COMP is a non-collagenous glycoprotein and is belongs to the thrombospondin family of extracellular proteins. (prospecbio.com)
COMP is not only cartilage-derived but is common in other tissues, such as synovium and tendon. (prospecbio.com)
Objective -To assay concentrations of cartilage oligomeric matrix protein (COMP) in canine sera and synovial fluid (SF), to compare COMP concentrations in clinically normal dogs and dogs with joint disease, and to analyze changes in COMP concentrations in dogs with experimentally induced acute synovitis. (avma.org)
The COMP concentrations were determined by use of an inhibition ELISA that had canine cartilage COMP and monoclonal antibody against human COMP. (avma.org)
Conclusions and Clinical Relevance -These results supported the hypothesis that COMP concentration in serum and SF of dogs may be altered after cartilage degradation or synovitis. (avma.org)
One such potential biological marker of arthritis is cartilage oligomeric matrix protein (COMP). (escholarship.org)
Cartilage oligomeric matrix protein (COMP) is a homopentameric protein in cartilage. (biomedcentral.com)
Finally, COMP-deficient and wild-type mice responded similarly to collagen antibody-induced arthritis, indicating no difference in how collagen II antibodies interact with COMP-deficient cartilage during the initial stages of arthritis. (biomedcentral.com)
In fact, the immunization with other cartilage proteins in some cases will cause a disease similar in type to CIA, which has been shown to be immunized with COMP [ 7 ]. (biomedcentral.com)
Pseudoachondroplasia (PSACH) is associated with mutations in the cartilage oligomeric matrix protein (COMP) gene and the clinical characteristics include short stature, deformities of the extremities involving the epiphyses and metaphyses, early onset arthritis, and ligament laxity. (nih.gov)
Cartilage oligomeric matrix protein (COMP) is a soluble pentameric protein expressed in cartilage and involved in collagen organization. (lu.se)
In vitro experiments confirmed that COMP-expressing cells had a more invasive phenotype, which could in part be attributed to an upregulation of matrix metalloprotease-9. (lu.se)
This observation was confirmed in vitro as COMP-expressing cells showed better survival as well as a higher rate of protein synthesis when treated with brefeldin A, compared with control cells. (lu.se)
Objective: To determine the effect of Alphacalcidol supplementation on pain based on WOMAC pain index and joint cartilage condition based on cartilage oligomeric matrix protein (COMP) serum markers in knee osteoarthritis (OA) elderly patients. (ui.ac.id)
Here, changes in cartilage oligomeric matrix protein (COMP), interleukin-6 (IL-6), and creatine phosphokinase (CPK) were monitored before and after 1hr of exposure to static axial trunk loading and again after 1hr of prone rest. (cdc.gov)
Serum cartilage oligomeric matrix protein (COMP) concentration is elevated in patients with early osteoarthritis and early rheumatoid arthritis, and may be a biomarker of cartilage turnover. (researchgate.net)
Cartilage oligomeric matrix protein-angiopoietin-1 (COMP-Ang1) is an angiogenic factor for vascular angiogenesis. (koreamed.org)
Serum concentrations of the inflammatory marker C-reactive protein (CRP) and the cartilage markers Alanine-Arginine-Glycine-Serine (ARGS)-aggrecan, cartilage oligomeric matrix protein (COMP), and type II collagen C2C were analyzed by immunoassays. (lu.se)
we found that the expression of cartilage protein COMP is associated with metastases and a poor prognosis for patients with various types of solid cancers. (lu.se)
Mesenchymal stem cells (MSCs) play a key role in articular cartilage repair. (hindawi.com)
Native and concentrated BMA have been intensively studied in the context of articular cartilage repair. (hindawi.com)
Such enhanced techniques of marrow stimulation have been shown to improve articular cartilage repair in both animal models and patients. (hindawi.com)
Altered enchondral ossification may be associated with changes in the articular cartilage. (medscape.com)
The resultant articular cartilage is deficient in underlying osseous support and fails to withstand normal cyclical loading. (medscape.com)
Collagen6
Binding to other ECM proteins such as collagen appears to depend on divalent cations. (wikipedia.org)
The development of arthritis, like collagen-induced arthritis (CIA), involves cartilage as a target tissue. (biomedcentral.com)
In the CIA model, an immunization against one specific cartilage protein, collagen II (CII), starts an autoimmune reaction leading to arthritis. (biomedcentral.com)
The collagen in tendons are held together with proteoglycan (a compound consisting of a protein bonded to glycosaminoglycan groups, present especially in connective tissue) components including decorin and, in compressed regions of tendon, aggrecan , which are capable of binding to the collagen fibrils at specific locations. (handwiki.org)
Levels of cartilage oligome1
Further analysis showed that levels of cartilage oligomeric matrix protein, resistin, monocyte chemoattractant protein-1, and nerve growth factor were significantly different between patients with psoriatic arthritis and those with osteoarthritis. (mdedge.com)
A panel of four biomarkers of cartilage metabolism, metabolic syndrome, and inflammation could help physicians to distinguish between osteoarthritis and psoriatic arthritis, new research suggests. (mdedge.com)
The authors noted that previous research has observed high expression of monocyte chemoattractant protein-1 and resistin in patients with psoriatic arthritis when compared with those with osteoarthritis. (mdedge.com)
Similarly, higher cartilage oligomeric matrix protein levels are associated with a higher risk of knee osteoarthritis. (mdedge.com)
The aim of this study was to explore the associations between PA or self-reported joint function and molecular biomarkers of cartilage and inflammation in individuals with hip and/or knee osteoarthritis (OA). (lu.se)
Data are also lacking on their distinguishing abilities from other cartilage-damaging diseases, such as osteoarthritis (OA) and their usefulness as a monitoring tool in patients with RA. (biomedcentral.com)
Cartilage and bone metabolism in rheumatoid arthritis. (wikipedia.org)
A bone marrow clot forms within the cartilage defect either as a result of marrow stimulation or during the course of the spontaneous repair of osteochondral defects. (hindawi.com)
The additional application of a bone marrow aspirate (BMA) to the procedure of marrow stimulation is thought to enhance cartilage repair as it may provide both an additional cell population capable of chondrogenesis and a source of growth factors stimulating cartilage repair. (hindawi.com)
If bone marrow fills a cartilage defect either as a result of marrow stimulation for chondral defects or the course of the spontaneous repair of osteochondral defects, a bone marrow clot forms within the cartilage defect. (hindawi.com)
In the orthopaedic field, additional application of a bone marrow aspirate (BMA) to the procedure of marrow stimulation has been recently studied, since the bone marrow itself is both a source of MSCs, providing a cell population capable of chondrogenesis and of various growth factors stimulating cartilage repair [ 7 - 10 ]. (hindawi.com)
Skeletal dysplasias, also known as osteochondrodysplasias, are a heterogeneous group of heritable disorders characterized by abnormalities of cartilage and bone growth, resulting in abnormal shape and size of the skeleton and disproportion of the long bones, spine, and head. (medscape.com)
Persistent synovitis causes bone and cartilage damage, leading to joint destruction and deformity. (biomedcentral.com)
Generally, alkaline phosphatase (ALP), COL1A1, BSP, RUNX2, transforming growth factor-beta 1 (TGFB1), osteonectin (ON), and bone morphogenetic protein-2 (BMP2) are known to be early markers of osteoblastic differentiation, whereas OC and osteopontin (OPN) are expressed later in the differentiation process [ 20 ]. (biomedcentral.com)
Biomarkers2
As part of a proteomic analysis of knee synovial fluid from normal and OA patients, differentially expressed proteins were identified that could represent potential biomarkers for OA. (harvard.edu)
This study aimed to use mass spectrometry assays to identify representative peptides from several proteins in synovial fluid and peripheral blood, and assess their levels as biomarkers of OA progression. (harvard.edu)
Methods: Multiplexed high throughput selected reaction monitoring (SRM) assays were developed to measure tryptic peptides representative of 23 proteins in matched serum and synovial fluid samples from late OA subjects at the time of joint replacement. (harvard.edu)
Subsequently plasma samples from the baseline visit of 173 subjects in an observational OA cohort were tested by SRM for peptides from nine of these proteins: afamin, clusterin, cartilage oligomeric matrix protein, hepatocyte growth factor, kallistatin, insulin-like growth factor binding protein, acid labile subunit, lubricin, lumican, and pigment epithelium-derived factor. (harvard.edu)
A high correlation between different peptides from individual proteins was observed, indicating our assays correctly measured their target proteins. (harvard.edu)
Amino acids6
Scalar light instructions are able to assemble and maintain molecules of amino acids and proteins crucial to human and animal quantum health. (scalarlight.com)
In practice, the Scalar Light Amino Acid & Protein Program administers scalar light instructions in order to assemble and maintain amino acids and proteins inside the quantum body or scalar light force field. (scalarlight.com)
Below are the lists of amino acids and proteins that are assembled by way of the Scalar Light Amino Acid and Protein Program. (scalarlight.com)
Additionally, enzymes and micro-nutrients are likewise assembled as these nutrients serve to abet and catalyze the assembling of amino acids and proteins. (scalarlight.com)
The Scalar Light Amino Acid and Protein Program operates twenty-four (24) hours per day seven (7) days per week thereby assuring a constant creation and delivery of amino acids and proteins to the quantum, human body. (scalarlight.com)
The study showed that the reduction in transport of large amino acids by the encoded SLC7A5 protein leads to neurons switching from metabolizing lipids instead of amino acids and higher levels of neuronal cell death. (genewhisperer.com)
Rheumatoid3
This study aimed to provide an overview of ultrasonographic cartilage evaluation in patients with rheumatoid arthritis (RA) and identify research gaps in the utilization of cartilage evaluation. (biomedcentral.com)
A systematic literature search of the PubMed, Embase, and Cochrane Library databases was conducted for articles published up to July 2022 using the search term variations of "cartilage," "ultrasonography," and "rheumatoid arthritis. (biomedcentral.com)
The search terms included were variations of "cartilage," "ultrasonography," and "rheumatoid arthritis. (biomedcentral.com)
Kinase3
Valmu L , Autero M, Siljander P, Patarroyo M and Gahmberg C G (1991) Phosphorylation of the ß-subunit of CD11/CD18 in-tegrins by protein kinase C correlates with leukocyte adhesion. (leenavalmu.fi)
Kovanen P E, Junttila K, Takaluoma K, Saharinen P, Valmu L , Li W and Silvennoinen O (2000) Regulation of Jak2 tyrosine kinase by protein kinase C during macrophage differentation of IL-3-dependent myeloid progenitor cell. (leenavalmu.fi)
Ivanov K I, Puustinen P, Gabrenaite R, Vihinen H, Rönnstrand L, Valmu L , Kalkkinen N and Mäkinen K (2003) Phosphorylation of the Potyvirus Capsid Protein by Protein Kinase CK2 and Its relevance for Virus Infection. (leenavalmu.fi)
Degradation2
A valuable approach to monitor arthritis would be by measuring biological markers of cartilage degradation and repair to reflect variations in joint remodeling. (escholarship.org)
TNF-α activates fibroblasts and synovial macrophages to secrete degradation enzymes and supress cartilage proteoglycan synthesis, leading to histopathological changes in cartilages. (unpad.ac.id)
Cell Adhesion1
Integrins are transmembrane receptors that mediate cell adhesion by forming links between the extracellular matrix and cytoskeleton. (biologists.com)
Recombinant1
In addition, you will have the opportunity to learn microbiologic and immunologic techniques and to express and purify recombinant proteins. (lu.se)
Glycosaminoglycans1
Interaction with glycosaminoglycans and cartilage oligomeric matrix protein. (leenavalmu.fi)
Genes3
We have updated the nomenclature of a number of genes based on the identification of their encoded proteins as being associated with microtubules. (genewhisperer.com)
The following genes that previously had placeholder symbols have recently been shown to encode proteins that are found in the lumen of microtubules. (genewhisperer.com)
Mapping of the genes encoding human protein matches to pathways point to targets that could explain the observed presentation of symptoms in COVID-19 disease. (danielsolis.cz)
Thrombospondin1
It was found in the thrombospondin protein where it is repeated 3 times. (embl.de)
Expression2
Depending on the cultivation technique we found significant differences in both gen and protein expression. (biomedcentral.com)
We found very high levels of expression of the central complement protein, C3, and complement inhibitor CD59 in human pancreatic islets. (lu.se)
Human7
Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. (medchemexpress.com)
Homology between human and viral proteins is an established factor in viral- or vaccine-induced autoimmunity. (danielsolis.cz)
SAR-CoV-2 spike proteins, and all other SARS-CoV-2 proteins, immunogenic epitopes in each SARS-CoV-2 protein were compared to human proteins in search of high local homologous matching. (danielsolis.cz)
Only one immunogenic epitope in a SARS-CoV-2 had no homology to human proteins. (danielsolis.cz)
If all of the parts of the epitopes that are homologous to human proteins are excluded from consideration due to risk of pathogenic priming, the remaining immunogenic parts of the epitopes may be still immunogenic and remain as potentially viable candidates for vaccine development. (danielsolis.cz)
Blom A. M . , Berggård K., Webb J. H., Villoutreix B., Lindahl G. and Dahlbäck B. (2000) Human C4b-binding protein has overlapping but not identical binding sites for C4b and streptococcal M-proteins. (lu.se)
Mark L., Lee W. H., Villoutreix B. O., Proctor D., Blackbourn, D., Spiller B. O. and Blom A. M. (2004) KSHV complement control protein mimics human molecular mechanisms for inhibition of the complement system. (lu.se)
Subunit1
Kask L., Hillarp A., Ramesh B., Dahlbäck B., and Blom A. M. (2002) Structural requirements for the intra-cellular subunit polymerization of the complement inhibitor C4b-binding protein. (lu.se)
Inflammation1
Sjöberg A., Önnerfjord, P., Mörgelin, M., Heinegård, D. and Blom A. M. (2005) Extracellular matrix and inflammation: fibromodulin activates the classical pathway of complement by directly binding C1q. (lu.se)
Erosion1
In the chronic stage of the disease, when the erosion of the cartilage is taking place, it is possible that immune reactions to other cartilage proteins are initiated and contribute to the disease course. (biomedcentral.com)
Knee1
Reduction of TNF-α level and histopathological improvement are found in rabbit knee cartilage with arthritis when fractionated Papuan ant nest is given. (unpad.ac.id)
Synovial1
Results: In the matched cohort, 17 proteins could be identified in synovial fluid and 16 proteins were detected in serum. (harvard.edu)
Joints1
therefore, it is considered useful for cartilage evaluation, including small joints. (biomedcentral.com)
Keratin ( / ˈ k ɛr ə t ɪ n / [1] [2] ) is one of a family of structural fibrous proteins also known as scleroproteins . (wikipedia.org)
Spider silk is classified as keratin, [9] although production of the protein may have evolved independently of the process in vertebrates. (wikipedia.org)