Polyurethanes
Toluene 2,4-Diisocyanate
Paint
Peripheral Nervous System Agents
Air Pollutants, Occupational
Occupational Exposure
Chemical Industry
Xylenes
A family of isomeric, colorless aromatic hydrocarbon liquids, that contain the general formula C6H4(CH3)2. They are produced by the destructive distillation of coal or by the catalytic reforming of petroleum naphthenic fractions. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Inhalation Exposure
Alveolitis, Extrinsic Allergic
A common interstitial lung disease caused by hypersensitivity reactions of PULMONARY ALVEOLI after inhalation of and sensitization to environmental antigens of microbial, animal, or chemical sources. The disease is characterized by lymphocytic alveolitis and granulomatous pneumonitis.
Ecotoxicology
Atmosphere Exposure Chambers
Local Lymph Node Assay
The local lymph node assay (LLNA) is an alternative method for the identification of chemicals that have the ability to cause skin sensitization and allergic contact dermatitis. Endpoints have been established so fewer animals are required and less painful procedures are used.
Immunoproteins
Automobiles
Methacholine Chloride
A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)
Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Phenylenediamines
Phenylenediamines are chemical compounds that contain two amino groups (-NH2) linked to a phenyl ring, which have been used in certain pharmaceuticals and industrial applications, but can also pose health risks as potential allergens and carcinogens.
Industry
Respiratory Protective Devices
Environmental Monitoring
Benzene
Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.
Methacholine Compounds
Allergens
Benzene Derivatives
Bronchi
Aerosols
Immunoglobulin E
Pseudomonas putida
Respiratory Hypersensitivity
A form of hypersensitivity affecting the respiratory tract. It includes ASTHMA and RHINITIS, ALLERGIC, SEASONAL.
Solvents
Administration, Inhalation
Oxygenases
Serum Albumin
Trichloroethylene
Receptors, Histamine H1
A class of histamine receptors discriminated by their pharmacology and mode of action. Most histamine H1 receptors operate through the inositol phosphate/diacylglycerol second messenger system. Among the many responses mediated by these receptors are smooth muscle contraction, increased vascular permeability, hormone release, and cerebral glyconeogenesis. (From Biochem Soc Trans 1992 Feb;20(1):122-5)
Bronchial Provocation Tests
Hydrocarbons, Aromatic
Albumins
Carbon-Carbon Lyases
Cresols
Cresols, also known as hydroxytoluene, are a group of phenolic compounds including ortho-cresol, meta-cresol, and para-cresol, which differ in the position of the hydroxyl group on the benzene ring.
Environmental Exposure
Lung
Pseudomonas
Bronchoalveolar Lavage Fluid
Pseudomonas mendocina
A species of gram-negative bacteria in the genus PSEUDOMONAS, which is found in SOIL and WATER.
Hydrocarbons
Hydrocarbons are organic compounds consisting entirely of hydrogen and carbon atoms, forming the basis of classes such as alkanes, alkenes, alkynes, and aromatic hydrocarbons, which play a vital role in energy production and chemical synthesis.
Chlorobenzenes
Guinea Pigs
Volatilization
Immunoglobulin G
Enzyme-Linked Immunosorbent Assay
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Biological Markers
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.