EthyolEffect of amifostinePlus amifostineRadioprotectionMesnaChemotherapyOrganic thiophosphateCytoprotectiveRadiation therapyRadiotherapyMetabolitesCisplatinCarboplatinDosesToxicityProdrugCytoprotectionTumorInjectionMucositisMouth caused by radiationTissuesIntravenouslyTherapyPatientsNauseaMagnesiumTreatmentEffectsReceiveMinutesActiveConnectPhaseDrugBlood pressure
Ethyol2
- ZUHL, Germany-Amifostine (Ethyol) used as cytoprotective therapy can reduce the occurrence of xero-stomia, loss of taste, and fibrosis associated with radiochemotherapy for head and neck cancer. (cancernetwork.com)
- The purpose of the study was to draw upan experimental model of hepatic veno-occlusive disease (VOD) induced by dactinomycin (ACT) and to investigate the possible hepatoprotective effects of Ethyol (amifostine). (viamedica.pl)
Effect of amifostine3
- The effect of amifostine on submandibular gland histology after radiat" by Jacqueline C Junn, James J Sciubba et al. (lvhn.org)
- The effect of amifostine on submandibular gland histology after radiation. (lvhn.org)
- Radioprotective effect of amifostine on cells from cancer prone patients and healthy individuals studied by the G2 and PCC assays. (bvsalud.org)
Plus amifostine2
- Another 14 patients received the same regimen plus amifostine 500 mg given prior to carboplatin as a short infusion over approximately 10 minutes. (cancernetwork.com)
- Mesna alone and mesna plus amifostine prevented cellular glutathione depletion. (uaeu.ac.ae)
Radioprotection2
- To assess the role of the polyamine transport system in radioprotection by amifostine derivatives, human DU-145 prostate cancer cells were transfected with a cDNA that encodes antizyme (OAZ), a polyamine-inducible protein that suppresses polyamine transport under control of a minimal heat shock promoter. (aacrjournals.org)
- Although the precise mechanisms of radioprotection caused by amifostine remain unclear, the results obtained using premature chromosome condensation reveal that amifostine does not act on cells only as a free radical scavenger and as a repair enhancer of DNA damage . (bvsalud.org)
Mesna2
- The Pediatric Oncology Group study for metastatic Ewing's sarcoma used amifostine and mesna with the alkylating agents. (uaeu.ac.ae)
- Amifostine administration during mesna infusion caused transient increase in mesna levels. (uaeu.ac.ae)
Chemotherapy9
- Amifostine (ethiofos) is a cytoprotective adjuvant used in cancer chemotherapy and radiotherapy involving DNA-binding chemotherapeutic agents. (wikipedia.org)
- Amifostine is used protect the kidneys from harmful effects of the chemotherapy drug cisplatin in patients that receive this medication for the treatment of ovarian cancer. (medlineplus.gov)
- When amifostine is used to protect the kidneys against the harmful effects of cisplatin, it is usually given over 15 minutes starting 30 minutes before you receive your chemotherapy treatment. (medlineplus.gov)
- Amifostine is also sometimes used to prevent and decrease side effects associated with certain chemotherapy medications or radiation treatment and in the treatment of some types of blood cell diseases. (medlineplus.gov)
- Dr. Buentzel concluded that amifostine could reduce the typical acute chemotherapy-related toxicities and should be able to reduce radiation-induced acute toxicities but must be administered within an interval of no more than 60 minutes following the end of radiotherapy. (cancernetwork.com)
- These were the first data to show a reduction of mucositis from amifostine given prior to chemotherapy. (cancernetwork.com)
- Amifostine (WR-2721), a phosphoaminothioate, is capable of providing marked protection from both radiation- and selected chemotherapy-induced damage for a wide variety of tissues in both rodents and humans (1, 2, 3, 4, 5, 6) . (aacrjournals.org)
- Amifostine is a Cytoprotective Adjuvant used during chemotherapy and radiation treatments. (medschat.com)
- Only one drug, Amifostine, has been approved to date by the federal Food and Drug Administration, to help protect normal tissue from the side effects of chemotherapy and radiation, and researchers would like to develop new and improved agents. (news-medical.net)
Organic thiophosphate2
- Amifostine is an organic thiophosphate prodrug which is hydrolysed in vivo by alkaline phosphatase to the active cytoprotective thiol metabolite, WR-1065. (wikipedia.org)
- Amifostine is an intravenously-administered organic thiophosphate, believed to function as a free radical scavenger that inhibits up-regulation of inflammatory pathways and "thus, may allow compliance with the planned treatment regimens while preserving the patient's quality of life," the authors wrote. (cancertherapyadvisor.com)
Cytoprotective1
- Although patients did not receive a full dose of amifostine due to side effects, varying doses of amifostine had no apparent evident cytoprotective effects in three groups of cancer patients treated with primary chemoradiation. (lvhn.org)
Radiation therapy2
- Purpose: To test whether intrarectal amifostine limits symptoms of radiation proctitis, measured by using the Radiation Therapy Oncology Group (RTOG) gastrointestinal (GI) toxicity score and the Expanded Prostate Cancer Index Composite (EPIC) score. (johnshopkins.edu)
- Methods and Materials: Patients with localized prostate cancer received amifostine as a rectal suspension 30-45 minutes before daily three-dimensional conformal radiation therapy. (johnshopkins.edu)
Radiotherapy4
- Amifostine is also indicated to reduce the incidence of xerostomia in patients undergoing radiotherapy for head and neck cancer. (wikipedia.org)
- The time interval between amifostine administration and the end of daily irradiation was less than 60 minutes, and no cytoprotectant was given on days of radiotherapy alone. (cancernetwork.com)
- Amifostine reduces the incidence of acute and late radiotherapy-associated xerostomia among patients with head and neck cancer , for example. (cancertherapyadvisor.com)
- OBJECTIVES: I. Evaluate the efficacy of paclitaxel and carboplatin with amifostine on progression free survival and overall survival in patients with metastatic or recurrent epithelial endometrial carcinoma not amenable to surgery or radiotherapy. (knowcancer.com)
Metabolites2
- Inside cells, amifostine detoxifies reactive metabolites of platinum and alkylating agents, as well as scavenges free radicals. (wikipedia.org)
- Amifostine metabolites WR-1065 and the disulfide WR-33278are thiol-containing polyamine analogues with potent radio- and chemoprotective properties. (aacrjournals.org)
Cisplatin2
- Amifostine is used therapeutically to reduce the incidence of neutropenia-related fever and infection induced by DNA-binding chemotherapeutic agents including alkylating agents (e.g. cyclophosphamide) and platinum-containing agents (e.g. cisplatin). (wikipedia.org)
- Amifostine was originally indicated to reduce the cumulative renal toxicity from cisplatin in non-small cell lung cancer. (wikipedia.org)
Carboplatin2
- This study was followed by a controlled, phase II dose-intensification study to evaluate the role of intensified carboplatin dosage with amifostine protection and concomitant radiochemotherapy in locally advanced pharyngeal cancer. (cancernetwork.com)
- OUTLINE: Patients receive paclitaxel IV over 3 hours, then amifostine IV over 10 minutes, followed fifteen minutes later by carboplatin IV over 30-60 minutes on day 1. (knowcancer.com)
Doses3
- The team's review of studies published between 1966 and 2010 found many studies to included "major flaws" in methodology (such as lack of controls or randomization), and differences between studies in doses and timing of amifostine administration, cancer therapy modalities, and "the complex pathophysiology of mucosal injury," that might explain inconsistent and conflicting results, the authors reported. (cancertherapyadvisor.com)
- Conclusions: Higher doses of amifostine produced significant improvements in acute and late bowel QoL (up to 1 year after therapy), measured using the EPIC score. (johnshopkins.edu)
- They gave the embryos different doses of ionizing radiation as well as treatment by either Amifostine, which acted as a control agent, or CD60_DF1. (news-medical.net)
Toxicity1
- Determine the toxicity of amifostine in these patients. (knowcancer.com)
Prodrug2
- Amifostine is a prodrug that is dephosphorylated by alkaline phosphatase to its active component (12) . (aacrjournals.org)
- Amifostine is a prodrug that is dephosphorylated by alkaline phosphatase in tissues to a pharmacologically active free thiol metabolite. (rxreasoner.com)
Cytoprotection2
- OBJECTIVES: I. Assess the efficacy and role of amifostine as a cytoprotection agent with concurrent chemoradiotherapy in advanced, previously irradiated or metastatic head and neck cancer. (knowcancer.com)
- Some studies suggest that amifostine exerts differential cytoprotection in normal versus neoplastic tissues, but this finding remains controversial. (aacrjournals.org)
Tumor3
- Additional data have shown that amifostine-mediated tumor protection, in any clinical scenario, is unlikely. (wikipedia.org)
- At 5 years after treatment, the survival rate in the amifostine group is a little bit better than in the control group, and we have no sign of tumor protection. (cancernetwork.com)
- Differences in gender, tumor stage, amifostine dose, age, number of days after neck dissection, and smoking history (pack years) exposure were not significant between the three groups, although there was a difference between groups in the primary subsite (P = 0.006). (lvhn.org)
Injection3
- tell your doctor and pharmacist if you are allergic to amifostine, any other medications, or any of the ingredients in amifostine injection. (medlineplus.gov)
- Your doctor will tell you to stop taking your blood pressure medicine 24 hours before you receive amifostine injection. (medlineplus.gov)
- Subcutaneous injection of amifostine has been shown to have the same cyctoprotective effect in the presence of radiation with reduced severity of side effects. (medschat.com)
Mucositis3
- In our review, we could not demonstrate any evidence to support the use of amifostine for the prevention or the treatment of oral mucositis in any cancer setting," reported the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology. (cancertherapyadvisor.com)
- The conflicting results, insufficient data, and methodological flaws "did not allow any guideline related to the use of amifostine in the prevention of oral mucositis," they wrote. (cancertherapyadvisor.com)
- The efficacy of amifostine in the prevention of oral mucositis should be evaluated in new, well-designed, sufficiently powered, randomized, controlled trials," they concluded. (cancertherapyadvisor.com)
Mouth caused by radiation2
- Amifostine is also used to decrease dryness in the mouth caused by radiation treatment after surgery for head and neck cancer. (medlineplus.gov)
- When amifostine is used to reduce the severe dry mouth caused by radiation treatment, it is usually given over 3 minutes starting 15-30 minutes before your radiation treatment. (medlineplus.gov)
Tissues1
- Selective exclusion of amifostine derivatives by the polyamine transporter could account for differential radio- or chemoprotection in normal versus neoplastic tissues in specific situations. (aacrjournals.org)
Intravenously3
- Amifostine can be administered intravenously or subcutaneously after reconstitution with normal saline. (wikipedia.org)
- Amifostine comes as a powder to be mixed with liquid to be injected intravenously (into a vein) by a doctor or nurse in a medical facility. (medlineplus.gov)
- The article on amifostine says it can ONLY be administered intravenously but this is NOT TRUE. (medschat.com)
Therapy2
- radiaation therapy ## Manufacturing formula of Amifostine suppository & one of the article of this topic. (medschat.com)
- The purpose of this study was to assess the effects of amifostine on submandibular gland histology in patients receiving chemoradiation therapy. (lvhn.org)
Patients6
- All patients received 500 mg of amifostine. (cancernetwork.com)
- We conducted a retrospective submandibular gland histologic slide review of HNSCC patients receiving chemoradiation for head and neck squamous cell carcinoma with three different levels of amifostine exposure. (lvhn.org)
- To investigate whether amifostine is effective at reducing the yield of chromatid breaks when present during G(2)-phase irradiation of human normal cells and cells from cancer prone patients , as well as to study the mechanisms underlying the radioprotective effect of amifostine . (bvsalud.org)
- G(2) chromosomal radiosensitivity in the presence or absence of amifostine was studied in healthy donors , cancer patients , ataxia -telangietasia (A-T) patients and five human lymphoblastoid cell lines with genes predisposing to cancer . (bvsalud.org)
- Amifostine reduces the mean yield of chromatid breaks in normal cells and in cells from cancer prone patients when present during G(2) irradiation. (bvsalud.org)
- The first 18 patients received 1 g of amifostine, and the next 12 patients received 2 g. (johnshopkins.edu)
Nausea1
- Your doctor will give you medicine to reduce nausea while you receive amifostine. (stjude.org)
Magnesium1
- The staff will check calcium and magnesium levels in the blood throughout the day and for up to one (1) week after you receive amifostine. (stjude.org)
Treatment3
- You should not breast-feed during your treatment with amifostine. (medlineplus.gov)
- Amifostine has been reported as potentially beneficial for treatment of COVID-19. (c19early.org)
- The nonparametric Cuzick's test for histologic parameters with varied amifostine treatment showed no significance among the three groups. (lvhn.org)
Effects3
- Amifostine is believed to radioprotect normal tissue via Warburg-type effects. (wikipedia.org)
- Amifostine may cause side effects. (medlineplus.gov)
- In addition to preventing cytotoxicity, amifostine derivatives display anticarcinogenic (7, 8) and antimutagenic (9) properties in rodent model systems as well as hematopoiesis-promoting effects (10, 11) . (aacrjournals.org)
Receive3
- If you are taking medicine for high blood pressure, you should stop taking it 24 hours before you receive amifostine. (stjude.org)
- Your doctor or nurse will ask you to lie down while you receive IV amifostine and for one (1) hour after receiving the drug. (stjude.org)
- Drinking large amounts of fluid will help you feel better while you receive amifostine. (stjude.org)
Minutes3
- Amifostine is a liquid given by the vein (IV) for 5-15 minutes. (stjude.org)
- Amifostine IV is administered over 5 minutes on days 1-5. (knowcancer.com)
- They found that CD60_DF1 given before and even immediately after - up to 30 minutes - exposure to X-rays reduced organ damage by one-half to two-thirds, which was as good as the level of protection given by Amifostine. (news-medical.net)
Active1
- Recently active Amifostine forums and community discussion threads. (medschat.com)
Connect1
- Post your question or story about Amifostine and connect with others who have experience with the same medications. (medschat.com)
Phase1
- chromatid breaks were scored directly in G(2) or G(0) phase using premature chromosome condensation , the presence of amifostine did not affect the yields obtained. (bvsalud.org)
Drug2
- www.drugguide.com/ddo/view/Davis-Drug-Guide/51036/all/amifostine. (drugguide.com)
- Nursing Central , nursing.unboundmedicine.com/nursingcentral/view/Davis-Drug-Guide/51036/11.0/amifostine. (unboundmedicine.com)
Blood pressure1
- The nurse will check your blood pressure while you are receiving IV amifostine. (stjude.org)