Pericytes. Medical search. Frequent questions (1)

We develop several mouse models to culture, identify, characterize, and follow simultaneously single endothelial cells and pericytes during angiogenesis. (unito.it)
Our results help elucidating several relevant mechanisms of interactions between endothelial cells and pericytes. (unito.it)
Microvessels comprise two cell types, endothelial cells and pericytes. (biomedcentral.com)
RESULTS: Ischemic injury or diabetes-induced retinal capillary degeneration were associated with an increased expression of Epac1 in the mouse retinal vasculature, including both endothelial cells and pericytes. (opticnervenetwork.com)
[ 2 ] Diagnosed in 50% of patients with VHL disease, these hemangiomas are composed of endothelial cells and pericytes. (medscape.com)

When this hormone was mixed with cerebral endothelial cells as well as astrocytes, the pericytes grouped into structures that resembled capillaries. (wikipedia.org)
however, the pericyte-like cell-containing cortical organoids played the role of viral replication hubs with the produced virus spreading to nearby astrocytes. (stemcellsportal.com)
The amount of vascular endothelial growth factor (VEGF)-A and the pericyte coverage were determined by immunohistochemistry and enzyme-linked immunosorbent assay in human and mouse brain sections, primary mouse astrocytes and pericytes, and human astrocytes derived from induced pluripotent stem cells. (nih.gov)
Our findings suggest that the inflammation-prone HD astrocytes provide less pericyte coverage by promoting angiogenesis and reducing the number of pericytes and that these changes can explain the inferior VR in HD mice. (nih.gov)
Human brain vascular pericytes treated with either scrambled or RGS5 targeting siRNA, will be co-cultured in a spheroid model of the BBB together with human brain endothelial cells and human astrocytes. (lu.se)

Pericytes have been postulated to regulate capillary blood flow and the clearance and phagocytosis of cellular debris in vitro. (wikipedia.org)
PromoCell Pericyte Growth Medium 2 has been developed for the in vitro cultivation of human pericytes from all tissues. (promocell.com)
To test this hypothesis, pericytes were obtained from healthy or immobilized skeletal muscle and exposed to a hydrogen peroxide load in vitro. (illinois.edu)
discovered that the integration of ACE2-expressing pericyte-like cells (generated in vitro from human pluripotent stem cell-derived neural crest stem cells) into cortical brain organoids at the corticogenesis stage (60-74 days of in vitro culture) promoted astrocytic maturation, increased basement membrane component production, and supported ongoing neurogenesis in the absence of viral infection, Importantly, these features are typically attributed to human brain pericytes in vivo. (stemcellsportal.com)
Expression of high levels of anti-inflammatory cytokines was detected in vitro and in vivo in brain pericytes that interacted with GBM cells (GBC-PC). (oncotarget.com)
Taking our in vitro results back into mouse models, we present evidence that pericyte relaxation contributes to the opening of the gaps between pericytes and to the enlargement of the LERs in the vascular BM, facilitating PMN extravasation. (tamu.edu)
A pericyte-like differentiation of human adipose-derived mesenchymal stem cells (ASCs) was tested in in vitro experiments for possible therapeutic applications in cases of diabetic retinopathy (DR) to replace irreversibly lost pericytes. (unime.it)
Here, we successfully derive pericyte-like cells with cranial neural crest (CNC) origin from hPSCs (designated as hPSC-CNC PCs), which may represent an ideal cell source for the treatment of pericyte dysfunction-related disorders and help to model the human BBB in vitro for the study of the pathogenesis of such neurological diseases. (researchsquare.com)
We have established a method allowing to study the cell-specific secretome of pericytes in vitro-using Turbo-ID, a mutant non-toxic biotin ligase (6). (lu.se)

Examinations with electron microscopy revealed that brain pericytes were laden with dense granular bodies, cytoplasmic vacuoles and lipid droplets. (elsevierpure.com)

Pericytes (formerly called Rouget cells) are multi-functional mural cells of the microcirculation that wrap around the endothelial cells that line the capillaries throughout the body. (wikipedia.org)
Pericytes are embedded in the basement membrane of blood capillaries, where they communicate with endothelial cells by means of both direct physical contact and paracrine signaling. (wikipedia.org)
Certain pericytes, known as microvascular pericytes, develop around the walls of capillaries and help to serve this function. (wikipedia.org)
The SARS-CoV-2 receptor, ACE2, is found on pericytes, contractile cells enwrapping capillaries that regulate brain, heart and kidney blood flow. (ox.ac.uk)
When associated with capillaries, mural cells appear as sparse solitary cells and are referred to as pericytes. (silverchair.com)
Ultrastructural morphometric techniques were used to asses differences in endothelial cells and in pericyte structure and distribution in rat retinal and uveal capillaries. (utmb.edu)
Corresponding data for the choriocapillaris indicated that pericyte coverage of these capillaries was ~50% of that observed in the other eye microcirculations. (utmb.edu)
The number of pericyte processes per capillary varied markedly in the different vasculatures, with an average of three for capillaries in the retina and choriocapillaris and nine to eleven for capillaries in the iris and ciliary processes. (utmb.edu)
RGS5 expression is followed by pericyte detachment from the microvessels, leaving the capillaries leaky (1, 3). (lu.se)

Perivascular cells, including Myh11+ vascular smooth muscle cells (vSMCs) and NG2+ pericytes, are a key cell population involved in new vessel formation critical to primary tumor pathogenesis. (cancer.gov)
Vascular physiology relies on the concerted dynamics of several cell types, including pericytes, endothelial, and vascular smooth muscle cells. (unito.it)
Blood vessel development is in part regulated by pericytes/presumptive vascular smooth muscle cells (PC/pvSMCs). (johnshopkins.edu)

Pericytes are also associated with endothelial cell differentiation and multiplication, angiogenesis, survival of apoptotic signals and travel. (wikipedia.org)
The successful differentiation of brain pericyte-like cells from human pluripotent stem cells may allow us to study their biological characteristics and their applications in the treatment of pericyte dysfunction-related neurodegenerative diseases, including ischemic stroke, Parkinson's disease (PD) and so on. (researchsquare.com)
The protocol we present in the study provides a cranial neural crest originated, fast and robust forebrain pericyte-like cells differentiation method using either human embryonic stem cells or human induced pluripotent stem cells as a starting material. (researchsquare.com)

Here we report that TcdB induces neurogenic inflammation by targeting gut-innervating afferent neurons and pericytes through receptors, including the Frizzled receptors (FZD1, FZD2 and FZD7) in neurons and chondroitin sulfate proteoglycan 4 (CSPG4) in pericytes. (nature.com)
TcdB stimulates the secretion of the neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) from neurons and pro-inflammatory cytokines from pericytes. (nature.com)
Fig. 2: TcdB targets neurons through FZD1/2/7 and pericytes through CSPG4. (nature.com)

Microvascular pericytes may not be contractile cells, as they lack alpha-actin isoforms, structures that are common amongst other contractile cells. (wikipedia.org)
Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 - implications for microvascular inflammation and hypercoagulopathy in COVID-19. (stemcellsportal.com)
Microvascular changes often involve pathological pericyte activation and bloodbrain barrier dysfunction. (lu.se)
We hypothesized that microvascular pericytes constitute a cellular link between microvascular damage and fibrosis by transdifferentiating into myofibroblasts. (biomedcentral.com)
These observations suggest that the presence of myofibroblasts may represent a transitional phase during the fibrotic stages of dcSSc and that Thy-1 +ve pericytes participate in the fibrogenic development of dcSSc by synthesizing ED-A FN, which may be associated with a proliferation and transition of pericytes and fibroblasts to myofibroblasts, thus linking microvascular damage and fibrosis. (biomedcentral.com)
Analyses of microvascular changes in dcSSc have focussed almost solely on the contribution of endothelial cells, largely overlooking the potential role of pericytes. (biomedcentral.com)
Consistent with this idea, we have previously demonstrated that microvascular pericytes become activated and express platelet-derived growth factor-beta (PDGF-β) receptors in dcSSc, a phenotype not seen in normal skin [ 4 ]. (biomedcentral.com)

Pericytes are mural cells that support vascular development, remodeling, and homeostasis, and are involved in a number of pathological situations including cancer. (unito.it)

Although PEComa family tumors commonly demonstrate a perivascular growth pattern, pericyte antigen expression has not yet been examined among this unique tumor group. (nih.gov)
Typical angiomyolipoma (AML) specimens showed variable expression of pericyte antigens among both perivascular and myoid-appearing cells. (nih.gov)
Our laboratory previously demonstrated that muscle-resident perivascular stem cells (NG2+ and CD146+ pericytes), also considered the primary mesenchymal stem cell (MSC) in muscle, can effectively recover muscle mass in young adult mice following a period of immobilization. (illinois.edu)
Using confocal intravital microscopy, investigators observed directed abluminal neutrophil motility along pericyte processes towards perivascular mast cells, a response that created neutrophil extravasation hotspots. (stemcellsciencenews.com)
Pericytes are perivascular cells that line the entire microvasculature. (lu.se)
Regulator of G-protein signaling 5 regulates the shift from perivascular to parenchymal pericytes in the chronic phase after stroke. (lu.se)
CD146+ cells were utilized as pericyte-like cells (PLCs) given the high expression of the marker in perivascular cells, while CD146− cells were induced into an osteogenic phenotype generating osteoblast-like cells (OLCs). (wustl.edu)

Interestingly, extracellular vesicles derived from pericytes in culture were able to significantly improve myofiber size and collagen degradation in both adult and aged mice after immobilization. (illinois.edu)
Interestingly, changes such as pericyte activation and blood-brain-barrier leakage are already observed at the early stages of the disorder, even before behavioral changes or dopaminergic cell loss can be detected, explains Gesine Paul-Visse. (lu.se)
Interestingly, loss of RGS5 in pericytes in RGS5-KO mice prevents this detachment and reduces BBB leakage suggesting that RGS5 has an important role in the process of BBB breakdown (3, 4). (lu.se)

And could pericytes provide similar benefits in aged mice? (illinois.edu)
In Chapter 2, pericytes were isolated based on two cell surface markers (NG2 and CD146) and then transplanted into tibialis anterior muscle (TA) in young adult mice after two weeks of immobilization. (illinois.edu)
Overexpression of the Parkinson-related protein, α-synuclein, leads to blood-brain barrier leakage and pericyte activation in mice. (lu.se)
We report that inhibiting the generation of progeny by a subclass of pericytes led to decreased fibrosis and extracellular matrix deposition after spinal cord injury in mice. (scilifelab.se)
Furthermore, the mean number of brain pericytes in CatD -/- mice began to decline significantly on P16 and almost disappeared on P24, and oxidative DNA damage was first detected in brain pericytes on P12. (elsevierpure.com)
Notch3 mutant mice exhibit progressive loss of retinal pericytes. (utmb.edu)
We utilized a pericyte-expressed LacZ transgene (XlacZ4) to examine pericyte loss in retinas of a type I diabetic mouse model (Ins2Akita) and Notch3-deficient mice. (utmb.edu)

Pancreatic pericytes directly support β-cells through mostly unidentified secreted factors. (nature.com)
Compared to ECs, pancreatic pericytes produce significantly higher levels of α2 and α4 laminin chains, which constitute the peri-islet and vascular BM. (nature.com)
While pericytes of coelomic organs were proposed to differentiate from the mesothelium, a single-layer squamous epithelium, the embryonic origin of pancreatic pericytes has yet to be reported. (tau.ac.il)
Here, we show that adult pancreatic pericytes originate from the embryonic pancreatic mesenchyme. (tau.ac.il)
Thus, our study indicates the embryonic pancreatic mesenchyme as the primary origin to adult pancreatic pericytes. (tau.ac.il)

It has been shown in vivo that pericytes release a hormone known as pericytic aminopeptidase N/pAPN that may help to promote angiogenesis. (wikipedia.org)
Similarly, skeletal muscle pericytes can support endothelial cell organization during angiogenesis and vasculogenesis, but can also differentiate in skeletal myocytes. (bris.ac.uk)

Importantly, we show that the vast majority of pancreatic mesenchymal cells differentiate into pericytes already at embryonic day 13.5 and progressively acquires a more mature pericyte phenotype during later stages of pancreas organogenesis. (tau.ac.il)
It has become increasingly clear that pericytes are vital in maintaining normal vascular homeostasis and regulating vascular phenotype in disease [ 3 ]. (biomedcentral.com)
Given their central role in modulating endothelial cell function, it is clear that the pronounced changes observed in endothelial cells during dcSSc will also alter pericyte phenotype and function. (biomedcentral.com)
Brain pericytes acquire a microglial phenotype after stroke. (lu.se)

The pericyte-like ASCs obtained in these experiments represent a valuable tool for the treatment of retinal damages occurring in diabetic patients. (unime.it)
The cellular and molecular mechanisms of Epac1-mediated pericyte dysfunction in response to high glucose were investigated by specific modulation of Epac1 activity in primary human retinal pericytes using Epac1-specific RNA interference and a pharmacological inhibitor. (opticnervenetwork.com)
Furthermore, high glucose-induced Epac1 expression in retinal pericytes was accompanied by increased Drp1 phosphorylation, mitochondrial fission, reactive oxygen species production, and caspase 3 activation. (opticnervenetwork.com)
CONCLUSIONS: Our study reveals an important role of Epac1 signaling in mitochondrial dynamics, reactive oxygen species production, and apoptosis in retinal pericytes and identifies Epac1 as a therapeutic target for treating ischemic retinopathy. (opticnervenetwork.com)

Given that diabetic retinopathy is associated with pericyte loss, we sought to determine whether perturbation of Notch3 signaling contributes to diabetes-induced pericyte dropout and capillary degeneration. (utmb.edu)
These results are the first to demonstrate an association between Notch3 signaling, pericyte loss, and diabetic retinopathy. (utmb.edu)
This study investigates the involvement of exchange protein directly activated by cAMP (Epac)1 signaling in pericyte injury during ischemic retinopathy, including diabetic retinopathy, a disease that threatens vision. (opticnervenetwork.com)

We observed substantial brain pathology in SARS-CoV-2-infected dogs, particularly involving blood-brain barrier damage resembling small vessel disease, including changes in tight junction proteins, reduced laminin levels, and decreased pericyte coverage. (cdc.gov)

In standard culture media pericytes tend to grow slowly and undergo early senescence, whereas in PromoCell Pericyte Growth Medium 2 the cells are optimally supported for cell proliferation and maintenance of multipotency. (promocell.com)
We find that pericytes are recruited on the developing sprout by proliferation, migrate independently from endothelial cells, and can proliferate on the growing capillary. (unito.it)
In vivo , orthotopic xenotransplant of human glioblastoma in an immunocompetent mouse model showed significant GBM cell proliferation and tumor growth after the establishment of interspecific immunotolerance that followed GMB interaction with pericytes. (oncotarget.com)
Conditional loss- and gain-of-function experiments provide evidence that Notch3 signaling positively regulates brain pericyte proliferation. (silverchair.com)
In fact, even after glucose addition, ASCs pre-cultured in the pericyte medium (pmASCs) showed high proliferation rate, viability and migration ability. (unime.it)

Genetic deletion of Epac1 protected ischemic injury-induced pericyte loss and capillary degeneration in the mouse retina. (opticnervenetwork.com)

Our team has recently demonstrated a crucial new role for chaperone-mediated autophagy (CMA) in pericytes (PC)-acquired immunosuppressive function, which prevents anti-tumor immune responses and facilitates GB progression. (physiciansweekly.com)

Adventitial pericytes share markers of mesenchymal progenitors and contributes to the remodelling of the vessel wall in pathological conditions. (bris.ac.uk)
These observations suggest that increased lysosomal storage due to CatD deficiency causes oxidative damage in brain pericytes, subsequently resulting in an increased vessel diameter, enhanced permeability of the BBB and the infiltration of PBMCs. (elsevierpure.com)
Berger M, Bergers G, Arnold B, Hammerling GJ, and Ganss R. Regulator of G-protein signaling-5 induction in pericytes coincides with active vessel remodeling during neovascularization. (lu.se)

The embryonic origin of pericytes is heterogeneous, both between and within organs. (tau.ac.il)

Deficiencies of brain pericytes are associated with neonatal intracranial hemorrhage in human fetuses, as well as stroke and neurodegeneration in adults. (silverchair.com)

Cellular mechanisms of CNS pericytes. (meharryresearch.org)
Despite the important functions of brain pericytes, the mechanisms underlying their development are not well understood and little is known about how pericyte density is regulated across the brain. (silverchair.com)
however, mechanisms contributing to pericyte dropout are not understood. (utmb.edu)

Pericytes play an essential role in the maintenance of the BBB and the dysfunction or degeneration of the pericytes contributes to the pathogenesis of diverse CNS disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease, ischemic stroke and so on 1 . (researchsquare.com)

This study identifies temporal transcriptional changes in the acute phase of ischemic stroke that reflect the early response of pericytes to the ischemic insult and its secondary consequences and may constitute potential future therapeutic targets. (lu.se)
What cell surface marker provided the best means to isolate therapeutic pericytes? (illinois.edu)
Understanding their reparative potential and how pathologicalconditions associated with ischemia affect these cells is crucial in order to fullyexploit their therapeutic potential.The following chapter will therefore address the biological characteristics ofadventitial and skeletal muscle pericytes in health and tissue-specific diseases. (bris.ac.uk)
In conclusion, attenuation of pericyte-derived fibrosis represents a promising therapeutic approach to facilitate recovery following CNS injury. (scilifelab.se)
Accordingly, human pluripotent stem cells (hPSCs) with the properties of self-renewal and pluripotency present an ideal cell model for the isolation of pericytes to study their development or the therapeutic effect in pericyte-related diseases. (researchsquare.com)

These types of pericyte can also phagocytose exogenous proteins. (wikipedia.org)
The next step would be to investigate which proteins are secreted from pericytes and endothelial cells in α-synuclein mouse models. (lu.se)

In contrast, AML specimens with a predominant spindled morphology showed diffuse expression of pericyte markers, including αSMA, CD146, and PDGFRβ. (nih.gov)
AML samples with predominant epithelioid morphology showed a marked reduction in or the absence of immunoreactivity for pericyte markers. (nih.gov)
Chaperone-Mediated Autophagy Ablation in Pericytes Reveals New Glioblastoma Prognostic Markers and Efficient Treatment Against Tumor Progression. (physiciansweekly.com)

Pericytic marker expression in PEComa may represent a true pericytic cell of origin, or alternatively aberrant pericyte marker adoption. (nih.gov)

Using single-cell RNA sequencing in a mouse model of permanent middle cerebral artery occlusion, we investigated the temporal differences in transcriptomic signatures in pericytes at 1, 12, and 24 h after stroke. (lu.se)
Capillary pericytes regulate cerebral blood flow in health and disease. (stemcellsportal.com)
SARS-CoV-2 triggers pericyte-mediated cerebral capillary constriction. (ox.ac.uk)
Brain pericytes, in particular, regulate key aspects of cerebral vascular function. (silverchair.com)

In summary, pericyte antigen expression is variable among PEComa family tumors and largely varies by tumor morphology. (nih.gov)
Proliferating cell nuclear antigen was also expressed by myofibroblasts and pericytes in dcSSc skin while being absent in control skin. (biomedcentral.com)
Listeria-based vaccination against the pericyte antigen RGS5 elicits anti-vascular effects and colon cancer protection. (bvsalud.org)
We, therefore, advance the strategy of initiating immunity in syngeneic mouse models against the endogenous pericyte antigen RGS5, which is a critical mediator of pathological vascularization. (bvsalud.org)

Pericytes help to maintain homeostatic and hemostatic functions in the brain, one of the organs with higher pericyte coverage, and also sustain the blood-brain barrier. (wikipedia.org)
A deficiency of pericytes in the central nervous system can cause increased permeability of the blood-brain barrier. (wikipedia.org)
Pericytes located at the blood/brain interface are one of the first responders to hypoxia in stroke and therefore a potential target cell for early stroke interventions. (lu.se)
Reports have linked the onset of central nervous system pathologies with severe acute respiratory syndrome coronavirus 2 (SARS ‑ CoV ‑ 2) infections [1] , and recent evidence proposes neurovascular components, and neural crest stem cell-derived brain pericytes in particular [2-5] , as viral entry points using angiotensin-converting enzyme 2 (ACE2) as a receptor. (stemcellsportal.com)
SARS-CoV-2 spike protein induces brain pericyte immunoreactivity in absence of productive viral infection. (stemcellsportal.com)
Pericytes: a link between Parkinson-related protein and blood-brain barrier disruption? (lu.se)
Pericytes are uniquely positioned at the blood-brain interface. (lu.se)
Hence, it is possible that the dysregulation of the blood-brain barrier induced by α-synuclein depends on pericytes also in the brain. (lu.se)
Cells in the brain called pericytes that have not been high on the list of targets for treating diseases like Alzheimer's may play a more crucial role in the development of neurodegenerative diseases than has been realized. (scienceblog.com)
Moreover, pepstatin A, a specific aspartic protease inhibitor, induced mitochondria-derived reactive oxygen species (ROS) production in the isolated brain pericytes, which decreased the cell viability. (elsevierpure.com)
Therefore, protecting brain pericytes against lysosomal storage-induced oxidative stress may represent an alternative treatment strategy for congenital NCL. (elsevierpure.com)
In brain slices from hamster, which has an ACE2 sequence similar to human ACE2, angiotensin II evoked a small pericyte-mediated capillary constriction via AT1 receptors, but evoked a large constriction when the SARS-CoV-2 receptor binding domain (RBD, original Wuhan variant) was present. (ox.ac.uk)
Thus, AT1 receptor blockers could be protective in Covid-19 by preventing pericyte-mediated blood flow reductions in the brain, and perhaps the heart and kidney. (ox.ac.uk)
Brain pericytes are important regulators of brain vascular integrity, permeability and blood flow. (silverchair.com)
We show that zebrafish brain pericytes express notch3 and that notch3 mutant zebrafish have a deficit of brain pericytes and impaired blood-brain barrier function. (silverchair.com)
These findings establish a new role for Notch signaling in brain vascular development whereby Notch3 signaling promotes expansion of the brain pericyte population. (silverchair.com)
Upon brain hypoxia, pericytes are one of the first responders at the blood/brain interface. (lu.se)
Enstrom A, Carlsson R, Ozen I, and Paul G. RGS5: a novel role as a hypoxia-responsive protein that suppresses chemokinetic and chemotactic migration in brain pericytes. (lu.se)

Breast cancer circulating tumor cells (CTCs) establish metastatic tumors in the bone after a close interaction with local bone marrow cells including pericytes and osteoblasts, both related to resident mesenchymal stem/stromal cells (BM-MSCs) progenitors. (wustl.edu)

Our analysis reveals that pancreatic mesenchymal cells acquire various pericyte characteristics, including gene expression, typical morphology, and periendothelial location, during embryogenesis. (tau.ac.il)

A study published in Scientific Reports identifies pericytes as potential target cells for early interventions. (lu.se)

In this work we show for the first time that GBM cells induce immunomodulatory changes in pericytes in a cell interaction-dependent manner, acquiring an immunosuppresive function that possibly assists the evasion of the anti-tumor immune response and consequently participates in tumor growth promotion. (oncotarget.com)

The morphology, distribution, density and molecular fingerprints of pericytes vary between organs and vascular beds. (wikipedia.org)
As pericytes of other coelomic organs were suggested to differentiate from the mesothelium, our findings point to a distinct origin of these cells in the pancreas. (tau.ac.il)
Thus, our study proposes a complex ontogeny of pericytes of coelomic organs. (tau.ac.il)

CLEC14A and CD248 can bind MMRN2 simultaneously and this occurs at the interface between endothelium and pericytes in human pancreatic cancer. (ox.ac.uk)
During inflammation polymorphonuclear neutrophils (PMNs) traverse venular walls, composed of the endothelium, pericyte sheath and vascular basement membrane. (tamu.edu)
Pericytes reside at the abluminal surface of microvessels and are in intimate contact with the underlying endothelium through numerous points of cell-cell contact. (biomedcentral.com)

Aside from creating and remodeling blood vessels, pericytes have been found to protect endothelial cells from death via apoptosis or cytotoxic elements. (wikipedia.org)
Moreover, an astrocytic inflammatory response, which reduces the survival of pericytes through an IκB kinase-dependent pathway, mediates the low pericyte coverage of blood vessels in HD brains. (nih.gov)

Adventitial and skeletal muscle pericytes possess intrinsic reparative capacity, both in situ where they participate to tissue repair and remodelling and when used as a cell therapy option. (bris.ac.uk)
The following chapter will therefore address the biological characteristics of adventitial and skeletal muscle pericytes in health and tissue-specific diseases. (bris.ac.uk)
Skeletal muscle pericytes also play central roles in the development, homeostasis and ageing of their native tissue and play a central role in diabetes-related endothelial dysfunction. (bris.ac.uk)

CD248 (alternatively known as endosialin or tumour endothelial marker-1) is also a member of this family and is expressed by tumour-associated fibroblasts and pericytes. (ox.ac.uk)

In Chapter 3, single-cell RNA sequencing was conducted on hindlimb muscle two weeks after immobilization to evaluate differential gene expression in pericytes and other mononuclear cells. (illinois.edu)

Their specific biological features render these two subclasses of pericytes especially attractive tools in the development of tissue regeneration strategies to treat ischemic tissues damage. (bris.ac.uk)

Both pericytes and endothelial cells share a basement membrane where a variety of intercellular connections are made. (wikipedia.org)
Many types of integrin molecules facilitate communication between pericytes and endothelial cells separated by the basement membrane. (wikipedia.org)
These plaques facilitate the connection of the basement membrane to the cytoskeletal structure composed of actin, and the plasma membrane of the pericytes and endothelial cells. (wikipedia.org)
Pericytes regulate vascular basement membrane remodeling and govern neutrophil extravasation during inflammation. (tamu.edu)

Only the healthy pericytes were able to mount an antioxidant response to oxidative stress. (illinois.edu)
Overall, the findings presented in this dissertation demonstrate that CD146+ pericytes and CD146+ pericyte-derived extracellular vesicles possess high capacity to stimulate muscle regrowth after immobilization, which may in part be due to resolution of oxidative stress. (illinois.edu)

Pericytes also project finger-like extensions that wrap around the capillary wall, allowing the cells to regulate capillary blood flow. (wikipedia.org)

Although there are several protocols describing the derivation of pericytes from hPSCs, they are either time-consuming or may generate heterogeneous pericyte population with different origins 5 , 6 . (researchsquare.com)

Notch3 has been implicated in pericyte stability and survival, and linked to vascular integrity. (utmb.edu)
Liu, H , Zhang, W & Lilly, B 2018, ' Evaluation of Notch3 deficiency in diabetes-induced pericyte loss in the Retina ', Journal of Vascular Research , vol. 55, no. 5, pp. 308-318. (utmb.edu)

Exploring how PMNs modulate pericyte behavior, we discovered that direct PMN-pericyte contacts induce relaxation rather than contraction of pericyte cytoskeletons, an unexpected response that is mediated by inhibition of the RhoA/ROCK signaling pathway in pericytes. (tamu.edu)

What was the mechanistic basis by which pericyte transplantation assisted in the recovery of muscle after disuse? (illinois.edu)
However, the scarcity of material sources greatly limits the application of primary pericytes in disease modeling and cell transplantation studies. (researchsquare.com)

Cell culture medium for human pericytes from all tissues. (promocell.com)
Human Pericytes isolated from human placenta tissue. (promocell.com)

The first pericyte subtype (Type-1) can differentiate into fat cells while the other (Type-2) into muscle cells. (wikipedia.org)

Here, we describe the presence of pericyte antigens across a diverse group of PEComa family tumors (n = 19 specimens). (nih.gov)

The Pericyte Growth Medium 2 is a low serum media and is more standardized version for an optimal culture. (promocell.com)

We used a combination of immunohistochemistry and double immunofluorescence labelling of frozen skin biopsies taken from normal and dcSSc patients to determine whether a phenotypic link between pericytes and myofibroblasts exists in dcSSc. (biomedcentral.com)

Anatomy13

Organisms1

Diseases2

Chemicals and Drugs6

Phenomena and Processes2

Endothelial cells and pericytes5

Astrocytes5

Vitro9

Revealed that brain pericytes1

Capillaries9

Vascular smooth muscl3

Differentiation3

Neurons3

Microvascular7

Mural cells1

Perivascular7

Interestingly3

Mice7

Pancreatic pericytes5

Angiogenesis2

Phenotype4

Retinal4

Diabetic retinopathy3

Laminin1

Proliferation5

Capillary degeneration1

Immunosuppressive function1

Vessel3

Embryonic1

Neurodegeneration1

Mechanisms3

Contributes1

Therapeutic5

Proteins2

Markers3

Pericytic1

Cerebral4

Antigen4

Brain18

Stromal cells1

Mesenchymal cells1

Identifies1

Cells induce1

Organs3

Endothelium3

Blood vessels2

Skeletal muscle3

Fibroblasts1

Gene expression1

Ischemic1

Basement membrane4

Oxidative stress2

Regulate capillary1

Heterogeneous1

Notch32

Behavior1

Transplantation2

Human2

Differentiate1

Tumors1

Growth Medium1

Immunohistochemistry1