Recombination genetic. Medical search. Frequent questions

In both meiotic and mitotic cells, recombination between homologous chromosomes is a common mechanism used in DNA repair. (wikipedia.org)
The RAD51 protein is required for mitotic and meiotic recombination, whereas the DNA repair protein, DMC1, is specific to meiotic recombination. (wikipedia.org)
We offer an alternative interpretation of the sequencing data of meiotic products, including the number and type of recombination events, to illustrate the potential for mistakes in single-nucleotide polymorphism calling. (psu.edu)
Meiotic recombination is an essential component of eukaryotic sexual reproduction but its frequency varies within and between genomes. (nih.gov)
meiotic recombination. (nih.gov)
Meiotic recombination introduces variation around that expectation (Mendelian noise) and related pedigree founders systematically bias Pedigree F downward. (nature.com)
Effects of meiotic recombination on Marker F were reversed, such that the same number of molecular markers yielded more precise estimates of GWIBD in zebra finches than in humans. (nature.com)
Our studies provide a direct observation of human meiotic recombination products. (nih.gov)
These results are consistent with the hypothesis that minimum efficient processing segments, which have been characterized in Escherichia coli, yeast, and cultured mammalian cells, may be required for efficient homologous meiotic recombination in humans. (nih.gov)
The PAR is a region of conserved sequence identity between the X and Y chromosomes over which the meiotic program of pairing, synapsis, and recombination unfolds to ensure correct sex chromosome segregation. (jax.org)

During meiosis in eukaryotes, genetic recombination involves the pairing of homologous chromosomes. (wikipedia.org)
In meiosis and mitosis, recombination occurs between similar molecules of DNA (homologous sequences). (wikipedia.org)
In meiosis, non-sister homologous chromosomes pair with each other so that recombination characteristically occurs between non-sister homologues. (wikipedia.org)
Gene conversion - the process during which homologous sequences are made identical also falls under genetic recombination. (wikipedia.org)
During meiosis, synapsis (the pairing of homologous chromosomes) ordinarily precedes genetic recombination. (wikipedia.org)
While in this formation, homologous sites on two chromatids can closely pair with one another, and may exchange genetic information. (wikipedia.org)
The HNPP (hereditary neuropathy with liability to pressure palsies) deletion and CMT1A (Charcot-Marie-Tooth disease type 1A) duplication are the reciprocal products of homologous recombination events between misaligned flanking CMT1A-REP repeats on chromosome 17p11. (nih.gov)
A 1.7-kb hotspot for homologous recombination was previously identified wherein the relative risk of an exchange event is 50 times higher than in the surrounding 98.7% identical sequence shared by the CMT1A-REPs. To refine the region of exchange further, we designed a PCR strategy to amplify the recombinant CMT1A-REP from HNPP patients as well as the proximal and distal CMT1A-REPs from control individuals. (nih.gov)
Roughly half of patients with advanced ovarian cancer have homologous recombination deficiency (HRD)-positive tumors, including those with a BRCA mutation, and one in four women have a BRCA mutation. (merck.com)
The yeast ML01 was modified using a shuttle vector containing a chromosome integration cassette with genes for malolactic enzyme, malate transporter (permease), regulatory genes and a sequence directing homologous recombination at a chromosomal locus (not specified in the FDA report), and the antibiotic phleomycin gene was used as a selectable marker via another plasmid. (i-sis.org.uk)
The modification of bacteria and yeast is based on homologous recombination while modification of plants is based on illegitimate recombination. (i-sis.org.uk)
A multifunctional heterogeneous-nuclear ribonucleoprotein that may play a role in homologous DNA pairing and recombination. (bvsalud.org)

The shuffling of genes brought about by genetic recombination produces increased genetic variation. (wikipedia.org)
This demonstrates that recombination is an important mechanism driving genetic variation in E. faecalis and suggests an epidemic population structure for E. faecalis. (uax.es)
Our results highlight the significance of 3D organization of regulatory elements and suggest that the topology of long-range genetic variations may affect gene expression as well as phenotype variation. (nature.com)
Despite their fundamental significance for chromosome transmission and genome stability, little is known about the levels and patterns of genetic diversity across centromeres and the PAR, or the biological impacts of this variation. (jax.org)
In parallel, we are pursuing experimental tests of the functional consequences of genetic variation across these loci. (jax.org)
My research aims to understand the causes and consequences of variation in the mechanisms that govern DNA inheritance: chromosome segregation, recombination, and de novo mutation. (jax.org)

The variable region is diversified by somatic hypermutation while the constant region may be changed by class-switch recombination. (lu.se)

The heterogeneous distribution of recessive deleterious mutations, the environment and other genetic factors like epistatic interactions are introducing noise into that relation. (nature.com)
Viruses like SARS-CoV-2 continuously evolve as changes in the genetic code (caused by genetic mutations or viral recombination) occur during replication of the genome. (cdc.gov)
A variant is a viral genome (genetic code) that may contain one or more mutations. (cdc.gov)
Mutations that disrupt centromere integrity or reduce homology between X- and Y-linked PARs can lead to chromosome segregation errors and constitute important genetic mechanisms for cancer, cellular senescence, and infertility. (jax.org)
More specifically, the team of Canadian researchers led by Dr. Philip Awadalla discovered the following: the segments of the human genome that don't recombine as often as others also tend to carry a significantly greater proportion of the more disease-enabling genetic mutations. (sciencedaily.com)
Until chromosome recombination eventually occurs, these segments accumulate more and more bad mutations. (sciencedaily.com)
Thankfully, disease-enabling mutations are eventually shuffled off our genetic code through sexual reproduction. (sciencedaily.com)

We employed GalK recombination-mediated genetic engineering (recombineering) of MVA-BAC to delete five selected viral genes. (ox.ac.uk)
On the basis of a genetic recombination model between sex‐determining genes and the centromere, the first maternal type was defined as heterogametic (WY) and the second as homogametic (WW). (biu.ac.il)
Avtalion, RR & Don, J 1990, ' Sex‐determining genes in tilapia: a model of genetic recombination emerging from sex ratio results of three generations of diploid gynogenetic Oreochromis aureus ', Journal of Fish Biology , vol. 37, no. 1, pp. 167-173. (biu.ac.il)
Map-based cloning and manipulation of genes controlling important traits for crop remains a great challenge due to the complex of crop genomes and lack of a high resolution of genetic and physical maps. (usda.gov)
Therefore, the use of a combination of genetic and physical mapping methods can be very useful for advancing knowledge on the number and distance between genes of interests as well as to better understand the topography and organization of the genome. (usda.gov)
The organism that develops from the fertilized ovum receives certain of the parents' characters through these genes, and the genetic material in the fertilized egg, that is to say, all these genes combined, determines the development of the organism. (nobelprize.org)

A predominance of HRV-C over HRV-A and HRV-B was observed, and two subspecies of HRV-C were identified, the diversity of which seemed to be related to recombination with former HRV-A strains. (plos.org)
Genetic diversity and potential recombination between ferret coronaviruses from European and American lineages. (ox.ac.uk)
We investigated the genetic diversity and dynamics of this gammacoronavirus using untargeted metagenomic sequencing of 223 faecal samples from swans of known age and sex, and RT-PCR screening of 1632 additional bird samples. (ox.ac.uk)
The simplified and known genetic background of captive mouse populations such as the Collaborative Cross, BXD recombinant inbred strain panel, the Diversity Outbred population, and collections of diverse inbred strains render them uniquely powerful resources for studying the mechanisms of short-term genome evolution and genomic inheritance. (jax.org)
As a consequence of their unique historical origins, the genetic diversity captured in laboratory mice represents an extremely limited sample of the diversity found in wild mouse populations. (jax.org)

Recombination may also occur during mitosis in eukaryotes where it ordinarily involves the two sister chromosomes formed after chromosomal replication. (wikipedia.org)

Identification of a locus which shows no genetic recombination with the autosomal dominant polycystic kidney disease gene on chromosome 16. (ox.ac.uk)
Three additional probes have now been mapped within an existing array of genetic markers flanking this locus. (ox.ac.uk)
recombination fraction [straight theta] 0 at locus D15S206 ). (medscape.com)
A new high-density genetic linkage map was constructed by using specific locus amplified fragment sequencing technology. (frontiersin.org)
Recombination between vector and chromosomal gene disrupts the target chromosomal gene and inserts the transgene, and frequently also a selectable marker, into the yeast target locus [3]. (i-sis.org.uk)
The large deletions of the STS gene are generated by inaccurate recombination at the STS locus. (medscape.com)

DNA polymorphisms are important markers in genetic analyses and are increasingly detected by using genome resequencing. (psu.edu)
One whole genome was fully characterised, and revealed that the virus originated from a recombination event involving an undescribed gammacoronavirus species. (ox.ac.uk)
A mutation refers to a single change in a virus's genome (genetic code). (cdc.gov)
Chromosomes recombine frequently in some segments of the genome, while recombination is less frequent in others. (sciencedaily.com)
Without the activity of enzymes and proteins, the genetic information in the genome would not be able to be expressed and translated into functional proteins. (proprofs.com)

Chromosomal crossover involves recombination between the paired chromosomes inherited from each of one's parents, generally occurring during meiosis. (wikipedia.org)

Dr. Awadalla and his team studied the sequenced genomes of hundreds of individuals from Canada's CARTaGENE genetic data repository and the multinational 1000 Genomes Project. (sciencedaily.com)

We conducted sequence analyses of 32 genetic loci of 53 C. hominis specimens isolated from a longitudinally followed cohort of children living in a small community. (cdc.gov)
[ 10 ] Assuming complete penetrance, haplotype analysis of recombination events defined an interval of 10 centimorgans between loci D15S1023 and D15S979 . (medscape.com)
Construction of High-Density Genetic Map and Mapping Quantitative Trait Loci for Growth Habit-Related Traits of Peanut (Arachis hypogaea L. (frontiersin.org)

In eukaryotes, genetic recombination during meiosis can lead to a novel set of genetic information that can be further passed on from parents to offspring. (wikipedia.org)
In eukaryotes, recombination during meiosis is facilitated by chromosomal crossover. (wikipedia.org)

More precisely, EAs maintain a POPULATION of structures, that evolve according to rules of SELECTION and other operators, that are referred to as "search operators", (or GENETIC OPERATORs), such as RECOMBINATION and MUTATION. (cmu.edu)
Recombination and mutation perturb those individuals, providing general heuristics for EXPLORATION. (cmu.edu)
Intergenerational DNA transmission is shaped by the fundamental processes of chromosome segregation, recombination, and de novo mutation. (jax.org)
X-linked ichthyosis is a genetic disorder caused by a mutation in the enzyme steroid sulfatase (STS). (medscape.com)

When analyzing a fragment of the 5′ UTR, we characterized at least two subspecies of HRV-C: HRV-Cc, which clustered differently from HRV-A and HRV-B, and HRV-Ca, which resulted from previous recombination in this region with sequences related to HRV-A. The full-length sequence of one strain of each HRV-Ca and HRV-Cc subspecies was obtained for comparative analysis. (plos.org)

Yeast cells in wine were found to be hyperactive in mitotic recombination, contributing to the observed instability of wine yeasts [7]. (i-sis.org.uk)

This region escapes X-chromosome inactivation and has the highest ratio of chromosomal deletions among all genetic disorders. (medscape.com)

For an example we need turn only to the previous Nobel Prize in Genetics, awarded to H.J. Muller for his discovery that X-ray irradiation can change the genetic material in living organisms. (nobelprize.org)

Bacterial recombination In Bacteria there are regular bacterial recombination, as well as noneffective transfer of genetic material, expressed as unsuccessful transfer or abortive transfer which is any bacterial DNA transfer of the donor cell to recipients who have set the incoming DNA as part of the genetic material of the recipient. (wikipedia.org)
Recombination-mediated genetic engineering of a bacterial artificial chromosome clone of modified vaccinia virus Ankara (MVA). (ox.ac.uk)

Many genetic variations outside protein-coding regions are associated with maize phenotypes. (nature.com)
The name FUS refers to the fact that genetic recombination events result in fusion oncogene proteins (ONCOGENE PROTEINS, FUSION) that contain the N-terminal region of this protein. (bvsalud.org)
The human bone morphogenet ic protein (rhBMP) developed by genetic engineering, was isolated by Urist, in 1965, and it is considered a substance capable of inducing differentiation of mesenchymal stem cells into osteoblasts, the cells that are responsible for the synthesis of bone matrix. (bvsalud.org)

and reasons for emergence of virulent subtypes are poorly understood because of availability of only limited genomic sequence data and lack of robust cultivation systems and genetic manipulation tools ( 13 ). (cdc.gov)
As a postdoctoral trainee at the University of Washington, I used computational approaches to mine large-scale genomic datasets to identify and catalog signatures of one specific subclass of recombination - gene conversion - within structurally complex and repetitive genomic regions. (jax.org)
Genomic analyses are widely applied to epidemiological, population genetic and experimental studies of pathogenic fungi. (cdc.gov)

Genetic recombination (also known as genetic reshuffling) is the exchange of genetic material between different organisms which leads to production of offspring with combinations of traits that differ from those found in either parent. (wikipedia.org)
Five individuals also had interspersed patches of proximal or distal repeat specific DNA sequence indicating potential gene conversion during the exchange of genetic material. (nih.gov)
As humans procreate, generation after generation, the exchange of genetic material between man and woman causes our species to evolve little by little. (sciencedaily.com)

Autosomal dominant is a pattern of inheritance characteristic of some genetic disorders. (genome.gov)
Huntington's disease is an example of an autosomal dominant genetic disorder. (genome.gov)
Autosomal recessive is a pattern of inheritance characteristic of some genetic disorders. (genome.gov)
Sickle cell anemia is an example of an autosomal recessive genetic disorder. (genome.gov)

We confirmed the close relationship of their structural proteins but showed apparent additional recombination events in the 2A gene and 3′UTR of the HRV-Ca strain. (plos.org)
In the early tvventieth century it was thought that proteins might carry genetic information. (proprofs.com)
In the early twentieth century, it was believed that proteins might carry genetic information because proteins were known to be composed of 20 distinct amino acids, whereas DNA is composed of only 4 nucleotides. (proprofs.com)
This difference in complexity led scientists to speculate that proteins, with their larger variety of building blocks, might be better suited to carry genetic information. (proprofs.com)

We identified by linkage disequilibrium and recombination analyses only limited genetic recombination, which occurred exclusively within the 60-kDa glycoprotein gene subtype IbA10G2, a predominant subtype for outbreaks in industrialized nations and a virulent subtype in the study community. (cdc.gov)

Recombination can be artificially induced in laboratory (in vitro) settings, producing recombinant DNA for purposes including vaccine development. (wikipedia.org)
The lineage that results from recombination is called a "recombinant. (cdc.gov)

For decades, theories on the genetic advantage of sexual reproduction had been put forward, but none had ever been proven in humans, until now. (sciencedaily.com)
Antigenic shifts are probably due to genetic recombination (an exchange of a gene segment) between influenza A viruses that affect humans and/or animals. (cdc.gov)
In the contest between humans and pathogens, each faction has an evolutionary advantage: we have the brains to plot antimicrobial strategies but they have the means to defeat them through rapid reproduction, genetic selection, and recombination. (cdc.gov)

Without the renewal such a constant recombination of characters involves, an animal or plant species would not be able to survive the struggle for existence. (nobelprize.org)
My PhD work combined phylogenetic, cytogenetic, and quantitative methods to address the genetic and evolutionary causes of species differences in recombination rate. (jax.org)

Because recombination can occur with small probability at any location along chromosome, the frequency of recombination between two locations depends on the distance separating them. (wikipedia.org)
Although both genetic events can occur concurrently within germinal centre B cells, there are examples of each occurring independently of the other. (lu.se)

In some cases, a lineage or group of lineages with similar genetic changes, may be designated by the World Health Organization (WHO) or the U.S. SARS-CoV-2 Interagency Group (SIG) as a Variant of Interest (VOI), Variant of Concern (VOC), Variant of High Consequence (VOHC) or Variant Being Monitored (VBM) due to shared attributes and characteristics that may require public health action. (cdc.gov)

Our novel MLST scheme provides an excellent tool for investigating local and short-term epidemiology as well as global epidemiology, population structure, and genetic evolution of E. faecalis. (uax.es)

Overall similarity of local recombination rates among our samples was unrelated to geographic or phylogenetic distance of the populations that our samples were derived from. (nih.gov)
Circumstantial evidence pointed to a similarity of the genetic mechanisms throughout the entire plant and animal kingdoms. (nobelprize.org)

These data are contributing to an increasing comparative effort to gain an understanding of the intra-specific variability of recombination rates and their evolutionary role in honey bees and other social insects. (nih.gov)

The flow of genetic information in cells is that DNA is first transcribed into RNA through a process called transcription. (proprofs.com)

We conducted a comparative population genetic analysis of virulent C. homini s subtype IbA10G2 in children living in a periurban community in Lima, Peru, by multilocus sequence typing (MLST) of 32 genetic markers. (cdc.gov)

Classical recombination operators are studied and empirically evaluated in this context. (mit.edu)

Genetic Modification and Recombination of Salivary Gland Organ Cultures. (albany.edu)
Genetic modification of yeast and bacteria differs fundamentally from modification of plants. (i-sis.org.uk)

We show that Mhf1 and Mhf2 in fission yeast, as in vertebrates, serve a dual function, aiding DNA repair/recombination and localizing to centromeres to promote chromosome segregation. (elsevierpure.com)

Erratum: MHF1-2/CENP-S-X performs distinct roles in centromere metabolism and genetic recombination (Open Biology (2013) 3 (130102) DOI: 10.1098/rsob.130102), Sonali Bhattacharjee, Fekret Osman, Laura Feeney, Alexander Lorenz, Claire Bryer, Matthew C. Whitby, 2018, vol. 8, issue 2. (elsevierpure.com)

Here we compare the contributions of classs-witch recombination and somatic hypermutation to the diversification of the serum immunoglobulin repertoire and review evidence that suggests that, despite clear differences, the two processes may share some aspects of their mechanism in common. (lu.se)

Genetic recombination and recombinational DNA repair also occurs in bacteria and archaea, which use asexual reproduction. (wikipedia.org)

A codon is a DNA or RNA sequence of three nucleotides (a trinucleotide) that forms a unit of genetic information encoding a particular amino acid. (genome.gov)
The use of genetic engineering and modern techniques such as transcriptomics, proteomics and sequence analysis are included in the course. (lu.se)

V(D)J recombination in organisms with an adaptive immune system is a type of site-specific genetic recombination that helps immune cells rapidly diversify to recognize and adapt to new pathogens. (wikipedia.org)
Over the past few decades, the diverse molecular genetic causes of SCID have been identified with progress from studies of the immune system. (medscape.com)
With the advances in BMT and gene therapy, patients now have a better likelihood of developing a functional immune system in a previously lethal genetic disease. (medscape.com)

Although it is well-established that honey bees have a high recombination rate with about 20 cM/Mbp, the proximate and ultimate causes of this exceptional rate are poorly understood. (nih.gov)
In contrast to previous studies, we found only in two datasets a significant relation between local recombination rate and GC content. (nih.gov)
To keep up with world demand, soybean needs to increase its rate of genetic gain for key agronomic traits and to consistently produce high yields across diverse environments. (unl.edu)

be able to describe molecular genetic processes in bacteria. (lu.se)

Focusing on regions of particularly increased or decreased recombination in specific maps, we identified several enriched gene ontologies in these regions and speculate about their local adaptive relevance. (nih.gov)

Recombinases are key enzymes that catalyse the strand transfer step during recombination. (wikipedia.org)

1. Hansman GS, Oka T, Katayama K, Take- sults of a computed tomographic scan da N. Human sapoviruses: genetic diver- of the brain were within normal limits. (cdc.gov)
In recent years, advances in technology, especially in the fields of genetic engineering, biochemistry, nanotechnologies, and artificial intelligence, have provided human beings with new ways of being, understanding and acting in the world. (bvsalud.org)

Anatomy18

Organisms16

Diseases6

Chemicals and Drugs73

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes147

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science5

Health Care4

Meiotic10

Homologous12

Variation6

Class-switch recomb1

Mutations7

Genes6

Diversity5

Replication1

Locus6

Genome5

Chromosomes1

Genomes1

Loci3

Meiosis2

Mutation4

Sequences1

Mitotic1

Chromosomal1

Genetics1

Bacterial2

Protein3

Genomic3

Exchange of genetic material3

Autosomal4

Proteins4

Analyses1

Recombinant2

Humans3

Species2

Occur2

Lineages1

Epidemiology1

Similarity2

Evolutionary1

Transcription1

Markers1

Operators1

Modification2

Chromosome segregation1

Centromere1

Differences1

Repair1

Sequence2

Immune3

Rate3

Molecular genetic1

Specific1

Strand1

Human2