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IonophoresLasalocidNigericinMonensinValinomycinCalcimycinIonomycinPotassium IonophoresEthersSodium IonophoresCarbonyl Cyanide m-Chlorophenyl HydrazoneCarbonyl Cyanide p-TrifluoromethoxyphenylhydrazoneGramicidinCalciumFuransButylaminesHydrogen-Ion ConcentrationBiological Transport, ActiveIon-Selective ElectrodesProton IonophoresPotassiumPotentiometryKineticsMethylaminesBiological TransportRuminantsVeterinary DrugsDicyclohexylcarbodiimideSalicylanilides2,4-DinitrophenolSodiumCoccidiostatsMembrane PotentialsProtonsCalcium IonophoresArsenazo IIIAnti-Bacterial AgentsAdenosine TriphosphateCattlePotassium CyanideAmmonium ChlorideClioquinolRumenPyransLanthanumUncoupling AgentsLiposomesMembranes, ArtificialCarboxylic AcidsEgtazic AcidCell MembraneArsenatesCations, DivalentCationsDinitrophenolsTerpenesTetradecanoylphorbol AcetateEubacteriumAnimal FeedAminoquinolinesMagnesiumGastrointestinal ContentsMethaneElectrochemistryCell Membrane PermeabilityLysosomesMacrolidesVerapamilThapsigarginEukaryotaEdetic AcidIonsCell LineIntracellular MembranesHistamine ReleaseOsmolar ConcentrationCytosolDigestionFluorescent DyesChloroquineAdenosine TriphosphatasesCells, CulturedGasesOligomycinsCyclic AMPModels, BiologicalProteolipidsFermentationZincStimulation, ChemicalAzidesElectrodesLactococcus lactisArachidonic Acid
A23187ChelatorsZinc IonophoreControl of coccidiosisMembraneCalcium IonophoresSelective ionophoreChemical compoundsGABAAntibioticsCoccidiosis in poultryElectrodesIonsNigericinPotassiumGramicidinEnzymeAntibioticMonensinCoccidiaParasitesQuercetinConcentrationsCationsLysosomalMoleculesRuminantsBacteriaImmunityLipophilicProteinsResistanceSelectivityComplexPotentAdvantagesFungiDairyExposureErythrocytesDrugsChelating agentsBiologicalInvestigateFertilizationCellImprove
A231872
  • Human peripheral blood leukocytes (PMN) are induced to release lysosomal enzymes by the calcium ionophore A23187 in the presence but not the absence of extracellular Ca++. (rupress.org)
  • In addition to the microvesicles released during the treatment of human erythrocytes with Ca2+ and ionophore A23187, a new subpopulation of still smaller dense vesicles ('nanovesicles') has now been identified. (uea.ac.uk)
Chelators1
  • Use this guide to find the optimal Ca 2+ indicator, chelators, and ionophores for your experiments. (abcam.com)
Zinc Ionophore3
  • How Does Immune Charge+ Zinc Ionophore Work? (drvitaminsolutions.com)
  • Recent data, from peer reviewed studies, scientific data and clinical trials show that synergistic supplement combinations involving zinc and the zinc ionophore quercetin may be effective antiviral prevention and therapeutic agents against COVID-19. (ivermektin.online)
  • Quercetin, a natural anti-oxidant and anti-inflammatory compound contained in abundance in various fruits and vegetables, is a zinc ionophore. (ivermektin.online)
Control of coccidiosis3
  • This video will discuss how ionophores provide the first long-term, consistent control of coccidiosis, maintaining intestinal integrity over the life of the broiler. (poultryworld.net)
  • In terms of control of coccidiosis, the ionophores have helped to establish the perfect balance between the coccidia and the broiler. (poultryworld.net)
  • Removal or reduction of ionophores for the control of coccidiosis in poultry could lead to increased antibiotic use, higher production costs and negative impacts on climate-change mitigation efforts, according to a new review paper in VetRecord . (poultryhealthtoday.com)
Membrane8
  • Many ionophores are lipid-soluble entities that transport ions across the cell membrane. (wikipedia.org)
  • Structurally, an ionophore contains a hydrophilic center and a hydrophobic portion that interacts with the membrane. (wikipedia.org)
  • Multiple synthetic membrane-spanning ionophores have also been synthesized. (wikipedia.org)
  • Ionophores that transport hydrogen ions (H+, i.e. protons) across the cell membrane are called protonophores. (wikipedia.org)
  • Whereas contractions parallel to the plasma membrane could occur in the absence of enzyme release (ionophore alone) and enzyme release could occur in the absence of such contractions (ionophore plus calcium plus cytochalasin B), contraction toward the cytocenter occurred in all experimental conditions in which significant enzyme release was obtained. (rupress.org)
  • An ionophore is a substance that transports ions across a lipid membrane in a cell by combining with the ion, or by increasing the absorptivity or sponginess of the membrane. (siouxnationag.com)
  • Zinc ionophores transport extracellular Zinc (Zn 2+ ) ions across a cell membrane, and have been studied for their antiviral and anti-cancer activities. (ivermektin.online)
  • The potentiometric response characteristics (slope, detection limit, selectivity, and pH sensitivity) of sensors prepared with different membrane compositions (ionophore, ionophore concentration, anion exchanger concentration, and plasticizer) were evaluated. (abo.fi)
Calcium Ionophores3
  • Calcium Ionophores" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • This graph shows the total number of publications written about "Calcium Ionophores" by people in this website by year, and whether "Calcium Ionophores" was a major or minor topic of these publications. (umassmed.edu)
  • Below are the most recent publications written about "Calcium Ionophores" by people in Profiles. (umassmed.edu)
Selective ionophore2
  • TD19C6 is an ammonium ion selective ionophore. (dojindo.com)
  • This compound has a potential for the use as selective-ionophore for the development of a Pb2+ selective sensing system. (dcu.ie)
Chemical compounds1
  • Ionophores are chemical compounds that reversibly bind and transport ions through biological membranes in the absence of a protein pore. (wikipedia.org)
GABA3
  • We also provide evidence that ethanol does not enhance [ 3 H]diazepam directly at the benzodiazepine binding site, but, rather, indirectly via the picrotoxinin-sensitive site of the benzodiazepine-GABA receptor-ionophore complex. (aspetjournals.org)
  • Other pesticides, the type-II pyrethroids and several organochlorines interact with the GABA receptor/ionophore complex. (cdc.gov)
  • Interactions of pentamethylenetetrazole and tetrazole analogues with the picrotoxinin site of the benzodiazepine-GABA receptor-ionophore complex. (bvsalud.org)
Antibiotics9
  • Salinomycin and Naracin belong to the group of polyether antibiotics (ionophores) and are fermentation products of the fungi Streptomyces albus and S. Aureofaciens, respectively. (pacificlab.vn)
  • Polyether antibiotics or carboxyl ionophores disrupt ion concentration gradient (Calcium, Potassium, Sodium). (siouxnationag.com)
  • Another regular use of antibiotics, although not considered as therapeutics, is to improve performance by including ionophores in the diet of dairy or beef cattle. (pigprogress.net)
  • Ionophores have been used for decades as performance enhancers in livestock, and although they are categorised as antibiotics, they are not therapeutic antibiotics. (pigprogress.net)
  • The review stresses the advantages of the use of ionophores as feed additives as a means of combatting coccidiosis, including better intestinal integrity, reduced use of antibiotics and economic gains. (poultryhealthtoday.com)
  • Are ionophores antibiotics? (poultryhealthtoday.com)
  • Accordingly, they suggest ionophores should be classified as antibiotics rather than simply antimicrobials - and as such, they should be part of antibiotic-reduction targets, set up with the aim of reducing the development of resistance traits in pathogens. (poultryhealthtoday.com)
  • Since no medically significant bacterial resistance has been described for ionophores in over 49 years of use, it is highly unlikely that there will be an impact on human health by their use as anticoccidials either through co-selection of resistance or any co-resistance to antibiotics important in humans," they explained. (poultryhealthtoday.com)
  • The veterinarians suggested that removal of ionophores may result in an increase in the use of therapeutic antibiotics and a greater risk of resistance developing, running against World Health Organization goals. (poultryhealthtoday.com)
Coccidiosis in poultry1
  • The main therapeutic application of ionophores is the prevention and treatment of coccidiosis in poultry. (pacificlab.vn)
Electrodes2
  • Ionophores catalyze ion transport across hydrophobic membranes, such as liquid polymeric membranes (carrier-based ion selective electrodes) or lipid bilayers found in the living cells or synthetic vesicles (liposomes). (wikipedia.org)
  • Solid-contact ion-selective electrodes with carbazole-derived ionophores were prepared. (abo.fi)
Ions7
  • In chemistry, an ionophore (from Greek ion and -phore 'ion carrier') is a chemical species that reversibly binds ions. (wikipedia.org)
  • Some ionophores are synthesized by microorganisms to import ions into their cells. (wikipedia.org)
  • However, these ionophores become unable to transport ions under very low temperatures. (wikipedia.org)
  • This type of ionophores can maintain their ability to transfer ions at low temperatures, unlike carrier ionophores. (wikipedia.org)
  • Ionophores modify the permeability of biological membranes toward certain ions to which they show affinity and selectivity. (wikipedia.org)
  • Ions are bound to the hydrophilic center and form an ionophore-ion complex. (wikipedia.org)
  • A 38183A acts as an ionophore, aiding the partitioning of Mg+ and Ca+ ions into organic solvents and transport of ferric ions into mitochondria. (toku-e.com)
Nigericin4
  • The term ionophore (from Greek ion carrier or ion bearer) was proposed by Berton Pressman in 1967 when he and his colleagues were investigating the antibiotic mechanisms of valinomycin and nigericin. (wikipedia.org)
  • Nigericin, a H+ and K+ ionophore, possesses unique pharmacological effects. (bvsalud.org)
  • MATERIALS AND METHODS: We examined the cytotoxic effects of the K+ ionophores, nigericin, nonactin, and valinomycin, on various B-lymphoma cells including PEL. (bvsalud.org)
  • RESULTS: Although the three tested ionophores inhibited the proliferation of several B-lymphoma cell lines, nigericin inhibited the proliferation of PEL cells compared to KSHV-negative cells. (bvsalud.org)
Potassium1
Gramicidin1
Enzyme1
  • The Ionophore ELISA is a competitive enzyme immunoassay based on antibodies directed against salinomycin. (pacificlab.vn)
Antibiotic3
  • A 39183A is a rare 9,9'-bianthryl antibiotic related to setomimycin and it acts as an ionophore. (toku-e.com)
  • Unlike the antibiotic-resistance development seen to other compounds such as beta-lactams - which are usually associated with a single gene or point mutation in the bacteria - resistance to ionophores would require multiple gene mutations, they said. (poultryhealthtoday.com)
  • Twelve non-pregnant and non-lactating cows (675 ± 63 kg of BW) were randomly assigned to three treatments: control group (non-antibiotic), enramycin-treated group (non-ionophore antibiotic) and monensin-treated group (ionophore antibiotic). (usp.br)
Monensin1
  • Ionophores form lipid soluble, reversible complexes with cations and facilitate ion transport across membranes, as well as a monensin-electroneutral exchange of sodium and protons. (siouxnationag.com)
Coccidia3
  • Ionophores kill coccidia before it can infect the animal. (siouxnationag.com)
  • The ionophores we found have a unique mode of action whereby they allow some subclinical cycling of the coccidia, allowing the broiler to develop immunity, while being protected from clinical coccidiosis by the ionophore. (poultryworld.net)
  • In recent years, there have been calls from some scientists in Europe to consider scaling back the use of ionophores in poultry production due to concerns that they also show action against Gram-positive bacteria, in addition to having an effect on coccidia. (poultryhealthtoday.com)
Parasites2
  • The ionophores do not kill 100% of the parasites, so it is normal to observe mild lesions in production systems using ionophores. (poultryworld.net)
  • The monovalent ionophores efficiently killed both asexual parasites and gametocytes with a nanomolar 50% inhibitory concentration (IC50). (unicam.it)
Quercetin2
  • As it turns out, the ideal ingredients to act as zinc ionophores come in the form of plant polyphenols , most particularly the flavonoid quercetin . (drvitaminsolutions.com)
  • The emerging scientific data from peer reviewed journals and clinical trials show that zinc ionophores, including Quercetin, may have significant effects against COVID-19. (ivermektin.online)
Concentrations3
  • The objective of this study was to determine the relative effectiveness of composting conditions to reduce concentrations of four widely used ionophore feed supplements in dairy manure and poultry litter. (itu.edu.tr)
  • The selectivity, detection limit, and linear range were improved by choosing a suitable plasticizer and by reducing the ionophore and anion exchanger concentrations. (abo.fi)
  • A slow reacting substance is produced when mixed peritoneal cells from rats are incubated with low concentrations of the calcium ionophore A 23187 in the presence of 0.01 M cysteine. (aai.org)
Cations1
  • Ionophores selective for cations and anions have found many applications in analysis. (wikipedia.org)
Lysosomal1
  • Microfilaments and microtubules in calcium ionophore-induced secretion of lysosomal enzymes from human polymorphonuclear leukocytes. (rupress.org)
Molecules2
Ruminants1
  • Due to the mechanism of action, animals that are not ruminants are not able to use ionophores and can die following low levels of ionophore ingestion. (siouxnationag.com)
Bacteria1
  • When fed ionophores, the bacteria population in the rumen shifts from a gram positive bacteria (which produces acetate) to a more gram negative population (increased proprionate). (siouxnationag.com)
Immunity1
  • Ionophores enable the bird to develop immunity while protecting from the cocci challenge. (poultryworld.net)
Lipophilic2
  • The carbazole-derived ionophores effectively decreased the interference from lipophilic anions, such as bromide, nitrate, iodide, and thiocyanate. (abo.fi)
  • Cation sensing material was prepared by coating pellicular-type ODS (octadecylsilica) beads with a lipophilic organic liquid which incorporates a novel neutral calcium ionophore and a lipophilic anionic dye of the diphenyl amine type. (elsevierpure.com)
Proteins1
  • Channel forming ionophores are usually large proteins. (wikipedia.org)
Resistance2
  • Because ionophores do not apply high selection pressure the driving force for resistance development is low. (poultryworld.net)
  • Ionophores' biophysical mode of action explains the very low likelihood of resistance developing, they continued. (poultryhealthtoday.com)
Selectivity1
  • The results show that for the macrocyclic ionophores, a larger cavity provided better selectivity. (abo.fi)
Complex2
  • The structure of the ionophore-ion complex has been verified by X-ray crystallography. (wikipedia.org)
  • The activity of an ionophore-metal complex depends on its geometric configuration and the coordinating sites and atoms which create coordination environment surrounding the metal center. (wikipedia.org)
Potent1
  • If the cells of your body struggles to maintain adequate levels of zinc then ionophores may be the key to accessing the potent immune system support of this essential trace mineral. (drvitaminsolutions.com)
Advantages1
  • While there are many worthwhile advantages to using ionophores, several precautions should be taken. (siouxnationag.com)
Fungi1
  • Many ionophores are produced naturally by a variety of microbes, fungi and plants, and act as a defense against competing or pathogenic species. (wikipedia.org)
Dairy1
  • Finally, it has shown similar performance and feed efficiency compared to ionophores in beef and dairy productions, making it a natural alternative for partial or total replacement of ionophores used as AGP. (pigprogress.net)
Exposure1
  • Transient exposure to calcium ionophore enables in vitro fertilization in sterile mouse models. (umassmed.edu)
Erythrocytes1
  • Potential toxicity due to hemolysis was excluded, since only infected and not normal erythrocytes were damaged by ionophores. (unicam.it)
Drugs1
  • The aim of the present work was to investigate whether the class of monovalent ionophores, which includes drugs used in veterinary medicine and that were recently proposed as human anticancer agents, meets these requirements. (unicam.it)
Chelating agents1
  • Iron ionophores and chelating agents are collectively called siderophores. (wikipedia.org)
Biological1
  • One study on the subject concluded "The ionophore activity of dietary polyphenols may underlay the raising of labile zinc levels triggered in cells by polyphenols and thus many of their biological actions. (drvitaminsolutions.com)
Investigate1
  • In this report, we investigate the toxicity of the ionophore thiomaltol (Htma) and Cu salts to melanoma. (nau.edu)
Fertilization2
  • Next, calcium ionophore was applied following the ICSI procedure to improve the chances for fertilization. (jri.ir)
  • It is suggested that assisted oocyte activation with Ca++ ionophore and electrical or mechanical stimulation might increase fertilization rates (9-11). (jri.ir)
Cell1
  • Find the best indicator and ionophore for imaging Ca 2 + and cell function. (abcam.com)
Improve2
  • Ionophores improve the digestive process of the ruminant, reducing waste products including methane. (siouxnationag.com)
  • Not only will these ionophores improve your rates of gain, they will also help protect your herd from ailments such as coccidiosis, acidosis and bloat. (southernstates.com)