... are a class of mitogen-activated protein kinases (MAPKs) that are responsive to stress ... MKK3 and SEK activate p38 MAP kinase by phosphorylation at Thr-180 and Tyr-182. Activated p38 MAP kinase has been shown to ... p38+Mitogen-Activated+Protein+Kinases at the U.S. National Library of Medicine Medical Subject Headings (MeSH) P38mapkPathway ... a novel p38 mitogen-activated protein kinase inhibitor: preclinical analysis of efficacy and selectivity". The Journal of ...
Yang TT, Xiong Q, Enslen H, Davis RJ, Chow CW (Jun 2002). "Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases ... Nuclear factor of activated T-cells, cytoplasmic 4 is a protein that in humans is encoded by the NFATC4 gene. The product of ... NFATC4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text ... Other members of this family of nuclear factors of activated T cells also participate in the formation of this complex. The ...
Yang SH, Galanis A, Sharrocks AD (June 1999). "Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors ... Yang SH, Galanis A, Sharrocks AD (1999). "Targeting of p38 Mitogen-Activated Protein Kinases to MEF2 Transcription Factors". ... with a mitogen-activated protein kinase, ERK5/BMK1". Nucleic Acids Res. 26 (20): 4771-7. doi:10.1093/nar/26.20.4771. PMC 147902 ... "Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins". Nucleic Acids Res. 29 (3): 732-42. doi: ...
Yang SH, Galanis A, Sharrocks AD (Jun 1999). "Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors ... with a mitogen-activated protein kinase, ERK5/BMK1". Nucleic Acids Research. 26 (20): 4771-7. doi:10.1093/nar/26.20.4771. PMC ... with a mitogen-activated protein kinase, ERK5/BMK1". Nucleic Acids Research. 26 (20): 4771-7. doi:10.1093/nar/26.20.4771. PMC ... "Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation". Nature. 386 (6622): 296-9. Bibcode: ...
Stein B, Yang MX, Young DB, Janknecht R, Hunter T, Murray BW, Barbosa MS (1997). "p38-2, a novel mitogen-activated protein ... mitogen-activated protein kinase". J. Biol. Chem. 272 (7): 4219-24. doi:10.1074/jbc.272.7.4219. PMID 9020136. Janknecht R, ... Kamakura S, Moriguchi T, Nishida E (1999). "Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. ... The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been ...
"Tenascin-X induces cell detachment through p38 mitogen-activated protein kinase activation". Biological & Pharmaceutical ... A member of the tenascin family, tenascin X (TN-X) also known as flexillin or hexabrachion-like protein is a 450kDa ... May 2014). "Tenascin-X promotes epithelial-to-mesenchymal transition by activating latent TGF-β". The Journal of Cell Biology. ...
"Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver". Proc. Natl. ... "Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions". Mol. Cell. Biol. 17 (6): 3094-102 ... JUNB+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text ... Fuchs SY, Xie B, Adler V, Fried VA, Davis RJ, Ronai Z (1998). "c-Jun NH2-terminal kinases target the ubiquitination of their ...
These include extracellular signal-regulated kinase, p38 mitogen-activated protein kinases, and c-Jun N-terminal kinases. The ... evidence for the involvement of protein kinase C and the mitogen-activated protein kinase signaling cascade". Journal of ... "Stress-induced p38 mitogen-activated protein kinase activation mediates kappa-opioid-dependent dysphoria". The Journal of ... and recent work also implicates the mitogen-activated protein kinase cascade and pCREB in KOR-dependent behaviors. While the ...
... "p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR". Human Molecular Genetics. 18 (21): ... Survival of motor neuron 2 (SMN2) is a gene that encodes the SMN protein (full and truncated) in humans. The SMN2 gene is part ... Chen HH, Chang JG, Lu RM, Peng TY, Tarn WY (November 2008). "The RNA binding protein hnRNP Q modulates the utilization of exon ... Yong J, Wan L, Dreyfuss G (May 2004). "Why do cells need an assembly machine for RNA-protein complexes?". Trends in Cell ...
The authors found that KOR activates p38, a member of the mitogen-activated protein kinase (MAPK) family, through ... "Stress-Induced p38 Mitogen-Activated Protein Kinase Activation Mediates κ-Opioid-Dependent Dysphoria". J. Neurosci. 27 (43): ... causes an increase in phosphorylated p38 mitogen-activated protein kinase (MAPK) in microglia in the dorsal horn of the spinal ... "Prostaglandin E2 release evoked by intrathecal dynorphin is dependent on spinal p38 mitogen activated protein kinase". ...
"Voltage-gated sodium channel Nav1.6 is modulated by p38 mitogen-activated protein kinase". The Journal of Neuroscience. 25 (28 ... Sodium channels are modulated by protein kinase A and protein kinase C (PKC) phosphorylation, which reduce peak sodium currents ... Sodium channel protein type 8 subunit alpha also known as Nav1.6 is a membrane protein encoded by the SCN8A gene. Nav1.6 is one ... However, NaV1.6 channels lacks adequate protein kinase sites. Phosphorylation sites at amino acid residues Ser573 and Ser687 ...
"Promyelocytic leukemia is a direct inhibitor of SAPK2/p38 mitogen-activated protein kinase". The Journal of Biological ... is the protein product of the PML gene. PML protein is a tumor suppressor protein required for the assembly of a number of ... PML activates p53 by recruiting the protein to a PML-NBs site and promoting its activation, while inhibiting regulators of the ... The proteins held by PML-NBs are then sumoylated, inactivating the virions permanently. Promyelocytic leukemia protein has been ...
Dahl discovered a series of alpha-ketoamides as selective inhibitors of the p38 mitogen-activated protein kinase that became ... orally active inhibitor of p38 mitogen-activated protein kinase". European Journal of Pharmacology. 632 (1-3): 93-102. doi: ... alpha-ketoamide-based p38 MAP kinase inhibitors". Bioorganic & Medicinal Chemistry Letters. 18 (20): 5456-5459. doi:10.1016/j. ... "The design and synthesis of novel alpha-ketoamide-based p38 MAP kinase inhibitors". Bioorganic & Medicinal Chemistry Letters. ...
"Stimulation of glucose transport by AMP-activated protein kinase via activation of p38 mitogen-activated protein kinase". J. ... 1996). "Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the ... Bolster DR, Crozier SJ, Kimball SR, Jefferson LS (2002). "AMP-activated protein kinase suppresses protein synthesis in rat ... AMP-activated protein kinase catalytic subunit alpha-1 is an enzyme that in humans is encoded by the PRKAA1 gene. The protein ...
November 2001). "Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular ... Yan W, Nehrke K, Choi J, Barber DL (August 2001). "The Nck-interacting kinase (NIK) phosphorylates the Na+-H+ exchanger NHE1 ... It is inhibited by the non-specific diuretic drug amiloride and activated by a variety of signals including growth factors, ... Pang T, Su X, Wakabayashi S, Shigekawa M (May 2001). "Calcineurin homologous protein as an essential cofactor for Na+/H+ ...
"Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1". Journal of Biological ... "Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual ... Zarubin, Tyler; Han, Jiahuai (January 2005). "Activation and signaling of the p38 MAP kinase pathway". Cell Research. 15 (1): ... Han is mainly known for his work in innate immune signaling, especially the discovery of p38 signaling pathway. Han was born in ...
... induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases". ... C-C motif chemokine 11 also known as eosinophil chemotactic protein and eotaxin-1 is a protein that in humans is encoded by the ... The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine ... Jinquan T, Quan S, Feili G, Larsen CG, Thestrup-Pedersen K (Apr 1999). "Eotaxin activates T cells to chemotaxis and adhesion ...
This complex then activates p38 mitogen-activated protein kinase (MAPK). Activation of p38 MAPK is regulated by Cdc42 and Rac1 ... depends on p38 mitogen-activated protein kinase (MAPK). The addition of a p38 MAPK inhibitor was found to correlate with ... "Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways". Mol. Cell. Biol. ... Additionally, activated Brx also recruits and physically interacts with JIP4, a p38 MAPK-specific scaffold protein. JIP4 binds ...
2000). "Stress-induced activation of protein kinase CK2 by direct interaction with p38 mitogen-activated protein kinase". J. ... This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely ... Serine/threonine-protein kinase VRK1 is an enzyme that in humans is encoded by the VRK1 gene. ... This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and C- ...
... mitogen-activated protein kinase)-dependent pathway. Usually, the p38 within the dendritic cell expresses TLR 4 (toll-like ... This causes the p38 MAPK to be phosphorylated. This phosphorylation activates the p38 MAPK to begin producing IL-10 and IL-12. ... for proteins involved in mitochondrial respiration and for cytoskeleton-related proteins. Morphine has long been known to act ... Morphine is a phenanthrene opioid receptor agonist - its main effect is binding to and activating the μ-opioid receptor (MOR) ...
2018). "The p38 mitogen activated protein kinase inhibitor losmapimod in chronic obstructive pulmonary disease patients with ... Losmapimod selectively inhibits enzymes p38α/β mitogen-activated protein kinases (MAPKs), which are modulators of DUX4 ... September 2012). "Effects of p38 mitogen-activated protein kinase inhibition on vascular and systemic inflammation in patients ... September 2014). "Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial ...
... synaptic NMDA excitation caused a decrease in the intracellular concentration of p38 mitogen-activated protein kinase (p38MAPK ... which contain residues that can be directly modified by a series of protein kinases and protein phosphatases, as well as ... Calcium/calmodulin-dependent protein kinases Laube B, Hirai H, Sturgess M, Betz H, Kuhse J (March 1997). "Molecular ... Yu XM, Askalan R, Keil GJ, Salter MW (January 1997). "NMDA channel regulation by channel-associated protein tyrosine kinase Src ...
"Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase ... Fibronectin domain-containing protein 5 is a membrane protein comprising a short cytoplasmic domain, a transmembrane segment, ... potentially generating a protein that begins at methionine-76 (Met-76). A protein initiated at Met-76 would be missing the ... In mice, this causes production of the FNDC5 protein which is cleaved to give a new product irisin. Due to its production ...
... which then activates the downstream kinases, Jun-N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK), ... of CHOP-mediated myocardial apoptosis in pressure-overloaded dominant negative p38α mitogen-activated protein kinase mice". ... Those processes are mainly regulated by three factors: protein kinase RNA-like endoplasmic reticulum kinase (PERK), activating ... proteins in the ER activates the integrated stress response through protein kinase RNA-like endoplasmic reticulum kinase (PERK ...
The anti-inflammatory effects of CO are attributed to activation of the p38 mitogen-activated protein kinase (MAPK) pathway. ... HMOX is a heme-containing member of the heat shock protein (HSP) family identified as HSP32. Three isoforms of HMOX have been ... While CO commonly interacts with the ferrous iron atom of heme in a hemoprotein, it has been demonstrated that CO activates ... One such HYCO includes a dimethyl fumarate moiety which activates NRF2 to thereby induce HO-1, whilst the CORM moiety also ...
... encodes p38α mitogen-activated protein kinase (MAPK) which is the prototypic member of the p38 MAPK family. p38 MAPKs ... Johnson GL, Lapadat R (Dec 2002). "Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases". ... "Stress-induced activation of protein kinase CK2 by direct interaction with p38 mitogen-activated protein kinase". The Journal ... "Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase ...
"Stress-induced activation of protein kinase CK2 by direct interaction with p38 mitogen-activated protein kinase". J. Biol. Chem ... Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as ... Allende JE, Allende CC (1995). "Protein kinases. 4. Protein kinase CK2: an enzyme with multiple substrates and a puzzling ... "Interactions of protein kinase CK2beta subunit within the holoenzyme and with other proteins". Mol. Cell. Biochem. 191 (1-2): ...
... lacks the ability to inhibit the cAMP-dependent pathway but gained the ability to induce P38 mitogen-activated protein kinases ... Articles with short description, Short description matches Wikidata, Protein pages needing a picture, Genes on human chromosome ...
"Catalytic activation of mitogen-activated protein (MAP) kinase phosphatase-1 by binding to p38 MAP kinase: critical role of the ... "Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual ... and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its ... "Expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) in primary human ovarian carcinoma". International Journal ...
The p38 mitogen activated protein kinase (MAPK) pathway is similar to the JNK pathway but differs from the ERK pathway. The p38 ... MAP kinase, JNK MAP kinase, and ERK MAP kinase are all types of mammalian MAP kinases. The p38 MAP kinase is activated by two ... MKK4 is also known to activate the JNK MAP kinase, however, MKK3 is unique to the p38 MAP kinase. The p38 MAPK pathway is ... "Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual ...