• Piperidine and its derivatives are ubiquitous building blocks in pharmaceuticals and fine chemicals. (wikipedia.org)
  • Therefore, we first focused on an in-depth analysis of the protonation states of piperazine and piperidine derivatives in the studied compounds. (iasp-pain.org)
  • A simple and efficient protocol has been developed for the synthesis of highly substituted Piperidines derivatives. (lupinepublishers.com)
  • Part 3: Tropenyl and homotropenyl-piperidine urea derivatives. (bvsalud.org)
  • However, we kept in mind that within the previous series, a pair of closely related compounds, and , differing only in the piperazine/piperidine moiety in the structural core showed a significantly different affinity at sigma-1 receptors (σRs). (iasp-pain.org)
  • Piperidine is a widely used building block and chemical reagent in the synthesis of organic compounds, including pharmaceuticals such as vasodilators and antipsychotic medications (PMID: 25255204). (foodb.ca)
  • Belongs to the class of organic compounds known as piperidines. (foodb.ca)
  • Piperidines are compounds containing a piperidine ring, which is a saturated aliphatic six-member ring with one nitrogen atom and five carbon atoms. (foodb.ca)
  • The Piperidines and its analogues represent one of the most prominent compound classes which are widely distributed in biologically active compounds, pharmaceuticals and natural products [1]. (lupinepublishers.com)
  • Several compounds possessing Piperidines scaffold have been reported to exhibit a wide range of valuable bioactive properties including antihypertensive, neuro-protective, antiinflammatory, antibacterial, anti malarial and anticonvulsant activities [2]. (lupinepublishers.com)
  • Piperidine is a colourless fuming liquid and is a widely used amine for synthesis of organic compounds. (jubilantingrevia.com)
  • Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst: C5H5N + 3 H2 → C5H10NH Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol. (wikipedia.org)
  • Vertellus is a U.S. based company and one of the leading player in pyridine, piperidine and picoline manufacturing. (marketsandmarkets.com)
  • The mixture was stirred at -60 C for 30 min and a solution of 4- (3-chlorobenzyl)piperidine (200 mg, 0.96 mmol) and pyridine (253 mg, 3.2 mmol) in dichloromethane (5 mL) was added at -60 C. The resulting mixture was stirred at 25 C for 16 h. (ambeed.com)
  • 1-N-Boc-4-(Phenylamino)piperidine 125541-22-2 Melting point 136-137 Boiling point 400.6±38.0 °C(Predicted) density 1.107±0.06 g/cm3(Predicted) storage temp. (croozi.com)
  • Piperidine is also commonly used as a base for the deprotection of Fmoc-amino acids used in solid-phase peptide synthesis. (wikipedia.org)
  • Piperidine is widely used in crop protection, as active pharmaceutical ingredient (API) in drug manufacturing, as a solvent in organic synthesis. (marketsandmarkets.com)
  • Piperidine is a versatile building block and important intermediate in many applications especially for synthesis of pharmaceuticals, agro chemicals and rubber chemicals. (basf.com)
  • So far, to the best of our knowledge, there is no report available on the use of camphor sulfonic acid as an organ catalyst for the synthesis of highly substituted Piperidines. (lupinepublishers.com)
  • The pot atom step economic (PASE) synthesis of highly substituted Piperidines from relatively simple starting materials has been reported in the literature. (lupinepublishers.com)
  • Synthesis of highly substituted Piperidines involves three component reactions of two equivalents of aldehydes, two equivalents of anilines and one equivalent Β-ketoesters. (lupinepublishers.com)
  • For more information, please view Spec of 4-(3-bromophenyl)piperidine hydrochloride 1159825-25-8.pdf . (capotchem.com)
  • Piperidine is widely used to convert ketones to enamines. (wikipedia.org)
  • Boehm in 1943 reported the first multi component reaction between an amine, aldehydes and 1,3-dicarbonyl to synthesize functionalized piperidines [14]. (lupinepublishers.com)
  • Recent syntheses of azetidines, pyrrolidines, piperidines and azepines through cycloaddition or sigmatropic rearrangements of vinylaziridines are described. (mdpi.com)
  • Piperidines" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
  • BASF offers Piperidine global in a purity of at least min. (basf.com)
  • A significant industrial application of piperidine is for the production of dipiperidinyl dithiuram tetrasulfide, which is used as an accelerator of the sulfur vulcanization of rubber. (wikipedia.org)
  • The major application of Piperidine is for the production of Dipiperidinyl Dithium Tetrasulfide, which is used as a rubber vulcanisation accelerator. (jubilantingrevia.com)
  • 13C NMR: (CDCl3, ppm) 47, 27.2, 25.2[citation needed] 1H NMR: (CDCl3, ppm) 2.79, 2.19, 1.51[citation needed] Piperidine is used as a solvent and as a base. (wikipedia.org)
  • Piperidine is used as a solvent and as a base. (foodb.ca)
  • Piperidine is also used as a solvent and base in agrochemical and pharmaceutical industries for Mepiquat Chloride, Dipyridamole and Minoxidil. (jubilantingrevia.com)
  • Piperidine is listed as a Table II precursor under the United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances due to its use (peaking in the 1970s) in the clandestine manufacture of phencyclidine. (wikipedia.org)
  • History or evidence of allergy or hypersensitivity to Fexofenadine, Loratadine, Levocetirizine, Cetirizine, Hydroxyzine or any piperidine derivative drugs or any of the excipients of this product. (who.int)
  • The key players in the piperidine market are BASF SE (Germany), Koei Chemical Co. Ltd. (Japan), Vertellus (US), Jubilant Ingrevia Limited (India), Vasudha Pharma (India), Taj Pharmaceuticals Ltd. (India), Avantor Inc. (US), Allchem Lifescience Pvt. (marketsandmarkets.com)
  • Fire ant venom contains a chemical called piperidine. (medlineplus.gov)
  • Piperidine, named after the genus Piper, which is Latin for pepper, has the molecular formula (CH2)5NH. (foodb.ca)
  • Especially, highly substituted Piperidines have been recognized as an important class of therapeutic agents in the treatment of cancer metastasis, influenza, Parkinson's disease, viral infections including AIDS and diabetes [4]. (lupinepublishers.com)
  • Although piperidine is a common organic compound, it is best known as a representative structure element within many pharmaceuticals and alkaloids, such as natural-occurring solenopsins. (wikipedia.org)
  • Piperidine is an organic compound with the molecular formula (CH2)5NH. (wikipedia.org)
  • The piperidine market report analyzes the key growth strategies adopted by the leading market players, between 2020 and 2022, which include expansions, mergers & acquisition, new product developments/launch, and collaborations. (marketsandmarkets.com)
  • Enamines derived from piperidine are substrates in the Stork enamine alkylation reaction. (wikipedia.org)
  • Fourier transform infrared spectrometry/attenuated total reflectance study of the reaction of pentanal and propanal with 2-(hydroxymethyl)piperidine. (cdc.gov)
  • The global piperidine market is projected to grow from USD 64 million in 2022 to USD 86 million by 2027, at a CAGR of 5.9% from 2022 to 2027. (marketsandmarkets.com)
  • Piperidine is a versatile building block and important intermediate in many applications. (basf.com)
  • This graph shows the total number of publications written about "Piperidines" by people in this website by year, and whether "Piperidines" was a major or minor topic of these publications. (childrensmercy.org)
  • EN] - This website uses third-party analytical cookies. (actim.com)
  • Piperidine was first reported in 1850 by the Scottish chemist Thomas Anderson and again, independently, in 1852 by the French chemist Auguste Cahours, who named it. (wikipedia.org)