... a protein that interacts with the intracellular domain of the type 1 TNF receptor: identity with subunit 2 of the 26S protease ... Tumor necrosis factor receptor 1 (TNFR1), also known as tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) and ... "The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 ... This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate the transcription ...
March 2007). "A functional M196R polymorphism of tumour necrosis factor receptor type 2 is associated with systemic lupus ... Tumor necrosis factor receptor 2 (TNFR2), also known as tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) and ... tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B ... is one of two membrane receptors that binds tumor necrosis factor-alpha (TNFα). Like its counterpart, tumor necrosis factor ...
TNF can bind two receptors, TNFR1 (TNF receptor type 1; CD120a; p55/60) and TNFR2 (TNF receptor type 2; CD120b; p75/80). TNFR1 ... Tumor necrosis factor (TNF, cachexin, or cachectin; formerly known as tumor necrosis factor alpha or TNF-α) is an adipokine and ... "Tumor Necrosis Factor-alpha". Drug Information Portal. U.S. National Library of Medicine. Tumor Necrosis Factor-alpha at the U. ... reported another cytotoxic factor produced by macrophages and named it tumor necrosis factor (TNF). Both factors were described ...
"Soluble forms of tumor necrosis factor receptors (TNF-Rs). The cDNA for the type I TNF-R, cloned using amino acid sequence data ... "RNPS1 inhibits excessive tumor necrosis factor/tumor necrosis factor receptor signaling to support hematopoiesis in mice". ... Peppel, K.; Crawford, D.; Beutler, B. (December 1, 1991). "A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric ... Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors". The Journal of Biological ...
Tumor necrosis factor receptor superfamily member 12A also known as the TWEAK receptor (TWEAKR) is a protein that in humans is ... "The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration". J ... "Entrez Gene: TNFRSF12A tumor necrosis factor receptor superfamily, member 12A". Campbell S, Michaelson J, Burkly L, Putterman C ... 2005). "The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling ...
1997). "Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in ... family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but ... role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB". ... It is a member of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is a member of the tumor ...
Ashkenazi, Avi (1 June 2002). "Targeting death and decoy receptors of the tumour-necrosis factor superfamily". Nature Reviews ... "IL1R2 interleukin 1 receptor, type II [ Homo sapiens (human) ]". ncbi.nlm.nih.gov. National Center for Biotechnology ... A decoy receptor is a receptor that is able to recognize and bind specific growth factors or cytokines efficiently, but is not ... 1994). "The type II "receptor" as a decoy target for interleukin 1 in polymorphonuclear leukocytes: characterization of ...
"A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains". The Journal of Biological ... Mutations in SPOP lead to a type of prostate tumor thought to be involved in about 15% of all prostate cancers. GRCh38: Ensembl ... "A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains". The Journal of Biological ... "Entrez Gene: SPOP speckle-type POZ protein". Heidi Evans (20 May 2012). "Scientists find new type of prostate cancer - ...
"Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor". J Biol Chem. 270 (8 ... 2004). "Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta- ... "Iron chelation study in a normal human hepatocyte cell line suggests that tumor necrosis factor receptor-associated protein 1 ( ... "A novel protein distinguishes between quiescent and activated forms of the type I transforming growth factor beta receptor". J ...
... mouse RAW 264.7 and peritoneal macrophages from secreting the pro-inflammatory cytokines tumor necrosis factor-α (i.e., TNF-α) ... "Discovery of Novel and Selective G-Protein Coupled Receptor 120 (GPR120) Agonists for the Treatment of Type 2 Diabetes Mellitus ... "Identification of G-protein-coupled receptor 120 as a tumor-promoting receptor that induces angiogenesis and migration in human ... Free Fatty acid receptor 4 (FFAR4), also termed G-protein coupled receptor 120 (GPR120), is a protein that in humans is encoded ...
... role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB". ... Saha SK, Cheng G (April 2006). "TRAF3: a new regulator of type I interferons". Cell Cycle. 5 (8): 804-7. doi:10.4161/cc.5.8. ... role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB". ... "The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor ...
... (DR5), also known as TRAIL receptor 2 (TRAILR2) and tumor necrosis factor receptor superfamily member 10B ( ... targeting DR5 have been developed and are currently under clinical trials for patients suffer from a variety of cancer types, ... This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and ... "Entrez Gene: TNFRSF10B tumor necrosis factor receptor superfamily, member 10b". Gajate C, Mollinedo F (Mar 2005). "Cytoskeleton ...
The tumor necrosis factor (TNF) superfamily is a protein superfamily of type II transmembrane proteins containing TNF homology ... The superfamily contains 19 members that bind to 29 members of TNF receptor superfamily. An occurrence of orthologs in ... Necrosis+Factors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) pex1 tumor necrosis factor gene ( ... Baeyens KJ, De Bondt HL, Raeymaekers A, Fiers W, De Ranter CJ (April 1999). "The structure of mouse tumour-necrosis factor at ...
"A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis". ... GITR is type I transmembrane protein and is described in 4 different isoforms. GITR human orthologue, also called activation- ... 2006). "Glucocorticoid-induced tumour necrosis factor receptor (GITR) and its ligand (GITRL) in atopic dermatitis". Acta Derm. ... Human activation-inducible tumor necrosis factor receptor (AITR) and its ligand, AITRL, are important costimulatory molecules ...
... shows homology to other members of the tumor necrosis factor superfamily. It is composed of 281 amino acids and has ... It causes apoptosis primarily in tumor cells, by binding to certain death receptors. TRAIL and its receptors have been used as ... was investigated in mice with various tumour types. Small molecule ONC201 causes expression of TRAIL which kills some cancer ... Bucur O, Ray S, Bucur MC, Almasan A (May 2006). "APO2 ligand/tumor necrosis factor-related apoptosis-inducing ligand in ...
Tumor necrosis factor ligand superfamily member 12 also known as TNF-related weak inducer of apoptosis (TWEAK) is a protein ... is a multifunctional cytokine that binds the TweakR/Fn14 receptor". Cytokine & Growth Factor Reviews. 14 (3-4): 241-9. doi: ... TWEAK can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to ... The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ...
DcR3: Decoy receptor 3 (DcR3) is a recently discovered decoy receptor of the tumor necrosis factor superfamily that binds to ... Fas ligand or FasL is a homotrimeric type II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. It ... Yu KY, Kwon B, Ni J, Zhai Y, Ebner R, Kwon BS (May 1999). "A newly identified member of tumor necrosis factor receptor ... Tumor necrosis factor ligand superfamily member 6) at the PDBe-KB. (Articles with short description, Short description matches ...
... , a member of the tumor necrosis factor (TNF) receptor family, is a type 1 transmembrane protein, expressed on surfaces of ... "4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor- ... "4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor- ... a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family". Gene. 134 (2): 295-298. doi:10.1016/0378- ...
2002). "Etk/Bmx as a Tumor Necrosis Factor Receptor Type 2-Specific Kinase: Role in Endothelial Cell Migration and Angiogenesis ... vascular endothelial growth factor 2 and recruits phosphatidylinositol 3-kinase to mediate the tumor necrosis factor-induced ... "Entrez Gene: BMX BMX non-receptor tyrosine kinase". Bagheri-Yarmand R, Mandal M, Taludker AH, Wang RA, Vadlamudi RK, Kung HJ, ... Tyrosine kinases are either receptor molecules, which contain transmembrane and extracellular domains, or nonreceptor proteins ...
"Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor". Biochem ... a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11". Eur J Biochem. 239 (3): 912- ... subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A ... a protein that interacts with the intracellular domain of the type 1 TNF receptor: identity with subunit 2 of the 26S protease ...
Similarly to etanercept, pegsunercept is a soluble tumor necrosis factor receptor. Pegsunercept is a PEGylated protein. ... "A phase 2 dose-finding study of PEGylated recombinant methionyl human soluble tumor necrosis factor type I in patients with ...
The MyD88-dependent pathway recruits several effector molecules such as IRAK1/4 and tumor necrosis factor receptor-associated ... "Association of the response to tumor necrosis factor antagonists with plasma type I interferon activity and interferon-beta/ ... type I and type II, based on their interactions to a specific cell surface receptor. In recent years, a novel class of ... The type I IFNs bind to the interferon alpha receptor (IFNAR), which consists of two subunits, IFNAR1 (α-subunit) and IFNAR2 (β ...
... a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and ... Mutations in this gene have been recurrently been associated to cases of diffuse large B-cell lymphoma and pediatric-type ... a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and ... also known as tumor necrosis factor receptor superfamily member 14 (TNFRSF14), is a human cell surface receptor of the TNF- ...
Four stimulatory checkpoint molecules are members of the tumor necrosis factor (TNF) receptor superfamily-CD27, CD40, OX40, ... Inhibitory checkpoint molecules are targets for cancer immunotherapy due to their potential for use in multiple types of ... B7-H3's receptors have not yet been identified. B7-H4: also called VTCN1, is expressed by tumor cells and tumor-associated ... KIR: short for Killer-cell Immunoglobulin-like Receptor, is a receptor for MHC Class I molecules on Natural Killer cells. ...
IRE-1α also recruits tumor necrosis factor receptor-associated factor 2 (TRAF2). This kinase cascade that is dependent on IRE-1 ... October 2004). "Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes". Science. 306 (5695): 457-61. ... ATF6 (activating transcription factor 6) is a basic leucine zipper transcription factor. Upon Grp78 dissociation, the entire ... is upregulated downstream of the bZIP transcription factor ATF4 (activating transcription factor 4) and uniquely responsive to ...
Tumor necrosis factor receptor type 1-associated DEATH domain protein is a protein that in humans is encoded by the TRADD gene ... "The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 ... "The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 ... "Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death ...
The biologic drugs that are currently used in treatment of panuveitis include anti tumor necrosis factor, cytokine receptor ... Panuitis is a type of uveitis in which inflammation occurs throughout the uveal tract, with no specific areas of predominant ... "Uveitis: Symptoms, Causes, Treatment & Types". Cleveland Clinic. Retrieved 2023-02-05. "Panuveitis". eyewiki.aao.org. Retrieved ...
... a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated ... Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for ... 2002). "Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on tumor necrosis factor alpha-induced apoptosis ... Iwasaki K, Toyonaga R (2000). "The Rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function in synaptic transmission". ...
Other studies have suggested tumor necrosis factor and EPH receptor A2 as potential progranulin facilitators. After binding to ... In the extracellular matrix, progranulin binds to receptors on several cell types resulting in either activation of a signal ... Serrero G (August 2003). "Autocrine growth factor revisited: PC-cell-derived growth factor (progranulin), a critical player in ... Hoque M, Young TM, Lee CG, Serrero G, Mathews MB, Pe'ery T (March 2003). "The growth factor granulin interacts with cyclin T1 ...
Tumor necrosis factor-alpha (TNFα) is a cytokine produced by lymphocytes and macrophages, two types of white blood cells. It ... "Drugs@FDA: FDA-Approved Drugs". Peppel K, Crawford D, Beutler B (December 1991). "A tumor necrosis factor (TNF) receptor-IgG ... which is a receptor that binds to tumor necrosis factor-alpha. Second, they isolated the DNA sequence that codes the human gene ... Tumor necrosis factor alpha (TNFα) is the "master regulator" of the inflammatory (immune) response in many organ systems. ...