... (UBE3B) is an enzyme encoded by UBE3B gene in humans. UBE3B has an N-terminal IQ motif, which ... "Loss of function of the E3 ubiquitin-protein ligase UBE3B causes Kaufman oculocerebrofacial syndrome". Journal of Medical ... "Deficiency for the ubiquitin ligase UBE3B in a blepharophimosis-ptosis-intellectual-disability syndrome". American Journal of ... "The ubiquitin ligase UBE3B, disrupted in intellectual disability and absent speech, regulates metabolic pathways by targeting ...
... is a protein that in humans is encoded by the NEURL3 gene. GRCh38: Ensembl release 89 ... "Entrez Gene: Neuralized E3 ubiquitin protein ligase 3". Retrieved 2016-02-18. v t e (Articles with short description, Short ...
Probable E3 ubiquitin-protein ligase DTX3 is a protein that in humans is encoded by the DTX3 gene. DTX3 functions as an E3 ... "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity". J. Biol. ... "Entrez Gene: Deltex E3 ubiquitin ligase 3". Retrieved 2016-09-26. Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, ... ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]). GRCh38: Ensembl release 89: ENSG00000178498 - Ensembl, May 2017 ...
... is a protein that in humans is encoded by the DTX4 gene. GRCm38: Ensembl release 89: ... "Entrez Gene: Deltex E3 ubiquitin ligase 4". Retrieved 2018-07-05. Cui J, Li Y, Zhu L, Liu D, Songyang Z, Wang HY, Wang RF ( ... "NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase ...
Ubiquitin ligases target proteins for degradation through ubiquitin modification. Protein aggregation can be caused by problems ... The E3 ubiquitin ligase is able to recognize misfolded proteins and ubiquinate them. HDAC6 can then bind to the ubiquitin and ... ubiquitin ligases). Chaperones help with protein refolding by providing a safe environment for the protein to fold. ... In mammalian cells, the E3 ligase, carboxy-terminal Hsp70 interacting protein (CHIP), targets Hsp70-bound proteins. In yeast, ...
... is a mammalian gene encoding the protein CBL which is an E3 ubiquitin-protein ligase involved in cell signalling and protein ... Fang N, Fang D, Wang HY, Altman A, Liu YC (2002). "Regulation of immune responses by E3 ubiquitin-protein ligases". Curr. Dir. ... RING domain function in ubiquitin-protein ligases". Cell. 102 (4): 533-9. doi:10.1016/S0092-8674(00)00057-X. PMID 10966114. ... Cbl functions as an E3 ligase, and therefore is able to catalyse the formation of a covalent bond between ubiquitin and Cbl's ...
E3 ubiquitin-protein ligase NEDD4, also known as neural precursor cell expressed developmentally down-regulated protein 4 ( ... Harvey KF, Kumar S (1999). "Nedd4-like proteins: an emerging family of ubiquitin-protein ligases implicated in diverse cellular ... 3-4 WW protein-protein interaction domains, and a carboxyl-terminal catalytic HECT ubiquitin ligase domain. The C2 domain ... "Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating ...
E3 ubiquitin-protein ligase ZNRF1 is an enzyme that in humans is encoded by the ZNRF1 gene. In a study identifying genes in rat ... Araki T, Milbrandt J (2003). "ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases". J. Neurosci. 23 (28): ... indicating that it may be involved in ubiquitin-mediated protein modification. The protein encoded by this human gene is highly ... 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs ...
CBL-B is an E3 ubiquitin-protein ligase that in humans is encoded by the CBLB gene. CBLB is a member of the CBL gene family. ... 2002). "Regulation of immune responses by E3 ubiquitin-protein ligases". In Altman A (ed.). Signal Transduction Pathways in ... 2001). "Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells". J. Biol. ... 1997). "Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation". Oncogene ...
Ubiquitin-protein ligase E3C is an enzyme that in humans is encoded by the UBE3C gene. GRCh38: Ensembl release 89: ... "Entrez Gene: UBE3C ubiquitin protein ligase E3C". Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and ... 2003). "Proteolytic targeting of transcriptional regulator TIP120B by a HECT domain E3 ligase". J. Biol. Chem. 278 (26): 23369- ...
SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases ... F-box/WD repeat-containing protein 10 is a protein that in humans is encoded by the FBXW10 gene. Members of the F-box protein ... F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein ... 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs ...
SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases ... F-box only protein 28 is a protein that in humans is encoded by the FBXO28 gene. Members of the F-box protein family, such as ... F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ...
SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases ... F-box only protein 31 is a protein that in humans is encoded by the FBXO31 gene. Members of the F-box protein family, such as ... F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein ... the F-box protein FBXO31, a candidate tumor suppressor encoded in 16q24.3 for which there is loss of heterozygosity in various ...
SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases ... F-box protein 40 is a protein that in humans is encoded by the FBXO40 gene. Fbxo40 induces ubiquitination of IRS1, thus ... F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein ... Fbxo40 in particular engages a unique substrate, IRS1, which is a protein in the IGF1 signaling pathway. In this way, Fbxo40 ...
"ITCH itchy E3 ubiquitin protein ligase [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2021-12-29. ... February 2005). "The ubiquitin-protein ligase Itch regulates p73 stability". The EMBO Journal. 24 (4): 836-848. doi:10.1038/sj. ... Bhandari D, Robia SL, Marchese A (March 2009). "The E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the ... August 2006). "The E3 ubiquitin ligase Itch controls the protein stability of p63". Proceedings of the National Academy of ...
... which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It ... E3 ubiquitin-protein ligase RNF5 is an enzyme that in humans is encoded by the RNF5 gene. The protein encoded by this gene ... is a membrane-bound ubiquitin ligase". Journal of Cell Science. 114 (Pt 10): 1949-57. doi:10.1242/jcs.114.10.1949. PMID ... "Recognition and ubiquitination of Salmonella type III effector SopA by a ubiquitin E3 ligase, HsRMA1". The Journal of ...
Listerin E3 ubiquitin protein ligase 1 (LTN1), otherwise known as listerin, is a protein that in humans is encoded by the LTN1 ... "Entrez Gene: Listerin E3 ubiquitin protein ligase 1". Chu J, Hong NA, Masuda CA, Jenkins BV, Nelms KA, Goodnow CC, Glynne RJ, ... Like most RING finger proteins, listerin functions as an E3 ubiquitin ligase. Listerin is a component of the ribosome quality ... "A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration". Proceedings of ...
Joazeiro CA, Weissman AM (2000). "RING finger proteins: mediators of ubiquitin ligase activity". Cell. 102 (5): 549-52. doi: ... This protein domain contains 40 to 60 amino acids. Many proteins containing a RING finger play a key role in the ubiquitination ... They bind DNA, RNA, protein and/or lipid substrates. Their binding properties depend on the amino acid sequence of the finger ... Brown RS (2005). "Zinc finger proteins: getting a grip on RNA". Curr. Opin. Struct. Biol. 15 (1): 94-8. doi:10.1016/j.sbi. ...
NFX1 is also a probable E3 ubiquitin-protein ligase. These enzymes are of interest as they have been shown to participate in 3 ... "Eyelid protein is key to allergy". BBC News. January 16, 2005. Archived from the original on July 14, 2022. Retrieved April 1, ... This factor can bind DNA, RNA and protein via a reiterated RING finger motifs in the central domain of the polypeptide. The ... Ono SJ; Liou HC; Davidon R; Strominger JL; Glimcher LH (May 1991). "Human X-box-binding protein 1 is required for the ...
HECT domain E3 ubiquitin protein ligase 4 is a protein that in humans is encoded by the HECTD4 gene. GRCh38: Ensembl release 89 ... "Entrez Gene: HECT domain E3 ubiquitin protein ligase 4". Retrieved 2016-10-24. Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR ( ...
Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating ... The human protein Mitochondrial E3 ubiquitin protein ligase 1 is ~40 kDa in size and composed of 352 amino acids. The ... Mitochondrial E3 ubiquitin protein ligase 1 (MUL1) is an enzyme that in humans is encoded by the MUL1 gene on chromosome 1. ... "Entrez Gene: MUL1 mitochondrial E3 ubiquitin protein ligase 1". Li W, Bengtson MH, Ulbrich A, Matsuda A, Reddy VA, Orth A, ...
"The E3 ubiquitin protein ligase HERC2 modulates the activity of tumor protein p53 by regulating its oligomerization". The ... HERC2 is a giant E3 ubiquitin protein ligase, implicated in DNA repair regulation, pigmentation and neurological disorders. It ... "Physical and functional interaction of the HECT ubiquitin-protein ligases E6AP and HERC2". The Journal of Biological Chemistry ... a RING finger ubiquitin ligase to the E2 ubiquitin-conjugating enzyme UBC13. This association is required for RNF8 mediated Lys ...
The E3 ubiquitin-protein ligases SMURF1 and SMURF2 regulate the levels of SMADs. They accept ubiquitin from an E2 conjugating ... Two such proteins that mediate the TGFβ pathway include SARA (the SMAD anchor for receptor activation) and HGS (Hepatocyte ... These proteins contain nine conserved cysteines which can form disulfide bridges. It is believed that DAN antagonizes GDF5, ... It is also a member of the TGF superfamily of proteins. It is asymmetrically expressed in the left side of murine embryos and ...
Chuang TH, Ulevitch RJ (May 2004). "Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors". Nature Immunology ... The MyD88 protein acts as an adapter, connecting proteins that receive signals from outside the cell to the proteins that relay ... After ligand binding, all TLRs apart from TLR3, interact with adaptor protein MyD88. Another adaptor protein, which is ... MyD88+Protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (All articles with dead external links, ...
Yogosawa S, Miyauchi Y, Honda R, Tanaka H, Yasuda H (March 2003). "Mammalian Numb is a target protein of Mdm2, ubiquitin ligase ... 2003). "Mammalian Numb is a target protein of Mdm2, ubiquitin ligase". Biochem. Biophys. Res. Commun. 302 (4): 869-72. doi: ... Protein numb homolog is a protein that in humans is encoded by the NUMB gene. The protein encoded by this gene plays a role in ... 2002). "LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent ...
"An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair". Journal of Molecular Biology. 337 (1): 157- ... The encoded protein interacts with CNOT1 and has ubiquitin ligase activity. Several transcript variants encoding different ... "Identification of a ubiquitin-protein ligase subunit within the CCR4-NOT transcription repressor complex". The EMBO Journal. 21 ... CCR4-NOT transcription complex, subunit 4 is a protein that in humans is encoded by the CNOT4 gene. The protein encoded by this ...
The protein encoded by this gene has ubiquitin-protein ligase activity. This protein binds with p53 and promotes the ubiquitin- ... "Cloning and characterization of an androgen receptor N-terminal-interacting protein with ubiquitin-protein ligase activity". ... "Cloning and characterization of an androgen receptor N-terminal-interacting protein with ubiquitin-protein ligase activity". ... a newly identified ubiquitin protein ligase, in lung cancer". Journal of the National Cancer Institute. 96 (22): 1718-21. doi: ...
... ubiquitin-conjugating enzymes (E2S) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin- ... Chin LS, Vavalle JP, Li L (2002). "Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation". J. ... 2004). "The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein". Proc ... 2001). "Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle- ...
E3 ubiquitin-protein ligase SMURF2 is an enzyme that in humans is encoded by the SMURF2 gene which is located at chromosome ... "Entrez Gene: SMURF2 SMAD specific E3 ubiquitin protein ligase 2". Bonni S, Wang HR, Causing CG, Kavsak P, Stroschein SL, Luo K ... Lin X, Liang M, Feng XH (Nov 2000). "Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in ... an E3 ubiquitin ligase". Proceedings of the National Academy of Sciences of the United States of America. 98 (3): 974-9. ...
The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating ... E3 ubiquitin-protein ligase RNF216 is an enzyme that in humans is encoded by the RNF216 gene. This gene encodes a cytoplasmic ... Chuang TH, Ulevitch RJ (2004). "Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors". Nat. Immunol. 5 (5): ... "Entrez Gene: TRIAD3 TRIAD3 protein". Chuang, Tsung-Hsien; Ulevitch Richard J (May 2004). "Triad3A, an E3 ubiquitin-protein ...