Chemotaxis. Medical search. Frequent questions

Chemotaxis assays with chemotactic and non-chemotactic (Δ cheA ) L. agilis strains revealed that low pH, organic acids, and bile salts served as repellents. (nature.com)
Chemotaxis assay revealed that V. cholerae -0139 swims towards the homogenates of aquatic plants and animals with a higher chemotactic response being observed for 4% solution of P. globosa homogenate. (scialert.net)
The influence of temperature and salinity on the chemotaxis of V. cholerae -0139 revealed that at 25 0 C and 1.7% salinity favoured the chemotactic motility towards the homogenates of aquatic flora and fauna. (scialert.net)
Here we identify the antimalarial compound artemisinin as a potent and selective inhibitor of neutrophil and macrophage chemotaxis induced by a range of chemotactic agents. (kcl.ac.uk)

Chemotaxis is triggered by the binding of ligands (chemoeffectors) to chemoreceptors called methyl-accepting chemotaxis proteins (MCPs) and transducer-like proteins (Tlps). (nature.com)
Periplasmic sensor domains from two methyl-accepting chemotaxis proteins from Geobacter sulfurreducens (encoded by genes GSU0935 and GSU0582) were expressed in Escherichia coli. (rcsb.org)
The swapped dimerization of these sensor domains and redox-linked ligand switch might be related to the mechanism of signal transduction by these chemotaxis proteins. (rcsb.org)
This sequence of biochemical events establishes a chain of communication that ultimately allows the chemotaxis receptor proteins to regulate the swimming pattern of the bacterial cell when it encounters gradients of attractant and repellent chemicals in its environment. (umd.edu)
It exhibits robust adaptation and has several homologues of the latter's chemotaxis proteins. (sontaglab.org)
Chemotaxis has been extensively studied in bacteria such as Escherichia coli and Salmonella enterica serovar Typhimurium, and depends on the activity of single copies of proteins in a linear pathway. (oregonstate.edu)
In this two-part explorative proteomic study, we demonstrate how proteins associated with tissue remodeling, inflammation and chemotaxis such as MMP7, CXCL13 and CCL19 are released in response to aberrant extracellular matrix (ECM) in IPF lung. (lu.se)
This review summarizes some immunological factors involved in the development and control of this oral disease, such as: the participation of inflammatory cells in local inflammation, the synthesis of chemotaxis proteins with activation of the complement system and a range of antimicrobial peptides, such as defensins, cathelicidin and saposins. (bvsalud.org)

Polymorphonuclear leukocyte chemotaxis was investigated in 35 patients with recurrent polyserositis during attacks and during spontaneous or colchicine-induced remissions. (tau.ac.il)

A method for measuring chemotaxis and use of the method to determine optimum conditions for chemotaxis by Escherichia coli . (scialert.net)
The chemotaxis pathway of the bacterium Rhodobacter sphaeroides has many similarities to that of Escherichia coli. (sontaglab.org)
Here we address this issue in experiments using chemotaxis of Escherichia coli, one of the best-characterized sensory systems. (mcmaster.ca)

However, SWCNT suppressed chemotaxis of primary human monocytes in a standard chemotaxis assay. (cdc.gov)

内容先容： We study global existence and long-time behavior of solutions for hyperbolic-parabolic PDE models of chemotaxis. (lgn1.com)

L. agilis BKN88 was more sensitive to bile and acid than the gut-derived non-motile lactobacilli, implying that L. agilis might utilize motility and chemotaxis instead of exhibiting stress tolerance/resistance. (nature.com)
We used the system to study motility and chemotaxis by a score of Dictyostelium discoideum wild-type and mutant strains, including "streamer" mutants which are generally regarded as being altered in chemotaxis. (uni-regensburg.de)
Motility and chemotaxis. (lu.se)

Chemotaxis , a kind of taxis , is the phenomenon in which bodily cells, bacteria , and other single-cell or multicellular organisms direct their movements according to certain chemicals in their environment. (wikidoc.org)
This dissertation focuses on understanding some of the biochemical events that take place in the chemotaxis signal transduction pathway of bacteria. (umd.edu)
Bacterial chemotaxis is one of the important mechanisms of association of bacteria and other living biota. (scialert.net)
This behavior, called chemotaxis, is mediated by the bacteria changing direction by briefly reversing the direction of rotation of the flagellar motors. (oregonstate.edu)
However, growing evidence suggests that chemotaxis in other bacteria is more complex with many bacterial species having multiple paralogues of the various chemotaxis genes found in E. coli and, in most cases, the detailed functions of these potentially redundant genes have not been elucidated. (oregonstate.edu)
Chemotaxis signaling pathways enable bacteria to sense and respond to their chemical environment and, in some species, are critical for lifestyle processes such as biofilm formation and pathogenesis. (ox.ac.uk)

The most important aspects in quality control of chemotaxis assays were described by H. Harris in the 1950s. (wikipedia.org)
Chemotaxis assays using a series of chemoreceptor mutants revealed that each of the five chemoreceptors could sense multiple chemoeffectors and that these chemoreceptors were functionally redundant. (nature.com)

Although involving more steps than conventional chemotaxis that relies on a single chemoattractant, we show that this chemical ``pinging'' mechanism can provide cells with flexibility in regulating behavior and finding different targets. (aps.org)
We also analyzed the relationship between turning behavior and the direction of travel during chemotaxis in stable gradients. (uni-regensburg.de)
The signal transduction underlying chemotaxis behavior is mediated by large, highly ordered protein complexes known as chemosensory arrays. (ox.ac.uk)

In addition, it has been recognized that mechanisms that allow chemotaxis in animals can be subverted during cancer metastasis. (wikipedia.org)
PDF ] Keyword(s): chemotaxis, cancer, metastasis. (sontaglab.org)

The amebae moved in a novel chemotaxis chamber designed to provide stable linear attractant gradients in a thin agarose gel. (uni-regensburg.de)
Using a modified Boyden chamber assay, tumor cells migrated to a gradient of soluble thrombospondin (chemotaxis). (rupress.org)
Over a wide range, the number of cells migrating toward a given concentration of chemotaxin was directly proportional to the number added to the chemotaxis chamber. (uni-regensburg.de)
BioVision's Cell Migration/Chemotaxis Assay Kit utilizes a Boyden chamber, where the cells migrate through a semipermeable membrane under different stimuli. (transcriptionfactor.org)

On November 3 , 2006 , Dr. Dennis Bray of University of Cambridge was awarded the Microsoft European Science Award for his work on chemotaxis on E. coli . (wikidoc.org)
Mechanisms of E. coli chemotaxis signaling pathways visualized using cryoET and computational approaches. (ox.ac.uk)

However, during the acute phase of inflammation , particularly as a result of bacterial infection , neutrophils leave the vasculature and migrate toward the site of inflammation in a process called chemotaxis . (bionity.com)
Neutrophils undergo a process called chemotaxis that allows them to migrate toward sites of infection or inflammation. (bionity.com)

Chemotaxis describes the directed movement of cells/organisms in response to chemical signals. (utoronto.ca)
Immune cell chemotaxis to the sites of pathogen invasion is critical for fighting infection, but in life-threatening conditions such as sepsis and Covid-19, excess activation of the innate immune system is thought to cause a damaging invasion of immune cells into tissues and a consequent excessive release of cytokines, chemokines and neutrophil extracellular traps (NETs). (kcl.ac.uk)
A series of human melanoma and carcinoma cells were compared for their relative motility stimulation by thrombospondin haptotaxis vs. chemotaxis. (rupress.org)
Human monocyte chemotaxis: migrating cells are a subpopulation with multiple chemotaxin specificities on each cell. (uni-regensburg.de)
Chemotaxis is a cellular sensing mechanism that guides immune cells to sites of infection and leads fibroblasts to sites of injury. (unibas.ch)
Analysis of cAMP chemotaxis shows that Dderk2 - cells are defective in chemotaxis to high concentrations of cAMP. (elsevierpure.com)
Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. (cellbiolabs.com)
Chemotaxis: Dendritic cells as trendsetters of the immune response. (bvsalud.org)
Chemokine-enhanced chemotaxis of lymphangioleiomyomatosis cells with mutations in the tumor suppressor TSC2 gene. (cdc.gov)

Chemotaxis (from chemo- + taxis) is the movement of an organism or entity in response to a chemical stimulus. (wikipedia.org)
In multicellular organisms, chemotaxis is critical to early development (e.g., movement of sperm towards the egg during fertilization) and development (e.g., migration of neurons or lymphocytes) as well as in normal function and health (e.g., migration of leukocytes during injury or infection). (wikipedia.org)
negative chemotaxis if the movement is in the opposite direction. (wikipedia.org)
Chemotaxis is called positive if movement is in the direction of a higher concentration of the chemical in question, and negative if the direction is opposite. (wikidoc.org)
If the movement is up to the chemical concentration gradient, it is called attractive chemotaxis, otherwise repulsive chemotaxis. (utoronto.ca)
Geotaxis is the movement of living things in response to the Earth's gravity, and chemotaxis is the movement of organisms in response to chemicals. (larioja.org)

Although the completed genome of Vibrio cholerae, the causative agent of cholera, predicted a multitude of genes with homology to known chemotaxis-related genes, little is known about their relative contribution to chemotaxis or other cellular functions. (oregonstate.edu)

Chemotaxis is usually modeled by cellular responses to an imposed, exogenous chemoattractant gradient. (aps.org)
The pathogenesis of the disease is unclear, but altered expression of cytokines and cellular adhesion molecules, important for chemotaxis of LC, are thought to be involved in its development. (medscape.com)

To investigate the role of chemotaxis that might function for association of Vibrio cholerae -0139 with different aquatic flora and fauna, the homogenates of four aquatic plants and animals namely water hyacinth ( Eichhornia crassipes ), water cress ( Pistia stratiotes ), oyster ( Lamellidens marginalis ) and snail ( Pila globosa ) were examined in chemotaxis capillary assay. (scialert.net)
Chemotaxis in Vibrio cholerae. (oregonstate.edu)

This review will focus on the complex relationship between chemotaxis and virulence in V. cholerae. (oregonstate.edu)

Here, we report that exposure to glucose in diabetic range results in impaired chemotaxis signaling through the formyl peptide receptor (FPR) in neutrophils, culminating in reduced chemotaxis and delayed neutrophil trafficking in the wound of Lepr db (db/db) type 2 diabetic mice, rendering diabetic wound vulnerable to infection. (elifesciences.org)
In this model, chemotaxis does not require spatial integration but is instead a stochastic process in which each receptor binding event within the leading edge triggers a local lamellipod extension and a small turn in the direction of migration. (unibas.ch)
LuxP, LuxQ = receptor that binds (AI2)…induces chemotaxis….how? (vdocuments.net)

The 140-kD fragment of thrombospondin lacking the heparin-binding amino-terminal region retained the property to fully mediate haptotaxis but not chemotaxis. (rupress.org)

Thrombospondin-induced tumor cell migration: haptotaxis and chemotaxis are mediated by different molecular domains. (rupress.org)
Separate structural domains of thrombospondin are therefore required for tumor cell haptotaxis vs. chemotaxis. (rupress.org)

Furthermore, the role of chemotaxis during the environmental or infectious phases of this organism is not yet fully understood. (oregonstate.edu)

To illustrate this theoretically predicted limitation, we discuss two common biomolecular network motifs, an incoherent feedforward loop and a feedback system, as well as a published model of the chemotaxis signaling pathway of Dictyostelium discoideum. (sontaglab.org)

Chemotaxis is one of the most basic cell physiological responses. (wikidoc.org)

Phosphotransfer in Rhodobacter sphaeroides chemotaxis. (ox.ac.uk)

Simulated worms moving au(cid:173) tonomously in simulated chemical environments display a variety of chemotaxis strategies similar to those of biological worms. (nips.cc)

The dependence of chemotaxis on cAMP concentration, gradient steepness, and temporal changes in the gradient were investigated. (uni-regensburg.de)
The results suggest that during chemotaxis D. discoideum amebae spatially integrate information about local increases in cAMP concentration at various points on the cell surface. (uni-regensburg.de)
We focus on how response and adaptation to attractant signals vary with systematic changes in the intracellular concentration of the components of the chemotaxis network. (mcmaster.ca)
We study a two-dimensional chemotaxis-fluid system in a bounded convex domain with smooth boundary under no-flux boundary conditions for bacterial density and oxygen concentration and no-slip boundary condition for fluid velocity. (elsevierpure.com)

None of the mutants were altered in chemotaxis in the optimal cAMP gradient of 25 nM/mm, with a midpoint of 25 nM. (uni-regensburg.de)

We train recurrent networks to control chemotaxis in a computer model of the nematode C. elegans. (nips.cc)

Furthermore, it is shown that these assumptions make FCD a property of this system that is robust to structural and parametric variations in the chemotaxis pathway, in agreement with experimental results. (sontaglab.org)
Moreover, we find oscillatory traveling wave solutions to an attractive chemotaxis system which are biologically relevant. (lgn1.com)
The two-component sensing system controlling bacterial chemotaxis is one of the best studied in biology. (ox.ac.uk)
摘要： In this talk, we consider a coupled chemotaxis-Navier-Stokes system with logistic source term in a bounded domain. (hit.edu.cn)

These findings led to a model in which global cell polarization is independent from the chemotaxis mechanism. (unibas.ch)

The aberrant chemotaxis of leukocytes and lymphocytes also contribute to inflammatory diseases such as atherosclerosis, asthma, and arthritis. (wikipedia.org)

Secondly, we study the (in-) stability of the homogeneous steady-state solution to the attractive-repulsive chemotaxis model that arises in studying on Alzheimer's disease. (utoronto.ca)
Finally, we consider the attraction-repulsion chemotaxis model arising from Alzheimer's disease withshow fast diffusive term and nonlinear source subject to Neumann boundary conditions. (utoronto.ca)
We consider two-dimensional versions of the Keller-Segel model for the chemotaxis with either classical (Brownian) or fractional (anomalous) diffusion. (aimsciences.org)

The significance of chemotaxis in biology and clinical pathology was widely accepted in the 1930s, and the most fundamental definitions underlying the phenomenon were drafted by this time. (wikipedia.org)
The significance of chemotaxis in biology and clinical pathology was widely accepted in the 1930s. (wikidoc.org)

P. Biler , G. Karch and J. Zienkiewicz , Optimal criteria for blowup of radial and $N$-symmetric solutions of chemotaxis systems, Nonlinearity , 28 (2015), 4369-4387. (aimsciences.org)

Discover these fascinating giant microbes and explore chemotaxis and the scientific method with these slimy experiments. (scienceinschool.org)

No chemotaxis occurred in response to these substances in the dark. (uea.ac.uk)
Our scope here is to address the previous questions for bacterial chemotaxis, one of the best characterized systems of response (5). (pdffox.com)

In multicellular organisms, chemotaxis is critical to development as well as normal function. (wikidoc.org)

Role of chemotaxis in establishing a specific nitrogen-fixing Cyanobacterial-bacterial association. (scialert.net)
Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. (cellbiolabs.com)

Screen, study, or characterize compounds that influence chemotaxis/cell migration. (transcriptionfactor.org)

Anatomy12

Organisms6

Chemicals and Drugs55

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes18

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science3

Chemotactic4

Proteins8

Leukocyte chemotaxis1

Escherichia3

Monocytes1

Models of Chemotaxis1

Motility and chemotaxis3

Bacteria6

Assays2

Behavior3

Metastasis2

Chamber4

Coli2

Inflammation2

Cells9

Movement6

Genes1

Cellular2

Vibrio2

Cholerae1

Receptor3

Mediate1

Tumor2

Organism1

Dictyostelium1

Physiological1

Rhodobacter1

Biological1

Concentration4

Mutants1

Recurrent1

System4

Mechanism1

Leukocytes1

Model3

Biology2

Optimal1

Experiments1

Response2

Function1

Role2

Migration1