• Osteopontin (OPN), also known as bone /sialoprotein I (BSP-1 or BNSP), early T-lymphocyte activation (ETA-1), secreted phosphoprotein 1 (SPP1), 2ar and Rickettsia resistance (Ric), is a protein that in humans is encoded by the SPP1 gene (secreted phosphoprotein 1). (wikipedia.org)
  • Osteopontin (SPP1, OPN) is an extra cellular matrix glycoprotein and cytokine with a known role in granuloma formation and in autoimmune and inflammatory diseases. (iucc.ac.il)
  • abstract = "To investigate osteopontin of differing degrees of phosphorylation, we used iron affinity chromatography to separate phosphorylated (pOPN) and non-phosphorylated OPN (npOPN). (tmu.edu.tw)
  • Scientists have discovered that a protein called osteopontin is found in higher levels in mesothelioma tumors than in normal tissues. (survivingmesothelioma.com)
  • Scientists in Italy found that a protein called osteopontin is important to the growth of mesothelioma. (survivingmesothelioma.com)
  • The TRAP enzyme primarily regulates the activity of a protein called osteopontin, which is produced in bone cells called osteoclasts and in immune cells. (medlineplus.gov)
  • We examined mRNA expression using reverse transcriptase-polymerase chain reaction primers for 3 osteopontin isoforms in non-small-cell lung cancer and immortalized bronchial epithelial cell lines, and correlated expression with osteopontin secretion into media detected by enzyme-linked immunosorbent assay. (nih.gov)
  • OPNa mRNA expression correlated with osteopontin secretion in cell lines (r = 0.912, P = .0006). (nih.gov)
  • S100A4 induced ephrin-A1 mRNA and protein expression in adenocarcinoma, but not in squamous carcinoma cell lines, whereas the level of osteopontin was unaffected by S100A4 treatment. (uit.no)
  • mRNA transcripts for osteopontin were determined using RT- -PCR with specific primers. (bvsalud.org)
  • Osteopontin is a SIBLING (glycoprotein) that was first identified in 1986 in osteoblasts. (wikipedia.org)
  • Background: The Osteopontin (OPN) is a highly phosphorylated glycoprotein in numbers of bovine tissues and milk. (ijbiotech.com)
  • Osteopontin is a highly phosphorylated glycoprotein and is expressed in several tissues (13). (ijbiotech.com)
  • Osteopontin (OPN) is a multifunctional glycoprotein expressed by a number of cell types. (biomedcentral.com)
  • The metastasis-promoting protein S100A4 induces expression of ephrin-A1 and osteopontin in osteosarcoma cell lines. (uit.no)
  • Osteopontin induces growth of metastatic tumors in a preclinical model of non-small lung cancer. (cpcscientific.com)
  • Osteopontin (OPN) is a multifunctional protein found in all vertebrates. (au.dk)
  • Osteopontin is a multifunctional phosphoprotein with an important but poorly understood role in non-small cell lung cancer pathogenesis. (nih.gov)
  • Osteopontin is an extracellular structural protein and therefore an organic component of bone. (wikipedia.org)
  • Osteopontin-c has been suggested to facilitate the anchorage-independent phenotype of some human breast cancer cells due to its inability to associate with the extracellular matrix. (wikipedia.org)
  • Osteopontin: A Plurifunctional Molecule, Frontiers Between Science and Clinic in Odontology Volume Title: Phosphorylated Extracellular Matrix Proteins of Bone and Dentin (2012) 2: 283. (benthamscience.com)
  • Osteopontin (OPN) is an extracellular matrix protein whose expression is upregulated at sites of inflammation and cardiovascular injury. (tamu.edu)
  • Four NSCLC cell lines were treated with extracellular S100A4, and ephrin-A1 and osteopontin expression was analyzed by real time RT-PCR and Western blotting. (uit.no)
  • In primary tumors, moderate or strong immunoreactivity was observed in 57% of cases for cytoplasmic S100A4, 46% for nuclear S100A4, 86% for ephrin-A1 and 77% for osteopontin. (uit.no)
  • Osteopontin mediates biological function through signal transduction by binding to the cell surface receptors such as integrin αvβ3 and CD44 [ 5 ]. (biomedcentral.com)
  • We hypothesize that osteopontin isoforms (OPNa, OPNb, and OPNc) have divergent roles in non-small-cell lung cancer angiogenesis and divergent impact on vascular endothelial growth factor secretion. (nih.gov)
  • We demonstrated divergent effects of osteopontin isoforms on non-small-cell lung cancer angiogenesis and vascular endothelial growth factor secretion. (nih.gov)
  • Regulation of the osteopontin gene expression is incompletely understood. (wikipedia.org)
  • Osteopontin (OPN) expression is modulated by Schistosoma mansoni egg antigen. (wikipedia.org)
  • Here we have demonstrated that the expression of osteopontin (OPN) was dramatically up-regulated in OSCC tissues and cell lines. (jcancer.org)
  • The aim of this study was to investigate S100A4-mediated stimulation of ephrin-A1 and osteopontin in non-small cell lung cancer (NSCLC) cell lines, and to characterize the expression of these biomarkers in primary tumor tissue from NSCLC patients. (uit.no)
  • Interestingly, S100A4 expression was associated with ephrin-A1 also in vivo, but there was no association between S100A4 and osteopontin. (uit.no)
  • Our recent studies have shown an increase in the surface expression of CD44 isoforms (sCD44 and v4-v10 variant CD44) in prostate cancer cells over-expressing osteopontin (PC3/OPN) [ 15 ]. (biomedcentral.com)
  • Elevated osteopontin and thrombospondin expression identifies malignant human breast carcinoma but is not indicative of metastatic status. (elsevierpure.com)
  • The expression of osteopontin (OPN) correlated with the metastatic phenotype, whereas thrombospondin-1 (TSP-1) and tyrosinase-related protein-1 (TYRP-1) correlated with the nonmetastatic phenotype of independent MDA-MB-435 cell lines implanted orthotopically into athymic mice. (elsevierpure.com)
  • Dive into the research topics of 'Elevated osteopontin and thrombospondin expression identifies malignant human breast carcinoma but is not indicative of metastatic status. (elsevierpure.com)
  • Effects of ascorbic acid on osteopontin expression and axonal myelination in the developing cerebellum of lead-exposed rat pups. (bvsalud.org)
  • Identification of osteopontin as a prognostic plasma marker for head and neck squamous cell carcinomas. (ox.ac.uk)
  • Immunohistochemical staining for S100A4, ephrin-A1 and osteopontin was performed on tissue microarrays containing primary tumor samples from a cohort of 217 prospectively recruited NSCLC patients, and associations with clinicopathological parameters were investigated. (uit.no)
  • Here, we investigated the relationship between osteopontin (OPN), tumor pO(2), and prognosis in patients with head and neck squamous cell carcinomas (HNSCC). (ox.ac.uk)
  • Osteopontin (OPN), a secreted phosphoglycoprotein, has important roles in tumor growth , invasion and metastasis in numerous types of cancers . (bvsalud.org)
  • The cancer-specific splice variants are osteopontin-a, osteopontin-b, and osteopontin-c. (wikipedia.org)
  • Splice variants of osteopontin (OPN). (shu.edu)
  • Osteopontin (OPN) is an integrin-binding protein overexpressed in various experimental models of malignancy and appears to be involved in tumorigenesis and metastasis. (aacrjournals.org)
  • Osteopontin (OPN) is an inflammatory cytokine highly expressed in multiple sclerosis (MS) plaques. (unict.it)
  • Osteopontin gene and clinical severity of multiple sclerosis. (cdc.gov)
  • [ 19 ] Research published in 2015 also suggests that osteopontin, CD44, and survivin may be involved in the pathogenesis of oral lichen planus. (medscape.com)
  • Lung cancer osteopontin isoforms exhibit angiogenic functional heterogeneity. (nih.gov)
  • Angiogenic properties conferred by osteopontin isoforms were evaluated by transfecting cDNA plasmids specific to each isoform and controls into non-small-cell lung cancer cell lines, H153 and H358 (low endogenous osteopontin) and A549 and H460 (high endogenous osteopontin), analyzing conditioned media on a bovine capillary endothelial platform, and measuring vascular endothelial growth factor levels by enzyme-linked immunosorbent assay. (nih.gov)
  • These mutations affect both TRAP isoforms and impair or eliminate TRAP's ability to inactivate osteopontin. (medlineplus.gov)
  • They indicated that the Tn motif in OPN-3907, bears an osteopontin regulator element at further up to the gene promoter. (ijbiotech.com)
  • Vitamin D plays an essential role in asthma by cell proliferation, differentiation and immunomodulation, and Osteopontin (OPN) is also associated with airway remodeling and fibrosis. (biomedcentral.com)
  • Osteopontin enhances multi-walled carbon nanotube -triggered lung fibrosis by promoting TGF-β1 activation and myofibroblast differentiation. (cdc.gov)
  • The current study focuses on investigating the role of osteopontin (OPN) in the development of lung fibrosis upon exposure to multi-walled carbon nanotube s (MWCNTs). (cdc.gov)
  • Our findings suggest that S100A4, ephrin-A1 and osteopontin are involved in the biology of NSCLC, and further investigation of their potential use as biomarkers in NSCLC is warranted. (uit.no)
  • In these studies we explore the role of GIP, its receptor GIPR and their genetic variation, as well as their downstream target, the cytokine osteopontin (OPN) in the development of vascular complications of diabetes. (lu.se)
  • Osteopontin regulates the growth and invasion of liver cancer cells via DTL. (bvsalud.org)
  • After identifying that human milk has up to 20 times more osteopontin than conventional infant formula, AFI worked diligently to bring the osteopontin content in its offerings on par with human milk concentrations. (prnewswire.co.uk)
  • Previous proteomic studies from our lab showed that the matricellular protein osteopontin (OPN) was found in human aqueous humor (AH) at levels comparable to or higher than in serum. (arvojournals.org)
  • Recognizes human Osteopontin (aa 59-74). (antibodies-shop.com)
  • Accordingly, the CD44v7 ligand osteopontin, whose levels were elevated in Crohn's disease, specifically induced IL-6 in human monocytes, a cytokine also increased in these patients. (nature.com)
  • Osteopontin (OPN) is abundantly expressed in human calcified arteries. (silverchair.com)
  • Like TRAP5b in bone cells, the TRAP5a enzyme inactivates osteopontin in macrophages and dendritic cells when it is no longer needed. (medlineplus.gov)
  • Consequently, it pioneered the commercial use of osteopontin in infant formula with its product Lacprodan® OPN-10," said Arun Ramesh , Industry Analyst at Frost & Sullivan. (prnewswire.co.uk)
  • February 1, 2019 Raised levels of a protein osteopontin were shown to indicate lupus nephritis and higher disease activity, in a new study conducted at 33 centers by top lupus researchers worldwide. (lupusresearch.org)
  • Conclusions Osteopontin protein levels are elevated in sarcoidosis. (iucc.ac.il)
  • We found no evidence for an association between SNPs on the osteopontin gene and plasma OPN levels or the presence of sarcoidosis, however, an association between genotype and several phenotypic clinical parameters of disease was observed. (iucc.ac.il)
  • MCP-1 and osteopontin mRNAs, expressed at low levels in kidneys from normal (+/+) animals at all ages, were markedly elevated in kidneys from 3-week-old Cy/Cy animals. (fujita-hu.ac.jp)
  • Objective: Osteopontin (OPN), a sialoprotein present within atherosclerotic lesions, especially in calcified plaques, is linked to the progression of coronary artery disease and heart failure. (medipol.edu.tr)
  • Osteopontin (OPN) has been shown to play many roles in the progression of cancer. (biomedcentral.com)
  • Gan N, Zou S, Hang W, Yang D, Zhang X, Yin Y. Osteopontin is Critical for Hyperactive mTOR-Induced Tumorigenesis in Oral Squamous Cell Carcinoma. (jcancer.org)
  • Osteopontin OPN] has originally been identified from various sources, but initially research focused on its role in mineralization and bone homeostasis and remodelling. (benthamscience.com)
  • We have also recently described a role for the host protein Osteopontin (OPN), a pro-fibrogenic downstream effector of the Hedgehog pathway, in enhancing HCV replication (Choi et al , Clinical Sciences 2014). (bmj.com)
  • In the immune system, osteopontin is found primarily in cells called macrophages and dendritic cells. (medlineplus.gov)
  • After polyclonal stimulation, the CCR2 + CCR5 + T cells exhibited a distinct ability to produce matrix metalloproteinase-9 and osteopontin, which are involved in the CNS pathology of MS. Furthermore, after TCR stimulation, the CCR2 + CCR5 + T cells showed a higher invasive potential across an in vitro blood-brain barrier model compared with other T cells. (elsevierpure.com)
  • We recently identified circulating osteopontin (OPN) released from the injured kidney after ischemic AKI as a key mediator of lung endothelial leakage, lung inflammation and respiratory failure in mice," says Dr. Herrlich, who is the Director of Translational Research in our Division. (wustl.edu)
  • Our work has the potential to identify osteopontin as a new drug target in humans that could ameliorate the detrimental effect that AKI has on the injured lung. (wustl.edu)
  • Osteopontin (OPN) is an integrin-binding protein, believed to be involved in a variety of physiological cellular functions (1) . (aacrjournals.org)
  • Osteopontin performs a variety of functions in these cells. (medlineplus.gov)
  • To examine the relationship between proinflammatory chemoattractants and the development of interstitial inflammation and ultimately renal failure in ADPKD, we evaluated monocyte chemoattractant protein-1 (MCP-1) and osteopontin mRNAs and proteins in kidneys from Han:SRPD rats. (fujita-hu.ac.jp)
  • Osteopontin gene (OPN) and PPARGC1A are located in the middle of chromosome 6 about 6 Mb apart, which is approximately 12 cM (6) and encodes osteopontin, the prime candidate among the six genes in the 420 Kb region (9). (ijbiotech.com)