PeptidesReceptorsFibrillationCardiodilatinPeptide receptorGuanylate cyclaseProteinsMyocytesHormoneProhormoneRatsBrainBradykininVasopressinOxytocinInsulinSubstancesStimulationSodiumArterialMyocardialConcentrationsRegulationKidneyCellsAbstractHypertensionSubstanceSuggestsFunctionClinicalTumorInvolvementFound
Peptides4
- Natriuretic peptides (ANP, BNP, and CNP) are a family of hormone/paracrine factors that are structurally related. (wikipedia.org)
- ANP is secreted in response to: Stretching of the atrial wall, via Atrial volume receptors Increased Sympathetic stimulation of β-adrenoceptors Increased sodium concentration (hypernatremia), though sodium concentration is not the direct stimulus for increased ANP secretion Endothelin, a potent vasoconstrictor Three types of atrial natriuretic peptide receptors have been identified on which natriuretic peptides act. (wikipedia.org)
- IDE hydrolyzes a variety of regulatory peptides, including insulin, glucagon, atrial natriuretic factor, and transforming growth factor-alpha in vitro (1). (rndsystems.com)
- A potent natriuretic and vasodilatory peptide or mixture of different-sized low molecular weight PEPTIDES derived from a common precursor and secreted mainly by the HEART ATRIUM . (nih.gov)
Receptors3
- These cells contain volume receptors which respond to increased stretching of the atrial wall due to increased atrial blood volume. (wikipedia.org)
- They are all cell surface receptors and designated: guanylyl cyclase-A (GC-A) also known as natriuretic peptide receptor-A (NPRA/ANPA) or NPR1 guanylyl cyclase-B (GC-B) also known as natriuretic peptide receptor-B (NPRB/ANPB) or NPR2 natriuretic peptide clearance receptor (NPRC/ANPC) or NPR3 NPR-A and NPR-B have a single membrane-spanning segment with an extracellular domain that binds the ligand. (wikipedia.org)
- CIP4 is a scaffold protein that regulates membrane deformation and tubulation, organization of the actin cytoskeleton, endocytosis of growth factor receptors, and vesicle trafficking. (biomedcentral.com)
Fibrillation1
- NPPA variants affect plasma ANP concentrations, blood pressure levels, and cardiovascular diseases such as atrial fibrillation (AF). (wikipedia.org)
Cardiodilatin1
- Sections of rat hypothalamus were examined immunocytochemically for coexistence of atrial natriuretic factor (cardiodilatin) and oxytocin. (nih.gov)
Peptide receptor3
- Here, we investigated the potential for a novel strategy for the treatment of itch that involves the inhibition of the NPPB receptor NPR1 (natriuretic peptide receptor 1). (nih.gov)
- 7. Hypertension associated with decreased testosterone levels in natriuretic peptide receptor-A gene-knockout and gene-duplicated mutant mouse models. (nih.gov)
- 12. Stimulation of atrial natriuretic peptide receptor/guanylyl cyclase- A signaling pathway antagonizes the activation of protein kinase C-alpha in murine Leydig cells. (nih.gov)
Guanylate cyclase1
- 13. Atrial natriuretic factor stimulates luteal guanylate cyclase. (nih.gov)
Proteins3
- The purpose is to develop understanding of the role of virus, viral proteins, immune cells, cytokine production, growth factor expression and co-infection with other pathogens in the altered function and disease manifestations of the cardiovascular system. (nih.gov)
- Current cardiac biomarkers have been roughly divided into i) leakage markers related to myocardial integrity, such as cardiac troponin (cTn), myoglobin and creatine kinase isoenzyme MB (CK-MB) and ii) functional markers related to specific proteins of cardiac functions, such as brain natriuretic peptide (BNP), atrial natriuretic peptide (ANP) and endothelin. (vin.com)
- Cell surface proteins that bind ATRIAL NATRIURETIC FACTOR with high affinity and trigger intracellular changes influencing the behavior of cells. (bvsalud.org)
Myocytes4
- The NPPA gene is expressed primarily in atrial myocytes and consists of 2 introns and three exons, with translation of this gene yielding a high molecular mass 151 amino acid polypeptide known as preproANP. (wikipedia.org)
- In the blood, BK is generated from circulating high- and low-molecular-weight kininogens chiefly by plasma kallikein (4), and ANP is secreted primarily by atrial myocytes in response to local wall stretching (5). (scielo.br)
- 7. Extracellular signal-regulated protein kinase activation is required for the anti-hypertrophic effect of atrial natriuretic factor in neonatal rat ventricular myocytes. (nih.gov)
- We now show using RNA interference that CIP4 expression in neonatal rat ventricular myocytes is required for the induction of non-mitotic, hypertrophic growth by the α-adrenergic agonist phenylephrine, the IL-6 cytokine leukemia inhibitor factor, and fetal bovine serum, as assayed using morphometry, immunocytochemistry for the hypertrophic marker atrial natriuretic factor and [ 3 H]leucine incorporation for de novo protein synthesis. (biomedcentral.com)
Hormone1
- Atrial natriuretic peptide (ANP) or atrial natriuretic factor (ANF) is a natriuretic peptide hormone secreted from the cardiac atria that in humans is encoded by the NPPA gene. (wikipedia.org)
Prohormone1
- Polypeptides of about 150 amino acids that serve as precursors to prohormone of ATRIAL NATRIURETIC FACTOR , a 126-amino acid polypeptide or ANP (1-126). (nih.gov)
Rats4
- they had natriuretic activity in rats. (portlandpress.com)
- Using a knock-in (KI) rat model, researchers found an AF-associated human variant in NPPA caused inflammation, fibroblast activation, atrial fibrosis, and AF in KI rats. (wikipedia.org)
- The present study was designed to examine the chronic (5 day) and acute (2 hr) hemodynamic effects of atrial natriuretic factor (ANF) in conscious normotensive rats. (tulane.edu)
- The nephron sites involved in the blunted natriuretic response to frusemide during sodium depletion were investigated using micropuncture techniques in anaesthetized rats. (portlandpress.com)
Brain6
- ANP is closely related to BNP (brain natriuretic peptide) and CNP (C-type natriuretic peptide), which all share a similar amino acid ring structure. (wikipedia.org)
- 5. Receptor-mediated stimulatory effect of atrial natriuretic factor, brain natriuretic peptide, and C-type natriuretic peptide on testosterone production in purified mouse Leydig cells: activation of cholesterol side-chain cleavage enzyme. (nih.gov)
- This study aimed to assess the role of diastolic dysfunction, abnormal myocardial strain and elevated brain natriuretic peptide (BNP) in the early identification of cardiac involvement in Chagas disease. (plos.org)
- Diastolic dysfunction and elevated brain natriuretic peptide levels are present in different cardiomyopathies and in advanced phases of Chagas disease. (plos.org)
- We conducted a study to assess the diastolic function, regional systolic abnormalities and brain natriuretic peptide levels in the different forms of Chagas disease. (plos.org)
- Most notable of these cardiac biomarkers are: atrial natriuretic peptide (ANP) 1 , brain natriuretic peptide (BNP) 2 , N-terminal proANP fragments (NT-pro ANP) 3 , NT proBNP fragments 4 and cardiac troponins (cTn) 5 . (vin.com)
Bradykinin4
- The purified enzyme hydrolyzed the Pro7-Phe8 bond of bradykinin and the Ser25-Tyr26 bond of atrial natriuretic peptide. (scielo.br)
- The high affinity of this endopeptidase for bradykinin (Km = 10 µM) and for atrial natriuretic peptide (Km = 5 µM) suggests that it may play a physiological role in the inactivation of these circulating hypotensive peptide hormones. (scielo.br)
- The purified enzyme hydrolyzed the Pro 7 -Phe 8 bond of bradykinin and the Ser 25 -Tyr 26 bond of atrial natriuretic peptide. (scielo.br)
- The circulating peptide hormones bradykinin (BK) and atrial natriuretic peptide (ANP) are very powerful vasodilators that may participate in the physiological control of arterial pressure (1-5). (scielo.br)
Vasopressin2
- 10. Atrial natriuretic peptide, oxytocin, and vasopressin increase guanosine 3',5'-monophosphate in LLC-PK1 kidney epithelial cells. (nih.gov)
- To elucidate the role of atrial natriuretic peptide (ANP) and vasopressin (VP) in a hypertensive state, ANP and VP receptor bindings in spontaneously hypertensive rat (SHR) kidney were analyzed using the radiolabeled receptor assay (RRA) technique. (elsevierpure.com)
Oxytocin1
- Coexistence of intestinal trefoil factor (hITF) and oxytocin in magnocellular neurons in the human hypothalamus. (nih.gov)
Insulin1
- To examine the relationship between the sodium-retaining actions of insulin and atrial natriuretic factor (ANF), 16 healthy subjects were studied on three occasions, ~1 wk apart, using standard clearance techniques to evaluate responses during the acute administration of insulin, low-dose ANF, or both. (biu.ac.il)
Substances1
- Both energetic substances up-regulated the manifestation of vascular endothelial development factor (VEGF) as well as the researchers demonstrated that activation from the VEGF pathway was adequate to suppress the phenotype from the gridlock mutation. (icsv20.org)
Stimulation3
- Following stimulation of atrial cells, proANP is released and rapidly converted to the 28-amino-acid C-terminal mature ANP on the cell surface by the cardiac transmembrane serine protease corin. (wikipedia.org)
- 9. Calcium and calmodulin regulate atrial natriuretic factor stimulation of cyclic GMP in a human renal cell line. (nih.gov)
- 16. Stimulation of testosterone production by atrial natriuretic peptide in isolated mouse Leydig cells results from a promiscuous activation of cyclic AMP-dependent protein kinase by cyclic GMP. (nih.gov)
Sodium3
- 1. The effect of partially purified rat atrial natriuretic factor on sodium efflux from sodium-loaded human erythrocytes was studied. (portlandpress.com)
- 14. Effects of atrial natriuretic peptide and sodium nitroprusside on epidermal growth factor-stimulated wound repair in rabbit corneal epithelial cells. (nih.gov)
- 19. Actions of C-type natriuretic peptide and sodium nitroprusside on carbachol-stimulated inositol phosphate formation and contraction in ciliary and iris sphincter smooth muscles. (nih.gov)
Arterial2
- Temperature dependence was also examined with respect to the effects of atrial natriuretic peptide (ANP) on drinking and arterial pressure. (bioone.org)
- The ScaI gene polymorphism of the atrial natriuretic factor and essential arterial hypertension in childhood. (cdc.gov)
Myocardial1
- Association of the ScaI atrial natriuretic peptide gene polymorphism with nonfatal myocardial infarction and extent of coronary artery disease. (cdc.gov)
Concentrations1
- Plasma concentrations of atrial natriuretic peptide (ANP) and hemodynamic parameters were investigated in five premature infants undergoing exchange transfusion. (elsevierpure.com)
Regulation1
- 1. The role of Ca2+ and calmodulin in the regulation of atrial natriuretic peptide-stimulated guanosine 3',5'-cyclic monophosphate accumulation by isolated mouse Leydig cells. (nih.gov)
Kidney2
- 4. The results suggest that atrial natriuretic factor acts in the kidney by mechanisms other than through inhibition of the Na + -K + exchange pump or the Na + -K + cotransport system. (portlandpress.com)
- The discovery of a natriuretic factor (one that promotes kidney excretion of salt and water) was first reported by Adolfo José de Bold in 1981 when rat atrial extracts were found to contain a substance that increased salt and urine output in the kidney. (wikipedia.org)
Cells6
- 2. Steroidogenic effect of atrial natriuretic factor in isolated mouse Leydig cells is mediated by cyclic GMP. (nih.gov)
- 3. Effect of a tumour-promoting phorbol ester on atrial peptide-induced testosterone production and cyclic GMP accumulation by isolated mouse Leydig cells. (nih.gov)
- 6. HS-142-1 inhibits testosterone production and guanosine-3':5'-cyclic monophosphate accumulation stimulated by atrial natriuretic peptide in isolated mouse Leydig cells. (nih.gov)
- 17. Histones inhibit human chorionic gonadotrophin-stimulated but not atrial peptide-stimulated testosterone production and cyclic nucleotide formation by isolated mouse Leydig cells. (nih.gov)
- WT1, a transcriptional factor for nephrin, was detected in nucleus in podocyte-like cells in all stages. (go.jp)
- In H9C2 cells, GRK2 overexpression increased atrial natriuretic factor (ANF) activity and enhanced phenylephrine-induced ANF response, and this is associated with an increase of NFκB transcriptional activity. (elsevierpure.com)
Abstract1
- abstract = "Circulating atrial natriuretic peptide (ANP) was assayed before and after postural change and exercise in 54 patients with familial dysautonomia (FD) and 20 controls. (princeton.edu)
Hypertension1
- Polymorphisms in the hANP (human atrial natriuretic peptide) gene, albuminuria, and hypertension. (cdc.gov)
Substance1
- Later, the substance was purified from heart tissue by several groups and named atrial natriuretic factor (ANF) or ANP. (wikipedia.org)
Suggests1
- This variability, or heterogeneity, in clinical presentation suggests complex interactions between environmental and biological factors, resulting in several underlying pathophysiological mechanisms in the development and progression of AUD. (nih.gov)
Function1
- 4. Effect of cyclic GMP-increasing agents nitric oxide and C-type natriuretic peptide on bovine chromaffin cell function: inhibitory role mediated by cyclic GMP-dependent protein kinase. (nih.gov)
Clinical1
- We sought to determine the degree to which B-type natriuretic peptide (BNP) adds to clinical judgment in the diagnosis of congestive heart failure (CHF). (nih.gov)
Tumor1
- C-reactive protein, tumor necrosis factor-α [TNF- α]), genetic markers (e.g. (vin.com)
Involvement1
- The sensitivity to ANP, a physiological regulator of drinking in eels, was not altered by the temperature, suggesting an involvement of other factors in the thermogenic drinking that is demonstrated in this study. (bioone.org)
Found1
- Neurons immunoreactive for atrial natriuretic factor were found in the supraoptic, periventricular and paraventricular nuclei. (nih.gov)