Concomitant trimethoprim significantly increased the plasma AUC(0-12) of both procainamide and NAPA (63% and 52%, respectively), with concurrent decreases in their renal clearances (47% and 13%, respectively) and a 39% increase in the mean urinary recovery of NAPA (as percentage of procainamide and NAPA recovery). (nih.gov)
The change in procainamide and NAPA renal clearances after trimethoprim coadministration strongly correlated with their baseline renal clearances (r = 0.84 and r = 0.74, respectively, p less than 0.0001). (nih.gov)
We conclude that trimethoprim increases the plasma concentrations of procainamide and NAPA by decreasing their renal clearances and allowing more conversion of procainamide to NAPA. (nih.gov)
Assuming the same renal clearances for PM patients accounts for approximately 9 and 4% of their median apparent oral clearances of (+)- and (-)-PHX, respectively. (edu.au)
Glucose5
Adverse carbohydrate and lipid metabolic effects: Monitor glucose in prediabetic and diabetic women taking CAMRESE. (nih.gov)
Insulin and glucagon are two counter regulatory hormones that control the systemic concentration of glucose, a metabolic intermediate used by cells as the primary source of energy. (stratech.co.uk)
Magnesium promotes peripheral circulation and assists the body with normal clearance of glucose in founder prone animals. (calabasassaddlery.com)
Together these two minerals support glucose uptake by the cell and a normal metabolic rate. (calabasassaddlery.com)
High metabolic rate2
Overall, the NCSU research consistently showed low bioavailability of ivermectin in chicken blood, likely due to rapid detoxifcation and clearance from the blood, among other traits, such as high metabolic rate, they said. (modernpoultry.media)
Fever in mammals is accompanied by an initially high metabolic rate associated with beneficial immune responses. (cdc.gov)
Humans1
A screen of 15 major human CYP isoforms for metabolic ability with respect to carbofuran metabolism demonstrated that CYP3A4 is the major isoform responsible for carbofuran oxidation in humans. (cdc.gov)
Insulin sensitivity and insulin clearance are heritable and have strong genetic correlation in Mexican Americans. (wakehealth.edu)
Endocrine1
This study demonstrates that camel milk during the 1st month of lactation have important effects on clinical, metabolic and endocrine traits. (scialert.net)
20231
2023. "Increasing the Clearance of Protein Bound Solutes by Recirculating Dialysate through Activated Carbon. (stanford.edu)
MENT1
In contrast, MENT more strongly suppressed bone turnover rate. (purerawz.co)
Urine4
Metabolic conversions are therefore required to increase their water-solubility and enable efficient excretion in urine. (saunaabc.com)
Molly Detection Rates In Your Urine: How Long Does It Stay? (galaei.org)
The detection of molly in urine tests depends heavily on the type of test used as well as other factors such as an individual's metabolic rate and overall health status. (galaei.org)
In order to gain a better grasp on the issue at hand, this article will provide an overview of current research regarding Molly detection rates in urine and discuss possible implications for individuals subject to drug testing procedures. (galaei.org)
Metabolism4
This results in increased rates of metabolism and body heat. (saunaabc.com)
Intrinsic clearance rate calculations indicate that HLM are 14-fold less efficient in the metabolism of carbofuran to 3-hydroxycarbofuran than RLM or MLM. (cdc.gov)
Normalization of HLM data with the average levels of each CYP in native HLM, indicates that carbofuran metabolism is primarily mediated by CYP3A4 (percent total normalized rate (% TNR)=77.5), although CYP1A2 and 2C19 play ancillary roles (% TNR=9.0 and 6.0, respectively). (cdc.gov)
When a bat is confronted by a viral antigen, the proportional increase in metabolism for raising an immune response may be trivial compared to the very large increase in the metabolic costs of flight. (cdc.gov)
Obesity2
Obesity in the US continues to increase at alarming rates. (stratech.co.uk)
Obesity is well known for causing morbidity, mortality, disability and has been associated to an increasing number of cardiovascular and metabolic comorbidities, such as hypertension and diabetes mellitus (DM). (researchsquare.com)
Mammals2
Though carbofuran has a long history of use, there is little information available with respect to its metabolic fate and disposition in mammals. (cdc.gov)
The metabolic cost of raising an immune response to experimental stimulation typically results in a general increase of about 10 to 30 percent of resting metabolic rates in a variety of nonvolant small mammals. (cdc.gov)
Apparent3
After trimethoprim coadministration, there was also a trend toward a decrease in the apparent acetylation clearance of procainamide (19%, p = 0.057). (nih.gov)
The apparent oral clearance of each enantiomer was calculated from their respective AUC rather than from trough concentrations and was enantioselective in both phenotypes, with higher apparent oral clearances of (-)-than (+)-PHX. (edu.au)
1% of the median apparent oral clearance of each enantiomer in EM patients. (edu.au)
Extent1
Mathematical modeling predicted the dependence of solute clearances on the extent to which solutes were taken up by the carbon block and were bound to plasma proteins.RESULTS: By itself, the conventional system provided clearances of the tightly bound solutes p-cresol sulfate (PCS) and indoxyl sulfate (IS) of only 18±10 and 19±11 ml/min, respectively (mean±sd). (stanford.edu)
Clinical2
This study investigated a novel perfusion formalism and metabolic clearance rate (MCR) model in pre-clinical stroke and in the healthy human brain. (ox.ac.uk)
No studies however have tested testing whether increasing the clearance of bound solutes provides clinical benefit. (stanford.edu)
Patients2
Many of these have lower metabolic clearance rates among Chinese, compared with Caucasians, and are prescribed at lower doses for Asian patients. (aspetjournals.org)
Patients with intraoperative complications have low success rate (20%) compared to patients without complications (92.3%), p=0.42. (bvsalud.org)
Higher2
Allele-specific polymerase chain reaction analysis of genomic DNA from 90 Chinese individuals revealed that the CYP2D6Ch1 allele was the most common one and its distribution correlated well with a higher metabolic ratio for debrisoquine. (aspetjournals.org)
Strains of laboratory mice that are inbred for higher metabolic rates show stronger immune responses to immune challenge with stronger antigen-specific IgM production than strains bred for lower metabolic rates. (cdc.gov)
Effects2
AIMS/HYPOTHESIS: The incretin hormone glucagon-like peptide 1 (GLP-1) has antihyperglycaemic effects, but its therapeutic usefulness is limited by its metabolic instability. (ku.dk)
In addition to these effects, it has been linked with physical side effects such as increased heart rate, dehydration, and loss of appetite. (galaei.org)
Faster1
Reasonable care in compiling the information the intake of AAS needs has a faster metabolic clearance rate. (theopeninter.net)
Lower2
Correct and consistent use of methods can result in lower failure rates. (rxlist.com)
Tend to be lower in people eating red, cheap order anabolic trace mineral needed for over 300 metabolic processes. (theopeninter.net)
Increase4
Practical means to increase the dialytic clearance of bound solutes are required to perform such studies.METHODS: Artificial plasma was dialyzed using two dialysis systems in series. (stanford.edu)
Chemical measurements tested the ability of the recirculating system to increase the clearance of selected solutes. (stanford.edu)
During flight, bats exhibit a high increase in metabolic rate over the resting metabolic rate of normeothermic, otherwise active bats. (cdc.gov)
This increase is estimated to be 15-16- fold, in comparison with the 7-fold increase in metabolic rates of rodents running to exhaustion or the 2-fold increase in metabolic rates of most flying birds. (cdc.gov)
Oral2
Table 2 lists the typical unintended pregnancy rates for users of combination oral contraceptives and other methods of contraception. (rxlist.com)
Anavar is an oral steroid which is excellent for enhancing the metabolic rate and lipolysis. (saunaabc.com)
Health1
Hyperpolarized carbon-13 magnetic resonance imaging is a promising technique for in vivo metabolic interrogation of alterations between health and disease. (ox.ac.uk)
Study2
This study introduces a formalism for quantifying the metabolic information in hyperpolarized imaging. (ox.ac.uk)
A total of 6,414 Finnish men (aged 57 ± 7 years, BMI 27.0 ± 3.9 kg/m 2 ) from our ongoing population-based METSIM (Metabolic Syndrome in Men) study were included. (diabetesjournals.org)
Plasma1
p class=\'abstract\'>BACKGROUND: Conventional hemodialysis provides limited clearance of uremic solutes that bind to plasma proteins. (stanford.edu)
Significantly1
The absence of intraoperative complications was significantly associated with success rate. (bvsalud.org)
Blood2
Hyponatraemia was interpreted as being secondary to prolonged diarrhoea and vomiting, hypokalaemia to stool losses, metabolic alkalosis to extra cellular compartment contraction and the initial but transient rise in blood pressure to secondary hyperaldosteronism. (who.int)
His height and weight were below the 3rd percentile, temperature was 38.7 °C, heart rate 98/min, respiratory rate 30/min, blood pressure 70/50 mmHg, O2 saturation 88% in room air and capillary refill 4 seconds. (who.int)
Vary2
Drug treatments, metabolic rates, bed bug behavior and drug-clearance rates vary under field conditions. (modernpoultry.media)
This period may vary due to individual metabolic differences and other environmental factors. (galaei.org)
Year1
The rate of progression to overt hypothyroidism is estimated to be about 5% per year. (medscape.com)
Production1
Cela permettra en retour de développer votre masse musculaire, via une production plus importante d'hormone de croissance : la testostérone. (jessilafree.com)
Factors2
Multivariate analysis was done to determine factors affecting stone clearance and success rate. (bvsalud.org)
The detection rate depends on several factors such as the amount ingested, how long ago it was used, and individual characteristics. (galaei.org)
Typical1
1994). The formation of ureas is the typical reaction of MDI in aqueous environments, and reaction rates for both MDI and TDI have been shown to be similar (Allport et al. (europa.eu)