Narcotic antagonists. Medical search. Frequent questions

The present double-blind, randomized study examined behavioral pain responses in healthy human volunteers during mindfulness meditation and a nonmanipulation control condition in response to noxious heat and intravenous administration of the opioid antagonist naloxone (0.15 mg/kg bolus + 0.1 mg/kg/h infusion) or saline placebo. (jneurosci.org)
To address this question, the present study examined pain reports during meditation in response to noxious heat and administration of the opioid antagonist naloxone and placebo saline. (jneurosci.org)
is reversed by administration of the opioid antagonist naloxone. (jneurosci.org)
endogenous or exogenous opioids and the pure narcotic antagonist, naloxone. (druglibrary.org)
The drugs include naloxone and the longer-acting opioid antagonist naltrexone. (cochrane.org)
We searched the Cochrane Tobacco Addiction Group Specialised Register for trials of naloxone, naltrexone and other opioid antagonists and conducted an additional search of MEDLINE using 'Narcotic antagonists' and smoking terms in April 2013. (cochrane.org)
During pregnancy, emergence of endogenous opioid inhibition of oxytocin neurons is revealed by increased oxytocin secretion after administration of the opioid receptor antagonist, naloxone. (ed.ac.uk)
Naloxone is an opioid antagonist used to treat narcotic overdoses and is generally considered the treatment of choice for immediate administration in instances of opioid overdose. (biospace.com)
Narcotic Antagonists: Naloxone Actions Opioid antagonists block ( or antagonize ) opiate-receptors sites, principal use is the treatment. (nursesnotehelp.com)

The present investigation sought to determine whether the stimulus properties of morphine and lysergic acid diethylamide (LSD) would generalize to several narcotic analgesics which vary in their subjective effects. (erowid.org)
After discriminated responding was stable, stimulus generalization tests with narcotic analgesics and antagonists showed that the stimulus properties of morphine generalized to methadone and meperidine, and partially to pentazocine, all of which produce morphine-like subjective effects in humans. (erowid.org)
Patients receiving Buprenex in the presence of other narcotic analgesics, general anesthetics, antihistamines, benzodiazepines, phenothiazines, other tranquilizers, sedative/hypnotics or other CNS depressants (including alcohol) may exhibit increased CNS depression. (druglib.com)
Using the technique of intracerebroventricular (i.c.v.) microinjection in conscious mice and rats, the possible involvement of putative central nervous system transmitter-substances in the anti-nociceptive effects of morphine and the narcotic-antagonist analgesics nalorphine and pentazocine has been investigated. (aston.ac.uk)
The picture with regard to the narcotic-antagonist analgesics is less clear, partly because of the inadequacies of the test methods available, and partly because the two agents chosen in this group (nalorphine and pentazocine) appear to possess quite different spectra of pharmacological activity, despite being classified in the same group. (aston.ac.uk)

Like morphine and heroin, methadone is a narcotic and therefore, by definition, an addicting drug. (druglibrary.org)
Opioid antagonists are a type of drug which blunts the effects of narcotics such as heroin and morphine, and might help reduce nicotine addiction by blocking some of the rewarding effects of smoking. (cochrane.org)
Stimulus generalization tests to each other narcotic antagonist, d-amphetamine (0.1-1.6 :ng/kg 8.C.), morphine (0.6 2.5 mg/kg s.c.), and LSD (0.025-0.4 mg/kg s.c.) were performed. (erowid.org)

Narcotic antagonist treatment using Naltrexone for opiate addicts usually is conducted in outpatient settings although initiation of the medication often begins after medical detoxification in a residential setting. (healthyplace.com)
Naltrexone is a long-acting synthetic opiate antagonist with few side effects that is taken orally either daily or three times a week for a sustained period of time. (healthyplace.com)
Do opioid antagonists such as naltrexone help people to stop smoking? (cochrane.org)
Our review identified eight trials of naltrexone, a long-acting opioid antagonist. (cochrane.org)
The available evidence does not suggest that opioid antagonists such as naltrexone assist smoking cessation. (cochrane.org)

I believe this underscores the need for additional treatment alternatives for narcotic overdose," said Dr. Dennis J. Carlo, President and Chief Executive Officer of Adamis Pharmaceuticals. (biospace.com)
If the proper narcotic antagonist (drug to counteract the effects of narcotics) can be given, recovery from an acute overdose occurs within 24 to 48 hours. (medlineplus.gov)
A narcotic antagonist used in opioid overdose. (drugbank.com)

Thus the antagonists, like methadone, are 'blocking agents. (druglibrary.org)
A psychiatrist who has had experience with both methadone and antagonist maintenance programs contrasts 'the relaxed, jovial atmosphere of a methadone ward,' where patients are free of the postaddiction syndrome, with 'the tension, frustration, and anxiety that characterize a cyclazocine ward. (druglibrary.org)

Narcotic antagonists and antidepressants can help. (projectstrada.org)
Some medications used to treat gambling addiction include antidepressants, mood stabilizers, and narcotic antagonists. (liguriapocket.com)

What the large-scale use of a long-acting narcotic antagonist would in fact produce, however, is a horde of men, women, and adolescents assailed by anxiety and depression, with a continuing craving for heroin and no way to assuage their distress (except, perhaps, via alcoholism). (druglibrary.org)
While it's prescribed to treat everything from severe diarrhea to cancer pain, "Oxy" also has an extremely high abuse potential, producing feelings of euphoria similar to another opioid narcotic: heroin. (thedailybeast.com)

Since beta-endorphins can bind both mu opioid and kappa-opioid receptors we investigated the effect of a mu specific receptor agonist, D-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin (DAMGO) and a mu specific antagonist, D-Phe-Cys-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP) on cardiovascular responses in conscious control and obese rats. (nih.gov)

We considered randomised controlled trials comparing opioid antagonists to placebo or an alternative therapeutic control for smoking cessation. (cochrane.org)

In May 2023, the Bureau of Narcotic Enforcement will be releasing an update to the Prescription Monitoring Program (PMP) Registry Confidential Drug Utilization Report. (ny.gov)

treatment involves narcotic antagonists and supportive therapy. (vin.com)
Methylnaltrexone is used to treat constipation caused by opioid (narcotic) pain medications in people with chronic (ongoing) pain that is not caused by cancer but may be related to a previous cancer or cancer treatment. (medlineplus.gov)

CTAP, the mu antagonist, paradoxically increased the MAP in both control and obese rats. (nih.gov)

It was suggested, for example, that a long-term supply or 'depot' of an antagonist might be implanted somewhere in the addict's body, surrounded by a membrane that would release the drug at the desired rate continuously over a period of a month or even six months. (druglibrary.org)
The civil-liberties implications of requiring the taking of a drug that not only perpetuates anxiety, depression, and craving but also blocks relief of that syndrome for prolonged periods deserves fuller consideration than was given the subject during the 1971 discussions of long-acting narcotics antagonists. (druglibrary.org)
By 2001, sales of the drug exceeded $1 billion, making Oxy the bestselling nongeneric narcotic pain reliever in the country. (thedailybeast.com)
BNE Narcotic Investigators investigate suspected drug diversion or illegal sales involving theft, forgery, and fraudulent visits to practitioners' offices, and work closely with local, state and federal law enforcement. (ny.gov)

Opioid (narcotic) antagonists are of particular interest to investigators as potential agents to attenuate the rewarding effects of cigarette smoking. (cochrane.org)
Studies utilizing NMDA-receptor antagonists like ketamine, known for creating narcotic and psychotomimetic effects, aim to understand schizophrenia-related glutamate signaling deficiencies. (news-medical.net)
Because of the narcotic antagonist activity of Buprenex, use in the physically dependent individual may result in withdrawal effects. (druglib.com)
It works by protecting the bowel from the effects of opioid (narcotic) medications. (medlineplus.gov)

To evaluate the efficacy of opioid antagonists in promoting long-term smoking cessation. (cochrane.org)

In a recent study published in the journal Scientific Reports , a group of researchers investigated the influence of ketamine, a N-Methyl-D-Aspartate (NMDA) receptor antagonist, on mentalizing deficits and associated neural responses, providing insights into glutamate's role in schizophrenia's social cognition impairments. (news-medical.net)

Agents inhibiting the effect of narcotics on the central nervous system. (nih.gov)

We also reviewed, for descriptive purposes, results from short-term laboratory-based studies of opioid antagonists designed to evaluate psycho-biological mediating variables associated with nicotine dependence. (cochrane.org)

In 1971, despite the earlier failures of narcotic antagonists, ** interest was renewed in these drugs as a potential 'cure for addiction. (druglibrary.org)
Inactive as either antagonists or agonists on the H2-receptor were psilocin, bufotenine, mescaline, different classes of anticonvulsant drugs, barbiturates and narcotic agonists and antagonists, as well as lithium chloride, chlordiazepc, ice, THC and procaine. (erowid.org)

the antagonist activity may provoke withdrawal Sx. (medscape.com)

The other major difference is that since the antagonists are not addicting, a patient can stop taking them at will. (druglibrary.org)
Generall) with low body an absorption rate and the patient requires a narcotic antagonist. (stonecottagegardens.com)

For IV: use only if a narcotic antagonist and facilities are immediately available to assist and control respiration. (oncologynurseadvisor.com)

Methylnaltrexone is to be taken by people who are taking opioid (narcotic) medications. (medlineplus.gov)

REVEX (nalmefene hydrochloride injection), an opioid antagonist, is a 6-methylene analogue of naltrexone. (nih.gov)
Interestingly, neither the non-selective opioid receptor antagonist, naltrexone nor beta-funaltrexamine (beta-FNA), a highly selective MOR antagonist, blocked fentanyl mediated inhibition of TNFalpha-induced CXCL10 expression. (nih.gov)
Naltrexone, a narcotic antagonist, can be an effective drug in the treatment of opiate addiction. (sbir.gov)
In spite of the availability of a narcotic antagonist, naltrexone, which could be successful in the attenuation of alcohol drinking behavior, the societal problems of alcohol addiction remain. (sbir.gov)
Structural analog of naltrexone, q.v., with opiate antagonist activity. (drugfuture.com)
Neither the MOR-selective antagonist, D-Phe-Cys-Tyr-D-Trp-Arg-Pen-Thr-NH 2 (CTAP) nor the nonselective opioid receptor antagonist, naltrexone inhibited IFNγ + HIV-1 Tat-induced CXCL10 expression. (okstate.edu)

Analgesic narcotic antagonists. (wikipedia.org)
Centrally acting analgesic with mixed narcotic agonist and antagonist action. (freezingblue.com)
Diphenoxylate is an antidiarrheal agent chemically related to the narcotic analgesic meperidine. (medscape.com)

Inactive as either antagonists or agonists on the H2-receptor were psilocin, bufotenine, mescaline, different classes of anticonvulsant drugs, barbiturates and narcotic agonists and antagonists, as well as lithium chloride, chlordiazepc, ice, THC and procaine. (erowid.org)

To assess the discriminative stimulus properties of mixed agonist- antagonist opioids in humans, postaddict volunteers were trained in a three- choice drug discrimination procedure to discriminate among the effects of saline (4 ml i.m.), hydromorphone (3 mg i.m.) and butorphanol (6 mg i.m. (johnshopkins.edu)
Preston, KL & Bigelow, GE 1994, ' Drug discrimination assessment of agonist-antagonist opioids in humans: A three-choice saline-hydromorphone-butorphanol procedure ', Journal of Pharmacology and Experimental Therapeutics , vol. 271, no. 1, pp. 48-60. (johnshopkins.edu)
Bigelow, G. E. / Drug discrimination assessment of agonist-antagonist opioids in humans : A three-choice saline-hydromorphone-butorphanol procedure . (johnshopkins.edu)

Afferent's lead investigational candidate, AF-219, is a selective, non-narcotic, orally-administered P2X3 antagonist currently being evaluated in a Phase 2b clinical trial for the treatment of refractory, chronic cough as well as in a Phase 2 clinical trial in idiopathic pulmonary fibrosis (IPF) with cough. (merck.com)
We have utilized proinflammatory-induced CXCL10 expression in normal human astrocytes (NHA) as a model in which to assess the anti-inflammatory actions of the selective, mu-opioid receptor (MOR) antagonist, β-funaltrexamine (β-FNA). (okstate.edu)

Conveys the views and recommendations of an expert committee commissioned to assess selected narcotic drugs and psychotropic substances and to determine which should be recommended for control under existing international treaties. (who.int)

Rats received microinjections of the μ-opioid receptor antagonist CTAP before these tests. (edu.au)

Small increments are used rather than a large bolus injection in order to prevent narcotic withdrawal in the patient who is dependent on opioids. (medscape.com)

noun an antagonist for estrogen that is used in the treatment of breast cancer tamoxifen . (niftyword.com)

3 Hl-antagonists (including cyproheptadine) blocked the H2 receptor (as shown by inhibition of dimaprit). (erowid.org)

Drug classes that may be considered in the medical management of patients with postcholecystectomy syndrome include bulking agents, gastrointestinal (GI) antispasmodic agents, bile acid sequestrants, histamine H2 antagonists, and proton pump inhibitors (PPIs). (medscape.com)

Clinical evaluation of narcotic antagonism: T. J. Gal, C. A. DiFazio, Anesthesiology 64, 175 (1986). (drugfuture.com)
Opioid antagonists reduce the rate of relapse to drinking in clinical trials and reduce reinstatement in animal models of drug seeking. (edu.au)

It is still an opioid narcotic, however, with potential for abuse, dependency, and the onset of withdrawal symptoms when the user attempts to stop using it. (articlecity.com)

This is a "connection" page, showing publications Tara Wright has written about Narcotic Antagonists. (musc.edu)

Understanding the mechanism by which chemokine expression is suppressed, particularly by the opioid antagonist, beta-FNA, may provide insights into the development of safe and effective treatments for neuroinflammation. (nih.gov)

Like antacids, H2-receptor antagonists do not reduce the frequency of reflux but do decrease the amount of acid in the refluxate by inhibiting acid production. (medscape.com)

Organisms2

Diseases8

Chemicals and Drugs49

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Psychiatry and Psychology5

Phenomena and Processes4

Anthropology, Education, Sociology and Social Phenomena2

Health Care3

Naloxone9

Analgesics5

Morphine3

Naltrexone5

Overdose3

Methadone2

Antidepressants2

Heroin2

Receptors1

Placebo1

20231

Treatment2

Rats1

Drug4

Effects4

Smoking cessation1

Responses1

Agents1

Studies1

Drugs2

Activity1

Patient2

Control1

People1

Naltrexone6

Analgesic3

Agonists1

Humans3

Selective2

Substances1

CTAP1

Opioids1

Estrogen1

Inhibition1

Gastrointestinal1

Clinical2

Potential for abuse1

Connection1

Effective1

Reduce1