• The osteoclast is a large, multinucleated cell that is differentiated from monocyte/macrophage lineage cells by macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ligand (RANKL). (nih.gov)
  • This review outlines the findings on osteoclast and RANKL/RANK signaling that have accumulated to date. (nih.gov)
  • Here we show that the in vivo administration of MPA triggers massive induction of the key osteoclast differentiation factor RANKL (receptor activator of NF-κB ligand) in mammary-gland epithelial cells. (nature.com)
  • We also found that rapid application of the osteoclast-activation factor RANKL converted many N osteoclasts to R, suggesting a novel point of action in RANKL-mediated control of mature osteoclast function. (jci.org)
  • Furthermore, we showed that Th17 cells, a subset of RANKL-expressing CD4 + T cells, could induce rapid N-to-R conversion of mature osteoclasts via cell-cell contact. (jci.org)
  • These findings provide new insights into the activities of mature osteoclasts in situ and identify actions of RANKL-expressing Th17 cells in inflammatory bone destruction. (jci.org)
  • The effect of pyrroloquinoline quinine (PQQ) on receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast formation was examined using RAW 264.7 macrophage-like cells. (nih.gov)
  • RANKL led to the formation of osteoclasts identified as tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells in the culture of RAW 264.7 cells. (nih.gov)
  • However, PQQ inhibited the appearance of osteoclasts and prevented the decrease of F4/80 macrophage maturation marker on RANKL-stimulated cells, suggesting a preventive action of PQQ on RANKL-induced osteoclast differentiation. (nih.gov)
  • Taken together, PQQ was suggested to prevent RANKL-induced osteoclast formation via the inactivation of NFATc1 by reduced c-Fos expression. (nih.gov)
  • However, tartrate-resistant acid phosphatase (TRAP) activity and the number of osteoclast cells (TRAP-positive multinucleated cells) were not changed by nSP treatment in the presence of receptor activator of nuclear factor κB ligand (RANKL) at doses that did not induce cytotoxicity by silica particles. (springer.com)
  • Collectively, the results suggested that nanosilica exerts no effect on RANKL-induced osteoclast differentiation of RAW264.7 cells, although a detailed mechanistic examination of the nSP70-mediated cytotoxic effect is needed. (springer.com)
  • The model results corroborate all behaviors of the bone remodeling system that we have simulated, including the tight coupling between osteoblasts and osteoclasts, the catabolic effect induced by continuous administration of PTH, the catabolic action of RANKL, as well as its reversal by soluble antagonist OPG. (cellml.org)
  • Osteoclasts and odontoclasts are multinucleated cells derived from hematogenous bone marrow, from the monocyte/macrophage cell lineage, and are formed by the fusion of these cells under the action of colony stimulating factor 1 (CSF-1), macrophage colony stimulating factor (M-CSF), monocyte chemotactic protein-1 (MCP-1) and RANKL (receptor activator of nuclear factor kappa-B ligand), which also have a role in chemotaxis and cell differentiation [1]. (oatext.com)
  • The differentiation of the osteoclast precursor into a mature osteoclast requires RANKL binding to its receptor RANK (receptor activator of nuclear factor kappa-B). However, OPG binding to RANKL will block RANKL binding to RANK, which will result in inhibition of osteoclastogenesis (Figure 1) [3]. (oatext.com)
  • In this study, we examined the potential of SF extract (SFE) to inhibit receptor activator of NF-κB ligand (RANKL) -induced osteoclast differentiation in cultured mouse-derived bone marrow macrophages (BMMs). (biomedcentral.com)
  • BMMs, that act as osteoclast precursors, were cultured with M-CSF (50 ng/ml) and RANKL (100 ng/ml) for 4 days to generate osteoclasts. (biomedcentral.com)
  • SFE attenuated the RANKL-mediated induction of NF-κB through inhibition of IκBα phosphorylation, which contributed to inhibiting of RANKL-induced osteoclast differentiation through downregulation of NFATc1. (biomedcentral.com)
  • Macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-κB ligand (RANKL) are two cytokines secreted mainly by osteoclast. (biomedcentral.com)
  • Osteoclast Culture Kit includes cryopreserved osteoclast precursor (OCP) cells from bone marrow and culture medium containing M-CSF and RANKL for researchers studying osteoporosis, bone reabsorption, or other bone metabolism disorders. (asone-int.com)
  • Osteoclast differentiation and function is controlled primarily by Macrophage Colony-Stimulating Factor (M-CSF) and Receptor for Activation of Nuclear Factor Kappa B Ligand (RANKL). (asone-int.com)
  • Recently the osteoclast differentiation factor (ODF), better termed RANKL (receptor activator of NF-kappaB ligand), expressed by osteoblasts has been cloned as well as its cognate signaling receptor, receptor activator of NFkappaB (RANK), and a secreted decoy receptor osteoprotegerin (OPG) that limits RANKL's biological action. (ox.ac.uk)
  • MCF-7, MDA-MB-231, and T47D cells did not act as surrogate osteoblasts to support osteoclast formation in coculture experiments, a result consistent with the fact that they do not express RANKL. (ox.ac.uk)
  • DAP12 -/- osteoclasts developed in vitro with macrophage colony-sfimulating factor (M-CSF) and RANKL formed only intensely TRACP + mononuclear cells and failed to generate multinuclear osteoclasts. (elsevierpure.com)
  • In contrast, TNF often acts on cell types other than osteoclasts, or synergically with RANKL to indirectly promote osteoclastogenesis and bone resorption. (frontiersin.org)
  • Osteoclast differentiation is induced by the master osteoclastogenic factor, RANKL, which acts in concert with M-CSF and ITAM-mediated co-stimulatory signaling. (frontiersin.org)
  • We found that interleukin 1β stimulated multinucleation and bone resorption of osteoclasts derived from the 3 precursors at different rates. (vu.nl)
  • Our results indicate that the different bone marrow osteoclast precursors are differently stimulated by interleukin 1β with respect to proliferation, multinucleation, life span, and bone resorption. (vu.nl)
  • Introduction: Osteoclasts are bone-resorbing cells derived from hematopoietic precursors in the myeloid lineage. (elsevierpure.com)
  • Restoration of DAP12 expression by retroviral transduction of DAP12 -/- osteoclast precursors rescued in vitro osteoclast multinucleation, Direct sfimulation of DAP12 expressed in RAW264.7 during in vitro osteoclastogenesis led to a marked increase in the number of TRACP + multinucleated osteoclast-like cells formed. (elsevierpure.com)
  • Recent studies have uncovered key intrinsic mechanisms by which TNF acts on osteoclast precursors to restrain osteoclastogenesis, including the mechanisms mediated by RBP-J signaling, RBP-J and ITAM (Immunoreceptor tyrosine-based activation motif) crosstalk, RBP-J mediated regulatory network, NF- κ B p100, IRF8, and Def6. (frontiersin.org)
  • ABSTRACT: We propose a mathematical model explaining the interactions between osteoblasts and osteoclasts, two cell types specialized in the maintenance of the bone integrity. (cellml.org)
  • Osteoblasts and osteoclasts differ in their function in the maintenance of bones. (pediaa.com)
  • Until recently many studies of bone remodeling at the cellular level have focused on the behavior of mature osteoblasts and osteoclasts, and their respective precursor cells, with the role of osteocytes and bone lining cells left largely unexplored. (ebi.ac.uk)
  • Osteoclasts are bone resorbing, multinucleate cells that differentiate from mononuclear macrophage/monocyte-lineage hematopoietic precursor cells. (jci.org)
  • Previously, we reported that distinct murine osteoclast precursor subsets, such as early blasts (CD31hi Ly-6C−), myeloid blasts (CD31+ Ly-6C+), and monocytes (CD31− Ly-6Chi), respond differently to the osteoclastogenesis-inducing cytokines, macrophage colony-stimulating factor, and receptor activator for nuclear factor κB ligand. (vu.nl)
  • Compared to saline treatments, bone-resorbing osteoclasts and bone marrow osteoclast precursor populations were also increased in ODE-treated WT but not IL-6 KO mice. (cdc.gov)
  • When osteoclast-inducing cytokines are used to convert macrophages to osteoclasts, very large cells that may reach 100 µm in diameter occur. (wikipedia.org)
  • The size of the multinucleated assembled osteoclast allows it to focus the ion transport, protein secretory and vesicular transport capabilities of many macrophages on a localized area of bone. (wikipedia.org)
  • The osteoclasts are developed from either monocytes or macrophages . (pediaa.com)
  • Osteoclasts are derived from circulating cells such as monocytes and macrophages. (pediaa.com)
  • An osteoclast is a large multinucleated cell and human osteoclasts on bone typically have four nuclei and are 150-200 µm in diameter. (wikipedia.org)
  • To investigate the validity of this claim we isolated human osteoclasts from giant-cell tumours of bone and rat osteoclasts from long bones. (ox.ac.uk)
  • Effects of zoledronic acid and geranylgeraniol on angiogenic gene expression in primary human osteoclasts. (bvsalud.org)
  • Replacement of the mevalonate pathway using geranylgeraniol (GGOH) was studied to determine the effects of ZA on angiogenic gene expression in primary human osteoclasts . (bvsalud.org)
  • We covalently bonded BP to functionalised HA (HA-BP) and found that HA-BP conjugates were highly specific to osteoclastic cells and reduced mature osteoclast numbers significantly more than free BP. (scilifelab.se)
  • Firstly, the expression of HSP90α in osteoclast differentiation was detected by western blotting in vitro, then the effect of HSP90α inhibition on the formation and differentiation of osteoclasts was examined. (spandidos-publications.com)
  • The in vitro metabolism of osteoclasts obtained from involved disease areas of two patients with idiopathic monostotic fibrous dysplasia and one patient with polyostotic fibrous dysplasia were compared with osteoclasts isolated from noninvolved bone in the same individuals and normal controls. (northwestern.edu)
  • Osteoclasts from regions of in vivo abnormal growth exhibited normal mineral metabolism in vitro. (northwestern.edu)
  • In this study, we show that human Btk-deficient osteoclasts are defective at resorption activity in vitro owing to a dysregulation of the actin cytoskeletal function. (uea.ac.uk)
  • Supplementation of osteoclast cultures from normal and XLA subjects with serum from XLA patients or recombinant inflammatory cytokines IL-6, IL-1β, and TNF-α resulted in a stimulation of osteoclast activity in vitro, whereas the addition of cytokine-neutralizing antibodies inhibited this stimulatory effect, confirming that elevated inflammatory cytokines in XLA serum heightened osteoclast activity in vitro. (uea.ac.uk)
  • We identify specific DAP12-associated receptors expressed by osteoclasts and examine function of DAP12 in murine osteoclasts in vivo and in vitro. (elsevierpure.com)
  • Materials and Methods: Osteoclasts from DAP12 -/- or control mice were analyzed in vitro for morphology, function, and for osteoclast markers. (elsevierpure.com)
  • Using a murine model of breast cancer metastasis to bone, we established that MCF-7 cells that overexpress PTHrP caused significantly more bone metastases, which were associated with increased osteoclast formation, elevated plasma PTHrP concentrations and hypercalcaemia compared with parental or empty vector controls. (ox.ac.uk)
  • Monocytes needed the longest time (95 h) for the generation of such large osteoclasts, but these cells had a longer life span (50 h). (vu.nl)
  • Osteoclast cells form from a hematopoietic stem cells called monocytes. (asone-int.com)
  • These may have dozens of nuclei, and typically express major osteoclast proteins but have significant differences from cells in living bone because of the not-natural substrate. (wikipedia.org)
  • Less clear is fluoride's impact on bone resorption and the cells (osteoclasts) that resorb bone. (fluoridealert.org)
  • Mature osteoclasts expressing TRAP-tdTomato signals ( A ), green fluorescent signals from high H + concentration ( B ), and merged images ( C ). Green fluorescent signals from the H + probes overlapped with static (low CDI, arrowheads) but not moving (high CDI, asterisk) osteoclasts, suggesting that former cells are secreting protons actively and resorbing bone tissues when observed in vivo. (jci.org)
  • Given the rate of transition from static to motile behavior of the osteoclasts, these areas are likely to be those undergoing resorption by previously static cells shortly before obtaining the image and characterizing the osteoclasts at motile. (jci.org)
  • showed that the osteoclastic potential of mandibular bone marrow stromal cells and the number of osteoclasts are higher compared to long-bone marrow stromal cells [2]. (oatext.com)
  • Osteoclasts are bone-resorbing cells and targets for treating bone diseases. (vu.nl)
  • Introduction: Breast Cancer with osteoclast-like stromal giant cells (OLGCs) is a rare pattern of invasive non-special type ductal carcinoma. (uniba.it)
  • Discussion: The origin and mechanism for developing osteoclast-like giant cells is unknown. (uniba.it)
  • The osteoclasts are a type of bone cells. (biologyonline.com)
  • The four main types of bone cells are the (1) osteoclasts, (2) osteoblast s, (3) osteocyte s, and (4) lining cells. (biologyonline.com)
  • The osteoclasts, in particular, are large, multinucleated cells that are involved in the absorption and removal of bone, particularly dissolving the fibers and the matrix of bone. (biologyonline.com)
  • During an active bone resorption, the osteoclasts may appear as cells with ruffled border. (biologyonline.com)
  • Examples of these cells are Kupffer cell s in liver , histiocyte s in lymph nodes, Langerhans cells of skin and mucosa, Hofbauer cells in placenta , microglia in central nervous system , and, as already mentioned, the osteoclasts in bone . (biologyonline.com)
  • It has been stated that the multinucleated cells which contain wear particles are not bone-resorbing osteoclasts. (ox.ac.uk)
  • Our findings demonstrate that osteoclasts are capable of phagocytosing particles of a wide range of size, including particles of polymeric and metallic biomaterials found in periprosthetic tissues, and that after particle phagocytosis, they remain fully functional, hormone-responsive, bone-resorbing cells. (ox.ac.uk)
  • Developed silver grains of 125 I‐eCT were localized into multinucleated osteoclasts and mononuclear cells that were ultrastructurally defined as "preosteoclasts. (elsevierpure.com)
  • Breast Cancer Cells Interact with Osteoblasts to Support Osteoclast Formation1. (ox.ac.uk)
  • cocultures with MCF-7 or MCF-7 cells transfected with pcDNAIneo required exogenous agents for osteoclast formation. (ox.ac.uk)
  • Osteoblast and osteoclast are two types of cells found in the bone. (pediaa.com)
  • Osteoclasts are multinucleated cells with about 200 nuclei per cell. (pediaa.com)
  • The digestion of the fragments occurs in the cytoplasmic vacuoles inside the osteoclast cells. (pediaa.com)
  • These mononuclear cells are functional osteoclast-like cells because, by RT-PCR, they express other osteoclast markers and generate resorption pits on dentine slices, although quantitative assessment of bone resorption shows decreased resorption by DAP12 -/- osteoclasts compared with C57BL/6 osteoclasts. (elsevierpure.com)
  • Bone matrix must be renewed over time in order to maintain its mechanical properties, and myeloid lineage cells called osteoclasts (OCs) are the specialized cells that perform this critical function. (wustl.edu)
  • A rare variant of undifferentiated pancreatic carcinoma characterized by the presence of non-neoplastic osteoclast-like giant cells. (nih.gov)
  • Case report: Pathological and genetic features of pancreatic undifferentiated carcinoma with osteoclast-like giant cells. (nih.gov)
  • Negative prognostic impact of PD-L1 expression in tumor cells of undifferentiated (anaplastic) carcinoma with osteoclast-like giant cells of the pancreas: study of 13 cases comparing ductal pancreatic carcinoma and review of the literature. (nih.gov)
  • Osteoclasts are bone cells derived from monocyte/macrophage lineage and are exclusively responsible for bone resorption, which contributes to skeletal development, bone homeostasis, and remodeling. (frontiersin.org)
  • Osteoclast cultures were generated from peripheral blood mononuclear cells of three patients using the peripheral blood mononuclear cell isolation. (bvsalud.org)
  • The TRAP enzyme primarily regulates the activity of a protein called osteopontin, which is produced in bone cells called osteoclasts and in immune cells. (medlineplus.gov)
  • Two versions (isoforms) of the TRAP enzyme are produced: TRAP5a is found primarily in immune cells and TRAP5b is found primarily in bone cells called osteoclasts. (medlineplus.gov)
  • Osteoclasts are specialized cells that break down and remove (resorb) bone tissue that is no longer needed. (medlineplus.gov)
  • As a result, osteopontin is abnormally active, prolonging bone breakdown by osteoclasts and triggering abnormal inflammation and immune responses by immune cells. (medlineplus.gov)
  • Prolia works by blocking a protein called RANK (receptor activator of nuclear factor kappa beta) and helps prevent bone cells called osteoclasts from breaking down bone in the body. (medlineplus.gov)
  • A viral etiology, such as measles, has been proposed because nuclear inclusions in diseased osteoclasts that are similar to those seen in paramyxovirus-infected cells have been seen on electron microscopy. (msdmanuals.com)
  • Osteoclasts that resorb bone play an important role in bone remodelling. (springer.com)
  • Osteoclasts resorb bone by attaching to the bone surface and lowering the surrounding pH to an acidic level of around 4.5. (asone-int.com)
  • 20 nuclei) and highest level of bone resorption (16.3%) was by myeloid blast-derived osteoclasts. (vu.nl)
  • Interleukin 1β particularly accelerated proliferation of early blasts and the most small osteoclasts (3-5 nuclei) formed on plastic. (vu.nl)
  • It is also multinucleated, e.g. a human osteoclast typically has five nuclei . (biologyonline.com)
  • Many of the osteoclasts comprise around 5 to 20 nuclei per cell. (pediaa.com)
  • Excessively active osteoclasts are often large and contain many nuclei. (msdmanuals.com)
  • However, PTH stimulates the osteoblasts to secrete the cytokine called osteoclast-stimulating factor, which is a potent stimulator of the osteoclastic activity. (wikipedia.org)
  • Our studies revealed that nSP induced high ROS and pro-inflammatory cytokine production, and these cellular responses may induce excess osteoclast differentiation. (springer.com)
  • In XLA patients, however, these inherent osteoclast defects are corrected by increased inflammatory cytokine levels, restoring osteoclast activity and leading to the normalization of bone density. (uea.ac.uk)
  • It is unknown, however, how these cell types respond to the osteoclast-stimulating inflammatory cytokine interleukin 1β. (vu.nl)
  • Osteoprotegerin is a key molecule in this biosignalling pathway as it inhibits osteoclastogenesis and osteoclast activation to prevent run-away bone resorption. (brighton.ac.uk)
  • Pharmaceutical inhibition of osteoclast differentiation is a current therapeutic approach for the treatment of bone loss-related diseases. (biomedcentral.com)
  • However, inhibition of osteoclast formation via blocking RANK signaling can result in long-term bone remodeling defects. (frontiersin.org)
  • The main difference between osteoblast and osteoclast is that osteoblast is involved in the formation and mineralization of bones whereas osteoclast is involved in the breakdown and resorption of bones . (pediaa.com)
  • Both osteoblast and osteoclast are involved in the repair and breakdown of bones. (pediaa.com)
  • The OLGCs are specific type of macrophage and are likely distinct from true osteoclasts. (uniba.it)
  • Regarding the underlying mechanism, inhibition of HSP90α could block the nuclear import of PPARγ to inhibit osteoclast differentiation and proliferation. (spandidos-publications.com)
  • Current treatments for excessive bone resorption utilize RANK receptor blockers or neutralizing antibodies, which are able to inhibit osteoclast formation. (frontiersin.org)
  • The osteoclasts do not have receptors for parathyroid hormone (PTH). (wikipedia.org)
  • In this study, we have exploited the natural affinity of high (H) and low (L) molecular-weight hyaluronic acid (HA) towards a cluster of differentiation 44 (CD44) receptors on osteoclasts to use it as a biodegradable targeting vehicle. (scilifelab.se)
  • Osteoclast differentiation was measured by tartrate-resistant acidic phosphatase (TRAP) staining and the TRAP solution assay. (biomedcentral.com)
  • Under inflammatory conditions, abnormal osteoclast differentiation and function often results in excessive bone resorption, which is a common characteristic of many diseases, such as osteoporosis, rheumatoid arthritis (RA), psoriatic arthritis and periodontitis ( 1 - 5 ). (frontiersin.org)
  • Although a viral cause remains controversial, it is hypothesized that in genetically predisposed patients an as yet unidentified virus triggers abnormal osteoclast activity. (msdmanuals.com)
  • The activity of osteoclasts is controlled by hormones and cytokines. (wikipedia.org)
  • The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. (nature.com)
  • The aim of the present study was to investigate the role of HSP90α involved in the regulation of osteoclast formation and the process of osteoporosis. (spandidos-publications.com)
  • Inhibition of HSP90α could block the formation and differentiation of osteoclasts, and remit osteoporosis in mice. (spandidos-publications.com)
  • In conclusion, these data indicated that the inhibition of HSP90α could block osteoclast formation and remit osteoporosis by reducing the nuclear import of PPARγ. (spandidos-publications.com)
  • These data show a new role for DAP12 signaling in regulating formation of multinucleated osteoclasts. (elsevierpure.com)
  • Conclusion: Our studies indicate that stimulation of the DAP12 adapter protein plays a significant role in formation of multinuclear osteoclasts and that DAP12 and DARs likely participate in the regulation of bony remodeling. (elsevierpure.com)
  • The present study investigates the effects of nSP on osteoclast differentiation and the relationship between particle size and these effects. (springer.com)
  • Furthermore, because we indicated previously that nSP induced different cellular responses from submicron-sized silica particles, such as those described above, it was of interest to analyse the effects of particle size on osteoclast differentiation. (springer.com)
  • however, markers of osteoblastic activity rise only slightly, whereas osteoclasts have a significant increase in their activity, peaking at 10 weeks following the injury with values 10 times the upper limits of normal (ULN). (medscape.com)
  • Using osteoclasts derived from mice genetically deficient for Syk, DAP12, SLP- 76, or the SLP-family member BLNK, we defined the c-Fms and αvβ3 signaling integrin pathways, both functionally and biochemically. (wustl.edu)
  • We report that transgenic mice expressing measles virus nucleocapsid protein (MVNP) in osteoclasts (OCLs) (MVNP mice) are Paget's disease (PD) models and that OCLs from patients with PD and MVNP mice express high levels of OCL-derived IGF1 (OCL-IGF1). (jci.org)
  • Because of their phagocytic properties, osteoclasts are considered to be a component of the mononuclear phagocyte system (MPS). (wikipedia.org)
  • Apart from the skeletal system, the osteoclasts are also regarded as part of the mononuclear phagocyte system , which in turn is part of the immune system . (biologyonline.com)
  • Several other mutations associated with Paget disease have been identified, many affecting the RANK (receptor activator of nuclear factor kappa-B) signaling pathway that is critical for osteoclast generation and activity. (msdmanuals.com)
  • At a site of active bone resorption, the osteoclast forms a specialized cell membrane, the "ruffled border", that opposes the surface of the bone tissue. (wikipedia.org)
  • On such surfaces, the osteoclasts are seen to be located in shallow depressions called resorption bays (Howship's lacunae). (wikipedia.org)
  • In bone, osteoclasts are found in pits in the bone surface which are called resorption bays, or Howship's lacunae. (wikipedia.org)
  • The osteoclasts from the involved regions formed similar resorption lacunae compared with osteoclasts isolated from both normal and noninvolved bone. (northwestern.edu)
  • The small depressions on the bone surface which are occupied by osteoclasts are called Howship lacunae. (pediaa.com)
  • Three theories were dominant: from 1949 to 1970 the connective tissue origin was popular, which stated that osteoclasts and osteoblasts are of the same lineage, and osteoblasts fuse together to form osteoclasts. (wikipedia.org)
  • The osteoclast is the exclusive cell responsible for bone resorption, making it a therapeutic target for treating skeletal disease. (wustl.edu)
  • Veis, D & Mbalaviele, G 2017, Osteoclasts-key players in skeletal health and disease . (wustl.edu)
  • The main pathogenesis of OP is excessive proliferation and differentiation of osteoclasts, in which the peroxisome proliferator‑activated receptor γ (PPARγ) pathway has a pivotal role. (spandidos-publications.com)
  • As a result, in the process of osteoclast differentiation and proliferation, the expression of HSP90α was upregulated. (spandidos-publications.com)
  • abstract = "The control of osteoblast/osteoclast cross-talk is crucial in the bone remodelling processand provides a target mechanism in the development of drugs for bone metabolic diseases.Osteoprotegerin is a key molecule in this biosignalling pathway as it inhibits osteoclastogenesisand osteoclast activation to prevent run-away bone resorption. (brighton.ac.uk)
  • abstract = "The binding sites and chronologic localization of elcatonin (eCT) in osteoclasts were examined by autoradiography using [125I]elcatonin (125I‐eCT). (elsevierpure.com)
  • While evidence does indicate that fluoride can inhibit osteoclasts and bone resorption, evidence also indicates that fluoride can increase osteoclast activity and bone resorption. (fluoridealert.org)
  • 2) The CT in Golgi apparatus may keep its activity and cause the prolonged effect of CT on osteoclast activity. (elsevierpure.com)
  • Scholars@Duke publication: Effects of Roux-en-Y Gastric Bypass on Osteoclast Activity and Bone Density in Morbidly Obese Patients with Type 2 Diabetes. (duke.edu)
  • MAIN OUTCOME MEASURE: Osteoclast activity, bone mineral density. (duke.edu)
  • We verified the presence of DAP12 in pre-osteoclasts and osteoclasts derived from C57BL/6 or the pre-osteoclast line RAW 264.7 and idenfified the DARs expressed. (elsevierpure.com)
  • Moreover, SLP-76 regulates osteoclast function in vivo. (wustl.edu)
  • An osteoclast (from Ancient Greek ὀστέον (osteon) 'bone', and κλαστός (clastos) 'broken') is a type of bone cell that breaks down bone tissue. (wikipedia.org)
  • An osteoclast refers to a type of bone cell responsible for the bone resorption. (pediaa.com)
  • An osteoclast is a type of bone cell that is responsible for the bone resorption. (pediaa.com)
  • The resorption bays are created by the erosive action of osteoclasts on the underlying bone. (wikipedia.org)
  • Cytologically, the osteoclasts appear to have a foamy homogenous cytoplasm because of the presence of several vesicles, vacuole s, and lysosome s filled with acid phosphatase. (biologyonline.com)
  • Bone fractures induce the aggregation of DC-STAMP+ osteoclasts to osteoblast proximity. (rochester.edu)
  • This extensively folded or ruffled border facilitates bone removal by dramatically increasing the cell surface for secretion and uptake of the resorption compartment contents and is a morphologic characteristic of an osteoclast that is actively resorbing bone. (wikipedia.org)
  • D ) The H + secretion index of mature osteoclasts. (jci.org)
  • The H + secretion index was defined as the ratio of the number of osteoclasts overlapping with green fluorescent acid pH signals divided by the total number of osteoclasts of the indicated type that were imaged ( n = 3, from 3 independent experiments). (jci.org)
  • RANK is essential for osteoclast and lymph node development. (nature.com)
  • An iliac crest bone biopsy revealed an increased amount of thick unmineralized osteoid as well as a large number of osteoclasts and associated resorption cavities, consistent with osteomalacia. (fluoridealert.org)
  • We observed osteoclasts resorbing bone beneath osteoid seams, and fragments of osteoid isolated in the bone marrow. (fluoridealert.org)
  • Osteoclasts do not work on the osteoid. (pediaa.com)
  • The acid phosphatases secreted by the osteoclasts dissolve both collagen, calcium, and phosphorus in the bone. (pediaa.com)
  • DARs were identified in osteoclast cultures through reverse transcriptase-polymerase chain reaction (RT-PCR). (elsevierpure.com)
  • In addition to defining the role of SLP-76 in osteoclast function, we also delineated the pathway for αvβ3 and c-Fms-mediated SLP-76 activation via the Syk tyrosine kinase and the immunoreceptor activation motif (ITAM)-containing adaptor protein, DAP12. (wustl.edu)
  • These results show that the systemic IL-6 effector pathway mediates bone deterioration induced by repetitive inhalant ODE exposures through an effect on osteoclasts, but a positive role for IL-6 in the airway was not demonstrated. (cdc.gov)
  • Osteoclasts are specialized as the only bone-resorbing cell type and increased numbers are implicated in the development of bone loss-accompanied diseases such as osteoporosis, periodontitis, rheumatoid arthritis, osteosarcoma, and bone cancer metastases [ 2 - 4 ]. (biomedcentral.com)
  • Bisphosphonate-functionalized hyaluronic acid showing selective affinity for osteoclasts as a potential treatment for osteoporosis. (scilifelab.se)