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  • thrombocytosis
  • The 5q-syndrome is characterized by macrocytic anemia, often a moderate thrombocytosis, erythroblastopenia, megakaryocyte hyperplasia with nuclear hypolobation, and an isolated interstitial deletion of chromosome 5. (wikipedia.org)
  • anaphase
  • E) Megakaryocyte in anaphase A was stained with DAPI (a), anti-α-tubulin antibody (b), anticentromere antibody (c), or all three (d). (nih.gov)
  • membrane
  • Studies of cultured megakaryocytes will include evaluation of granule membrane and soluble proteins using fluorescent antibodies and immunoelectron microscopy and comparison of RNA and protein expression patterns between normal and patient cells. (clinicaltrials.gov)
  • nucleus
  • As a result, the nucleus of the megakaryocyte may contain up to 32 copies of the normal complement of DNA in a human cell. (sciencephoto.com)
  • Anticentriole antibody (Fig. 3 A, c) and anti-α-tubulin antibody (Fig. 3 A, b) stainings confirmed that multiple mitotic spindle poles were formed and assembled outside the nucleus in a megakaryocyte in prophase, as described above. (nih.gov)
  • human
  • Here we show that adenosine diphosphate elicits, in human megakaryocytes, an increase in cytosolic calcium concentration, followed by a plateau, which is lowered in absence of extracellular calcium, suggesting the involvement of Store-Operated Calcium Entry. (haematologica.org)
  • These findings provide the first evidence that both calcium mobilization from intracellular stores and extracellular calcium entry specifically regulate human megakaryocyte functions. (haematologica.org)