Serum osteocalcinOsteoblastsProtein osteocalcinVitamin K dependent proteinAlkalineCollagen2021UcOCAntibodySynthesisCalcificationExtracellularReceptorFragmentsOsteoporosisGeneSensitivityPROTEINSStimulatesBiosynthesisMarker of bone formationSkeletonStructuralIncreasesDifferentiationAmino acidsGlucoseFertilityHormoneEndocrineFormationLevelsMiceRegulationPatientsHumanIncreased in boneBonesStableCirculationDifferencesSignificantlyAdultCalciumTypeImportant
Serum osteocalcin5
- It has been observed that higher serum osteocalcin levels are relatively well correlated with increases in bone mineral density during treatment with anabolic bone formation drugs for osteoporosis, such as teriparatide. (wikipedia.org)
- Serum osteocalcin is considered a specific marker of osteoblast function, as its levels correlate with the bone formation rate. (medscape.com)
- Serum osteocalcin may not reflect bone formation in patients treated with 1,25 dihydroxy vitamin D. This is because osteocalcin is regulated by 1,25 dihydroxy vitamin D. (medscape.com)
- Serum osteocalcin (1-43) is also generated by the catabolic breakdown of osteocalcin (1-49) in circulation, liver, and kidney. (epitopediagnostics.com)
- Total serum osteocalcin, prolonged hypercalcemia and extrathyroidal manifestations. (lorenzopetrantoni.com)
Osteoblasts9
- Osteocalcin is secreted solely by osteoblasts and thought to play a role in the body's metabolic regulation. (wikipedia.org)
- As osteocalcin is produced by osteoblasts, it is often used as a marker for the bone formation process. (wikipedia.org)
- Importantly, osteocalcin is secreted solely by osteoblasts but only has minor effects on bone mineralization and density. (nih.gov)
- To study the effects and importance of fluoride on FBs in the development of extraperiosteal calcification and the ossification of skeletal fluorosis, the presence of the osteogenic phenotype, which is indicated by the expression of core-binding factor a1 (Cbfa1) and osteocalcin (OCN), in an FB cell line (L929) and in osteoblasts (OBs) exposed to fluoride was determined. (fluoridealert.org)
- Osteocalcin is a vitamin K dependent protein produced by osteoblasts and found in high concentrations in bone. (cryopep.com)
- Osteocalcin is a small protein (49 amino acids) synthesized by mature osteoblasts, odontoblasts, and hypertrophic chondrocytes. (medscape.com)
- Osteoblasts produce osteocalcin and incorporate it into the bone matrix. (medscape.com)
- Osteocalcin is a structural protein of the bone matrix, which is synthesized by osteoblasts and enters the bloodstream in the process of bone resorption. (dntb.gov.ua)
- Alkaline phosphatase (ALP), osteocalcin (OCN), osteopontin (OPN), and runt-related transcription factor 2 (Runx2) are commonly used to evaluate differentiation and maturation of osteoblasts. (frontiersin.org)
Protein osteocalcin3
- Context: The undercarboxylated form of the osteoblast-secreted protein osteocalcin has favorable effects on fat and glucose metabolism in mice. (johnshopkins.edu)
- Dr. Dowd investigates the role of the bone protein osteocalcin on glucose homeostasis, insulin sensitivity, secretion, bone properties and bone fracture using osteocalcin knockout mice (KO). (cuny.edu)
- Over the past two decades, French geneticist and physician Gerard Karsenty has been studying the protein osteocalcin, which is found in high concentrations in the skeleton. (meltmethod.com)
Vitamin K dependent protein2
- Osteocalcin (cOC) is a vitamin K-dependent protein. (nutraingredients.com)
- Osteocalcin is another vitamin K-dependent protein that is present in bone and may be involved in bone mineralization or turnover [ 5 ]. (nih.gov)
Alkaline3
- To assess the possible occurrence of a similar phenomenon in humans, serum markers of bone formation, osteocalcin and alkaline phosphatase, were measured in marrow donors before the aspiration of large amounts of iliac marrow and 1 day to 5 weeks thereafter. (tau.ac.il)
- Both osteocalcin and alkaline phosphatase showed significant increases, with peak values 1-3 and 2-4 weeks postaspiration, respectively. (tau.ac.il)
- The Lyophilised Serum Bone Marker Control is intended for use with in vitro diagnostic assays for the quantitative determination of Procollagen Type 1 N-Terminal Propeptide (P1NP), N-MID Osteocalcin (OC) and Bone Alkaline Phosphatase (B-ALP) in serum samples. (randox.com)
Collagen2
- Immunolocalization of BSPII, osteocalcin and collagen I in archaeological human bone slices. (figshare.com)
- Archaeological human femur slices (60 μm thick) were labeled for BSPII, osteocalcin and collagen I, and developed using DAB (brown). (figshare.com)
20211
- 2021. https://nursing.unboundmedicine.com/nursingcentral/view/Tabers-Dictionary/746549/all/osteocalcin. (unboundmedicine.com)
UcOC2
- Objective: We investigated whether changes in undercarboxylated osteocalcin (ucOC) during osteoporosis treatment are associated with changes in metabolic parameters. (johnshopkins.edu)
- Without adequate vitamin K, the osteocalcin remains inactive (uncarboxylated osteocalcin, ucOC), and thus not effective. (nutraingredients.com)
Antibody1
- Human IgG antibody Laboratories manufactures the osteocalcin assay zoledronic acid reagents distributed by Genprice. (todayfinancialnews.com)
Synthesis3
- Because osteocalcin has gla domains, its synthesis is vitamin K dependent. (wikipedia.org)
- The production of osteocalcin is stimulated by 1 , 25 dihydroxy vitamin D and depends on vitamin K. Vitamin K increases the carboxylation of osteocalcin, but it does not increase its overall rate of synthesis. (medscape.com)
- Stimulates the synthesis of osteocalcin, an important protein involved in bone formation. (dragonherbs.com)
Calcification1
- Osteocalcin, Vascular Calcification, and Atherosclerosis: A Systematic Review and Meta-analysis. (nottingham.ac.uk)
Extracellular2
- Age- and gender-related changes in the distribution of osteocalcin in the extracellular matrix of normal male and female bone. (jci.org)
- In this study, we determined the immunohistochemical distribution of osteocalcin in the extracellular matrix of iliac crest bone biopsies obtained from normal male and female volunteers, 20-80 yr old. (jci.org)
Receptor3
- There is evidence that GPR37 might be the third osteocalcin receptor. (wikipedia.org)
- We show that YY1 and vitamin D receptor (VDR)/retinoid X receptor heterodimers compete for binding at the osteocalcin VDRE. (umassmed.edu)
- The condyles were analyzed histologically, histomorphometrically, and immunohistochemically using the antibodies for bone sialoprotein (BSP), osteocalcin (OCC) and receptor activator of nuclear factor kappa-B ligand (RANKL). (bvsalud.org)
Fragments3
- The resulting heterogeneity of the osteocalcin fragments in the serum leads to limitations with the use of this marker. (medscape.com)
- Because different antibodies recognize different fragments, no standard currently exists for osteocalcin assays. (medscape.com)
- Both osteocalcin (1-49) and its fragments, including osteocalcin (1-43) are released into the blood stream. (epitopediagnostics.com)
Osteoporosis2
- Osteocalcin levels vary widely among healthy individuals and those patients with osteoporosis , Paget disease , and chronic renal failure. (medscape.com)
- Osteocalcin levels should not be used to diagnose osteoporosis. (medscape.com)
Gene4
- In humans, osteocalcin is encoded by the BGLAP gene. (wikipedia.org)
- Here we demonstrate that the multifunctional regulator YY1 represses 1,25-dihydroxyvitamin D3 (vitamin D)-induced transactivation of the bone tissue-specific osteocalcin gene. (umassmed.edu)
- We identify YY1 recognition sequences within the vitamin D response element (VDRE) of the osteocalcin gene that are critical for YY1-dependent repression of vitamin D-enhanced promoter activity. (umassmed.edu)
- Our results suggest that YY1 regulates vitamin D enhancement of osteocalcin gene transcription in vivo by interfering with the interactions of the VDR with both the VDRE and TFIIB. (umassmed.edu)
Sensitivity2
- In fat cells, osteocalcin triggers the release of the hormone adiponectin, which increases sensitivity to insulin. (wikipedia.org)
- Osteocalcin promotes pancreatic β-cell proliferation and insulin secretion, and also affects the insulin sensitivity of peripheral tissues. (dntb.gov.ua)
PROTEINS1
- The vitamin K-dependent proteins, osteocalcin and matrix gamma-carboxy-glutamyl (Gla) protein, may have important roles in bone and other tissues. (msdmanuals.com)
Stimulates1
- An acute stress response (ASR), colloquially known as the fight-or-flight response, stimulates osteocalcin release from bone within minutes in mice, rats, and humans. (wikipedia.org)
Biosynthesis1
- In the testes, osteocalcin acts on Leydig cells, stimulating testosterone biosynthesis and therefore affects male fertility. (wikipedia.org)
Marker of bone formation2
- Osteocalcin is released into the circulation from the matrix during bone resorption and, therefore, is considered a marker of bone turnover rather than a specific marker of bone formation. (medscape.com)
- The level of osteocalcin in the serum is used as a specific marker of bone formation. (dntb.gov.ua)
Skeleton1
- One of the factors released by the skeleton is osteocalcin. (nih.gov)
Structural1
- Structural studies of osteocalcin are conducted to understand its function in bone and metabolic disorders as well. (cuny.edu)
Increases1
- Osteocalcin increases during high bone turnover (such as with hyperparathyroidism , acromegaly , and Paget disease). (medscape.com)
Differentiation1
- [ 15 ] Osteocalcin is a late marker of osteoblast differentiation. (medscape.com)
Amino acids2
- Both the large N-terminal/midregion (N-MID) fragment (amino acids 1-43) and intact osteocalcin (amino acids 1-49) and are found in blood. (medscape.com)
- [ 4 ] Because of protease cleavage between amino acids 43 and 44, intact osteocalcin is unstable. (medscape.com)
Glucose1
- Among bone hormones, osteocalcin plays an important role as a coordinator of bone modeling processes, energy homeostasis, metabolism of glucose, lipids and minerals. (dntb.gov.ua)
Fertility1
- Granted osteocalcin isn't the only hormone or protein that plays a role in regulating insulin, fertility, and brain function but it does seem to be a very relevant element in many brain functions and neurotransmission. (meltmethod.com)
Hormone1
- Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a small (49-amino-acid) noncollagenous protein hormone found in bone and dentin, first identified as a calcium-binding protein. (wikipedia.org)
Endocrine1
- An osteocalcin-deficient mouse strain without endocrine abnormalities. (cuny.edu)
Formation3
- In many studies, osteocalcin is used as a preliminary biomarker on the effectiveness of a given drug on bone formation. (wikipedia.org)
- For instance, one study which aimed to study the effectiveness of a glycoprotein called lactoferrin on bone formation used osteocalcin as a measure of osteoblast activity. (wikipedia.org)
- This, in turn would increase the levels of osteocalcin which is responsible for bone formation. (umc.edu)
Levels6
- Injections of high levels of osteocalcin alone can trigger an ASR in the presence of adrenal insufficiency. (wikipedia.org)
- Osteocalcin levels are related to increased bone turnover. (medscape.com)
- Decreasing osteocalcin levels indicate effective response to treatment. (medscape.com)
- Within 3-6 months after surgical cure, osteocalcin levels in patients with primary hyperparathyroidism should return to the reference range. (medscape.com)
- impaired renal function causes osteocalcin levels to increase. (medscape.com)
- At the molecular level, intracellular cyclic adenosine monophosphate (cAMP) levels are increased and osteocalcin is decreased. (medscape.com)
Mice1
- Karsenty showed in the lab that if the bones in mice were absent of osteocalcin that they would show signs of depression, have trouble breeding, and alter mice's fat storage processes in the liver, muscles, pancreas and brain. (meltmethod.com)
Regulation1
- Well, it turns out as the brain helps regulate bone mass through signals sent from our bones, with the osteocalcin produced helping modulate this regulation and other functions of the brain. (meltmethod.com)
Patients1
- It is shown that the level of osteocalcin in the blood serum is significantly reduced compared to healthy controls, both in patients with type 1 diabetes mellitus and, especially, in type 2 diabetes mellitus. (dntb.gov.ua)
Human2
- The Osteocalcin Assay Zoledronic Acid reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (todayfinancialnews.com)
- This ELISA (enzyme-linked immunosorbent assay) kit is intended for the quantitative determination of both human osteocalcin (1-49) and osteocalcin (1-43), also referred to as N-terminal & mid-regional osteocalcin, in serum or plasma samples. (epitopediagnostics.com)
Increased in bone1
- Osteons that contained osteocalcin-positive resting lines (type IV) increased in bone obtained from males with increasing age but were unchanged in females. (jci.org)
Bones1
- They are a source for vitamin K1, which activates the noncollagen protein within the bones known as osteocalcin. (gardenguides.com)
Stable2
- The N-MID-fragment, which results from cleavage, is considerably more stable, some assays are able to detect both intact osteocalcin and the stable N-MID-fragment. (medscape.com)
- Several studies have confirmed that measurement of the more stable N-terminal and mid-regional osteocalcin (osteocalcin 1-43/49) as being more clinically useful, which may contribute to a more accurate assessment of the bone turnover rate. (epitopediagnostics.com)
Circulation1
- in circulation, the half-life of osteocalcin is about 5 minutes. (medscape.com)
Differences2
- Whether age- and/or gender-related differences exist in the distribution of osteocalcin within individual bone remodeling units is not known. (jci.org)
- These results suggest that differences in the distribution of osteocalcin in bone matrix may be responsible, in part, for the altered remodeling of bone associated with gender and aging. (jci.org)
Significantly1
- The absolute maximal increase in osteocalcin was significantly higher in adolescent and child donors than in adults. (tau.ac.il)
Adult1
- The reference intervals for osteocalcin are about 1.1-11 ng/mL (adult male) and 0.7-6.5 ng/mL (adultfemale). (medscape.com)
Calcium4
- The study included measuring the level of thyroid hormones (T3, TSH), osteocalcin, vitamin D and calcium Ca2+, as the first group (G1) includes samples that have a level (hyperactivity of the thyroid gland). (sjpas.com)
- RÉSUMÉ Le présent essai clinique randomisé, en double aveugle, contrôlé contre placebo, a évalué l'effet de la supplémentation en zinc sur les taux de zinc et de calcium sériques chez des femmes ostéoporotiques ménopausées. (who.int)
- Les mesures anthropométriques, l'apport alimentaire en zinc et en calcium, les taux de zinc et de calcium sériques ont été évalués au début de l'étude puis à 60 jours. (who.int)
- Les concentrations moyennes initiales en zinc sérique étaient nettement inférieures aux valeurs normales, mais les taux de calcium sérique moyens étaient normaux. (who.int)
Type1
- The proportion of osteons that lack osteocalcin in the matrix immediately adjacent to Haversian canals (type III) increased in females and males with age. (jci.org)
Important1
- In the brain, osteocalcin plays an important role in development and functioning including spatial learning and memory. (wikipedia.org)