Interleukin 1alpha. Medical search. Frequent questions

This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. (nih.gov)
Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. (nih.gov)
Interleukin-16 is a cytokine known for involvement in numerous diseases including HIV-1 infection, asthma, arthritis, systemic lupus erythematosus, colitis, atopic dermatitis, multiple sclerosis and delayed hypersensitivity. (fujifilm.com)
The IL1A gene encodes the IL1a protein, a member of the interleukin 1 cytokine family which is involved in various immune responses and inflammatory processes. (ox.ac.uk)
IL-23 (Interleukin-23) is a disulfide-linked cytokine composed of a p19 subunit that is unique to IL-23 and a p40 subunit that is shared with IL-12. (rndsystems.com)
The quintessential pro-inflammatory cytokine Interleukin-1 (IL-1) canonically triggers a broad spectrum of physiological consequences. (biomedcentral.com)

Furthermore, LPLI induces the synthesis or release of many molecules, like growth factors, interleukins, inflammatory cytokines and others, which are related to promotive effects of LPLI. (biomedcentral.com)
Cytokines and growth factors (interleukin-8 transforming growth factor-beta stromal cell-derived factor-1alpha and vascular endothelial growth factor) that mediate endogenous bone regeneration were also produced by expanded MSCs from SCD patients. (bioskinrevive.com)
Interleukin-1 alpha(IL-1 alpha) and interleukin-1 beta(IL-1 beta) are two biochemically distinct, but distantly related, polypeptidic cytokines that play a key role in inflammation, immunologic reactions, and tissue repair. (rockland.com)

Graves DT, Cochran D. The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction. (medlineplus.gov)

Interleukin-1 alpha is described as "pro-inflammatory" because it stimulates the activity of genes involved in inflammation and immunity. (medlineplus.gov)
Studies suggest that the effects of IL1A variations are probably related to the role of interleukin-1 alpha in promoting inflammation. (medlineplus.gov)
Evaluation of the sensitization phase as an endpoint stimulate keratinocytes present in the epidermis of the skin results in a reduced time for animals to be on study and to release inflammatory mediators such as interleukins 1, 6 eliminates the discomfort associated with the development of and 18, granulocyte-macrophage colony-stimulating factor, inflammation in the elicitation phase of the response. (cdc.gov)

Th1 immunocytes produce interleukin 12 and RANTES/MIP-1alpha and granulomas. (medscape.com)

Kawaguchi Y, Tochimoto A, Hara M, Kawamoto M, Sugiura T, Saito S, Kamatani N. Contribution of single nucleotide polymorphisms of the IL1A gene to the cleavage of precursor IL-1alpha and its transcription activity. (medlineplus.gov)
Interleukin 12B rs3212227 and rs6887695 single nucleotide polymorphisms are associated with the susceptibility to preeclampsia: Genetic, haplotype and bioinformatics analysis. (nih.gov)
STUDY QUESTION: Are single-nucleotide polymorphisms (SNPs) at the interleukin 1A (IL1A) gene locus associated with endometriosis risk? (ox.ac.uk)

Genetic polymorphisms at interleukin(IL)-1alpha and IL-1beta have been recently suggested to be associated with severity of adult periodontitis. (rockland.com)

Previously we have shown that the cilium is essential for the anabolic response to loading and the inflammatory response to interleukin-1β (IL-1β). (biomedcentral.com)

The standard product used in this kit is recombinant rat IL-1alpha with the molecular mass of 18kDa. (rockland.com)

The IL1A gene provides instructions for making a protein called interleukin-1 alpha. (medlineplus.gov)
Interleukin-1 alpha is initially produced as a relatively long protein that is trapped within cells. (medlineplus.gov)
Another protein, called calpain, cuts (cleaves) this precursor protein to create a shorter, mature version of interleukin-1 alpha. (medlineplus.gov)
Each of these variations changes a single protein building block (amino acid) in interleukin-1 alpha. (medlineplus.gov)
Serum was tested for levels of interleukin-1alpha (IL-1) protein. (cdc.gov)

Obtaining the SC from the skin surface by adhesive tape, interleukin (IL) 1α and IL-1 receptor antagonist (IL-1ra) in the SC and cornified envelope (CE) maturation were determined. (karger.com)

Recently, it has been shown that IL-1 alpha is identical to hematopoietin 1, which is described as a hematopoietic growth factor acting on early progenitor cells in synergy with other hematopoietic growth factors.1 The human interleukin 1 alpha gene is assigned to chromosome 2. (rockland.com)

Association between endometriosis and the interleukin 1A (IL1A) locus. (ox.ac.uk)

Interleukins are a group of proteins that are made primarily in immune system cells. (medlineplus.gov)

T). This variation affects the production of interleukin-1 alpha within cells. (medlineplus.gov)
This variation likely affects the sensitivity of interleukin-1 alpha to cleavage by calpain. (medlineplus.gov)

The specific protease responsible for the processing of IL-beta, designated interleukin 1 beta -converting enzyme (ICE), has been described. (rndsystems.com)

Interleukin-1 alpha is described as "pro-inflammatory" because it stimulates the activity of genes involved in inflammation and immunity. (medlineplus.gov)
lt;p>The review provides information on single nucleotide polymorphisms (SNPs) in genes encoding some interleukins belonging to the interleukin-1 (IL-1) superfamily and on their association with different infectious and non-infectious human diseases. (crie.ru)

2. Anusaksathien O, Sukboon A, Sitthiphong P, Teanpaisan R. Distribution of interleukin-1beta(+3954) and IL-1alpha(-889) genetic variations in a Thai population group. (bvsalud.org)
Genetic polymorphisms at interleukin(IL)-1alpha and IL-1beta have been recently suggested to be associated with severity of adult periodontitis. (rockland.com)

Interleukins are a group of proteins that are made primarily in immune system cells. (medlineplus.gov)
the two major agonistic proteins, IL-1alpha and IL-1beta, are pleiotropic and affect mainly inflammation, immunity and haemopoiesis. (biologicalworld.com)
Interleukin-1 (IL-1) represents a family of two agonistic proteins, IL-1alpha and IL-1beta, that are pleiotropic and affect hemopoiesis, inflammation, and immunity. (biologicalworld.com)
As associated from dopamine, RORA binds ROR proteins( ROREs) in fact and is the kinases PPARGC1A( PGC-1alpha) and p300( EP300, a promoter homeostasis) to channel tyrosine. (familie-vos.de)
The digital cleavage of electron against excitatory proteins requires an Interleukin-1 factor of binds to the pathology of inositol-1,4,5-trisphosphate. (familie-vos.de)

Inhibition of the function of IL-1 by the inhibitor of IL-1, interleukin-1 receptor antagonist (IL-1Ra), reduces tumour invasiveness and alleviates tumour-mediated suppression, pointing to its feasible use in cancer therapy. (biologicalworld.com)

Kawaguchi Y, Tochimoto A, Hara M, Kawamoto M, Sugiura T, Saito S, Kamatani N. Contribution of single nucleotide polymorphisms of the IL1A gene to the cleavage of precursor IL-1alpha and its transcription activity. (medlineplus.gov)
Polymorphisms of interleukin (IL)-1alpha, IL-1beta, IL-6, IL-10, and IL-18 and the risk of ovarian cancer. (cdc.gov)

Recombinant equine interleukin-1 beta is a 17 kDa protein containing 153 amino acid residues and it shares 63 %~70 % a.a. sequence identity with canine, cotton rat, porcine, feline, human, mouse, rat, and rhesus IL1β. (watson-bio.cn)
The standard product used in this kit is recombinant rat IL-1alpha with the molecular mass of 18kDa. (rockland.com)

An interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form. (nih.gov)
An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. (wakehealth.edu)

PTAE (0.01-1 microg/ml) dose-dependently inhibited the EtOH-induced interleukin-1alpha (IL-1alpha) secretion. (nih.gov)

Unlike INTERLEUKIN-1BETA both membrane-bound and secreted forms of interleukin-1alpha are biologically active. (nih.gov)

1. [Expression of hypoxia-inducible factor-1alpha in endometriosis]. (nih.gov)
2. Expression of vascular endothelial growth factor (VEGF), hypoxia inducible factor-1alpha (HIF-1alpha), and microvessel density in endometrial tissue in women with adenomyosis. (nih.gov)
3. Aberrant expression of leptin in human endometriotic stromal cells is induced by elevated levels of hypoxia inducible factor-1alpha. (nih.gov)
9. Neoangiogenesis and expression of hypoxia-inducible factor 1alpha, vascular endothelial growth factor, and glucose transporter-1 in endometrioid type endometrium adenocarcinomas. (nih.gov)
10. [Expression of hypoxia-inducible factor-1alpha, vascular endothelial growth factor and sFlt-1 in preeclampsia placenta]. (nih.gov)
11. Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma. (nih.gov)
12. [Expression of hypoxia-inducible factor-1alpha and vessel endothelial growth factor in esophageal squamous cell carcinoma and clinico-pathological significance thereof]. (nih.gov)
14. Effect of endothelial PAS domain protein 1 and hypoxia inducible factor 1alpha on vascular endothelial growth factor expression in human pancreatic carcinoma. (nih.gov)
15. Quantitative analysis of hepatic hypoxia-inducible factor-1alpha and its abnormal gene expression during the formation of hepatocellular carcinoma. (nih.gov)
16. [Phosphoinositide 3-kinase/Akt pathway involved in regulation of hypoxia inducible factor 1alpha in hypoxia ischemia brain damage of neonatal rats]. (nih.gov)
19. [Relationship between hypoxia-inducible factor-1alpha expression and extracellular signal-regulated kinase in hypoxic-ischemic cortical neurons]. (nih.gov)
20. Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma. (nih.gov)
ET-1 expression in hfPSMC was strongly increased by several factors such as transforming growth factor-beta1 (TGF-beta1), interleukin-1alpha (IL-1alpha), ET-1 itself and prolonged (24 h) hypoxia. (unifi.it)

Effects of micro-environment- and malignant cell-derived interleukin-1 in carcinogenesis, tumour invasiveness and tumour-host interactions. (biologicalworld.com)
Differential manipulation of IL-1alpha and IL-1beta in malignant cells or in the tumour's micro-environment may open new possibilities for using IL-1 in cancer immunotherapy. (biologicalworld.com)

Both IL-1alpha and IL-1β binds to the same receptor and has similar but not identical biological properties. (watson-bio.cn)

Another protein, called calpain, cuts (cleaves) this precursor protein to create a shorter, mature version of interleukin-1 alpha. (medlineplus.gov)
IL-1beta is active solely in its secreted form, whereas IL-1alpha is active mainly as an intracellular precursor. (biologicalworld.com)
Proteolytic processing of the precursor form by CASPASE 1 results in release of the active form of interleukin-1beta from the membrane. (wakehealth.edu)

Lipopolysaccharide induces alveolar macrophage necrosis via cd14 and the p2x7 receptor leading to interleukin-1alpha release. (raddar.info)

This variation likely affects the sensitivity of interleukin-1 alpha to cleavage by calpain. (medlineplus.gov)

Recently, it has been shown that IL-1 alpha is identical to hematopoietin 1, which is described as a hematopoietic growth factor acting on early progenitor cells in synergy with other hematopoietic growth factors.1 The human interleukin 1 alpha gene is assigned to chromosome 2. (rockland.com)
To investigate the role of interleukin-6 (IL-6) and transforming growth factor beta 1 (TGF beta 1) in the regulation of tissue inhibitor of metalloproteinases-1 (TIMP-1) synthesis in human articular chondrocytes. (uni-bielefeld.de)

At 8 weeks, serum levels of IL-1alpha increased significantly above week 0. (cdc.gov)

Interleukin-1beta" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)

Cardiac magnetic resonance imaging and interleukin-1 inhibitors form the backbone for individualized treatment of recurrent pericarditis which has led to a paradigm shift by considerably decreasing the total treatment duration. (acc.org)

Neuroendocrine-immune interactions in fish: a role for interleukin-1. (biologicalworld.com)

IL-1alpha is detectable in the majority of patients with infrarenal abdominal aortic aneurysms. (cusabio.com)
IL-1alpha synthesis alone was reduced in 2 patients and IL-1beta synthesis alone was reduced in 2 patients. (ox.ac.uk)
Reductions in IL-1alpha and IL-1beta synthesis were demonstrated in a subgroup of patients. (ox.ac.uk)

Furthermore, we found that PTAE inhibited the IL-1alpha-induced apoptosis of Hep G2 cells. (nih.gov)

This graph shows the total number of publications written about "Interleukin-1beta" by people in this website by year, and whether "Interleukin-1beta" was a major or minor topic of these publications. (wakehealth.edu)

Interleukin-6 (IL-6) was discovered in 1986 as a B cell stimulatory factor initiating IgG production ( 1 ). (frontiersin.org)

Abdalla AE, Lambert N, Duan X, Xie J. Interleukin-10 Family and Tuberculosis: An Old Story Renewed. (ijbs.com)

A comparison of the solution structure of the interleukin-8 dimer determined by nuclear magnetic resonance spectroscopy with that of the 2 A resolution X-ray structure, solved by molecular replacement using the solution structure as a starting model, is presented. (nih.gov)

Interactions of interleukin-1 with neurotrophic factors in the central nervous system: beneficial or detrimental? (biologicalworld.com)

Anatomy36

Organisms11

Diseases4

Chemicals and Drugs144

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes40

Disciplines and Occupations1

Information Science4

Cytokine6

Cytokines3

Tumor1

Inflammation3

RANTES1

Single nucleotide po3

1beta1

Inflammatory1

Recombinant1

Protein5

Receptor1

Gene1

IL1A1

Immune1

Alpha2

Beta1

Genes2

Genetic2

Proteins5

Receptor antagonist1

Polymorphisms2

Recombinant2

Subtype2

Secretion1

Membrane-bound1

Hypoxia13

Malignant2

Binds1

Precursor3

Macrophage1

Cleavage1

Growth2

Serum1

MeSH1

Form1

Role1

Patients3

Cells1

Major1

Factor1

Family1

Structure1

Central1