... may refer to: Coagulation factor IXa, an enzyme Coagulation factor XIa, an enzyme This ... disambiguation page lists articles associated with the title Activated blood coagulation factor XI. If an internal link led you ...
Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a ... Coagulation factor XIII A chain is a protein that in humans is encoded by the F13A1 gene. This gene encodes the coagulation ... Hilgenfeld R, Liesum A, Storm R, Metzner HJ, Karges HE (1990). "Crystallization of blood coagulation factor XIII by an ... Takahashi N, Takahashi Y, Putnam FW (1986). "Primary structure of blood coagulation factor XIIIa (fibrinoligase, ...
"Blood-coagulation factor XIII". Drug Information Portal. U.S. National Library of Medicine. Portal: Medicine v t e (Webarchive ... congenital factor XIII A-subunit deficiency, which is a kind of Factor XIII deficiency. The medication prevents bleeding in ... Catridecacog, sold under the brand name Tretten in the US and NovoThirteen in the EU) is a class of recombinant factor XIII A- ... The Pharmacist February 01, 2014 Korte W (9 July 2014). "Catridecacog: a breakthrough in the treatment of congenital factor ...
"Blood-coagulation factor VIII, procoagulant". Drug Information Portal. U.S. National Library of Medicine. "Beroctocog alfa". ... a recombinant antihemophilic factor VIII Turoctocog alfa, a recombinant antihemophilic factor VIII "Coagulation Factor VIII, ... The cost of Factor VIII and similar clotting factors has been described as "highly expensive". The cost of the clotting factors ... Factor VIII is delivered by intravenous infusion. This transfer of a plasma byproduct into the blood stream of a hemophiliac ...
... participates in blood coagulation; it is a cofactor for factor IXa, which, in the presence of Ca2+ and ... The active protein (sometimes written as coagulation factor VIIIa) interacts with another coagulation factor called factor IX. ... Factor VIII (FVIII) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF). In humans, factor VIII ... "NIH: F8 - coagulation factor VIII". National Institutes of Health. "Entrez Gene: F8 coagulation factor VIII, procoagulant ...
"Hepatocytes express blood coagulation factor XII (Hageman factor)". The Journal of Laboratory and Clinical Medicine. 115 (4): ... Coagulation factor XII, also known as Hageman factor, is a plasma protein. It is the zymogen form of factor XIIa, an enzyme (EC ... "Characterization of human blood coagulation factor XII cDNA. Prediction of the primary structure of factor XII and the tertiary ... "Coagulation factor XII (Hageman factor) Washington D.C.: inactive factor XIIa results from Cys-571----Ser substitution". ...
"Recombinant Factor XIII". 2010. "Factor XIII". 2014-03-05. Muszbek, Laszlo; et al. (1999). "Blood coagulation factor XIII: ... Recombinant factor XIII (rFXIII) is the only drug alternative to receiving blood transfusions, the traditional treatment for ... Factor XIII Dorgalaleh A, Naderi M, Hosseini MS, Alizadeh S, Hosseini S, Tabibian S, et al. (2015). "Factor XIII Deficiency in ... "Safety and pharmacokinetics of recombinant factor XIII-A2 administration in patients with congenital factor XIII deficiency". ...
Examples are blood clots (coagulation factor XIII), skin, and hair. The catalytic reaction is generally viewed as being ... The exact biochemical activity of transglutaminases was discovered in blood coagulation protein factor XIII in 1968. Nine ... Deficiency of factor XIII (a rare genetic condition) predisposes to hemorrhage; concentrated enzyme can be used to correct the ... doi:10.1016/0003-9861(59)90413-8. Pisano JJ, Finlayson JS, Peyton MP (May 1968). "[Cross-link in fibrin polymerized by factor ...
Gailani D, Broze GJ (Aug 1991). "Factor XI activation in a revised model of blood coagulation". Science. 253 (5022): 909-12. ... In contrast to HMWK, LMWK is not involved in blood coagulation. Kininogen-1 is a constituent of the blood coagulation system as ... HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing ... Williams-Fitzgerald-Flaujeac factor or the HMWK-kallikrein factor is a protein that in humans is encoded by the KNG1 gene. ...
"Activation of human blood coagulation factor XI independent of factor XII. Factor XI is activated by thrombin and factor XIa in ... "Coagulation factor XI: a database of mutations and polymorphisms associated with factor XI deficiency". Blood Coagulation & ... "Expression of human blood coagulation factor XI: characterization of the defect in factor XI type III deficiency". Blood. 79 (6 ... factor XII, factor XI, and factor IX). Factor XIa activates factor IX by selectively cleaving arg-ala and arg-val peptide bonds ...
These are important in protein-protein interactions with blood coagulation factors. Their name refers to the Kringle, a ... Patthy L (1985). "Evolution of the proteases of blood coagulation and fibrinolysis by assembly from modules". Cell. 41 (3): 657 ... and coagulation factor XII". J. Mol. Evol. 26 (4): 358-369. Bibcode:1987JMolE..26..358C. doi:10.1007/BF02101155. PMID 3131537. ... "Amino acid sequence of the heavy chain of human alpha-factor XIIa (activated Hageman factor)". J. Biol. Chem. 260 (9): 5328- ...
Type II domains have also been found in a range of proteins including blood coagulation factor XII; bovine seminal plasma ... Structural similarity of the protease precursor to blood coagulation factor XII". J. Biol. Chem. 268 (14): 10024-10028. doi: ... Fibronectins are involved in a number of important functions e.g., wound healing; cell adhesion; blood coagulation; cell ... Kornfeld S (1992). "Structure and function of the mannose 6-phosphate/insulinlike growth factor II receptors". Annu. Rev. ...
Kisiel W, Canfield WM (1981). Snake venom proteases that activate blood-coagulation factor V. Methods in Enzymology. Vol. 80 Pt ... Snake+venom+factor+V+activator at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (CS1: ... Snake venom factor V activator (EC 3.4.21.95) is an enzyme. This enzyme catalyses the following chemical reaction Fully ... Tokunaga F, Nagasawa K, Tamura S, Miyata T, Iwanaga S, Kisiel W (November 1988). "The factor V-activating enzyme (RVV-V) from ...
Fresh normal plasma has all the blood coagulation factors with normal levels. Plasma from patients on oral anticoagulants ( ... Factor VII, Factor IX, and Factor X. Aged plasma is deficient in Factor V & Factor VIIIC. Serum is deficient in factors I, V & ... Mixing studies are tests performed on blood plasma of patients or test subjects to distinguish factor deficiencies from factor ... Factor deficient plasmas (Adsorbed Plasma & Aged Plasma, etc.) are used in mixing studies. Plasma with known factor ...
The best known function of tissue factor is its role in blood coagulation. The complex of TF with factor VIIa catalyzes the ... Tissue factor has been shown to interact with Factor VII. Tissue factor Blood plasma after the addition of tissue factor ... the interface between factor Xa and tissue factor in the quaternary complex tissue factor-factor VIIa-factor Xa-tissue factor ... Engelmann B (2007). "Initiation of coagulation by tissue factor carriers in blood". Blood Cells, Molecules & Diseases. 36 (2): ...
Leytus SP, Foster DC, Kurachi K, Davie EW (September 1986). "Gene for human factor X: a blood coagulation factor whose gene ... "Kcentra- prothrombin, coagulation factor vii human, coagulation factor ix human, coagulation factor x human, protein c, protein ... Factor X is activated, by hydrolysis, into factor Xa by both factor IX (with its cofactor, factor VIII in a complex known as ... The result is a Factor VIIa/TF complex, which catalyzes the activation of Factor X and Factor IX. Factor Xa formed on the ...
... of the blood coagulation-factor activity of FFP. Given the fact that there is typically an overabundance of coagulation factors ... Much of the donor blood supply is obtained at "remote" blood donation events, such as blood drives at colleges, community ... However, the (male) donor blood can be separated into packed red blood cells and plasma within 24 hours (and usually less).[ ... It differs from fresh-frozen plasma (FFP) in that it is frozen within 24 hours of blood collection, whereas FFP is frozen ...
Heikinheimo, R (1963). "Effect of filicin administered as an anthelmintic on the coagulation factors of the blood". Annales ...
doi:10.1182/blood-2002-01-0290. PMID 12393635. S2CID 8885302. Duga S, Asselta R, Tenchini ML (August 2004). "Coagulation factor ... Factor V (pronounced factor five) is a protein of the coagulation system, rarely referred to as proaccelerin or labile factor. ... All prothrombotic factor V mutations (factor V Leiden, factor V Cambridge, factor V Hong Kong) make it resistant to cleavage by ... Villoutreix BO, Dahlbäck B (June 1998). "Structural investigation of the A domains of human blood coagulation factor V by ...
May 1994). "Mutation in blood coagulation factor V associated with resistance to activated protein C". Nature. 369 (6475): 64-7 ... of human factor V (one of several substances that helps blood clot), which causes an increase in blood clotting ( ... "Factor V Leiden: The Copenhagen City Heart Study and 2 meta-analyses". Blood. 100 (1): 3-10. doi:10.1182/blood-2002-01-0111. ... The risk of developing a clot in a blood vessel depends on whether a person inherits one or two copies of the factor V Leiden ...
... is caused by abnormalities in blood consistency, which is determined by the levels of coagulation factors and ... The combination activates factor X to factor Xa and factor IX to factor IXa. Factor Xa (in the presence of factor V) activates ... Normal coagulation is initiated by the release of tissue factor from damaged tissue. Tissue factor binds to circulating factor ... and there are higher levels of coagulation proteins such as von Willebrand factor, fibrinogen, factor VII and factor VIII. ...
TAP and antistasin were used to estimate factor Xa as a drug target. Blood coagulation is a complex process by which the blood ... Heparin targets multiple factors in the blood coagulation cascade, one of them being FXa. At first, it had many side effects ... Factor Xa is an activated serine protease that occupies a key role in the blood coagulation pathway by converting prothrombin ... These factors activate each other in a blood coagulation cascade that occurs through two separate pathways that interact, the ...
This is a highly selective inhibitor of factor Xa in the blood coagulation pathways. TAP molecules are highly dipolar, and are ... a factor Xa inhibitor from the tick Ornithodoros moubata". FEBS Lett. 352 (2): 251-7. doi:10.1016/0014-5793(94)00941-4. PMID ... and tissue factor pathway inhibitor (TFPI). Kunitz STI protease inhibitor, the trypsin inhibitor initially studied by Moses ... tissue factor pathway inhibitor precursor; and Kunitz STI protease inhibitor contained in legume seeds. Kunitz domains are ...
... or blood-coagulation factor VIIa, activated blood coagulation factor VII), which in turn activates factor IX and factor X. ... the interface between factor Xa and tissue factor in the quaternary complex tissue factor-factor VIIa-factor Xa-tissue factor ... The main role of factor VII (FVII) is to initiate the process of coagulation in conjunction with tissue factor (TF/factor III ... The complex of factor VIIa with TF catalyzes the conversion of factor IX and factor X into the active proteases, factor IXa and ...
This also activates protein kinase C which stimulates platelet aggregation and therefore blood coagulation further down the ... Proteinase-activated receptor 1 (PAR1) also known as protease-activated receptor 1 or coagulation factor II (thrombin) receptor ... Blood. 89 (6): 1944-53. doi:10.1182/blood.V89.6.1944. PMID 9058715. Overview of all the structural information available in the ... Blood. 82 (5): 1532-7. doi:10.1182/blood.V82.5.1532.1532. PMID 8395910. "José RJ, Williams AE, Chambers RC (February 2014). " ...
... coagulation factor concentrates; and immunoglobulins. Blood products may also be called blood-based products to differ from ... A blood product is any therapeutic substance prepared from human blood. This includes whole blood; blood components; and plasma ... Whole blood is not commonly used in transfusion medicine. Blood components include: red blood cell concentrates or suspensions ... Cryoprecipitate Cryosupernatant Fresh frozen plasma PF24 Platelet transfusion Red blood cells The Clinical Use of Blood ...
The production of blood coagulation factors by the liver is disrupted, causing hemophiliac-like symptoms. Acute liver failure ... Again, synthetic function of the liver in terms of blood coagulation factors is impaired in addition to enlargement of the ... Patient responsiveness to nitisinone is assessed by measuring blood coagulation activity and SA levels in blood and urine. ... marked by the lack of formation of coagulation factors in blood. Patients are prone to infections at this stage accompanied by ...
"Blood coagulation factor IX residues Glu78 and Arg94 provide a link between both epidermal growth factor-like domains that is ... or trisaccharides may occur at a serine residue between the first two cysteines of blood coagulation factors VII and IX. Factor ... The cause of hemophilia B is decreased activity or deficiency of blood coagulation factor IX. Point mutations resulting in ... In the blood-clotting cascade, coagulation factors VII, IX and X and protein C contain a tandem of two cbEGF modules, whereas ...
"Lonomia obliqua Caterpillar Spicules Trigger Human Blood Coagulation via Activation of Factor X and Prothrombin". Thrombosis ... This anti-clotting agent would attach to another protein of the body's cells and cause them to leak as blood is unable to clot ... If blood products are required, they must be given cautiously to avoid fueling the constant consumptive coagulopathy. An ... Disseminated intravascular coagulation occurs as the toxin interacts with the victim's body. One serious effect on envenomed ...
... the blood coagulation factors II (prothrombin), VII, IX, and X, the anticoagulant proteins C and S, and the factor X-targeting ... involved in coagulation Factor VII (F7) - involved in coagulation Factor IX (F9) - involved in coagulation Factor X (F10) - ... Coagulation factor, Gla region InterPro: IPR002383 Thrombin (F2) (a.k.a. coagulation factor II; also its precursor prothrombin ... "Identification of the phospholipid binding site in the vitamin K-dependent blood coagulation protein factor IX". J. Biol. Chem ...