AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceNamed GroupsHealth CareGeographicals
Multiple Endocrine Neoplasia Type 1Multiple Endocrine Neoplasia Type 2aMultiple Endocrine Neoplasia Type 2bMultiple Endocrine NeoplasiaProto-Oncogene Proteins c-retCarcinoma, MedullaryGastrinomaPheochromocytomaAdrenal Gland NeoplasmsHyperparathyroidism, PrimaryParathyroid NeoplasmsZollinger-Ellison SyndromeGerm-Line MutationThyroid NeoplasmsHyperparathyroidismProto-Oncogene ProteinsPituitary NeoplasmsInsulinomaNeuromaReceptor Protein-Tyrosine KinasesAngiofibromaPancreatic NeoplasmsPedigreeChromosomes, Human, Pair 11Bone Demineralization, PathologicThyroidectomyNeuroendocrine TumorsAdenomaParathyroidectomyAdenoma, Islet CellCalcitoninEndocrine Gland NeoplasmsMetanephrineDuodenal NeoplasmsCarcinoid Tumorvon Hippel-Lindau DiseaseHirschsprung DiseaseGlucagonomaDrosophila ProteinsGenetic TestingParathyroid GlandsGanglioneuromaProlactinomaParagangliomaMutationProto-OncogenesLoss of HeterozygosityCyclin-Dependent Kinase Inhibitor p18VipomaChromosomes, Human, Pair 10NormetanephrineDNA Mutational AnalysisNeoplastic Syndromes, HereditaryMutation, MissenseLipomaAcromegalyParathyroid DiseasesPolymorphism, Single-Stranded ConformationalNeoplasm ProteinsPancreatectomyPoint MutationGastrinsAdrenalectomyHeterozygoteNeoplasms, Multiple PrimaryHyperplasiaThymus NeoplasmsPhenotypeGenes, Tumor SuppressorGrowth Hormone-Secreting Pituitary AdenomaExonsSyndromePancreaticoduodenectomyHypercalcemiaPolymerase Chain ReactionDNA, NeoplasmCodonParathyroid HormoneThyroid GlandThymectomyHeterozygote DetectionEndocrine System DiseasesOctreotideEndocrine GlandsEndocrine SystemCyclin-Dependent Kinase Inhibitor p27Frameshift MutationGenetic MarkersAdrenal GlandsChromosome MappingGene DeletionCarcinomaTomography, X-Ray ComputedBase SequenceJapanAllelesFamily HealthSomatostatinGenetic Linkage3T3 Cells
MEN2ASyndromesMedullary thyroid cSyndromeTumorsFMTCFamilialGenotype-phenotypeHyperparathyroidismMutationsGlandsMEN1MutationNeoplasmsThyroidectomyPatientsPheochromocytomaGeneticsPheochromocytomasCarcinomaCalcitoninCDKN1BHypertensionTumorDiagnosisSymptomsPrevalenceAbnormalityCancerDistinctAffectsConsistentMeSHDiabetesReceptorFamilyTissues
MEN2A2
Syndromes13
Medullary thyroid c10
Syndrome12
  • Multiple endocrine neoplasia, type 2A (MEN 2A) is an autosomal dominant syndrome characterized by medullary carcinoma of the thyroid, pheochromocytoma, parathyroid hyperplasia or adenomas (causing hyperparathyroidism), and occasionally cutaneous lichen amyloidosis. (msdmanuals.com)
  • To describe the phenotype and clinical course in three family members with MEN 2A syndrome. (eurospe.org)
  • We report of three individuals diagnosed with MEN 2A syndrome. (eurospe.org)
  • The proband was a 4-year-old girl, that has been followed-up in our Department in the presence of a significant family history of MEN 2A syndrome. (eurospe.org)
  • Multiple endocrine neoplasia type 2 (MEN 2) is an autosomal dominant hereditary cancer syndrome due to germline variants in the REarranged during Transfection (RET) proto-oncogene. (nih.gov)
  • Although not transmitted in the germline, McCune-Albright syndrome is a genetic disorder characterized by endocrine neoplastic features involving endocrine glands that overlap with those involved in MEN1 or MEN2. (wikipedia.org)
  • Multiple Endocrine Neoplasia type 1 (MEN1) is a rare hereditary endocrine cancer syndrome characterized primarily by tumors of the parathyroid glands (95% of cases), endocrine gastroenteropancreatic (GEP) tract (30-80% of cases), and anterior pituitary (15-90% of cases). (wikipedia.org)
  • Multiple endocrine neoplasia type 1 is a rare genetic syndrome, characterized by the co-occurrence, in the same individual or in related individuals of the same family, of hyperparathyroidism, duodenopancraetic neuroendocrine tumors, pituitary adenomas, adrenocortical tumors, and neuroendocrine tumors (carcinoids) in the thymus, the bronchi, or the stomach. (nih.gov)
  • Multiple endocrine neoplasia type 2A syndrome is caused by a mutation (change) in a gene called RET. (wustl.edu)
  • Multiple endocrine neoplasia syndrome type 2: the value of screening and central registration. (probl-endojournals.ru)
  • I (W. Wertelecki, M.D.) consider the presence of visible nerve fibers of the sclera to be typical of this syndrome also known as MEN (Multiple Endocrine Neoplasia) Type 2A, an autosomal dominant disorder. (medword.net)
  • Multiple endocrine neoplasia, type 4 (MEN 4) is an autosomal dominant syndrome characterized by adenomas and sometimes hyperplasia of the parathyroid glands and tumors of the pancreatic islet cells and/or pituitary gland. (merckmanuals.com)
Tumors12
  • MEN 2A is a rare autosomal dominant disorder characterized by tumors of the C cells of the thyroid, adrenal medulla and parathyroid glands. (eurospe.org)
  • Other endocrine and non-endocrine neoplasms including adrenocortical and thyroid tumors, visceral and cutaneous lipomas, meningiomas, facial angiofibromas and collagenomas, and thymic, gastric, and bronchial carcinoids also occur. (wikipedia.org)
  • Multiple endocrine neoplasias type 2 (MEN2) is an inherited disorder characterized by the development of medullary thyroid cancer (MTC), parathyroid tumors, and pheochromocytoma . (medscape.com)
  • In addition to multidisciplinary approaches, every effort should be made to follow the recommendations and guidelines issued by national (the French Group of Endocrine Tumors) and international groups. (nih.gov)
  • Many different types of tumors are associated with multiple endocrine neoplasia. (medlineplus.gov)
  • Hyperparathyroidism is the most common feature, followed by tumors of the pituitary gland, additional endocrine glands, and other organs. (medlineplus.gov)
  • The loss of functional menin allows cells to divide too frequently, leading to the formation of tumors characteristic of multiple endocrine neoplasia type 1. (medlineplus.gov)
  • It is unclear why these tumors preferentially affect endocrine tissues. (medlineplus.gov)
  • This unchecked cell division can lead to the formation of tumors in endocrine glands and other tissues. (medlineplus.gov)
  • RET proto-oncogene: a review and update of genotype-phenotype correlations in hereditary medullary thyroid cancer and associated endocrine tumors. (probl-endojournals.ru)
  • 6. de Groot J.W., Links T.P., Plukker J.T., Lips C.J., Hofstra R.M. RET as a diagnostic and therapeutic target in sporadic and hereditary endocrine tumors. (probl-endojournals.ru)
  • The importance of identifying succinate dehydrogenase complex mutations is related to the risk for these patients of developing multiple tumors, including non-endocrine ones, showing an aggressive clinical presentation. (biomedcentral.com)
FMTC2
  • Among the subtypes of type 2, type 2A is the most common form, followed by FMTC. (medlineplus.gov)
  • 5. Donis-Keller H., Dou S., Chi D., Carlson K.M., Toshima K., Lairmore T.C., Howe J.R., Moley J.F., Goodfellow P., Wells S.A.Jr. Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC. (probl-endojournals.ru)
Familial1
  • There is significant intra- and inter-familial variability in the age of onset, the severity of disease, and tumor types. (wikipedia.org)
Genotype-phenotype2
Hyperparathyroidism2
Mutations10
  • Mutations in the RET gene have been described in subjects with multiple endocrine neoplasia Type 2 (MEN 2A). (eurospe.org)
  • Subjects with MEN 2A may exhibit a rapid progression and carriers of MEN 2A associated mutations need regular monitoring because of their genetic predisposition to tumor development. (eurospe.org)
  • A useful mnemonic to remember the associated neoplasias is below:[citation needed] MEN I (3 Ps) - Pituitary, Parathyroid, Pancreatic MEN IIa (2Ps, 1M) - Pheochromocytoma, Parathyroid, Medullary Thyroid Ca MEN IIb (1P, 2Ms) - Pheochromocytoma, Medullary Thyroid Ca, Marfanoid habitus/mucosal neuroma MEN1 gene mutations can be identified in 70-95% of MEN1 patients and in about 20% of familial isolated hyperparathyroidism cases. (wikipedia.org)
  • Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A. (rusmedserv.com)
  • Multiple endocrine neoplasia type 4 appears to have signs and symptoms similar to those of type 1, although it is caused by mutations in a different gene. (medlineplus.gov)
  • Mutations in the MEN1 , RET , and CDKN1B genes can cause multiple endocrine neoplasia. (medlineplus.gov)
  • Mutations in the MEN1 gene cause multiple endocrine neoplasia type 1. (medlineplus.gov)
  • Mutations in the RET gene cause multiple endocrine neoplasia type 2. (medlineplus.gov)
  • Germline RET Y791X mutations result in multiple endocrine neoplasia, type 2A (MEN 2A), which is associated with increased risk of developing thyroid medullary carcinoma (NCCN.org). (jax.org)
  • Mutations in the COL4A3/COL4A4 genes of type IV collagen account for about 40% of cases of thin basement membrane nephropathy, a condition that is estimated to affect 1% or more of the general population. (ucy.ac.cy)
Glands4
MEN12
  • The second hit is a MEN1 somatic mutation, usually a large deletion, that occurs in the predisposed endocrine cell as loss of the remaining wild-type allele and gives cells the survival advantage needed for tumor development. (wikipedia.org)
  • The phenotype of MEN1 is broad, and over 20 different combinations of endocrine and non-endocrine manifestations have been described. (wikipedia.org)
Mutation4
Neoplasms1
  • The most important questions to ask relate to a family history of multiple endocrine neoplasms. (medscape.com)
Thyroidectomy2
Patients6
  • Hypertension in MEN 2A patients with pheochromocytoma is more often paroxysmal than sustained, in contrast to the usual sporadic case. (msdmanuals.com)
  • Cutaneous lichen amyloidosis in MEN 2A patients manifests as multiple pruritic, hyperpigmented, lichenoid papules in the scapular area of the back. (medscape.com)
  • It primarily affects adults, especially women, but hereditary cases have also been reported in younger patients associated with multiple endocrine neoplasia type 2A (MEN 2A). (wikimsk.org)
  • A web-based project by the Society for Endocrinology that aims to give patients and the general public access to reliable online information on endocrine science. (yourhormones.info)
  • Despite the prevalence of type 2 DM, there are few effective long-term treatments for the patients. (escardio.org)
  • In the clinical trials conducted thus far, the use of SGLT2 inhibitors was shown to improve the quality of life of patients with type 2 DM, have benefit in treatment of HF, either with reduced or preserved ejection fraction of the left ventricle. (escardio.org)
Pheochromocytoma2
  • Pheochromocytoma occurs in 40 to 50% of people within a MEN 2A kindred. (msdmanuals.com)
  • Further laboratory and imaging studies revealed medullary thyroid cancer with multiple hepatic metastases and unilateral pheochromocytoma. (eurospe.org)
Genetics1
  • Utilising fly genetics, this study generated the first Drosophila model of human wild-type and P460L mutant EphA1 and tested the effects of Eph /ephrin signalling on AD-relevant behaviour and neurophysiology. (sdbonline.org)
Pheochromocytomas1
  • Anesthetic Management for Bilateral Pheochromocytomas in Multiple Endocrine Neoplasia Type 2a. (ekja.org)
Carcinoma1
  • Peak incidence of isolated medullary carcinoma of the thyroid (MTC) occurs in the fifth or sixth decade of life, and the peak incidence of MTC associated with multiple endocrine neoplasia (MEN) 2A or 2B occurs during the second or third decade of life. (medscape.com)
Calcitonin1
CDKN1B1
Hypertension1
Tumor1
  • Synergistic with immunotherapy, low-dose radiotherapy (LDRT) has been demonstrated to activate anti-tumor immunity - a transition from traditional radiation therapy geared toward local radical treatment to a type of immunological adjuvant. (bvsalud.org)
Diagnosis1
  • Non-invasive prenatal diagnosis of multiple endocrine neoplasia type 2A using COLD-PCR combined with HRM genotyping analysis from maternal serum. (repositoriosalud.es)
Symptoms2
Prevalence1
Abnormality1
  • Additional laboratory or radiologic tests may be needed if these tests suggest an endocrine abnormality related to MEN 1. (merckmanuals.com)
Cancer5
Distinct1
  • There are two distinct clinical entities: MEN 2A and MEN 2B. (nih.gov)
Affects2
  • Less often, NP affects people with multiple endocrine neoplasia type 2A (MEN 2A). (healthline.com)
  • multiple endocrine neoplasia type 2 affects an estimated 1 in 35,000 people. (medlineplus.gov)
Consistent1
  • Ultrasound of his neck, magnetic resonance imaging, and 1,4,7,10-tetraazacyclododecane-N(I),N(II),N(III),N(IIII)-tetraacetic acid(D)-Phe(1)-thy(3)-octreotide ( 68 Ga-DOTATOC) positron emission tomography-computed tomography and endocrine work-up were consistent with a carotid body paraganglioma with concomitant nodal enlargement in several body regions, which turned out to be a follicular lymphoma at histology. (biomedcentral.com)
MeSH1
  • Multiple Endocrine Neoplasia Type 2b" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
Diabetes3
  • Paternal and maternal obesity but not gestational weight gain is associated with type 1 diabetes. (uib.no)
  • b) latent autoimmune diabetes of adults (LADA), usually occurring in men over 40 years of age, in whom a progressive autoimmune process destroys the beta cells of pancreas, which is similar to type 1 DM. (escardio.org)
  • Another type of diabetes that is similar to type 2 DM, but developing at a younger age, is called maturity onset DM (MODY) [1]. (escardio.org)
Receptor1
  • EphA1 mis-expression did not cause neurodegeneration, shorten lifespan or affect memory but flies mis-expressing the wild-type or mutant receptor were hyper-aroused, had reduced sleep , a stronger circadian rhythm and increased clock neuron activity and excitability. (sdbonline.org)
Family1
  • Multiple endocrine neoplasia type 4: a new member of the MEN family. (merckmanuals.com)
Tissues1
  • DM develops due to either a lack of insulin production (type 1 DM), as a result of destroyed beta cells of pancreas due to an autoimmune reaction, or resistance to insulin (type 2 DM), where insulin is being produced at least in the early stages of disease because beta cells are still present, but tissues do not respond to insulin [1]. (escardio.org)