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  • Anatomie 93 questions
  • Organismes 37 questions Any living biological entity, such as an animal, plant, fungus, or bacterium.
  • Maladies 166 questions Any impairment of normal physiological function affecting all or part of an organism, esp a specific pathological change caused by infection, stress, etc, producing characteristic symptoms; illness or sickness in general.
    • Infections Bactériennes Et Mycoses 20 questions Infections caused by bacteria and fungi, general, specified, or unspecified.
    • Maladies Virales 5 questions Terme général pour désigner les maladies dues à des virus.
    • Maladies Parasitaires 4 questions Infections or infestations with parasitic organisms. They are often contracted through contact with an intermediate vector, but may occur as the result of direct exposure.
    • Tumeurs 12 questions Neoplasms composed of squamous cells of the epithelium. The concept does not refer to neoplasms located in tissue composed of squamous elements.
    • Maladies De L'Appareil Locomoteur 3 questions Maladies des muscles et de leurs ligaments et tissus conjonctifs associés ainsi que des os et des cartilages, considérés dans leur ensemble.
    • Maladie De L'Appareil Digestif 9 questions Diseases in any part of the GASTROINTESTINAL TRACT or the accessory organs (LIVER; BILIARY TRACT; PANCREAS).
    • Maladies Du Système Stomatognathique 2 questions Maladies générales ou non-spécifiques du système stomatognathique, comprenant la bouche, les dents, les mâchoires et le pharynx.
    • Maladies De L'Appareil Respiratoire 8 questions
    • Maladies Oto-Rhino-Laryngologiques 0 questions General or unspecified diseases of the ear, nose, and throat.
    • Maladies Du Système Nerveux 10 questions Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
      • Maladies Auto-Immunes Du Système Nerveux 0 questions Disorders caused by cellular or humoral immune responses primarily directed towards nervous system autoantigens. The immune response may be directed towards specific tissue components (e.g., myelin) and may be limited to the central nervous system (e.g., MULTIPLE SCLEROSIS) or the peripheral nervous system (e.g., GUILLAIN-BARRE SYNDROME).
      • Maladies Du Système Nerveux Autonome 1 question Diseases of the parasympathetic or sympathetic divisions of the AUTONOMIC NERVOUS SYSTEM; which has components located in the CENTRAL NERVOUS SYSTEM and PERIPHERAL NERVOUS SYSTEM. Autonomic dysfunction may be associated with HYPOTHALAMIC DISEASES; BRAIN STEM disorders; SPINAL CORD DISEASES; and PERIPHERAL NERVOUS SYSTEM DISEASES. Manifestations include impairments of vegetative functions including the maintenance of BLOOD PRESSURE; HEART RATE; pupil function; SWEATING; REPRODUCTIVE AND URINARY PHYSIOLOGY; and DIGESTION.
      • Maladie Du Système Nerveux Central 2 questions Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.
        • Encéphalopathies 2 questions Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.
          • Mutisme Akinétique 0 questions A syndrome characterized by a silent and inert state without voluntary motor activity despite preserved sensorimotor pathways and vigilance. Bilateral FRONTAL LOBE dysfunction involving the anterior cingulate gyrus and related brain injuries are associated with this condition. This may result in impaired abilities to communicate and initiate motor activities. (From Adams et al., Principles of Neurology, 6th ed, p348; Fortschr Neurol Psychiatr 1995 Feb;63(2):59-67)
          • Amblyopie 0 questions Terme non-spécifique se référant à l
          • Amnésie Globale Transitoire 0 questions Syndrome caractérisé par une perte transitoire de la capacité de mémorisation. Il survient principalement chez les personnes d'âge moyen ou âgés, les épisodes peuvent durer de quelques minutes à quelques heures. Durant cette période d'amnésie, les capacités de la mémoire immédiate et récente sont détériorées mais le niveau de conscience et la capacité à accomplir d'autres tâches intellectuelles sont préservés. Cet état est lié à un dysfonctionnement bilatéral des parties médianes de chaque lobe temporal. Le rétablissement complet est habituel et les récidives sont rares. (D'après Adams et al., Principles of Neurology, 6th ed, pp429-30)
          • Troubles De L'Audition Centrale 0 questions Disorders of hearing or auditory perception resulting from disease of the central auditory pathways or auditory association cortical areas. These include HEARING LOSS, CENTRAL; cortical deafness; and AUDITORY PERCEPTUAL DISORDERS. Above the level of the pons, bilateral lesions are usually required to produce auditory dysfunction.
          • Affections Des Ganglions De La Base 0 questions Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (most notably involuntary movements and alterations of the rate of movement) represent the primary clinical manifestations of these disorders. Common etiologies include CEREBROVASCULAR DISORDERS; NEURODEGENERATIVE DISEASES; and CRANIOCEREBRAL TRAUMA.
          • Abcès Cérébral 0 questions Une collection circonscrite d
          • Souffrance Cérébrale Chronique 0 questions A condition characterized by long-standing brain dysfunction or damage, usually of three months duration or longer. Potential etiologies include BRAIN INFARCTION; certain NEURODEGENERATIVE DISORDERS; CRANIOCEREBRAL TRAUMA; ANOXIA, BRAIN; ENCEPHALITIS; certain NEUROTOXICITY SYNDROMES; metabolic disorders (see BRAIN DISEASES, METABOLIC); and other conditions.
          • Mort Cérébrale 0 questions A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)
          • Encéphalopathies Métaboliques 0 questions Acquired or inborn metabolic diseases that produce brain dysfunction or damage. These include primary (i.e., disorders intrinsic to the brain) and secondary (i.e., extracranial) metabolic conditions that adversely affect cerebral function.
            • Encéphalopathies Métaboliques Congénitales 0 questions Erreurs dans le métabolisme du cerveau résultant principalement d'états innés de déficiences enzymatiques. La majorité de ces formes sont familiales, toutefois une mutation spontanée peut également se produire. L'activité enzymatique déficiente peut causer un dysfonctionnement du cerveau aboutissant à l'accumulation du substrat, à une formation réduite de produit, ou à provoquer le métabolisme par des voies alternatives.
              • Angiopathie Amyloïde Cérébrale Familiale 0 questions Maladie familialle marquée par un dépôt de AMYLOÏDES dans les parois de petits vaisseaux sanguins dans le cortex et les meninges cérébraux et caractérisée cliniquement par une ischémie cérébrale (voir l'ISCH
              • Galactosémies 0 questions Groupe de déficiences enzymatiques héréditaires qui provoquent une élévation de GALACTOSE dans le sang. Cette situation peut être associée aux insuffisances de GALACTOKINASE ; UDPGLUCOSE-HEXOSE-1-PHOSPHATE URIDYLYLTRANSFERASE ; ou UDPGLUCOSE 4-EPIMERASE. La forme classique est provoquée par une insuffisance d'UDPglucose-Hexose-1- Phosphate Uridylyltransferase, et associée dans la petite enfance avec un trouble du développement (TROUBLE DEVELOPPEMENT) ; un VOMISSEMENT ; et une HYPERTENSION INTRA-CR
              • Maladie De Hartnup 0 questions Anomalie du transport des acides aminés caractérisée par un début dans l''enfance (ou rarement chez l'adulte) de la dermatite photosensible et des symptômes neurologiques intermittents. L'ataxie, les changements de personnalité, les maux de tête de migraine, et la photophobie peuvent se produire périodiquement. Cette maladie résulte d'un défaut du transport sodium-dépendant des acides aminés neutres à travers la membrane en brosse du petit intestin et de l'épithélium tubulaire rénal. (From Menkes, Textbook of Child Neurology, 5th ed, pp59-60)
              • Dégénérescence Hépatolenticulaire 0 questions Maladie récessive autosomale rare caractérisée par un dépôt du cuivre dans le cerveau, le foie, la cornée, et d'autres organes. Les aspects cliniques incluent une cirrhose du foie, une crise de foie, une splénomégalie, des tremblements, une bradykinésie, une dysarthrie,une chorée, une rigidité musculaire, des anneaux de Kayser-Fleischer (lésions cornéennes pigmentées), une ataxie et une détérioration intellectuelle. Le dysfonctionnement hépatique peut précéder le dysfonctionnement neurologique de plusieurs années. (d'après Adams et al., Principles of Neurology, 6th ed pp969-71)
              • Maladies Démyélinisantes Héréditaires Du Système Nerveux Central 0 questions Inherited conditions characterized by a loss of myelin in the central nervous system.
              • Homocystinurie 0 questions Défaut congénital récessif autosomal du métabolisme de la méthionine habituellement provoqué par une insuffisance en CYSTATHIONINE BETA-SYNTHASE et lié à des élévations de l'homocystéine plasmatique et urinaire. Les signes cliniques incluent une constitution grande et mince, une SCOLIOSE, une arachnodactylie, une FAIBLESSE MUSCULAIRE, des jambes arquées, des cheveux blonds fins, un pic malar, une détérioration du cristallin, une plus grande incidence au retard mental, et une tendance de développer une fibrose des artères, fréquemment compliquée par des accidents cérébrovasculaires (ACCIDENT VASCULAIRES CEREBRAUX) et un INFARCTUS DU MYOCARDE. (From Adams et al., Principles of Neurology, 6th ed, p979)
              • Hyperglycinémie Non Cétosique 0 questions An autosomal recessive metabolic disorder caused by deficiencies in the mitochondrial GLYCINE cleavage system; an enzyme system with four components: P-, T-, H-, and L-proteins. Deficiency of the P-protein is the most prevalent form. Neonatal and juvenile presentations have been reported. Neonatal onset is more common and may be fatal. Clinical features include SEIZURES; hypotonia; APNEA; and COMA. When the illness presents in childhood there tends to be an associated progressive DEMENTIA accompanied by extrapyramidal signs. (Menkes, Textbook of Child Neurology, 5th ed, p46; Jpn J Hum Genet 1997 Mar;42(1):13-22)
              • Hyperlysinémies 0 questions A group of inherited metabolic disorders which have in common elevations of serum LYSINE levels. Enzyme deficiencies of alpha-aminoadipic semialdehyde dehydrogenase and the SACCHAROPINE DEHYDROGENASES have been associated with hyperlysinemia. Clinical manifestations include mental retardation, recurrent emesis, hypotonia, lethargy, diarrhea, and developmental delay. (From Menkes, Textbook of Child Neurology, 5th ed, p56)
              • Maladie De Leigh 0 questions A group of metabolic disorders primarily of infancy characterized by the subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, dysphagia, and lactic acidosis. Pathological features include spongy degeneration of the neuropile of the basal ganglia, thalamus, brain stem, and spinal cord. Patterns of inheritance include X-linked recessive, autosomal recessive, and mitochondrial. Leigh disease has been associated with mutations in genes for the PYRUVATE DEHYDROGENASE COMPLEX; CYTOCHROME-C OXIDASE; ATP synthase subunit 6; and subunits of mitochondrial complex I. (From Menkes, Textbook of Child Neurology, 5th ed, p850).
              • Syndrome De Lesch-Nyhan 0 questions An inherited disorder transmitted as a sex-linked trait and caused by a deficiency of an enzyme of purine metabolism; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE. Affected individuals are normal in the first year of life and then develop psychomotor retardation, extrapyramidal movement disorders, progressive spasticity, and seizures. Self-destructive behaviors such as biting of fingers and lips are seen frequently. Intellectual impairment may also occur but is typically not severe. Elevation of uric acid in the serum leads to the development of renal calculi and gouty arthritis. (Menkes, Textbook of Child Neurology, 5th ed, pp127)
              • Maladies Neurologiques De Surcharge Lysosomiale 0 questions A group of enzymatic disorders affecting the nervous system and to a variable degree the skeletal system, lymphoreticular system, and other organs. The conditions are marked by an abnormal accumulation of catabolic material within lysosomes.
                • Fucosidose 0 questions Maladie lysosomale récessive autosomale de stockage provoquée par une insuffisance d'activité d'Alpha-l-fucosidase se traduisant par une accumulation de fucose contenant des sphingolipides, des glycoprotéines, et des mucopolysaccharides (glycosaminoglycanes) dans les lysosomes. La forme infantile (le type I) comporte une détérioration psychomotrice, une spasticité du muscle, des traits faciaux accentués, un retard de croissance, des anomalies squelettiques, une viscéromégalie, des crises d'épilepsie, des infections récurrentes, et une macroglosie, avec la mort se produisant dans la première décennie de la vie. La fucosidose juvénile (le type II) est la variante la plus commune et comporte un déclin lent et progressif de la fonction nerveuse et un angiokératome diffus de Fabry. La survie d
                • Glycogénose De Type Ii 0 questions An autosomal recessively inherited glycogen storage disease caused by GLUCAN 1,4-ALPHA-GLUCOSIDASE deficiency. Large amounts of GLYCOGEN accumulate in the LYSOSOMES of skeletal muscle (MUSCLE, SKELETAL); HEART; LIVER; SPINAL CORD; and BRAIN. Three forms have been described: infantile, childhood, and adult. The infantile form is fatal in infancy and presents with hypotonia and a hypertrophic cardiomyopathy (CARDIOMYOPATHY, HYPERTROPHIC). The childhood form usually presents in the second year of life with proximal weakness and respiratory symptoms. The adult form consists of a slowly progressive proximal myopathy. (From Muscle Nerve 1995;3:S61-9; Menkes, Textbook of Child Neurology, 5th ed, pp73-4)
                • Mucolipidoses 0 questions A group of inherited metabolic diseases characterized by the accumulation of excessive amounts of acid mucopolysaccharides, sphingolipids, and/or glycolipids in visceral and mesenchymal cells. Abnormal amounts of sphingolipids or glycolipids are present in neural tissue. Mental retardation and skeletal changes, most notably dysostosis multiplex, occur frequently. (From Joynt, Clinical Neurology, 1992, Ch56, pp36-7)
                • Maladie De Surcharge En Acide Sialique 0 questions Autosomal recessive neurodegenerative disorders caused by lysosomal membrane transport defects that result in accumulation of free sialic acid (N-ACETYLNEURAMINIC ACID) within the lysosomes. The two main clinical phenotypes, which are allelic variants of the SLC17A5 gene, are ISSD, a severe infantile form, or Salla disease, a slowly progressive adult form, named for the geographic area in Finland where the kindred first studied resided.
                • Sphingolipidoses 0 questions A group of inherited metabolic disorders characterized by the intralysosomal accumulation of SPHINGOLIPIDS primarily in the CENTRAL NERVOUS SYSTEM and to a variable degree in the visceral organs. They are classified by the enzyme defect in the degradation pathway and the substrate accumulation (or storage). Clinical features vary in subtypes but neurodegeneration is a common sign.
              • Leucinose 0 questions An autosomal recessive inherited disorder with multiple forms of phenotypic expression, caused by a defect in the oxidative decarboxylation of branched-chain amino acids (AMINO ACIDS, BRANCHED-CHAIN). These metabolites accumulate in body fluids and render a "maple syrup" odor. The disease is divided into classic, intermediate, intermittent, and thiamine responsive subtypes. The classic form presents in the first week of life with ketoacidosis, hypoglycemia, emesis, neonatal seizures, and hypertonia. The intermediate and intermittent forms present in childhood or later with acute episodes of ataxia and vomiting. (From Adams et al., Principles of Neurology, 6th ed, p936)
              • Syndrome Melas 0 questions A mitochondrial disorder characterized by focal or generalized seizures, episodes of transient or persistent neurologic dysfunction resembling strokes, and ragged-red fibers on muscle biopsy. Affected individuals tend to be normal at birth through early childhood, then experience growth failure, episodic vomiting, and recurrent cerebral insults resulting in visual loss and hemiparesis. The cortical lesions tend to occur in the parietal and occipital lobes and are not associated with vascular occlusion. VASCULAR HEADACHE is frequently associated and the disorder tends to be familial. (From Joynt, Clinical Neurology, 1992, Ch56, p117)
              • Maladie De Menkes 0 questions An inherited disorder of copper metabolism transmitted as an X-linked trait and characterized by the infantile onset of HYPOTHERMIA, feeding difficulties, hypotonia, SEIZURES, bony deformities, pili torti (twisted hair), and severely impaired intellectual development. Defective copper transport across plasma and endoplasmic reticulum membranes results in copper being unavailable for the synthesis of several copper containing enzymes, including PROTEIN-LYSINE 6-OXIDASE; CERULOPLASMIN; and SUPEROXIDE DISMUTASE. Pathologic changes include defects in arterial elastin, neuronal loss, and gliosis. (From Menkes, Textbook of Child Neurology, 5th ed, p125)
              • Syndrome Merrf 0 questions A mitochondrial encephalomyopathy characterized clinically by a mixed seizure disorder, myoclonus, progressive ataxia, spasticity, and a mild myopathy. Dysarthria, optic atrophy, growth retardation, deafness, and dementia may also occur. This condition tends to present in childhood and to be transmitted via maternal lineage. Muscle biopsies reveal ragged-red fibers and respiratory chain enzymatic defects. (From Adams et al., Principles of Neurology, 6th ed, p986)
              • Syndrome De Lowe 0 questions A sex-linked recessive disorder affecting multiple systems including the EYE, the NERVOUS SYSTEM, and the KIDNEY. Clinical features include congenital CATARACT; MENTAL RETARDATION; and renal tubular dysfunction (FANCONI SYNDROME; RENAL TUBULAR ACIDOSIS; X-LINKED HYPOPHOSPHATEMIA or vitamin-D-resistant rickets) and SCOLIOSIS. This condition is due to a deficiency of phosphatidylinositol 4,5-bisphosphate-5-phosphatase leading to defects in PHOSPHATIDYLINOSITOL metabolism and INOSITOL signaling pathway. (from Menkes, Textbook of Child Neurology, 5th ed, p60; Am J Hum Genet 1997 Jun;60(6):1384-8)
              • Maladies Péroxysomiales 0 questions A heterogeneous group of inherited metabolic disorders marked by absent or dysfunctional PEROXISOMES. Peroxisomal enzymatic abnormalities may be single or multiple. Biosynthetic peroxisomal pathways are compromised, including the ability to synthesize ether lipids and to oxidize long-chain fatty acid precursors. Diseases in this category include ZELLWEGER SYNDROME; INFANTILE REFSUM DISEASE; rhizomelic chondrodysplasia (CHONDRODYSPLASIA PUNCTATA, RHIZOMELIC); hyperpipecolic acidemia; neonatal adrenoleukodystrophy; and ADRENOLEUKODYSTROPHY (X-linked). Neurologic dysfunction is a prominent feature of most peroxisomal disorders.
              • Phénylcétonuries 0 questions A group of autosomal recessive disorders marked by a deficiency of the hepatic enzyme PHENYLALANINE HYDROXYLASE or less frequently by reduced activity of DIHYDROPTERIDINE REDUCTASE (i.e., atypical phenylketonuria). Classical phenylketonuria is caused by a severe deficiency of phenylalanine hydroxylase and presents in infancy with developmental delay; SEIZURES; skin HYPOPIGMENTATION; ECZEMA; and demyelination in the central nervous system. (From Adams et al., Principles of Neurology, 6th ed, p952).
              • Déficit En Pyruvate Carboxylase 0 questions An autosomal recessive metabolic disorder caused by absent or decreased PYRUVATE CARBOXYLASE activity, the enzyme that regulates gluconeogenesis, lipogenesis, and neurotransmitter synthesis. Clinical manifestations include lactic acidosis, seizures, respiratory distress, marked psychomotor delay, periodic HYPOGLYCEMIA, and hypotonia. The clinical course may be similar to LEIGH DISEASE. (From Am J Hum Genet 1998 Jun;62(6):1312-9)
              • Déficit En Complexe Pyruvate-Déshydrogénase 0 questions An inherited metabolic disorder caused by deficient enzyme activity in the PYRUVATE DEHYDROGENASE COMPLEX, resulting in deficiency of acetyl CoA and reduced synthesis of acetylcholine. Two clinical forms are recognized: neonatal and juvenile. The neonatal form is a relatively common cause of lactic acidosis in the first weeks of life and may also feature an erythematous rash. The juvenile form presents with lactic acidosis, alopecia, intermittent ATAXIA; SEIZURES; and an erythematous rash. (From J Inherit Metab Dis 1996;19(4):452-62) Autosomal recessive and X-linked forms are caused by mutations in the genes for the three different enzyme components of this multisubunit pyruvate dehydrogenase complex. One of the mutations at Xp22.2-p22.1 in the gene for the E1 alpha component of the comple
              • Tyrosinémies 0 questions A group of disorders which have in common elevations of tyrosine in the blood and urine secondary to an enzyme deficiency. Type I tyrosinemia features episodic weakness, self-mutilation, hepatic necrosis, renal tubular injury, and seizures and is caused by a deficiency of the enzyme fumarylacetoacetase. Type II tyrosinemia features mental retardation, painful corneal ulcers, and keratoses of the palms and plantar surfaces and is caused by a deficiency of the enzyme TYROSINE TRANSAMINASE. Type III tyrosinemia features mental retardation and is caused by a deficiency of the enzyme 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE. (Menkes, Textbook of Child Neurology, 5th ed, pp42-3)
              • Urea Cycle Disorders, Inborn 0 questions
            • Encéphalopathie Hépatique 0 questions Syndrome caractérisé par un dysfonctionnement du système nerveux central en association avec une insuffisance hépatique, y compris les shunts porto-systémiques. Les signes cliniques incluent la léthargie, la confusion mentale (progressant fréquemment jusqu'au coma), un astérixis, un nystagmus pathologique, des réflexes oculovestibulaires vifs, une posture décortiquée et décérébrée, une spasticité musculaire, et des réflexes plantaires bilatéraux en extension (voir le R
            • Ictère Nucléaire 0 questions A term used pathologically to describe BILIRUBIN staining of the BASAL GANGLIA; BRAIN STEM; and CEREBELLUM and clinically to describe a syndrome associated with HYPERBILIRUBINEMIA. Clinical features include athetosis, MUSCLE SPASTICITY or hypotonia, impaired vertical gaze, and DEAFNESS. Nonconjugated bilirubin enters the brain and acts as a neurotoxin, often in association with conditions that impair the BLOOD-BRAIN BARRIER (e.g., SEPSIS). This condition occurs primarily in neonates (INFANT, NEWBORN), but may rarely occur in adults. (Menkes, Textbook of Child Neurology, 5th ed, p613)
            • Marchiafava-Bignami Disease 0 questions
            • Encéphalomyopathies Mitochondriales 0 questions A heterogenous group of disorders characterized by alterations of mitochondrial metabolism that result in muscle and nervous system dysfunction. These are often multisystemic and vary considerably in age at onset (usually in the first or second decade of life), distribution of affected muscles, severity, and course. (From Adams et al., Principles of Neurology, 6th ed, pp984-5)
            • Myélinolyse Centropontine 0 questions A demyelinating condition affecting the PONS and characterized clinically by an acute progressive QUADRIPLEGIA; DYSARTHRIA; DYSPHAGIA; and alterations of consciousness. Pathologic features include prominent demyelination in the central PONS with sparing of axons and neurons. This condition is usually associated with systemic disorders such as HYPONATREMIA; chronic ALCOHOLISM; LIVER FAILURE; severe BURNS; malignant NEOPLASMS; hemorrhagic PANCREATITIS; HEMODIALYSIS; and SEPSIS. The rapid medical correction of hyponatremia has been cited as a cause of this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1125-6)
            • Syndrome De Reye 0 questions A form of encephalopathy with fatty infiltration of the LIVER, characterized by brain EDEMA and VOMITING that may rapidly progress to SEIZURES; COMA; and DEATH. It is caused by a generalized loss of mitochondrial function leading to disturbances in fatty acid and CARNITINE metabolism.
            • Encéphalopathie De Gayet-Wernicke 0 questions An acute neurological disorder characterized by the triad of ophthalmoplegia, ataxia, and disturbances of mental activity or consciousness. Eye movement abnormalities include nystagmus, external rectus palsies, and reduced conjugate gaze. THIAMINE DEFICIENCY and chronic ALCOHOLISM are associated conditions. Pathologic features include periventricular petechial hemorrhages and neuropil breakdown in the diencephalon and brainstem. Chronic thiamine deficiency may lead to KORSAKOFF SYNDROME. (Adams et al., Principles of Neurology, 6th ed, pp1139-42; Davis & Robertson, Textbook of Neuropathology, 2nd ed, pp452-3)
          • Oedème Cérébral 0 questions Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
          • Traumatismes De L'Encéphale 0 questions Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
          • Tumeurs Du Cerveau 0 questions Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
          • Maladies Du Cervelet 1 question Maladies affectant la structure ou la fonction du cervelet. Les manifestations cardinales de la dysfonction cérébelleuse incluent la dysmétrie, la DEMARCHE ATAXIQUE et l'HYPOTONIE MUSCULAIRE.
          • Angiopathies Intracrâniennes 0 questions A broad category of disorders characterized by impairment of blood flow in the arteries and veins which supply the brain. These include CEREBRAL INFARCTION; BRAIN ISCHEMIA; HYPOXIA, BRAIN; INTRACRANIAL EMBOLISM AND THROMBOSIS; INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; and VASCULITIS, CENTRAL NERVOUS SYSTEM. In common usage, the term cerebrovascular disorders is not limited to conditions that affect the cerebrum, but refers to vascular disorders of the entire brain including the DIENCEPHALON; BRAIN STEM; and CEREBELLUM.
          • Démence 0 questions Trouble mental organique acquis avec perte de capacités intellectuelles de sévérité assez importante pour interférer avec le fonctionnement social ou professionnel. Le dysfonctionnement à plusieurs facettes et touche la mémoire, le comportement, la personnalité, le jugement, l'attention, les relations spatiales, la langue, la pensée abstraite, et d'autres fonctions exécutives. Le déclin intellectuel est habituellement progressif, et épargne au commencement le niveau de la conscience.
          • Sclérose Cérébrale Diffuse De Schilder 0 questions A rare central nervous system demyelinating condition affecting children and young adults. Pathologic findings include a large, sharply defined, asymmetric focus of myelin destruction that may involve an entire lobe or cerebral hemisphere. The clinical course tends to be progressive and includes dementia, cortical blindness, cortical deafness, spastic hemiplegia, and pseudobulbar palsy. Concentric sclerosis of Balo is differentiated from diffuse cerebral sclerosis of Schilder by the pathologic finding of alternating bands of destruction and preservation of myelin in concentric rings. Alpers' Syndrome refers to a heterogeneous group of diseases that feature progressive cerebral deterioration and liver disease. (From Adams et al., Principles of Neurology, 6th ed, p914; Dev Neurosci 1991;13(4
          • Encéphalite 0 questions Encéphalite provoquée par des virus transmis par des arthopodes (c.-à-d., arbovirus) comprenant principalement des virus des familles TOGAVIRIDAE, FLAVIVIRIDAE, BUNYAVIRIDAE, REOVIRIDAE et RHABDOVIRIDAE. Ces virus sont responsables de ZOONOSES avec pour hôtes intermédiaires des oiseaux ou des petits mammifères. Le virus est transmis aux hommes par piqûre de moustiques (CULICIDAE) ou de tiques. Les manifestations cliniques incluent de la fièvre, des céphalées, des modifications du comportement, des déficits neurologiques localisés puis un COMA. (From Clin Microbiol Rev 1994 Jan;7(1):89-116; Walton, Brain's Diseases of the Nervous System, 10th ed, p321)
          • Encéphalomalacie 0 questions Softening or loss of brain tissue following CEREBRAL INFARCTION; cerebral ischemia (see BRAIN ISCHEMIA), infection, CRANIOCEREBRAL TRAUMA, or other injury. The term is often used during gross pathologic inspection to describe blurred cortical margins and decreased consistency of brain tissue following infarction. Multicystic encephalomalacia refers to the formation of multiple cystic cavities of various sizes in the cerebral cortex of neonates and infants following injury, most notably perinatal hypoxia-ischemic events. (From Davis et al., Textbook of Neuropathology, 2nd ed, p665; J Neuropathol Exp Neurol, 1995 Mar;54(2):268-75)
          • Epilepsy 0 questions A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
          • Céphalées 0 questions Affections fréquentes caractérisées par céphalées persistantes et répétées (voir CEPHALEE). Les systèmes de classification des céphalées peuvent s
          • Hydrocéphalie 0 questions A form of compensated hydrocephalus characterized clinically by a slowly progressive gait disorder (see GAIT DISORDERS, NEUROLOGIC), progressive intellectual decline, and URINARY INCONTINENCE. Spinal fluid pressure tends to be in the high normal range. This condition may result from processes which interfere with the absorption of CSF including SUBARACHNOID HEMORRHAGE, chronic MENINGITIS, and other conditions. (From Adams et al., Principles of Neurology, 6th ed, pp631-3)
          • Maladies Hypothalamiques 0 questions Neoplastic, inflammatory, infectious, and other diseases of the hypothalamus. Clinical manifestations include appetite disorders; AUTONOMIC NERVOUS SYSTEM DISEASES; SLEEP DISORDERS; behavioral symptoms related to dysfunction of the LIMBIC SYSTEM; and neuroendocrine disorders.
          • Hypoxie Cérébrale 0 questions A reduction in brain oxygen supply. Severe hypoxia is referred to as anoxia, and is a relatively common cause of injury to the central nervous system. Prolonged brain anoxia may lead to BRAIN DEATH or a PERSISTENT VEGETATIVE STATE. Histologically, this condition is characterized by neuronal loss which is most prominent in the HIPPOCAMPUS; GLOBUS PALLIDUS; CEREBELLUM; and inferior olives. (From Adams et al., Principles of Neurology, 6th ed, pp1109-11)
          • Hypertension Intracrânienne 1 question Increased pressure within the cranial vault. This may result from several conditions, including HYDROCEPHALUS; BRAIN EDEMA; intracranial masses; severe systemic HYPERTENSION; PSEUDOTUMOR CEREBRI; and other disorders.
          • Hypotension Intracrânienne 0 questions Reduction of CEREBROSPINAL FLUID pressure characterized clinically by HEADACHE which is maximal in an upright posture and occasionally by an abducens nerve palsy (see ABDUCENS NERVE DISEASES), neck stiffness, hearing loss (see DEAFNESS); NAUSEA; and other symptoms. This condition may be spontaneous or secondary to SPINAL PUNCTURE; NEUROSURGICAL PROCEDURES; DEHYDRATION; UREMIA; trauma (see also CRANIOCEREBRAL TRAUMA); and other processes. Chronic hypotension may be associated with subdural hematomas (see HEMATOMA, SUBDURAL) or hygromas. (From Semin Neurol 1996 Mar;16(1):5-10; Adams et al., Principles of Neurology, 6th ed, pp637-8)
          • Syndrome De Klüver-Bucy 0 questions A neurobehavioral syndrome associated with bilateral medial temporal lobe dysfunction. Clinical manifestations include oral exploratory behavior; tactile exploratory behavior; hypersexuality; BULIMIA; MEMORY DISORDERS; placidity; and an inability to recognize objects or faces. This disorder may result from a variety of conditions, including CRANIOCEREBRAL TRAUMA; infections; ALZHEIMER DISEASE; PICK DISEASE OF THE BRAIN; and CEREBROVASCULAR DISORDERS.
          • Leukoencephalopathies 0 questions
          • Dystrophies Neuroaxonales 0 questions A nonspecific term referring both to the pathologic finding of swelling of distal portions of axons in the brain and to disorders which feature this finding. Neuroaxonal dystrophy is seen in various genetic diseases, vitamin deficiencies, and aging. Infantile neuroaxonal dystrophy is an autosomal recessive disease characterized by arrested psychomotor development at 6 months to 2 years of age, ataxia, brain stem dysfunction, and quadriparesis. Juvenile and adult forms also occur. Pathologic findings include brain atrophy and widespread accumulation of axonal spheroids throughout the neuroaxis, peripheral nerves, and dental pulp. (From Davis & Robertson, Textbook of Neuropathology, 2nd ed, p927)
          • Subdural Effusion 0 questions Leakage and accumulation of CEREBROSPINAL FLUID in the subdural space which may be associated with an infectious process; CRANIOCEREBRAL TRAUMA; BRAIN NEOPLASMS; INTRACRANIAL HYPOTENSION; and other conditions.
          • Maladies Thalamiques 0 questions Disorders of the centrally located thalamus, which integrates a wide range of cortical and subcortical information. Manifestations include sensory loss, MOVEMENT DISORDERS; ATAXIA, pain syndromes, visual disorders, a variety of neuropsychological conditions, and COMA. Relatively common etiologies include CEREBROVASCULAR DISORDERS; CRANIOCEREBRAL TRAUMA; BRAIN NEOPLASMS; BRAIN HYPOXIA; INTRACRANIAL HEMORRHAGES; and infectious processes.
        • Infections Du Système Nerveux Central 0 questions Pathogenic infections of the brain, spinal cord, and meninges. DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal infections; PROTOZOAN INFECTIONS; HELMINTHIASIS; and PRION DISEASES may involve the central nervous system as a primary or secondary process.
        • Encéphalomyélite 0 questions A form of arboviral encephalitis (which primarily affects horses) endemic to western and central regions of NORTH AMERICA. The causative organism (ENCEPHALOMYELITIS VIRUS, WESTERN EQUINE) may be transferred to humans via the bite of mosquitoes (CULEX tarsalis and others). Clinical manifestations include headache and influenza-like symptoms followed by alterations in mentation, SEIZURES, and COMA. DEATH occurs in a minority of cases. Survivors may recover fully or be left with residual neurologic dysfunction, including PARKINSONISM, POSTENCEPHALITIC. (From Joynt, Clinical Neurology, 1996, Ch26, pp8-9)
        • Syndrome Nerveux Des Hautes Pressions 0 questions A syndrome related to increased atmospheric pressure and characterized by tremors, nausea, dizziness, decreased motor and mental performance, and SEIZURES. This condition may occur in those who dive deeply (c. 1000 ft) usually while breathing a mixture of oxygen and helium. The condition is associated with a neuroexcitatory effect of helium.
        • Leukoencephalopathies 0 questions
        • Méningite 0 questions An acute purulent infection of the meninges and subarachnoid space caused by Streptococcus pneumoniae, most prevalent in children and adults over the age of 60. This illness may be associated with OTITIS MEDIA; MASTOIDITIS; SINUSITIS; RESPIRATORY TRACT INFECTIONS; sickle cell disease (ANEMIA, SICKLE CELL); skull fractures; and other disorders. Clinical manifestations include FEVER; HEADACHE; neck stiffness; and somnolence followed by SEIZURES; focal neurologic deficits (notably DEAFNESS); and COMA. (From Miller et al., Merritt's Textbook of Neurology, 9th ed, p111)
        • Troubles De La Motricité 0 questions Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerative, hereditary, post-infectious, medication-induced, post-inflammatory, and post-traumatic conditions.
        • Troubles De La Motilité Oculaire 0 questions Disorders that feature impairment of eye movements as a primary manifestation of disease. These conditions may be divided into infranuclear, nuclear, and supranuclear disorders. Diseases of the eye muscles or oculomotor cranial nerves (III, IV, and VI) are considered infranuclear. Nuclear disorders are caused by disease of the oculomotor, trochlear, or abducens nuclei in the BRAIN STEM. Supranuclear disorders are produced by dysfunction of higher order sensory and motor systems that control eye movements, including neural networks in the CEREBRAL CORTEX; BASAL GANGLIA; CEREBELLUM; and BRAIN STEM. Ocular torticollis refers to a head tilt that is caused by an ocular misalignment. Opsoclonus refers to rapid, conjugate oscillations of the eyes in multiple directions, which may occur as a parai
        • Pneumocéphale 0 questions Presence of air or gas within the intracranial cavity (e.g., epidural space, subdural space, intracerebral, etc.) which may result from traumatic injuries, fistulous tract formation, erosions of the skull from NEOPLASMS or infection, NEUROSURGICAL PROCEDURES, and other conditions.
        • Maladies De La Moelle 0 questions Pathologic conditions which feature SPINAL CORD damage or dysfunction, including disorders involving the meninges and perimeningeal spaces surrounding the spinal cord. Traumatic injuries, vascular diseases, infections, and inflammatory/autoimmune processes may affect the spinal cord.
      • Troubles Chronobiologiques 0 questions Disruptions of the rhythmic cycle of bodily functions or activities.
      • Atteintes Des Nerfs Crâniens 0 questions Disorders of one or more of the twelve cranial nerves. With the exception of the optic and olfactory nerves, this includes disorders of the brain stem nuclei from which the cranial nerves originate or terminate.
      • Maladies Démyélinisantes 0 questions Maladies caractérisées par la perte ou le dysfonctionnement de la myéline dans le système nerveux central ou périphérique.
      • Malformations Du Système Nerveux 0 questions Structural abnormalities of the central or peripheral nervous system resulting primarily from defects of embryogenesis.
      • Tumeurs Du Système Nerveux 0 questions Benign and malignant neoplastic processes arising from or involving components of the central, peripheral, and autonomic nervous systems, cranial nerves, and meninges. Included in this category are primary and metastatic nervous system neoplasms.
      • Syndromes Neurocutanés 0 questions A group of disorders characterized by ectodermal-based malformations and neoplastic growths in the skin, nervous system, and other organs.
      • Maladies Neurodégénératives 1 question Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.
      • Manifestations Neurologiques 2 questions Clinical signs and symptoms caused by nervous system injury or dysfunction.
      • Maladies Neuromusculaires 1 question Terme général comprenant : MALADIE DU NEURONE MOTEUR PERIPHERIQUE ; MALADIES DU SYSTEME NERVEUX PERIPHERIQUE ; et certaines MALADIES MUSCULAIRES. Les manifestations comprennent : AFAIBLISSEMENT MUSCULAIRE ; FASCICULATION ; ATROPHIE musculaire ; SPASME ; MyOKYMIE ; HYPERTONIE MUSCULAIRE, myalgies et HYPOTONIE MUSCULAIRE.
      • Syndromes Neurotoxiques 0 questions Troubles neurologiques provoqués par exposition à des substances toxiques, par ingestion, injection, application cutanée ou toute autre méthode. Sont inclues des conditions provoquées par les substances biologiques, chimiques et pharmaceutiques.
      • Troubles Du Sommeil 1 question Conditions characterized by disturbances of usual sleep patterns or behaviors. Sleep disorders may be divided into three major categories: DYSSOMNIAS (i.e. disorders characterized by insomnia or hypersomnia), PARASOMNIAS (abnormal sleep behaviors), and sleep disorders secondary to medical or psychiatric disorders. (From Thorpy, Sleep Disorders Medicine, 1994, p187)
      • Traumatismes Du Système Nerveux 1 question Traumatic injuries to the brain, cranial nerves, spinal cord, autonomic nervous system, or neuromuscular system, including iatrogenic injuries induced by surgical procedures.
    • Maladies De L'Oeil 3 questions
    • Maladies Urogénitales De L'Homme 6 questions Maladies de l
    • Maladies De L'Appareil Urogénital Féminin Et Complications De La Grossesse 6 questions Pathological processes of the female URINARY TRACT, the reproductive system (GENITALIA, FEMALE), and disorders related to PREGNANCY.
    • Maladies Cardiovasculaires 7 questions Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
    • Hémopathies Et Maladies Lymphatiques 2 questions Ensemble des maladies hématologiques et des maladies du système lymphatique. Les hémopathies comprennent des troubles impliquant les éléments figurés (Agrégation hématie par exemple) et les composants chimiques (par exemple, anomalie protéine sang); les maladies lymphatiques comprennent les troubles concernant la lymphe, les ganglions lymphatiques et les lymphocytes.
    • Malformations Et Maladies Congénitales, Héréditaires Et Néonatales 1 question Maladies existantes à la naissance et souvent auparavant ou qui se développent durant le premier mois de vie (Nouveau-né, maladies), toutes causalités confondues. Parmi ces maladies, celles caractérisées par des difformités structurelles sont désignées par le terme malformations.
    • Maladies De La Peau Et Du Tissu Conjonctif 7 questions A collective term for diseases of the skin and its appendages and of connective tissue.
    • Maladies Métaboliques Et Nutritionnelles 2 questions A collective term for nutritional disorders resulting from poor absorption or nutritional imbalance, and metabolic disorders resulting from defects in biosynthesis (ANABOLISM) or breakdown (CATABOLISM) of endogenous substances.
    • Maladies Endocriniennes 1 question Pathological processes of the ENDOCRINE GLANDS, and diseases resulting from abnormal level of available HORMONES.
    • Maladies Du Système Immunitaire 0 questions Disorders caused by abnormal or absent immunologic mechanisms, whether humoral, cell-mediated, or both.
    • Troubles Liés 0 questions Disorders related to substance abuse, the side effects of a medication, toxin exposure, and ALCOHOL-RELATED DISORDERS.
    • Maladies Animales 1 question
    • Signes Et Symptômes, 6 questions Les états anormaux, anatomiques ou physiologiques et les manisfestations objectives ou subjectives d'une maladie, qui ne sont pas classifiés comme maladie ou syndrome.
    • Maladies Professionnelles 0 questions Maladies dues à des facteurs liés à l'emploi d'une personne. (Tiré de Dorland, 28th ed)
    • Troubles Liés2 0 questions Disorders related to substance abuse, the side effects of a medication, toxin exposure, and ALCOHOL-RELATED DISORDERS.
    • Plaies Et Lésions Traumatiques 1 question Dommages infligés au corps résultatant, directement ou indirectement, d'une force extérieure, avec ou sans rupture de la continuité structurelle.
  • Produits chimiques et pharmaceutiques 79 questions Any substance used in or resulting from a reaction involving changes to atoms or molecules, especially one derived artificially for practical use and any synthetic, semisynthetic, or natural chemical substance used in the treatment, prevention, or diagnosis of disease, or for other medical reasons.
  • Techniques et équipements analytiques, diagnostiques et thérapeutiques 36 questions
  • Psychiatrie et psychologie 14 questions The branches of medicine concerned with the diagnosis and treatment of mental illness and the scientific study of all forms of human and animal behaviour, sometimes concerned with the methods through which behaviour can be modified.
  • Phénomènes et processus 17 questions
  • Disciplines et professions 9 questions
  • Anthropologie, enseignement, sociologie et phénoménes sociaux 5 questions
  • Technologie, industrie et agriculture 1 question
  • Sciences humaines 6 questions
  • Sciences De L'Information 1 question Champ de la connaissance, théorie, et technologie, traitant de la collection de faits et de calculs, ainsi que des processus et des méthodes impliqués dans leur manipulation, stockage, diffusion, publication, et recherche. Il inclut la communication, l'édition, la bibliothéconomie, et l'informatique.
  • Individus 5 questions
  • Santé 68 questions
  • Caractéristiques d'une publication 2 questions
  • Lieux géographiques 9 questions The study of the natural features of the earth's surface, including topography, climate, soil, vegetation, etc, and man's response to them.
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