We used a genome-wide single nucleotide polymorphism (SNP) array to study patients with chromosome aneuploidy mosaicism, UPD and one individual with XX/XY chimerism to gain insight into the developmental mechanism and timing of these events. (nih.gov)
While mosaicism is quite common, chimerism specifically is very rare in nature. (iflscience.com)
Genetic3
Human genetic chimerism, which can not only cause a wide range of illnesses but also lead to the same person having more than one profile in genetic fingerprinting, has served as a plot device in many works of fiction. (wikipedia.org)
Most known examples are subsequent to the 2004 book Free Culture, where author Lawrence Lessig digresses briefly to describe chimerism and suggest that it could, and had yet to, be well used as a television plot device (particularly for police procedurals involving genetic fingerprinting). (wikipedia.org)
Researchers later determined that the genetic mismatch was due to chimerism, a condition in which two genetically distinct cell lines are present in one body. (asu.edu)
The PCR-based assay was extremely sensitive and did not need donor and recipient samples for the assessment of chimerism. (celljournal.org)
Chimeric3
In Mother 3, chimerism is one of main themes, with chimeric animals being introduced early on in the game. (wikipedia.org)
After 1 year, only 33% of chimeric individuals survived but they are 40% bigger than not chimeric ones, suggesting that chimerism could confer a competitive advantage linked to increased growth rate. (ekt.gr)
Researchers in Jun Wu's lab compare normal mouse embryos (left) to horse-mouse chimeric embryos (right) to identify barriers to interspecies chimerism. (the-scientist.com)
Dive into the research topics of 'Mixed hematopoietic chimerism after marrow allografts. (northwestern.edu)
Here we show that a novel, nondepleting CD40 monoclonal antibody, 3A8, can combine with combined CTLA4Ig and sirolimus in a well-established primate bone marrow chimerism-induction model. (usuhs.edu)
Pigmentation1
One of the key signs of chimerism is differences in pigmentation . (iflscience.com)
Recipient1
CD3-positive T-cells: A low level of recipient chimerism below our established reliable analytical sensitivity (5%) was detected. (mayoclinic.org)
Deletion2
Deletion did not persist when chimerism was lost. (ca.gov)
Chimerism monitoring using biallelic single nucleotide or insertion/deletion polymorphisms : how many markers to screen? (ugent.be)
Gene3
Posted 8:58 am by Kayla Sheets & filed under Chimerism , Paternity Testing , Vibrant Gene . (vibrantgene.com)
The aim of the present study was to evaluate the application of the amelogenin gene for assessment of chimerism in PBL and/or BM samples of patients who received sex-mismatched BMT. (celljournal.org)
Fumarylacetoacetate hydrolase gene as a knockout target for hepatic chimerism and donor liver production. (nih.gov)
Widespread2
In the January issue of the journal Genome Research, two teams of scientists describe a widespread phenomenon in the human genome called transcription-induced chimerism (TIC), where two adjacent genes produce a single, fused RNA transcript. (cshlpress.com)
Chimerism appears to be more widespread than previously thought, but its actual incidence remains unknown ( also see this post ). (blogspot.com)
Tolerance2
Trogocytosis as a mechanistic link between chimerism and prenatal tolerance. (nature.com)
Is mixed chimerism really required in maintaining a skin allograft tolerance? (elsevierpure.com)
Phenomenon2
The phenomenon of chimerism in the Mediterranean red coral ( Corallium rubrum ) is reported and quantified in semi-natural conditions. (ekt.gr)
Finally, if the chimerism theory is true, exclusive homosexuality should be more common in populations with a higher incidence of twinning, such as sub-Saharan Africans. (blogspot.com)
From my personal experience and understanding, it's not common to have chimerism numbers fluctuate but it can happen. (mayoclinic.org)
For the type of chimerism mentioned in this blogpost (also known as 'tetragametic' chimerism ), the most common cause is a twin pregnancy that naturally reduces to a single baby. (vibrantgene.com)
An even more common form of chimerism is called microchimerism. (vibrantgene.com)
The extent of chimerism was explored within two wild populations of a common coral, Acropora millepora, on the Great Barrier Reef, Australia, by using up to 12 polymorphic DNA microsatellite loci. (edu.au)
Patients3
OBJECTIVES: I. Determine whether mixed or full donor chimerism can be safely established in older patients with acute myeloid leukemia (AML) treated with nonmyeloablative conditioning comprised of low dose total body irradiation, followed by allogeneic peripheral blood stem cell transplantation, followed by unrelated donor lymphocyte infusion (DLI). (knowcancer.com)
Determine whether mixed chimerism can be safely converted to full donor chimerism in patients treated with DLI. (knowcancer.com)
Eligible patients with mixed chimerism and no graft versus host disease (GVHD) receive the first donor lymphocyte infusion (DLI) on the same day that donor lymphocytes are collected. (knowcancer.com)
Coral2
Soft-coral natural chimerism: A window in ontogeny allows the creation of entities comprised of incongruous parts. (ekt.gr)
In scleractinian corals, fusion among allogeneic juveniles is known to occur following aggregated larval settlement in some brooding species, but no studies have investigated chimerism in juveniles of broadcast spawning corals or in adult populations of any coral species. (edu.au)
Condition1
Chimerism is a condition whereby a person has not one but two complete genomes (or sets of DNA) in their body. (vibrantgene.com)
Analysis1
According to sequencing analysis results showed that Y chromosome CNV attribute to the normal female phenotype of 46XX/46XY chimerism. (hilarispublisher.com)
Case Report1
Case Report: Identification of Germline Chimerism in Monochorionic Dizygotic Twins. (cdc.gov)
Cells1
Steve Sailer has entered this debate with a post on the chimerism theory , i.e., the idea that male homosexuality arises when a male fetus absorbs cells from a female twin that has died during early fetal development. (blogspot.com)
True1
These values are likely to be vast underestimates of the true extent of chimerism in wild populations, as the sampling protocol was restricted to a maximum of eight branches per colony, whereas most colonies consist of hundreds of branches. (edu.au)
Single2
This study demonstrates the power of this approach to accurately define leukocyte chimerism in a complex tissue such as the kidney transplant coupled with the ability to examine transcriptional profiles at single cell resolution. (biorxiv.org)
With the increase in IVF and other fertility treatments, we are noticing more DNA variations and chimerism and even have observed individuals in the uterus that are Siamese twins that rejoin into a single body before birth. (gp.org)
These results are the first to demonstrate prolonged chimerism in primates treated with CD28/mTOR blockade and nondepletional CD40 blockade, and support further investigation of combined costimulation blockade targeting the CD28 and CD40 pathways. (usuhs.edu)
Life1
Consequently, chimerism is likely to be an important strategy for maximizing survival of vulnerable early life history stages of corals. (edu.au)