Penta-O-galloyl-beta-D-glucose induces G1 arrest and DNA replicative S-phase arrest independently of cyclin-dependent kinase inhibitor 1A, cyclin-dependent kinase inhibitor 1B and P53 in human breast cancer cells and is orally active against triple negative xenograft growth.
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Extended access methamphetamine decreases immature neurons in the hippocampus which results from loss and altered development of neural progenitors without altered dynamics of the S-phase of the cell cycle.
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Xanthoxyletin, a coumarin induces S phase arrest and apoptosis in human gastric adenocarcinoma SGC-7901 cells.
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This study was conducted to explore the novel anticancer compounds from Chinese herbs. During the process of screening, to evaluate the potential chemopreventive effect of natural compounds, Xanthoxyletin was isolated from Erythrina variegata. It has been reported that Xanthoxyletin possesses antibacterial, fungicidal, and algicidal properties. In this study, we examined the antiproliferative effects of Xanthoxyletin against SGC-7901 cells and its ability to induce apoptosis and cell cycle arrest for the first time. We observed that its inhibitory effects on cells were associated with the DNA damage, apoptosis through mitochondrial dysfunction, and cell cycle arrest at S phase in a dose-dependent manner. Additionally, Xanthoxyletin also increased the production of reactive oxygen species in SGC-7901 cells. These results suggest that Xanthoxyletin may be promising anticancer agent and has worth for further mechanistic and therapeutic studies against gastric cancer. (+info)
Mechanism of T-oligo-induced cell cycle arrest in Mia-PaCa pancreatic cancer cells.
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Functional characterization of the Saccharomyces cerevisiae protein Chl1 reveals the role of sister chromatid cohesion in the maintenance of spindle length during S-phase arrest.
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