A junctional adhesion molecule subtype that is localized to high endothelial VENULES, heart ENDOTHELIUM, TROPHOBLASTS of the PLANCENTA, and in the ENDOTHELIUM of ARTERIOLES.

A family of membrane glycoproteins localized to TIGHT JUNCTIONS that contain two extracellular Ig-like domains, a single transmembrane segment, and a cytoplasmic tail of variable length.

A junctional adhesion molecule subtype that is expressed at high levels in PLACENTA; BRAIN; KIDNEY; and PLATELETS. It serves a variety of functions such as mediating leukocyte-platelet interactions, regulating trans-epithelial migration of POLYMORPHONUCLEAR LEUKOCYTES, and acting as a counter receptor for ALPHAM INTEGRIN.

Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.

A cell adhesion protein that is found within TIGHT JUNCTIONS of ENDOTHELIAL CELLS and on the CELL MEMBRANE surface of circulating PLATELETS.

Cell-cell junctions that seal adjacent epithelial cells together, preventing the passage of most dissolved molecules from one side of the epithelial sheet to the other. (Alberts et al., Molecular Biology of the Cell, 2nd ed, p22)

A species of the genus VESIVIRUS infecting cats. Transmission occurs via air and mechanical contact.

Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.

A 195-kDa zonula occludens protein that is distinguished by the presence of a ZU5 domain at the C-terminal of the molecule.

Adherence of cells to surfaces or to other cells.

A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.