Citrobacter rodentium. Medical search. Frequent questions

The formation of attaching and effacing (A/E) lesions on gut enterocytes is central to the pathogenesis of enterohemorrhagic (EHEC) Escherichia coli, enteropathogenic E. coli (EPEC), and the rodent pathogen Citrobacter rodentium. (nih.gov)
Slater and Frankel summarise this knowledge and focus on the in vivo approaches available to characterise effectors of enteropathogenic and enterohaemorrhagic Escherichia coli and the surrogate mouse pathogen Citrobacter rodentium . (frontiersin.org)
Upon oral challenge with the murine colonic pathogen Citrobacter rodentium, which induces colonic histopathology with similarities to human IBD, mice exposed to SDR (and thus having lower levels of L. reuteri) had a significant increase in pathogen-induced colitis as indicated by a significant increase in colonic histopathology, chemokines (e.g. (nih.gov)

Electrolyte analysis revealed reduction in serum levels of chloride and sodium in susceptible animals.The results support the hypothesis that mortality in C. rodentium-infected susceptible mice is associated with impaired intestinal ion transport and development of fatal fluid loss and dehydration. (nih.gov)
8. PAD4-dependent NETs generation are indispensable for intestinal clearance of Citrobacter rodentium. (nih.gov)
The findings are published in PNAS in an article titled, " Sialic acid plays a pivotal role in licensing Citrobacter rodentium's transition from the intestinal lumen to a mucosal adherent niche . (genengnews.com)
In the study, researchers examined Citrobacter rodentium , an intestinal bacterial pathogen of mice that is used to model infections with human E. coli . (genengnews.com)
Conversely, enteric (intestinal) pathogens, such as Escherichia coli in humans or Citrobacter rodentium in mice, need oxygen to survive. (medicilon.com)

Here we show that the LEE-encoded proteins EspA, EspB, Tir, and intimin are the targets of long-lived humoral immune responses in C. rodentium-infected mice. (nih.gov)
Mice infected with C. rodentium developed robust acquired immunity and were resistant to reinfection with wild-type C. rodentium or a C. rodentium derivative, DBS255(pCVD438), which expressed intimin derived from EPEC strain E2348/69. (nih.gov)
In response to C. rodentium infection, 5,123 probe sets were differentially expressed in one or both lines of mice. (nih.gov)
Importantly, preventing the stressor-induced reduction in L. reuteri by feeding L. reuteri to the mice during stressor exposure abrogated the effects of the stressor on C. rodentium-induced colitis. (nih.gov)
Our studies demonstrate that stressor-induced reduction in commensal Lactobacillus reuteri is involved with the observed increase in colonic histopathology in mice challenged with Citrobacter rodentium during exposure to a well characterized and widely used social stressor. (nih.gov)

observed that infection with Citrobacter rodentium induced anxiety-like behaviors via vagal sensory regulation. (nih.gov)
These results suggested that, in immune animals, SIgA is crucial for the protection of gastrointestinal surfaces against secreted bacterial toxins, may inhibit early colonization by C. rodentium, but is not essential for protection against re-infection with S. typhimurium or C. rodentium. (ox.ac.uk)
Symptoms include loss of hepatic cytochrome p480s by citrobacter rodentium infection in adults [384]. (moorelifeurgentcare.com)

A species of gram-negative bacteria in the genus CITROBACTER , family ENTEROBACTERIACEAE . (nih.gov)

Thus, the use of C. rodentium is an ideal model to determine whether the colonic epithelium is critical in the link between stress, the microbiota, and exacerbation of colitis. (nih.gov)
We recently found that IL-21 is necessary to optimize activation of interferon-stimulated genes (ISGs) in gut CD4 T cells to effectively clear a Citrobacter rodentium colitis. (nih.gov)

HVEM이 결핍된 생쥐는 병원성 장내 대장균 감염에 대한 모델인 Citrobacter rodentium에 의한 장내 감염에 높은 감수성을 가지며, Streptococcus pneumoniae에 의한 호흡기 감염에도 약한 것으로 밝혀졌다. (natureasia.com)

Like its human homologue (i.e., enteropathogenic E. coli), C. rodentium induces colonic inflammation by colonizing the colonic epithelium. (nih.gov)

Finally, we investigated the importance of SIgA in protection against recurrent infections with Citrobacter rodentium. (ox.ac.uk)
2021). Structural and Cellular Insights into the l , d -Transpeptidase YcbB as a Therapeutic Target in Citrobacter rodentium, Salmonella Typhimurium, and Salmonella Typhi Infections . (lightsource.ca)

Intimin subtypes found in other E. albertii respectively) and Citrobacter rodentium ( 1,2 ). (cdc.gov)

The findings from this study were published recently in Science in an article entitled "Virulence Factors Enhance Citrobacter rodentium Expansion through Aerobic Respiration. (medicilon.com)