TherapyMyeloproliferative neoplasmsCarcinogenesisMutationCell ProliferationOncologyTumorsCancerMelanomaMultiple MyelomaAntineoplasticGlioblastomaAnticancer drugsRadiotherapyChronic2018LungImmunotherapyMechanisms of drug resistancePredispositionLaboratoryTransplantationClonalCellsSurvivalChemotherapeutic drugHeterogeneityGeneSquamousAntimicrobialDoxorubicinAcute
Therapy6
- Subsequently, upfront combinatorial treatment or sequential therapy strategies may forestall drug resistance and improve patient outcome. (nih.gov)
- ORSERDU, a once-daily oral endocrine monotherapy, for the treatment of postmenopausal women or adult men, with ER+, HER2-, ESR1 -mutated advanced or metastatic breast cancer with disease progression following at least one line of endocrine therapy, was approved by the U.S. Food and Drug Administration in January 2023 under its priority review and fast track designation. (khon2.com)
- Combined detection and genotyp- performed before antimicrobial drug vey to assess the impact of chikungu- ing of Chikungunya virus by a specifi c therapy based on amoxicillin/clavu- nya fever and Aede s infestation levels. (cdc.gov)
- Targeted therapy" is a cancer treatment that uses drugs but is different from traditional chemotherapy. (bvsalud.org)
- Doxorubicin (DOX) is recognized by Pgp and therefore it can induce therapy resistance in breast cancer patients. (mtak.hu)
- Our results indicate that the favorable pharmacokinetics achieved with PLD can effectively overcome Pgp-mediated resistance, suggesting that PLD therapy could be a promising strategy for the treatment of therapy-resistant breast cancer patients. (mtak.hu)
Myeloproliferative neoplasms2
- She has conducted and participated in numerous clinical trials in leukemia, myelodysplastic syndromes and myeloproliferative neoplasms. (umms.org)
- Overview of Myeloproliferative Neoplasms Myeloproliferative neoplasms are clonal proliferations of bone marrow stem cells, which can manifest as an increased number of platelets, red blood cells (RBCs), or white blood cells (WBCs). (msdmanuals.com)
Carcinogenesis1
- Aldo-Keto Reductase Regulation by the Nrf2 System: Implications for Stress Response, Chemotherapy Drug Resistance, and Carcinogenesis. (nih.gov)
Mutation1
- And when you look at breast cancer , now we have, for example, our drug in ESR mutation. (medscape.com)
Cell Proliferation1
- In each category, studies related to growth control genes, cell proliferation, apoptosis, DNA repair genes, antioxidant and drug detoxification genes, genes of drug metabolizing enzymes, tissue remodeling genes and genes of antibody-dependent cellular cytotoxicity were discussed separately. (researchsquare.com)
Oncology1
- When you look at all the difficult-to-treat mutations or alterations, if you look at lung cancer, we have immune-oncology, but we now have drugs for ALK , Ros , and other things. (medscape.com)
Tumors3
- Specifically, the use of leukocyte-derived membrane proteins to functionalize nanovesicles (leukosomes) can enable their long circulation and target the inflamed endothelium present in many inflammatory pathologies and tumors, making them a promising and versatile drug delivery system. (frontiersin.org)
- Although the role of P-glycoprotein in tumor blood vessels needs to be further examined and more clearly defined, drug resistance in malignant primary brain tumors may result from characteristics not solely of neoplastic cells but also tumor vasculature. (mssm.edu)
- Consistent with the higher Pgp levels needed to confer resistance, PLD administration was able to overcome doxorubicin insensitivity of the mouse mammary tumors. (mtak.hu)
Cancer13
- Finally, innovative response assays, such as organoid cultures or patient-derived tumor xenografts, provide an extra dimension to correlate molecular profiles with drug efficacy and control cancer growth. (nih.gov)
- Distinct Receptor Tyrosine Kinase Subsets Mediate Anti-HER2 Drug Resistance in Breast Cancer. (duke.edu)
- Microvesicle removal of anticancer drugs contributes to drug resistance in human pancreatic cancer cells. (umassmed.edu)
- M, Bromberg J. Self-renewal of CD133(hi) cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer. (umassmed.edu)
- Polytherapy and Targeted Cancer Drug Resistance. (ucsf.edu)
- This timely new reference integrates the latest clinical results and laboratory studies on the resistance of specific cancers to chemotherapeutic drugs-covering drug resistance in lung, breast, ovary, and colon cancer as well as hematological malignancies. (routledge.com)
- Multidrug resistance for many types of cancer outside the central nervous system (CNS) has been found to be due to the overexpression of the multidrug resistance gene MDR1, of which the gene-product P-glycoprotein acts as a membrane-bound efflux pump for many anticancer drugs. (mssm.edu)
- The drugs can block or turn off signals that tell cancer cells to grow and divide, keep cells from living longer than usual, and destroy the cancer cells. (bvsalud.org)
- Pegylated liposomal formulation of doxorubicin overcomes drug resistance in a genetically engineered mouse model of breast cancer. (mtak.hu)
- Success of cancer treatment is often hampered by the emergence of multidrug resistance (MDR) mediated by P-glycoprotein (ABCB1/Pgp). (mtak.hu)
- Hyaluronic acid-modified multifunctional Q-graphene for targeted killing of drug-resistant lung cancer cells. (cdc.gov)
- Considering the urgent need to explore multifunctional drug delivery system for overcoming multidrug resistance, we prepared a new nanocarbon material Q-Graphene as a nanocarrier for killing drug-resistant lung cancer cells. (cdc.gov)
- Overall, a highly promising multifunctional nanoplatform was developed for tracking and monitoring targeted drug delivery for efficiently killing drug-resistant cancer cells. (cdc.gov)
Melanoma1
- We have studied the transgenic mouse strain, Tyrp-1-TAg, to try to gain insight into possible molecular mechanisms common to pigmented ocular neoplasms occurring spontaneously in the eyes of these mice and human choroidal melanoma. (molvis.org)
Multiple Myeloma1
- High-Throughput Drug Screening and Multi-Omic Analysis to Guide Individualized Treatment for Multiple Myeloma. (cdc.gov)
Antineoplastic2
- Overall, our study offers a novel conceptual framework for biomimetic NPs using a DoE strategy and consolidates the high therapeutic potential of leukosomes as a viable drug delivery system for anti-inflammatory and antineoplastic applications. (frontiersin.org)
- Use additional code (U85) , if desired, to identify resistance, non-responsiveness and refractive properties of the neoplasm to antineoplastic drugs. (who.int)
Glioblastoma1
- The production of DNA interstrand crosslinks (ISC) by BCNU and other bifunctional alkylators and the effects of these drugs on the repair of radiation-induced DNA-single strand breaks (SSB) were studied in two human glioblastoma used to assess both DNA-ISCs and DNA-SSBs. (duke.edu)
Anticancer drugs1
- Interstitial lung disease (ILD) is a serious adverse event common to many molecular targeted anticancer drugs. (bvsalud.org)
Radiotherapy1
- Some cases have been associated with resistance to radiotherapy or chemotherapy and local recurrence. (researchsquare.com)
Chronic1
- Primary myelofibrosis (PMF) is a chronic myeloproliferative neoplasm characterized by bone marrow fibrosis, splenomegaly, and anemia with nucleated and teardrop-shaped red blood cells. (msdmanuals.com)
20181
- ELZONRIS was approved by the FDA in December 2018 for the treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN) in adult and pediatric patients two years and older, in both treatment-naïve and previously-treated populations. (khon2.com)
Lung1
- Although these enzymes play clear cytoprotective roles and deal effectively with carbonyl stress, their upregulation by the Keap1/Nrf2 pathway also has a potential dark-side, which can lead to chemotherapeutic drug resistance and the metabolic activation of lung carcinogens (e.g., polycyclic aromatic hydrocarbons). (nih.gov)
Immunotherapy1
- Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy. (unc.edu)
Mechanisms of drug resistance1
- Her laboratory focuses on mechanisms of drug resistance in leukemia cells. (umms.org)
Predisposition1
- Hereditary Predisposition to Hematopoietic Neoplasms: When Bloodline Matters for Blood Cancers. (cdc.gov)
Laboratory1
- Experimental transplantation of neoplasms in laboratory animals for research purposes. (umassmed.edu)
Transplantation3
- Neoplasm Transplantation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
- This graph shows the total number of publications written about "Neoplasm Transplantation" by people in this website by year, and whether "Neoplasm Transplantation" was a major or minor topic of these publications. (umassmed.edu)
- Below are the most recent publications written about "Neoplasm Transplantation" by people in Profiles. (umassmed.edu)
Clonal1
- In particular we are interested in unravelling the biological mechanisms that drive clonal evolution, the emergence of drug resistance, and the role of tumor heterogeneity in these processes, ultimately leading to new effective therapies. (lu.se)
Cells3
- The development of biomimetic nanoparticles (NPs) has revolutionized the concept of nanomedicine by offering a completely new set of biocompatible materials to formulate innovative drug delivery systems capable of imitating the behavior of cells. (frontiersin.org)
- BCNU-treated UWR2 and UWR3 cells showed a significant BCNU dose-dependent increase in radiation-induced DNA-SSBs at 6 hrs post-drug treatment, and at 100 microM BCNU DNA-ISC was completely masked in UWR2 cells. (duke.edu)
- The loss of DYNLL1 enables DNA end resection and restores homologous recombination in BRCA1-mutant cells, thereby inducing resistance to platinum drugs and inhibitors of poly(ADP-ribose) polymerase. (broadinstitute.org)
Survival2
- A&G Pharmaceutical Inc. has discovered a novel target that plays a critical role in tumor growth, survival and resistance to current therapies. (inknowvation.com)
- Increased survival could be explained by the delayed onset of drug resistance. (mtak.hu)
Chemotherapeutic drug1
- We will determine if AG1 combined with each chemotherapeutic drug will potentiate its effect. (inknowvation.com)
Heterogeneity1
- The lack of reliable response assays reflective of in vivo tumor heterogeneity and associated resistance mechanisms hampers identification of reliable biomarkers. (nih.gov)
Gene1
- Our study was aimed to investigate whether mutations in the ATM gene occur in childhood T-lineage acute lymphoblastic leukaemia (T-ALL) that are linked to drug resistance and clinical outcome. (prinsesmaximacentrum.nl)
Squamous1
- Therefore, the current study investigated the role of different expression levels of miR-130a-3p and miR-148a-3p on drug resistance and tumor biology in four esophageal squamous cell carcinoma cell lines. (uni-luebeck.de)
Antimicrobial2
Doxorubicin1
- Additionally, doxorubicin (DOX) as a model drug was loaded on the surface of Q-Graphene via p-p stacking. (cdc.gov)
Acute1
- The T-lineage phenotype in children with acute lymphoblastic leukaemia (ALL) is associated with in vitro drug resistance and a higher relapse-risk compared to a precursor B phenotype. (prinsesmaximacentrum.nl)