Alkaptonuria (aku), an inborn error of metabolism caused by the loss of homogentisate 1,2-dioxygenase (HGD), has been described in a mouse model created by ethylnitrosoureamutagenesis but the mutation in these mice has not previously been identified. (elsevierpure.com)
This screening technique is currently being used to identify mutants induced by N-ethylnitrosourea (ENU) mutagenesis (Brown and Nolan, Hum Mol Genet 7, 1627, 1998). (ox.ac.uk)
Using mouse molecular genetics as a foundation, and a combination of biochemistry, physiology, and imaging techniques, we dissect these complex behaviors in mammals.We use two functional genomics approaches in mice-forward genetic ethylnitrosourea (ENU) mutagenesis screens and quantitative trait loci (QTL) analysis-to identify genes and pathways that regulate these behaviors. (iitm.ac.in)
Alkylating1
Alkylating agents like ethylnitrosourea, mustard gas and vinyl chloride can be removed by depurination method. (thesciencenotes.com)
Mutation1
We have identified an ethylnitrosourea (ENU)-induced recessive mouse mutation (Vcc) with a pleiotropic phenotype that includes cardiac, tracheoesophageal, anorectal, anteroposterior patterning defects, exomphalos, hindlimb hypoplasia, a presacral mass, renal and palatal agenesis, and pulmonary hypoplasia. (ox.ac.uk)
Mouse1
Indication of cocarcinogenic potential of chronic UMTS-modulated radiofrequency exposure in an ethylnitrosourea mouse model. (ethz.ch)
Mutants1
In a screen for embryonic patterning mutations induced by ethylnitrosourea, here we identify two mouse mutants, wimple (wim) and flexo (fxo), that lack ventral neural cell types and show other phenotypes characteristic of defects in Sonic hedgehog signalling. (nih.gov)
Strain1
A glucose-6-phosphate dehydrogenase (G6PD) deficient strain of mouse (GPDX) which was developed using the ethylating agent ethylnitrosourea (ENU) has been used to study clonality in epithelial tissues. (nih.gov)
Screen1
To address this limitation, we have developed a screen for heritable abnormalities of red blood cell morphology in mice with single-nucleotide changes induced by the chemical mutagen ethylnitrosourea (ENU). (ox.ac.uk)