December 1994). "Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK". Science. 266 ( ... a novel kinase inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK)-1 and MEK ... Mitogen-activated protein kinase kinases (MAP2Ks) are substrates for direct phosphorylation by the MAP3K1 protein kinase. The ... Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) is a signal transduction enzyme that in humans is encoded by the ...

"Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver". Proc. Natl. ... "Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions". Mol. Cell. Biol. 17 (6): 3094-102 ... JUNB+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text ... Fuchs SY, Xie B, Adler V, Fried VA, Davis RJ, Ronai Z (1998). "c-Jun NH2-terminal kinases target the ubiquitination of their ...

JNK mitogen-activated protein kinase, and actin filament assembly by the exchange factor FGD1". J. Biol. Chem. 273 (25): 15453- ... FGD1 also activates the c-Jun N-terminal kinase (JNK) signaling cascade, important in cell differentiation and apoptosis. It ... The mature human protein contains several characteristic motifs and domains that are involved in the protein's function. The ... FYVE, RhoGEF and PH domain-containing protein 1 (FGD1) also known as faciogenital dysplasia 1 protein (FGDY), zinc finger FYVE ...

JNK) mitogen-activated protein kinase". J. Biol. Chem. 272 (7): 4219-24. doi:10.1074/jbc.272.7.4219. PMID 9020136. Janknecht R ... a novel mitogen-activated protein kinase with distinct properties". J. Biol. Chem. 272 (31): 19509-17. doi:10.1074/jbc.272.31. ... Kamakura S, Moriguchi T, Nishida E (1999). "Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. ... The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been ...

"Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway". The Journal of ... "Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway". The Journal of ... "A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. ... "A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. ...

... the mesenteric lymph node triggers the amelioration of the JNK-mitogen-activated protein kinases (MAPKs) and p38 mitogen- ... activated protein kinases (p38MAPKs) signaling cascades. The same pathway was observed in peripheral blood lymphocytes. ... These pharmacology benefits arise through the modulating action of geniposide on several proteins and genes that are associated ... When this receptor is activated neurotrophic effects were induced in cells, such as neurite outgrowth, reducing amyloid plaques ...

... virus type 1 and its coat protein gp120 induce apoptosis and activate JNK and ERK mitogen-activated protein kinases in human ... JNK)-binding protein that enhances the activation of JNK by MEK kinase 1 and TGF-beta-activated kinase 1". FEBS Lett. 457 (3): ... Mitogen-activated protein kinase 10 also known as c-Jun N-terminal kinase 3 (JNK3) is an enzyme that in humans is encoded by ... "Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3". Mol. Cell. Biol. 20 (3): ...

... c-Jun N-terminal kinase (JNK), mitogen-activated protein kinases (MAPKs), and protein kinase B (PKB). While IL-10R2 is ... In addition, IL-26 activates extracellular signal-regulated kinases (ERK)-1/2, ... Interleukin-26 (IL-26) is a protein that in humans is encoded by the IL26 gene. IL-26 is the most recently identified member of ... IL-26 is a 171-amino acid protein that exhibits six alpha helices connected by loops and four conserved cysteine residues. ...

... stress-activated protein kinase (SAPK)/JNK, and p38 mitogen-activated protein kinase (p38 MAPK). Activation of the IRAK/MAPK ... The exact mechanism by which various concentrations of ethanol either activates or inhibits TLR4/IL-1RI signaling is not ... Ethanol interacts with the TLR4 and IL-1RI receptors on these cells to activate intracellular signal transduction pathways. ... This acetylation is an activating mark for pronociceptin. The nociceptin/nociceptin opioid receptor system is involved in the ...

Johnson GL, Lapadat R (Dec 2002). "Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases". ... "Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase ... "Mitogen-activated protein kinase 14". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). "Entrez Gene: MAPK14 mitogen- ... "Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase". Proceedings of the National ...

It activates c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases in a Raf-independent fashion in response ... characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase ... "Entrez Gene: MAP3K5 mitogen-activated protein kinase kinase kinase 5". Yoon KW, Cho JH, Lee JK, Kang YH, Chae JS, Kim YM, et al ... Apoptosis signal-regulating kinase 1 (ASK1) also known as mitogen-activated protein kinase 5 (MAP3K5) is a member of MAP kinase ...

Cyt A is thought to induce apoptosis by activating c-Jun N-terminal Kinase (JNK), p38 mitogen-activated protein kinase (MAPK), ... Cyt A also activates c-Jun N-terminal kinase, and its apoptotic effects are inhibited by dominant negative c-Jun. While the ... Kakeya, H.; Onose, R.; Osada, H. "Caspase-mediated activation of a 36-kDa myelin basic protein kinase during anticancer drug- ... and p36 myelin basic protein (MBP) kinase. Cytotrienin A is an ansamycin with a macrocyclic, twenty-one carbon, lactam, ...

In collaboration with another mitogen-activated protein kinase kinase MKK4, MKK7 work as crucial transducers upstream of JNK ... MKK7 JNK-activated kinase 2 MAPK/ERK kinase 7 (MEK7) Stress-activated protein kinase kinase 4 (SAPK kinase 4, SAPKK4) c-Jun N- ... "Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein ... terminal kinase kinase 2 (JNK kinase 2, JNKK2) Stress-activated / extracellular signal-regulated protein kinase kinase 2 (SEK2 ...

Mitogen-activated protein kinase for JNK signaling pathway description GRCh38: Ensembl release 89: ENSG00000127863 - Ensembl, ... and to activate c-Jun N-terminal kinases (JNK) signaling pathway when overexpressed in cells. This receptor is capable of ... 2000). "TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and ... The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during ...

The p38 mitogen activated protein kinase (MAPK) pathway is similar to the JNK pathway but differs from the ERK pathway. The p38 ... MAP kinase, JNK MAP kinase, and ERK MAP kinase are all types of mammalian MAP kinases. The p38 MAP kinase is activated by two ... MAPK Phosphatase 1 negatively regulates the activity of mitogen activate protein kinase (MAPK) activity. A deficiency of this ... MKK4 is also known to activate the JNK MAP kinase, however, MKK3 is unique to the p38 MAP kinase. The p38 MAPK pathway is ...

JNK+Mitogen-Activated+Protein+Kinases at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Getting a Handle ... They belong to the mitogen-activated protein kinase family, and are responsive to stress stimuli, such as cytokines, ... Activation is carried out by two MAP kinase kinases, MKK4 and MKK7, and JNK can be inactivated by Ser/Thr and Tyr protein ... JNKs can associate with scaffold proteins JNK interacting proteins (JIP) as well as their upstream kinases JNKK1 and JNKK2 ...

... mitogen-activated protein) kinases such as JNK, ERK and p38. In particular, JNK can be found in both cell death and survival ... to activate JNK (c-Jun N-terminal Kinases), it may be related to epidermal growth factor receptor signalling and it is largely ... to bind to the IkB kinase or IKK complex. To activate IKK, TAB2 and TAB3 adaptor proteins recruit TAK1 or MEKK3, which ... including RIPK1 and another enzyme from the Receptor Interacting Protein kinases family, RIPK3, as well as other proteins such ...

... which then activates the downstream kinases, Jun-N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK), ... Those processes are mainly regulated by three factors: protein kinase RNA-like endoplasmic reticulum kinase (PERK), activating ... proteins in the ER activates the integrated stress response through protein kinase RNA-like endoplasmic reticulum kinase (PERK ... double-stranded RNA-activated protein kinase (PKR) iron deficiency through heme-regulated inhibitor kinase (HRI) stress from ...

... mitogen-activated protein kinase) proteins ERK, JNK, and p38 with specificity distinct from that of individual MKP proteins. ... a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase". J ... 2004). "Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor". Mol ... Dual specificity protein phosphatase 7 is an enzyme that in humans is encoded by the DUSP7 gene. Dual-specificity phosphatases ...

c-Jun N-terminal kinase (JNK) signaling is part of the mitogen-activated protein kinase (MAPK) signaling pathway essential in ... which activates the Ras G protein. Ras activates Raf (MAPKKK), which activates Mek (MAPKK), which activates Erk (MAPK). Erk can ... Nagalingam A, Arbiser JL, Bonner MY, Saxena NK, Sharma D (February 2012). "Honokiol activates AMP-activated protein kinase in ... Thus, JNK activation plays a role in protein synthesis via subsequent downstream effectors of mTORC1 such as S6 kinase and eIFs ...

... impaired activation of the mitogen-activated protein (MAP) kinases p38, JNK, and somewhat inhibited ERK activation upon (BCR) ... "Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and ... Evidence suggests that BLNK is phosphorylated by the tyrosine-protein kinase Syk after B cell receptor activation. ... October 1999). "Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK--functional significance ...

They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are ... a dual specificity MAP kinase protein phosphatase". Proteins. 66 (1): 253-8. doi:10.1002/prot.21224. PMID 17078075. S2CID ... Dual specificity protein phosphatase 5 is an enzyme that in humans is encoded by the DUSP5 gene. The protein encoded by this ... Martell KJ, Kwak S, Hakes DJ, Dixon JE, Trent JM (Jul 1994). "Chromosomal localization of four human VH1-like protein-tyrosine ...

They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is ... Dual specificity protein phosphatase 12 is an enzyme that in humans is encoded by the DUSP12 gene. The protein encoded by this ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ... gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by ...

They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are ... 1995). "Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual ... Dual specificity protein phosphatase 2 is an enzyme that in humans is encoded by the DUSP2 gene. The protein encoded by this ... 1994). "Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1". Nature. 367 (6464): 651-4 ...

They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are ... a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase". ... "Extracellular signal-regulated kinases phosphorylate mitogen-activated protein kinase phosphatase 3/DUSP6 at serines 159 and ... "Mitogen-activated protein kinase phosphatase-3 (MKP-3) in the surgical wound is necessary for the resolution of postoperative ...

They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is ... Dual specificity phosphatase 8 is a protein that in humans is encoded by the DUSP8 gene. The protein encoded by this gene is a ... This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is ... Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases ...

They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are ... Hao L, ElShamy WM (2007). "BRCA1-IRIS activates cyclin D1 expression in breast cancer cells by downregulating the JNK ... Dual specificity protein phosphatase 3 is an enzyme that in humans is encoded by the DUSP3 gene. The protein encoded by this ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ...

The agonists are known to activate NF-κB, mitogen-activated protein kinases, Erk1/2 and JNK through IL-36R/IL-1RAcP, which ... IL-36 has been found to activate T cell proliferation and release of IL-2. Before the functions of the IL-36 cytokines were ... Binding of the IL-36R agonists to IL-1Rrp2 recruits IL-1RAcP, activating the signaling pathway. IL-36Ra binds to IL-36R, ... and IL-1F9 Signal through IL-1Rrp2 and IL-1RAcP to Activate the Pathway Leading to NF-κB and MAPKs*". Journal of Biological ...

... mitogen-activated protein kinases) such as ERK and JNK, bring about an increase in the synthesis of inflammatory factors that ... Also, FABP proteins have recently been shown to interact with a protein called synuclein to cause mitochondrial damage. ... A recent study has shown that levels of glial proteins, and NOT neuronal proteins, are most abnormal in Alzheimer's disease. ... astrocytes were generated by exposing human glial precursor cells to bone morphogenetic protein (bone morphogenetic protein is ...

JNK (MKK4 and MKK7), and ERK (MEK1 and MEK2) define independent MAP kinase signal transduction pathways. The acronym MEK ... Signal transduction MAP kinase MAP kinase kinase kinase MAP kinase kinase kinase kinase Dérijard B, et al. (1995). "Independent ... Mitogen-activated protein kinase kinase (also known as MAP2K, MEK, MAPKK) is a dual-specificity kinase enzyme which ... Mitogen-Activated+Protein+Kinase+Kinases at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: ...