• Mutations of this gene have been associated with basal cell nevus syndrome and holoprosencephaly. (nih.gov)
  • Mutations of PTCH1 gene in two pedigrees with bifid rib-basal cell nevus-jaw cyst syndrome. (nih.gov)
  • To the our best of knowledge, this is the first study to report the existence of homozygous and heterozygous mutations at positions 554, 555 and 559 in exon 4 of SLC35A3 gene in Indian Holstein cattle. (researchgate.net)
  • You can have either one or two mutations - or neither - on the MTHFR gene. (healthline.com)
  • There are two variants, or forms, of mutations that can occur on the MTHFR gene. (healthline.com)
  • It's also possible to acquire both C677T and A1298C mutations, which is one copy of each. (healthline.com)
  • Gene mutations are inherited, which means you acquire them from your parents. (healthline.com)
  • More than 30 variants (also known as mutations) in the ARID1A gene can cause Coffin-Siris syndrome. (medlineplus.gov)
  • The finding has, however, prompted the team to look for other mutations in interferon-related genes, in children who have had severe flu. (newscientist.com)
  • DNA mutations in a gene can change what protein is made. (cdc.gov)
  • Genetic testing from the Framingham Heart Study and the Jackson Heart Study , 2 large, U.S., population-based epidemiologic studies, have shown that the prevalence of likely disease-causing sarcomere gene mutations may be as high as 0.6% (nearly 2 million individuals in the U.S.), suggesting the lifetime prevalence of HCM is higher than that estimated by clinical imaging. (cdc.gov)
  • Antimicrobial resistance occurs through different mechanisms, which include spontaneous (natural) genetic mutations and horizontal transfer of resistant genes through deoxyribonucleic acid (DNA). (who.int)
  • Alterations in DNA methylation, lncRNAs and multiple genes may be involved in the regulation of FTLs . (nature.com)
  • We analyzed 137 B-lineage and 30 T-lineage childhood ALL cases using microarray analysis of DNA copy number alterations and gene expression, and genome-wide cytosine methylation profiling using the HpaII tiny fragment enrichment by ligation-mediated PCR (HELP) assay. (lu.se)
  • We found that the different genetic subtypes of ALL are characterized by distinct DNA methylation signatures that exhibit significant correlation with gene expression profiles. (lu.se)
  • Finally, we identified aberrant methylation in multiple genes also targeted by recurring DNA copy number alterations in ALL, suggesting that these genes are inactivated far more frequently than suggested by structural genomic analyses alone. (lu.se)
  • Four ethylene receptors genes ( AcERS1b , AcERS1b , AcETR2a , and AcETR2b ) have been cloned, and expression analysis showed that AcERS1b , AcETR2a , and AcETR2b play key roles in pineapple flowering 13 . (nature.com)
  • Whereas α2 laminins promoted islet cell clustering, they did not affect gene expression. (nature.com)
  • In contrast, culturing on Laminin-421 induced the expression of β-cell genes, including Ins1 , MafA , and Glut2 , and significantly improved glucose-stimulated insulin secretion. (nature.com)
  • They can bind to the 3′ untranslated region (3′UTR) of target messenger RNAs (mRNAs) in order to regulate gene expression post-transcriptionally with no sequence specificity but by potential electrostatic interactions with the phosphate backbone of RNA 2 , 3 . (nature.com)
  • The genes Cs RafS1 and CsGolS1 showed similar or greater expression in one of the transgenic lines with respect to control plants. (springer.com)
  • Together, these results suggest the potential for heterologous expression of the AtCBF3 gene to mediate tolerance to hydric and saline stress in citrus plants. (springer.com)
  • To understand the molecular-genetic basis of functional specialization and identify potential drug targets specific to each neuron subtype, we performed a genome wide assessment of both gene expression and splicing across EXC, PV, SST and VIP neurons from male and female mouse brains. (jneurosci.org)
  • These results reveal numerous examples where neuron subtype-specific gene expression, as well as splice-isoform usage, can explain functional differences between neuron subtypes, including in presynaptic plasticity, postsynaptic receptor function, and synaptic connectivity specification. (jneurosci.org)
  • We provide a searchable web resource for exploring differential mRNA expression and splice form usage between excitatory, PV, SST, and VIP neurons ( http://research-pub.gene.com/NeuronSubtypeTranscriptomes ). (jneurosci.org)
  • This resource, combining a unique new dataset and novel application of analysis methods to multiple relevant datasets, identifies numerous potential drug targets for manipulating circuit function, reveals neuron subtype-specific roles for disease-linked genes, and is useful for understanding gene expression changes observed in human patient brains. (jneurosci.org)
  • We used a genome-wide analysis which not only examined differential gene expression levels but could also detect differences in splice isoform usage. (jneurosci.org)
  • Here we demonstrate that, during brain maturation, the potential of the intrinsic apoptotic pathway is progressively reduced and that such repression is associated with downregulation of apoptotic protease-activating factor-1 (Apaf-1) and caspase-3 gene expression. (jneurosci.org)
  • These results suggest that differential expression of Apaf-1 and caspase-3 genes may underlie regulation of apoptotic susceptibility during brain development, as well as after acute injury to mature brain, through the intrinsic pathway of caspase activation. (jneurosci.org)
  • Our results demonstrate that expression of the kn1 gene enhances transformation efficiencies from 3 to 15 fold compared to a control vector, 3-11 fold relative to the highest transformation efficiencies reported for these citrus genotypes. (springer.com)
  • Interestingly, gene expression was largely rescued by subsequent reconstitution of cohesin function. (biorxiv.org)
  • These experiments show that cohesin is continuously required for neuronal gene expression and provide a tractable approach for addressing mechanisms of neuronal dysfunction in CdLS. (biorxiv.org)
  • MicroRNAs (miRNAs) are potent effectors in gene regulatory networks where aberrant miRNA expression can contribute to human diseases such as cancer. (hindawi.com)
  • For a better understanding of the regulatory role of miRNAs in coordinating gene expression, we here present a systems biology approach combining data-driven modeling and model-driven experiments. (hindawi.com)
  • Furthermore, mRNA expression of circadian clock genes is dampened in peripheral leucocytes of subjects with poor sleep quality. (hindawi.com)
  • Within a quantitative genetic framework, we sequenced RNA from Drosophila melanogaster at different developmental stages to examine sex-biased gene expression and how selection acts upon it. (biorxiv.org)
  • We found evidence that gene expression is constrained by both univariate and multivariate shared genetic variation between genes, sexes and developmental stages, but may be resolved by differential splicing. (biorxiv.org)
  • SWI/SNF complexes regulate gene activity (expression) by a process known as chromatin remodeling. (medlineplus.gov)
  • when DNA is tightly packed, gene expression is lower than when DNA is loosely packed. (medlineplus.gov)
  • The expression of antifungal genes from Trichoderma harzianum has been used to confer plant resistance to fungal diseases. (isaaa.org)
  • There was an increased burden of rare deletions in gene -sets related to brain function or expression in brain associated with more ADHD traits. (bvsalud.org)
  • Gene expression refers to the process of making proteins using the instructions from genes. (cdc.gov)
  • Changes in gene expression can affect how much of a protein is made, as well as when the protein is made. (cdc.gov)
  • We also identified an epigenetic signature common to all cases, with correlation to gene expression in 65% of these genes, suggesting that a core set of epigenetically deregulated genes is central to the initiation or maintenance of lymphoid transformation. (lu.se)
  • Another challenge to using transgenic plant technology in citrus is the long juvenile phase of immature tissues that ranges from 5 to 20 years, which greatly delays analysis of the effects of candidate genes. (springer.com)
  • The main themes of the center will be behavior and neurogenetics, addressing questions such as how genetic research impacts human identity and "what kinds of genes make humans human," Cho said, as well as the implications of genetic research to modify or enhance behavior. (news-medical.net)
  • The effects of a maize knotted1 ( kn1) gene under the control of the cauliflower mosaic virus 35S promoter on genetic transformation efficiencies of six citrus genotypes were tested. (springer.com)
  • With all six genotypes of citrus tested including Eureka lemon, a cultivar difficult to be transformed, our results demonstrate that the kn1 gene may provide an effective molecular tool to enhance genetic transformation efficiencies of various citrus varieties. (springer.com)
  • Using artificial intelligence, UT Southwestern researchers have discovered a new family of sensing genes in enteric bacteria that are linked by structure and probably function, but not genetic sequence. (news-medical.net)
  • It is likely that other genetic changes in addition to ARID1A gene variants are necessary for cancer development. (medlineplus.gov)
  • It is caused by a point mutation (G→T) at nucleotide position 559 of the gene, bovine solute carrier family 35 member 3 (SLC35A3). (researchgate.net)
  • Having two copies of the MTHFR gene mutation may raise your risk for certain health conditions, though more research is needed. (healthline.com)
  • About 30 to 40 percent of the American population may have a mutation at gene position C677T. (healthline.com)
  • However, in cases where a person holds two copies of the C677T mutation or one copy of each mutation, they may be at risk of high homocysteine (an amino acid) levels, which may affect the body's function. (healthline.com)
  • It's worth noting that the health conditions linked to MTHFR depend on your type of mutation and how many copies you contain. (healthline.com)
  • In cases where you have only one copy of the C677T or A1298C mutation , or two copies of the A1298C mutation, there are typically no health conditions or risks linked. (healthline.com)
  • The risk is possibly increased if a person has two gene variants or is homozygous for the MTHFR mutation. (healthline.com)
  • Each of her parents had a different mutation in one of their copies of the gene that codes for a protein called IRF7. (newscientist.com)
  • Those hardest hit by the 2009 "swine flu" pandemic were 20 times more likely to have a mutation disabling a gene called IFITM3 than those who got less sick. (newscientist.com)
  • Dominant diseases can be caused by only one copy of a gene with a DNA mutation. (cdc.gov)
  • For recessive diseases, both copies of a gene must have the DNA mutation for a person to have one of these diseases. (cdc.gov)
  • In up to 40% of affected people, HCM is caused by a specific change (mutation) in one of the genes that make up a structure called the cardiac sarcomere , which allows muscle cells to contract. (cdc.gov)
  • This gene encodes a member of the patched family of proteins and a component of the hedgehog signaling pathway. (nih.gov)
  • a map is constructed that shows interactions among molecular entities (such as genes, proteins and RNAs), using information from literature and databases. (hindawi.com)
  • Although microRNAs (miRNAs) are physically small, they have been shown to play an important role in gene regulation [ 1 ]. (hindawi.com)
  • The application of the systems biology approach to the analysis of a gene regulatory network is demonstrated with a case study of the regulation of p21 by multiple miRNAs [ 4 ]. (hindawi.com)
  • Alternatively, abnormal SWI/SNF complexes may disrupt the regulation of genes that help control the growth and division of cells, which leads to cancer. (medlineplus.gov)
  • Transcript levels of circadian clock genes ( BMAL1 , PER1 , PER2 , and PER3 ) were determined by real-time quantitative polymerase chain reaction. (hindawi.com)
  • On the other hand, mechanisms that impair the circadian clock genes, such as circadian locomotor output cycles kaput ( CLOCK ), brain and muscle Arnt-like protein 1 ( BMAL1 ), and period genes ( PER1 , PER2 , and PER3 ), contribute to defective beta-cell function and development of type 2 diabetes [ 7 - 12 ]. (hindawi.com)
  • [ 33 ] Findings of circadian rhythm- elated genes support the continued study of these genes in bipolar disorder and lithium response. (medscape.com)
  • Background ZNF597 , encoding a zinc-finger protein, is the human-specific maternally expressed imprinted gene located on 16p13.3. (bmj.com)
  • Analyzing 5′-upstream non-protein-encoding regions of the human mitochondrial function-associated genes, we speculate that mitochondrial functions could be recovered or improved at a transcriptional level. (intechopen.com)
  • The ARID1A gene provides instructions for making a protein that forms one piece (subunit) of several different SWI/SNF protein complexes. (medlineplus.gov)
  • The ARID1A gene variants involved in Coffin-Siris syndrome lead to an abnormally short, nonfunctional protein. (medlineplus.gov)
  • The gene codes for a protein that normally helps fight off flu - activated by interferon. (newscientist.com)
  • Knowing how the genes work might also help us tailor anti-flu defences to affected people, for example, by giving them the IFITM3 protein or extra interferon. (newscientist.com)
  • Patrick Cramer is carrying out research on the enzyme that transcribes the DNA code to enable a protein to be synthesized from a gene. (mpg.de)
  • The specific order, or sequence, of these bases determines the exact information carried in each gene (for example, instructions for making a specific protein). (cdc.gov)
  • A gene is a part of DNA that carries the information needed to make a protein. (cdc.gov)
  • The disease is caused by a mutated gene that leads to a lack of the building blocks needed to form the cell's protein factories (known as ribosomes). (lu.se)
  • Small interfering RNAs (siRNAs) expressed from short hairpin RNAs (shRNAs) are a powerful way to mediate gene specific RNA interference (RNAi) in mammalian cells. (sigmaaldrich.com)
  • Cervera M, Ortega C, Navarro A, Navarro L, Peña L (2000) Generation of transgenic citrus plants with the tolerance-to-salinity gene HAL2 from yeast. (springer.com)
  • Fu X, Khan E, Hu S, Fan Q, Liu J (2011) Overexpression of the betaine aldehyde dehydrogenase gene from Atriplex hortensis enhances salt tolerance in the transgenic trifoliate orange (Poncirus trifoliata L. Raf. (springer.com)
  • High transformation efficiency of citrus is of great importance for large scale characterization of gene functions and also cultivar development via transgenic and genome editing technologies. (springer.com)
  • The team of José A. Mercado of Universidad de Málaga in Spain developed transgenic strawberry plants expressing the glucanase gene bgn13.1 from T. harzianum . (isaaa.org)
  • Pathogenic sequence or copy number variants affecting his phenotypes were not identified, indicating that primary epimutation occurred postzygotically. (bmj.com)
  • Without any known genes with sequence identities similar to VtrC, the researchers turned to software released just two years ago called AlphaFold. (news-medical.net)
  • We characterized the transcriptional profile of cortical neurons from CdLS patients and found deregulation of hundreds of genes enriched for neuronal functions related to synaptic transmission, signalling processes, learning and behaviour. (biorxiv.org)
  • A recent study published in the journal Cell Reports seems to suggest so, indicating that elephants, the world's largest land mammal, bear special resistance to cancer that stems from the way their genes have changed throughout the centuries. (naturalnews.com)
  • According to the paper, elephants have an expanded number of what are known as TP53 genes that appear to boost their resistance to cancer in its many forms. (naturalnews.com)
  • are an important worldwide pest of cucumber (Cucumis sativus L.). Molecular markers linked to the Javanese root-knot nematode (M. javanica) resistance gene mj in cucumber may aid marker assisted selection. (scielo.br)
  • A new methicillin resistance mechanism gene, a divergent mec A homologue named mec C (formerly mec A LGA251 ), was recently described in Staphylococcus aureus ( 1 ). (cdc.gov)
  • This report presents the status of AMR in Africa by analysing the main types of resistance and the underlying genes where possible. (who.int)
  • Chondrichthyan species display two nanos1 genes (named nanos1A / 1B ), which were both retrieved in some Osteichthyes at basal positions in Sarcopterygii and Actinopterygii lineages. (nature.com)
  • The findings, published in PNAS, offer a new way of identifying the role of genes in unrelated species and could lead to new ways to fight intestinal bacterial infections. (news-medical.net)
  • Or how about the use of genes from other species to prevent cancer? (naturalnews.com)
  • Researchers still need to edit pig genes to avoid triggering a human immune system reaction and prevent toxic interactions in blood. (dailymaverick.co.za)
  • The MISSION product line is based on a viral vector-based RNAi library against annotated mouse and human genes. (sigmaaldrich.com)
  • Modern breakthroughs, such as the mapping of the human genome, the Nobel Prize-winning CRISPR gene editing scissors, the ability to rapidly map large amounts of DNA, and the Nobel Prize-winning discovery of how mature cells can be reprogrammed, have led to an increasing number of innovative biological therapies reaching patients. (lu.se)
  • Only one copy of a defective gene is needed to develop HCM (autosomal dominant). (cdc.gov)
  • Instead of lifelong treatment of a disease caused by, for example, a defective gene, ATMP medicines have the potential to cure the patient by fixing the gene," says Johan Flygare. (lu.se)
  • Each parent was able to produce interferon because their other copy of the gene was normal. (newscientist.com)
  • Certainly other genes involved with interferon affect how badly flu hits us. (newscientist.com)
  • These observations led us to retrospectively investigate the presence of mec C gene in a set of 361 mec A-negative S. aureus isolates collected during 2009-2012 ( Table ), independently of their susceptibility to cefoxitin. (cdc.gov)
  • These results indicate that, at one month of age, mice carrying two copies of the Ahl gene have an increased susceptibility to TTS from a low-frequency noise before they have any indication of age-related hearing or hair-cell loss. (cdc.gov)
  • The Ahl gene appears to play a role in susceptibility to NIHL but, other genes as well as systemic and local factors must also be involved. (cdc.gov)
  • Based on phylogenetic and synteny analyses, this study reveals that nanos1 gene has undergone multiple duplications and gene copies losses in Vertebrates. (nature.com)
  • The two successive nanos gene duplications may result from the second and third whole genome duplication events at the basis of Vertebrates and Teleosts respectively. (nature.com)
  • [ 44 ] Most studies on the GSK3B gene in bipolar disorder have been negative, but one study reported an increased number of copy-number variations (deletions or duplications) within the gene in a small sample of bipolar disorder patients. (medscape.com)
  • They then used a Scientists gene-edit piglets, bringing transplants to humans closer standard cloning technique to insert the edited DNA into egg cells that were placed into a surrogate mother. (dailymaverick.co.za)
  • For the study, scientists genetically altered the malaria-causing Plasmodium falciparum parasite by removing several genes to create a "minor version of malaria " that can't cause sickness in humans. (naturalnews.com)
  • Gene sequences from normal and carrier animals were compared using the software, codon code Aligner 4.0.4. (researchgate.net)
  • Sequivity is a custom swine vaccine platform … Sequivity only targets swine pathogen gene sequences of interest. (newstarget.com)
  • Although it is unclear how these changes affect SWI/SNF complexes, researchers suggest that ARID1A gene variants result in abnormal chromatin remodeling. (medlineplus.gov)
  • Variants in the ARID1A gene have been found in many types of cancer, including cancers of the ovaries and lining of the uterus (endometrium) in women and cancers of the kidney, stomach, bladder, lung, breast, and brain. (medlineplus.gov)
  • The mechanism by which variants in the ARID1A gene contribute to cancer is unknown, although it is thought that changes in SWI/SNF complexes are involved. (medlineplus.gov)
  • The maize homeobox gene knotted1 ( kn1 ) encodes an AP2/ERF transcription factor (Hake et al. (springer.com)
  • Genome imprinting is an epigenetic marking mechanism that causes genes to be expressed in a parental-origin-specific manner. (bmj.com)
  • Eldadah and Faden, 2000 ), we hypothesized that suppression of apoptotic capability during maturation of mammalian brain results from repression of genes involved in the caspase-3 activation pathway, and that injury-induced neuronal apoptosis in the mature brain results from reactivation of these genes. (jneurosci.org)
  • We performed genome-scale loss-of-function screens in 33 cancer cell lines to identify genes essential for proliferation/survival and found a strong correlation between increased gene copy number and decreased cell viability after genome editing. (broadinstitute.org)
  • Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting. (broadinstitute.org)
  • Within regions of copy-number gain, CRISPR/Cas9 targeting of both expressed and unexpressed genes, as well as intergenic loci, led to significantly decreased cell proliferation through induction of a G2 cell-cycle arrest. (broadinstitute.org)
  • These observations indicate that genome targeting by CRISPR/Cas9 elicits a gene-independent antiproliferative cell response. (broadinstitute.org)
  • This effect has important practical implications for the interpretation of CRISPR/Cas9 screening data and confounds the use of this technology for the identification of essential genes in amplified regions. (broadinstitute.org)
  • We assessed the relationship of gene copy number variation (CNV) in mental health /neurodevelopmental traits and diagnoses , physical health and cognition in a community sample of 7100 unrelated children and youth of European or East Asian ancestry (Spit for Science ). (bvsalud.org)
  • Since then, research into how genes affect our traits, health and disease has grown to include entirely new forms of medicines. (lu.se)
  • It would also require companies to share information about the potential transmissibility of gene-altering interventions, and asserts that fully informed consent must be given for all vaccines, gene therapies and medical interventions. (newstarget.com)
  • In the near future, novel chemo-/gene-therapies might be applied to treat cancer patient converting cancerous cells into normal differentiated cells. (intechopen.com)
  • Gene and cell therapies that improve cancer treatments. (lu.se)
  • These are therapies based on cells, genes or tissues and fall under the umbrella term ATMP (Advanced Therapy Medicinal Products). (lu.se)
  • The dose-dependent induction of FLOWERING LOCUS T-like genes ( FTLs ) may have contributed to dose-dependent flowering induction in pineapple by ethylene. (nature.com)
  • The kn1 gene construct was used to transform 'Pineapple', 'Hamlin', 'Sucarri' and 'Valencia' sweet orange [ Citrus sinensis (L.) Osbeck], 'Carrizo' Citrange [ Citrus sinensis (L.) Osbeck × Poncirus trifoliate (L.) Raf. (springer.com)
  • If the alleles of a gene are the same, the person is homozygous for the gene. (cdc.gov)
  • Our results show that one out of 60 bulls tested exhibited polymorphism (G→T) at position 559 in exon 4 of SLC35A3 gene. (researchgate.net)
  • A chromosome contains a single, long piece of DNA with many different genes. (cdc.gov)
  • Alvarez-Gerding X, Cortés-Bullemore R, Medina C, Romero-Romero JL, Inostroza-Blancheteau C, Aquea F, Arce-Johnson P (2015) Improved salinity tolerance in Carrizo Citrange rootstock through overexpression of glyoxalase system genes. (springer.com)
  • Inbred C57BL/6J mice carry two copies of an age-related hearing loss gene (Ahl). (cdc.gov)
  • Several functional studies have reported that the Ahl gene renders mice more susceptible to noise-induced hearing loss (NIHL) than strains which do not carry this gene [e.g. (cdc.gov)
  • Disruption of these clock genes affects locomotor activity, feeding behavior, metabolism, and glucose homeostasis [ 14 ]. (hindawi.com)
  • A role of this gene in Germinal Stem Cells maintenance may be evolutionarily conserved as Nanos2 is specifically expressed both in oogonia and in spermatogonia of adult medaka 11 and in a subpopulation of undifferentiated A spermatogonia in juvenile and spermiating male trout 12 . (nature.com)
  • For instance, identifying the genes linked to a likelihood of developing schizophrenia or autism could stigmatize those who possess the genes, and may even play a role in defining the conditions themselves. (news-medical.net)
  • One-hundred AFLP (EcoRI-MseI) and 112 SRAP were used to screen resistant and susceptible parents for polymorphisms to develop molecular markers linked to the mj gene. (scielo.br)
  • The results indicated that these markers should be useful to develop molecular markers flanking the mj gene. (scielo.br)
  • These medicines differ from 'ordinary' medicines because the active substance is produced in or purified from materials of biological origin such as living cells, genes or tissue," says Johan Flygare, researcher at the Lund Stem Cell Center and the Division of Molecular Medicine and Gene Therapy at Lund University. (lu.se)
  • Ali S, Mannan A, El Oirdi M, Waheed A, Mirza B (2012) Agrobacterium-mediated transformation of rough lime (Citrus jambhiri Lush) with yeast HAL2 gene. (springer.com)
  • In Vertebrates, Nanos paralogous genes were associated to partial redundancies and specific functional evolutions. (nature.com)
  • One study out of Northwestern University found that genes associated with Huntington's Disease may be useful in the treatment of cancer. (naturalnews.com)
  • For example, genes affect what a person will look like and whether the person might have certain diseases. (cdc.gov)
  • Two markers were identified that flanked the mj gene at distance of 16.3 and 19.3 cM. (scielo.br)
  • Markers within the cadherin (FAT) gene. (medscape.com)
  • In teleostean fish, two nanos1 genes were generated, probably during the Teleost specific whole genome duplication (3R). (nature.com)
  • Specific amplification of the mec C gene was performed as described ( 6 ). (cdc.gov)
  • It can also refer to the alleles that a person has for a specific gene. (cdc.gov)
  • Phenotype is how a person looks (on the outside and inside the body) due to his or her genes and the environment (for example, having a certain eye color, being a specific blood type, or being a certain height). (cdc.gov)
  • Though scientists have yet to fully understand how it all works, they've observed that somehow, in some way, this gene helps elephants to steer clear of the deadly disease. (naturalnews.com)
  • The scientists who conducted the trial used a gene-editing technology heavily promoted by Bill Gates. (naturalnews.com)
  • The systems biology approach, combining data-driven modeling and model-driven experiments, provides a systematic and comprehensive perspective on the regulatory roles of miRNAs in gene regulatory networks [ 3 - 5 ]. (hindawi.com)
  • We collect them and make sure to insert a healthy copy of the mutated gene into the cells which are then returned to the patient. (lu.se)
  • Taken together, these data identify Nanos as primordial genes with highly conserved functions for both, the migration of the germinal cells and their maintenance in adults. (nature.com)
  • The genes affected belonged to similar gene ontology classes and showed significant numerical overlap with those deregulated in CdLS. (biorxiv.org)
  • Once we identify the genes that predispose people to bad flu, we can prioritise those people for vaccines, says Peter Openshaw of Imperial College London, who was involved in the study on IFITM3 . (newscientist.com)
  • To investigate a gene regulatory network, an iterative process of four steps is needed. (hindawi.com)
  • This is why Johan Flygare has been working as part of Stefan Karlsson's research group to develop a curative gene therapy ever since he started his PhD at Lund University over 20 years ago. (lu.se)