Developing a metabolic clearance rate framework as a translational analysis approach for hyperpolarized 13C magnetic resonance...
This study investigated a novel perfusion formalism and metabolic clearance rate (MCR) model in pre-clinical stroke and in the ... This study introduces a formalism for quantifying the metabolic information in hyperpolarized imaging. ... Hyperpolarized carbon-13 magnetic resonance imaging is a promising technique for in vivo metabolic interrogation of alterations ... Developing a metabolic clearance rate framework as a translational analysis approach for hyperpolarized 13C magnetic resonance ...
Theophylline: new perspectives for an old drug
Trimethoprim alters the disposition of procainamide and N-acetylprocainamide
Metabolic Clearance Rate * Procainamide / analogs & derivatives* * Procainamide / pharmacokinetics* * Procainamide / ... We conclude that trimethoprim increases the plasma concentrations of procainamide and NAPA by decreasing their renal clearances ... and NAPA renal clearances after trimethoprim coadministration strongly correlated with their baseline renal clearances (r = ... there was also a trend toward a decrease in the apparent acetylation clearance of procainamide (19%, p = 0.057). The change in ...
Estrone sulfate - Wikipedia
Changes in Insulin Sensitivity and Insulin Release in Relation to Glycemia and Glucose Tolerance in 6,414 Finnish Men |...
Surrogate indexes were validated against MLBM/I. ISI, insulin sensitivity index; MCR, metabolic clearance rate; QUICKI, ... A total of 6,414 Finnish men (aged 57 ± 7 years, BMI 27.0 ± 3.9 kg/m2) from our ongoing population-based METSIM (Metabolic ... A total of 6,414 men from the ongoing population-based cross-sectional Metabolic Syndrome in Men (METSIM) study were included ... Metabolic characteristics of individuals with impaired fasting glucose and/or impaired glucose tolerance ...
Yasmin film-coated tablets 0.03mg/3mg - Summary of Product Characteristics (SmPC) - (emc)
The metabolic clearance rate of drospirenone in serum is 1.5 ± 0.2 ml/min/kg. Drospirenone is excreted only in trace amounts in ... The metabolite clearance rate of ethinylestradiol is about 5 ml/min/kg. ... Substances increasing the clearance of COCs (diminished efficacy of COCs by enzyme-induction), e.g.: ... Substances decreasing the clearance of COCs (enzyme inhibitors): The clinical relevance of potential interactions with enzyme ...
Thalidomide Embryopathy: An Enigmatic Challenge
Metabolic clearance rates may differ between species, meaning teratogenic forms of the drug may not be present for long. ... we know that individuals react differently to drugs and we know individuals have different metabolic rates. Birth defects can ... K. S. Bauer, S. C. Dixon, and W. D. Figg, "Inhibition of angiogenesis by thalidomide requires metabolic activation, which is ... D. Veselá, D. Veselý, and R. Jelínek, "Embryotoxicity in chick embryo of thalidomide hydrolysis products following metabolic ...
DHEA: MedlinePlus Supplements
Nestler, J. E. and Kahwash, Z. Sex-specific action of insulin to acutely increase the metabolic clearance rate of ... The use of constant infusion of unlabeled dehydroepiandrosterone for the assessment of its metabolic clearance rate, its half- ... each increases the resting metabolic rate of overweight adults. J Nutr Biochem 2007;18:629-634. View abstract. ... Cho, S. H., Choi, M. H., Sim, W. Y., Lee, W. Y., and Chung, B. C. Metabolic alterations of DHEA and cholesterol sulphates in ...
Euthyroid Sick Syndrome: Practice Essentials, Pathophysiology, Epidemiology
... this leads to a diminished metabolic clearance rate of rT3 and T4. ... The fractional rate of transport of T3 to tissues is unaltered. Production of T3 is decreased, but its clearance is unchanged. ... and the mortality rate was higher, in those suffering from both conditions. For example, the mortality rate during ... Endocrine and metabolic disorders associated with human immune deficiency virus infection. West Afr J Med. 2009 Jan. 28(1):3-9 ...
Lybrel (Levonorgestrel and Ethinyl Estradol Tablets): Uses, Dosage, Side Effects, Interactions, Warning
Metabolic clearance rates may differ among individuals by several-fold, and this may account in part for the wide variation ... Figure 3: Circulatory Disease Mortality Rates per 100,000 Woman Years by Age, Smoking. Status and Oral Contraceptive Use ... In comparison, average failure rates for other methods of birth control during the first year of use are as follows:. IUD: 0.1- ... The average failure rate of large numbers of pill users is approximately 5% per year (5 pregnancies per 100 women per year of ...
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Registration Dossier - ECHA
... or metabolic clearance rates within the skin compartments (Bartels, 2021). Relative differences in predicted absorption of the ... Metabolic rate data generated in the in vitro studies above were used to refine the models to more accurately predict behavior ... The initial rate of bis(GSH)-MDI formation (assuming pseudo first order kinetics) with 2,2-, 2,4- and 4,4-MDI in both ... However, as discussed above, the relative reactive dissolution of the NCO presenting molecule in the mixture (i.e. the rate of ...
These highlights do not include all the information needed to use CAMRESE safely and effectively. See full prescribing...
Metabolic clearance rates may differ among individuals by several-fold, and this may account in part for the wide variation ... adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to the rates in the clinical ... 5.7 Adverse Carbohydrate and Lipid Metabolic Effects 5.8 Headache 5.9 Bleeding Irregularities and Amenorrhea 5.10 Depression ... The pregnancy rate (Pearl Index [PI]) in women aged 18-35 years was 1.34 pregnancies per 100 women-years of use (95% confidence ...
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Changes in Amino Acids Profile of Camel Milk Protein During the Early Lactation
IGF binding protein patterns, hence metabolic clearance rates of IGF-I, can be altered by nutrition in neonatal calves (Hammon ... Delaying colostrum intake by one day has important effects on metabolic traits and on gastrointestinal and metabolic hormones ... Metabolic, endocrine and hematological changes in 1-week old calves after milk intake, in response to fasting and during total ... Metabolic and endocrine traits of neonatal calves are influenced by feeding colostrums for different durations or only milk ...
DailyMed - MIRENA- levonorgestrel intrauterine device
Metabolic clearance rates may differ among individuals by several-fold, and this may account in part for wide individual ... Table 5: Estimated in vivo release rates for Mirena: Time. Estimated in vivo release rate [μg/day] (rounded). ... Release rate of levonorgestrel (LNG) is 21 mcg/day after 24 days; this rate is reduced to about 11 mcg/day after 5 years and 7 ... Mirena contains 52 mg of levonorgestrel (LNG) released in vivo, at a rate of approximately 21 mcg/day after 24 days. This rate ...
Understanding the Role of Energy Homeostasis in Diabetes - Stratech
1986). Ingestion of a mixed meal does not affect the metabolic clearance rate of biosynthetic human C-peptide. Journal of ... Obesity in the US continues to increase at alarming rates. Diabetes is closely related to obesity, so the increase in obesity ... 1986). Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and type I ... Insulin and glucagon are two counter regulatory hormones that control the systemic concentration of glucose, a metabolic ...
Palaios
... habitats may have been characterized by higher clearance rates in contrast to infaunal bivalves with similar metabolic ... Based on actualistic evidence, brachiopods are able to thrive in nutrient-poor conditions due to low metabolic demands and are ... Patterns of longevity and rate of appearance of taxa in the fossil record indicate a different evolutionary dynamic between ... Among marine invertebrates, rates of taxonomic turnover declined through the Phanerozoic, with increasingly extinction- ...
Danazol: Uses, Interactions, Mechanism of Action | DrugBank Online
... and increases the metabolic clearance rate of progesterone. Another mechanism of action by which danazol may use to facilitate ... Reduce drug development failure rates. Build, train, & validate machine-learning models. with evidence-based and structured ... With structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates ... Mechanism of actionAbsorptionVolume of distributionProtein bindingMetabolismRoute of eliminationHalf-lifeClearanceAdverse ...
Wm. LeRoy Heinrichs' Profile | Stanford Profiles
The sex-unique metabolic network for steroids is induced neonatally in male rats. The metabolic clearance rates (MCR) of ... Experts rated the simulator as an effective teaching tool, giving it a mean score of 4.22 and 4.44 (maximum, 5) for teaching ... EOIS/THC Score and Volume Deficit are tightly linked to the Hemorrhage Rate. * Remedial actions include Wound care, Volume ... Prenatal testosterone does not exert a crucial role in presetting the peripheral metabolic network in rhesus monkeys. ...
Wm. LeRoy Heinrichs' Profile | Stanford Profiles
The sex-unique metabolic network for steroids is induced neonatally in male rats. The metabolic clearance rates (MCR) of ... Experts rated the simulator as an effective teaching tool, giving it a mean score of 4.22 and 4.44 (maximum, 5) for teaching ... EOIS/THC Score and Volume Deficit are tightly linked to the Hemorrhage Rate. * Remedial actions include Wound care, Volume ... Prenatal testosterone does not exert a crucial role in presetting the peripheral metabolic network in rhesus monkeys. ...
Table of Contents - March 1975, 64 (3)
METABOLIC CLEARANCE RATE, PRODUCTION RATE AND MAMMARY UPTAKE OF PROGESTERONE IN THE GOAT J Endocrinol 64 (3) 485-502, doi: ... METABOLIC EFFECTS OF 2-BROMO ERGOCRYPTINE-METHANE-SULPHONATE (CB 154) IN THE RAT J Endocrinol 64 (3) 587-588, doi: 10.1677/joe. ... METABOLIC PHENOTYPING GUIDELINES: Assessing glucose homeostasis in rodent models. *Vitamin D is crucial for maternal care and ...
CYP3A5 - hpluswiki
Metabolic Clearance Rate. *Neoplasm Proteins. *Polymorphism, Genetic. *Pulmonary Eosinophilia. *Syndrome. *Tacrolimus. *Weight ... FK506 clearance was not influenced by CYP3A5, multidrug resistance 1 or ABCG2 genotypes. None of the clinical parameters ... A time-course study showed that the occurrence of ES, but not acute GVHD, was related to increased clearance of FK506. When ... Engraftment syndrome, but not acute GVHD, younger age, CYP3A5 or MDR1 polymorphisms, increases tacrolimus clearance in ...
Computer Science - Works - Citation Index - NCSU Libraries
Metabolic Clearance Rate; Models, Biological; Rabbits; Sheep; Species Specificity; Swine ...
Adelaide Research & Scholarship: Steady-state pharmacokinetics of the enantiomers of perhexiline in CYP2D6 poor and extensive...
Metabolic Clearance Rate. -. dc.subject. Polymorphism, Genetic. -. dc.subject. Stereoisomerism. -. dc.subject. Chemistry, ... Assuming the same renal clearances for PM patients accounts for approximately 9 and 4% of their median apparent oral clearances ... The renal clearance of PHX enantiomers was not enantioselective and accounted for ,1% of the median apparent oral clearance of ... with higher apparent oral clearances of (-)-than (+)-PHX. Renal clearance, calculated for EM and subsequently assumed for PM, ...
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Another possibility is a difference in the adenosine clearance rate among distinct brain regions, where distribution and ... 2015) Metabolic connection of inflammatory pain: pivotal role of a pyruvate dehydrogenase kinase-pyruvate dehydrogenase-lactic ... ACSF or TNAP-I (3 μl, 10 mg/ml) was directly microinjected into the VLPO region for 30 min at a rate of 0.1 μl/min. The results ... C, Microdialysis was performed at a flow rate of 0.5 ml/min with or without photostimulation of the VLPO region for 120 min in ...
Adelaide Research & Scholarship: Search
Division of Nephrology, Hypertension & Apheresis - Research output - Research Profiles at Washington University School of...
Metabolic Clearance Rate 63% * Kidney 53% * Liver 51% 68 Scopus citations * Phase I study of single-dose pharmacokinetics and ...