) Biosorptive removal of Ni(Ii) from wastewater and industrial effluent.

The objective of the present work was to investigate the removal of Ni(II) by the fresh biomass (FBM) and chemically treated leached biomass (LBM) of Calotropis procera. The scope of the work included screening of the biosorbents for their metal uptake potential, batch equilibrium, column mode removal studies and kinetic studies at varying pH (2-6), contact time, biosorbent dosages (1-25 g/L) and initial metal ion concentration (5-500 mg/L). The development of batch kinetic model and determination of order, desorption studies, column studies were investigated. It was observed that pH had marked effect on the Ni(II) uptake. Langmuir and Freundlich models were used to correlate equilibrium data on sorption of Ni(II) metallic ion by using both FBM and LBM at 28 degrees C and pH 3 and different coefficients were calculated. It was found that both biomasses were statistically significant fit for Freundlich model. The biomass was successfully used for removal nickel from synthetic and industrial effluents and the technique appears industrially applicable and viable.  (+info)

(19/70) Malate metabolism in Hoya carnosa mitochondria and its role in photosynthesis during CAM phase III.

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(20/70) Antioxidant activities and phenolic contents of the methanol extracts of the stems of Acokanthera oppositifolia and Adenia gummifera.

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(21/70) Fly pollination in Ceropegia (Apocynaceae: Asclepiadoideae): biogeographic and phylogenetic perspectives.

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(22/70) Antibacterial and antifungal activity of extracts and exudates of the Amazonian medicinal tree Himatanthus articulatus (Vahl) Woodson (common name: sucuba).

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(23/70) The role of carbohydrates in seed germination and seedling establishment of Himatanthus sucuuba, an Amazonian tree with populations adapted to flooded and non-flooded conditions.

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(24/70) Potential of laticifer fluids for inhibiting Aedes aegypti larval development: evidence for the involvement of proteolytic activity.

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